SIMILAR PATTERNS OF AMINO ACIDS FOR 5OTR_A_ACTA401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  69
ARG A  73
ARG A 152
LEU A 174
 TPO  A 183 ( 2.8A)
TPO  A 183 ( 2.8A)
TPO  A 183 ( 2.8A)
None
 0.97A 5otrA-1cm8A:
28.5		 5otrA-1cm8A:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		4 ARG A  80
ARG A 155
LEU A 178
ASN A 189
 None
 0.27A 5otrA-1m2pA:
47.5		 5otrA-1m2pA:
74.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG X  81
ARG X 156
LEU X 179
ASN X 190
 None
 0.74A 5otrA-3e3bX:
45.7		 5otrA-3e3bX:
83.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 LYS A1026
ARG A1045
LEU A1014
ASN A1044
 None
 1.45A 5otrA-3vd8A:
undetectable		 5otrA-3vd8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LYS A  60
ARG A  63
ARG A 138
LEU A 160
 TPO  A 172 ( 3.5A)
TPO  A 172 ( 3.6A)
TPO  A 172 ( 2.4A)
None
 0.77A 5otrA-4cfhA:
7.8		 5otrA-4cfhA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ARG A  81
ARG A 194
LEU A 217
ASN A 228
 None
 0.35A 5otrA-4jr7A:
44.1		 5otrA-4jr7A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG E  80
ARG E 155
LEU E 178
ASN E 189
 None
 0.44A 5otrA-4md8E:
49.3		 5otrA-4md8E:
94.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7q INTERFERON-INDUCIBLE
PROTEIN AIM2

(Homo sapiens) 		PF02758
(PYRIN) 		4 LYS A  26
ARG A  45
LEU A  14
ASN A  44
 None
 1.40A 5otrA-4o7qA:
undetectable		 5otrA-4o7qA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		4 ARG A 333
ARG A 343
LEU A 321
ASN A 316
 None
 1.36A 5otrA-5c2iA:
0.0		 5otrA-5c2iA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A  80
ARG A 155
LEU A 178
ASN A 189
 None
 0.08A 5otrA-5movA:
50.8		 5otrA-5movA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE

(Brucella suis) 		PF00106
(adh_short) 		4 ARG A  16
ARG A 191
LEU A 149
ASN A 239
 None
 1.14A 5otrA-5tgdA:
undetectable		 5otrA-5tgdA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ARG A  84
ARG A 159
LEU A 182
ASN A 193
 SO4  A 401 (-2.8A)
SO4  A 401 (-3.0A)
None
SO4  A 401 (-3.7A)
 0.28A 5otrA-5xvuA:
45.9		 5otrA-5xvuA:
61.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 LYS A2245
ARG A2255
LEU A2285
ASN A2181
 None
 0.84A 5otrA-6emkA:
0.0		 5otrA-6emkA:
undetectable