SIMILAR PATTERNS OF AMINO ACIDS FOR 5OSP_A_ACTA403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 VAL A  93
ILE A  91
VAL A  38
ALA A  14
 None
 0.76A 5ospA-1ahiA:
0.0		 5ospA-1ahiA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7f PROTEIN (SXL-LETHAL
PROTEIN)

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		4 ILE A 242
VAL A 215
PRO A 219
ALA A 255
 None
 0.73A 5ospA-1b7fA:
undetectable		 5ospA-1b7fA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		4 TYR A 133
VAL A  47
VAL A  70
ALA A 122
 SO4  A 903 (-3.8A)
None
None
None
 0.76A 5ospA-1e3hA:
0.0		 5ospA-1e3hA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF01012
(ETF) 		4 VAL B 150
ILE B 152
VAL B 172
ALA B 157
 None
 0.71A 5ospA-1efpB:
undetectable		 5ospA-1efpB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 126
ASP A 128
PRO A 129
ALA A 103
 None
 0.76A 5ospA-1gycA:
0.0		 5ospA-1gycA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 VAL A 367
ILE A 364
PRO A 359
ALA A 345
 None
 0.71A 5ospA-1k32A:
0.8		 5ospA-1k32A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 126
ASP A 128
PRO A 129
ALA A 103
 None
 0.76A 5ospA-1kyaA:
0.0		 5ospA-1kyaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 137
ILE A  91
VAL A  34
ALA A 132
 None
 0.66A 5ospA-1lluA:
0.0		 5ospA-1lluA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 VAL A 603
ILE A 606
VAL A 548
ALA A 487
 None
 0.52A 5ospA-1mz5A:
0.5		 5ospA-1mz5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oul STRINGENT STARVATION
PROTEIN B HOMOLOG

(Haemophilus
influenzae) 		PF04386
(SspB) 		5 VAL A  31
ILE A  50
VAL A  38
PRO A  41
ALA A  33
 None
 1.46A 5ospA-1oulA:
undetectable		 5ospA-1oulA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		4 TYR A 323
ILE A 411
VAL A 347
ALA A 362
 None
 0.77A 5ospA-1pixA:
undetectable		 5ospA-1pixA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxz MAJOR POLLEN
ALLERGEN JUN A 1

(Juniperus ashei) 		PF00544
(Pec_lyase_C) 		4 VAL A 158
ILE A 185
VAL A 116
ALA A 161
 None
 0.71A 5ospA-1pxzA:
undetectable		 5ospA-1pxzA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sef CONSERVED
HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF05899
(Cupin_3)
PF07883
(Cupin_2) 		4 VAL A  48
ILE A  50
VAL A 132
ALA A  67
 None
 0.51A 5ospA-1sefA:
undetectable		 5ospA-1sefA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul1 FLAP ENDONUCLEASE-1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 TYR X  26
VAL X  31
ILE X  33
ALA X 176
 None
 0.72A 5ospA-1ul1X:
undetectable		 5ospA-1ul1X:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Nostoc sp. PCC
7120) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 TYR A 125
VAL A 127
ILE A  99
ALA A 325
 None
 0.76A 5ospA-1vquA:
undetectable		 5ospA-1vquA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyv CALCIUM CHANNEL
BETA-4SUBUNIT

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		4 VAL A 222
ILE A 315
VAL A 258
ALA A 312
 None
 0.71A 5ospA-1vyvA:
undetectable		 5ospA-1vyvA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wge HYPOTHETICAL PROTEIN
2610018L09RIK

(Mus musculus) 		PF05207
(zf-CSL) 		5 TYR A  29
VAL A  64
ILE A  62
PRO A  32
ALA A  53
 None
 1.20A 5ospA-1wgeA:
undetectable		 5ospA-1wgeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuq SUPEROXIDE DISMUTASE

(Bacillus
anthracis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 TYR A 199
VAL A 161
ILE A 162
PRO A  98
ALA A 195
 None
 1.29A 5ospA-1xuqA:
undetectable		 5ospA-1xuqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwv DER F II

(Dermatophagoides
farinae) 		PF02221
(E1_DerP2_DerF2) 		4 VAL A  65
ILE A  63
VAL A 106
ALA A  56
 PE3  A1001 ( 4.0A)
None
PE3  A1001 ( 4.7A)
PE3  A1001 ( 4.1A)
 0.65A 5ospA-1xwvA:
undetectable		 5ospA-1xwvA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3j COPPER-TRANSPORTING
ATPASE 1

(Homo sapiens) 		PF00403
(HMA) 		4 VAL A   9
ILE A   7
VAL A  36
ALA A  43
 None
 0.69A 5ospA-1y3jA:
undetectable		 5ospA-1y3jA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvc MRR5

(Methanococcus
maripaludis) 		PF01938
(TRAM) 		5 VAL A  21
ILE A  23
VAL A  41
PRO A  44
ALA A  34
 None
 0.92A 5ospA-1yvcA:
undetectable		 5ospA-1yvcA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzs SULFIREDOXIN

(Homo sapiens) 		PF02195
(ParBc) 		4 VAL A  81
ILE A  79
VAL A  44
ALA A 115
 None
 0.57A 5ospA-1yzsA:
undetectable		 5ospA-1yzsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 VAL A 358
ILE A 360
VAL A 419
ALA A 396
 None
 0.75A 5ospA-1zczA:
undetectable		 5ospA-1zczA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 TYR A 503
ILE A 427
VAL A 514
ALA A 451
 None
 0.78A 5ospA-2a7sA:
undetectable		 5ospA-2a7sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1)
PF13893
(RRM_5) 		4 VAL A 367
ILE A 369
VAL A 341
ALA A 377
 None
 0.52A 5ospA-2adcA:
undetectable		 5ospA-2adcA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au3 DNA PRIMASE

(Aquifex
aeolicus) 		PF01807
(zf-CHC2)
PF08275
(Toprim_N)
PF13155
(Toprim_2) 		4 VAL A 266
ILE A 239
VAL A 288
ALA A 245
 None
 0.67A 5ospA-2au3A:
undetectable		 5ospA-2au3A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cpi CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 4

(Mus musculus) 		PF00076
(RRM_1) 		4 VAL A 176
ILE A 173
VAL A 113
ALA A 188
 None
 0.71A 5ospA-2cpiA:
undetectable		 5ospA-2cpiA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02615
(Ldh_2) 		4 VAL A 280
ASP A 282
PRO A 283
ALA A 111
 None
 0.77A 5ospA-2cwfA:
undetectable		 5ospA-2cwfA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5a HYPOTHETICAL PROTEIN
PH1109

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2) 		5 TYR A  93
VAL A  71
ILE A  78
VAL A  28
ALA A  26
 COA  A 200 (-4.5A)
None
None
None
None
 1.15A 5ospA-2d5aA:
undetectable		 5ospA-2d5aA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5y ATP SYNTHASE EPSILON
CHAIN

(Bacillus sp.
PS3) 		PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N) 		4 VAL A  63
ILE A  61
VAL A  25
ALA A  50
 None
 0.71A 5ospA-2e5yA:
undetectable		 5ospA-2e5yA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A  51
ILE A  49
VAL A  29
ALA A   8
 None
 0.72A 5ospA-2eklA:
undetectable		 5ospA-2eklA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2evr COG0791: CELL
WALL-ASSOCIATED
HYDROLASES
(INVASION-ASSOCIATED
PROTEINS)

(Nostoc
punctiforme) 		PF00877
(NLPC_P60) 		4 ILE A 155
VAL A 166
ASP A 164
ALA A 222
 None
 0.75A 5ospA-2evrA:
undetectable		 5ospA-2evrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 VAL A  31
ILE A  34
VAL A  73
ALA A  39
 None
 0.76A 5ospA-2f43A:
undetectable		 5ospA-2f43A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A 189
ILE A 191
VAL A 153
PRO A 157
ALA A 198
 None
 0.66A 5ospA-2g4bA:
undetectable		 5ospA-2g4bA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		4 VAL A  79
ILE A  81
VAL A 184
ALA A 109
 None
 0.76A 5ospA-2gd2A:
undetectable		 5ospA-2gd2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge3 PROBABLE
ACETYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00583
(Acetyltransf_1) 		4 TYR A  97
VAL A   8
ILE A  10
ALA A  63
 None
 0.75A 5ospA-2ge3A:
undetectable		 5ospA-2ge3A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 126
ASP A 128
PRO A 129
ALA A 103
 None
 0.77A 5ospA-2hzhA:
undetectable		 5ospA-2hzhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iph THIOL PROTEASE P3C

(Norwalk virus) 		PF05416
(Peptidase_C37) 		4 VAL A1085
ILE A1087
ASP A1138
ALA A1141
 None
 0.77A 5ospA-2iphA:
undetectable		 5ospA-2iphA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Sulfolobus
solfataricus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 VAL A  21
ILE A  23
VAL A 182
ALA A 167
 None
 0.70A 5ospA-2izoA:
undetectable		 5ospA-2izoA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4q THIOREDOXIN

(Mycobacterium
tuberculosis) 		PF00085
(Thioredoxin) 		4 VAL A  12
ILE A  10
VAL A  30
ALA A  61
 None
 0.60A 5ospA-2l4qA:
undetectable		 5ospA-2l4qA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mtg LA-RELATED PROTEIN 6

(Homo sapiens) 		no annotation 4 VAL A 230
ILE A 232
VAL A 188
ALA A 259
 None
 0.67A 5ospA-2mtgA:
undetectable		 5ospA-2mtgA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 TYR A 509
VAL A 457
ILE A 459
ALA A 482
 None
 0.71A 5ospA-2o7qA:
undetectable		 5ospA-2o7qA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE

(Shewanella
oneidensis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 VAL A 118
ILE A 116
VAL A 171
ALA A 148
 None
 0.73A 5ospA-2oasA:
undetectable		 5ospA-2oasA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pww UNCHARACTERIZED
PROTEIN

(Bacillus
clausii) 		PF08868
(YugN) 		4 VAL A  71
ILE A  73
VAL A  38
ALA A  57
 None
 0.58A 5ospA-2pwwA:
undetectable		 5ospA-2pwwA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 467
ILE A 469
VAL A 392
ALA A 443
 None
 0.68A 5ospA-2q27A:
undetectable		 5ospA-2q27A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2b CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE

(Mus musculus) 		PF03061
(4HBT) 		4 VAL A 233
ILE A 236
VAL A 266
ALA A 286
 None
 0.71A 5ospA-2q2bA:
undetectable		 5ospA-2q2bA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qny 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Mycobacterium
tuberculosis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A 242
VAL A 315
PRO A 317
ALA A 299
 None
 0.74A 5ospA-2qnyA:
undetectable		 5ospA-2qnyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq2 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE

(Homo sapiens) 		PF03061
(4HBT) 		4 VAL A 265
ILE A 268
VAL A 298
ALA A 318
 None
 0.74A 5ospA-2qq2A:
undetectable		 5ospA-2qq2A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qrr METHIONINE IMPORT
ATP-BINDING PROTEIN
METN

(Vibrio
parahaemolyticus) 		PF09383
(NIL) 		4 VAL A  48
ILE A  50
VAL A  23
ALA A  68
 None
 0.77A 5ospA-2qrrA:
undetectable		 5ospA-2qrrA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rrb CDNA FLJ40872 FIS,
CLONE TUTER2000283,
HIGHLY SIMILAR TO
HOMO SAPIENS
TRANSFORMER-2-BETA
(SFRS10) GENE

(Homo sapiens) 		PF00076
(RRM_1) 		4 VAL A 147
ILE A 149
VAL A 122
ALA A 162
 None
 0.69A 5ospA-2rrbA:
undetectable		 5ospA-2rrbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 TYR A  52
VAL A  70
ILE A 130
VAL A  39
ALA A  54
 None
 1.49A 5ospA-2rsvA:
16.1		 5ospA-2rsvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjg FERROUS IRON
TRANSPORT PROTEIN B
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF02421
(FeoB_N) 		4 VAL A  86
ILE A  88
VAL A 142
ALA A 114
 None
 0.76A 5ospA-2wjgA:
undetectable		 5ospA-2wjgA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wji FERROUS IRON
TRANSPORT PROTEIN B
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF02421
(FeoB_N) 		4 VAL A  86
ILE A  88
VAL A 142
ALA A 114
 None
 0.70A 5ospA-2wjiA:
undetectable		 5ospA-2wjiA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 126
ASP A 128
PRO A 129
ALA A 103
 None
 0.73A 5ospA-2xybA:
undetectable		 5ospA-2xybA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn1 LGPCA THIOREDOXIN

(synthetic
construct) 		PF00085
(Thioredoxin) 		4 VAL A   6
ILE A   4
VAL A  24
ALA A  55
 None
 0.67A 5ospA-2yn1A:
undetectable		 5ospA-2yn1A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypd PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 VAL A2343
ILE A2345
VAL A2194
ALA A2457
 None
 0.66A 5ospA-2ypdA:
undetectable		 5ospA-2ypdA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625

(Thermus
thermophilus) 		PF13277
(YmdB) 		4 VAL A   9
ILE A   6
VAL A  61
ALA A  34
 None
 0.71A 5ospA-2z06A:
undetectable		 5ospA-2z06A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF03717
(PBP_dimer) 		4 VAL A 114
ILE A 178
VAL A 149
ALA A  98
 None
 0.74A 5ospA-2z2mA:
undetectable		 5ospA-2z2mA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z69 DNR PROTEIN

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding) 		4 VAL A  61
ILE A  63
VAL A  43
ALA A 100
 None
 0.73A 5ospA-2z69A:
undetectable		 5ospA-2z69A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2k TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		4 VAL A 374
ASP A 376
PRO A 377
ALA A 446
 None
 0.66A 5ospA-3a2kA:
undetectable		 5ospA-3a2kA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a45 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Acanthamoeba
polyphaga
mimivirus) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		5 ILE A 285
VAL A 264
ASP A 258
PRO A 259
ALA A 282
 None
 1.29A 5ospA-3a45A:
undetectable		 5ospA-3a45A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		4 VAL A  97
ILE A  95
VAL A  66
ALA A  36
 None
 0.60A 5ospA-3bfjA:
undetectable		 5ospA-3bfjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccq 50S RIBOSOMAL
PROTEIN L4P

(Haloarcula
marismortui) 		PF00573
(Ribosomal_L4) 		4 VAL C 139
VAL C  16
PRO C  19
ALA C   3
 None
 0.71A 5ospA-3ccqC:
undetectable		 5ospA-3ccqC:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2w TAR DNA-BINDING
PROTEIN 43

(Mus musculus) 		PF00076
(RRM_1) 		4 VAL A 220
ILE A 222
VAL A 195
ALA A 230
 None
 0.61A 5ospA-3d2wA:
undetectable		 5ospA-3d2wA:
13.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		5 TYR X  40
VAL X  68
ILE X  70
VAL X 102
ALA X 111
 None
 0.54A 5ospA-3e3bX:
46.6		 5ospA-3e3bX:
83.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 VAL A 572
ILE A 574
VAL A 502
PRO A 361
ALA A 509
 None
 1.21A 5ospA-3ecqA:
undetectable		 5ospA-3ecqA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fca CYSTEINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 VAL A 165
ILE A 171
VAL A 229
ALA A 190
 None
 0.75A 5ospA-3fcaA:
undetectable		 5ospA-3fcaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 348
ILE A 350
VAL A  62
ALA A  33
 None
 0.63A 5ospA-3fplA:
undetectable		 5ospA-3fplA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 348
ILE A 350
VAL A  62
ALA A  33
 None
 0.74A 5ospA-3fsrA:
undetectable		 5ospA-3fsrA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1

(Streptomyces
antibioticus) 		PF16670
(PI-PLC-C1) 		4 ILE A 194
VAL A 258
ASP A 260
ALA A 234
 None
None
EOH  A 358 (-4.1A)
None
 0.48A 5ospA-3h4xA:
undetectable		 5ospA-3h4xA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj7 TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF11734
(TilS_C) 		4 VAL A 374
ASP A 376
PRO A 377
ALA A 446
 None
None
None
CL  A   1 (-4.1A)
 0.72A 5ospA-3hj7A:
undetectable		 5ospA-3hj7A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjh TRANSCRIPTION-REPAIR
-COUPLING FACTOR

(Escherichia
coli) 		no annotation 5 VAL A 385
ILE A 444
VAL A 435
PRO A 359
ALA A 442
 None
 1.23A 5ospA-3hjhA:
undetectable		 5ospA-3hjhA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 TYR A 278
ILE A  50
VAL A  18
ASP A 164
 None
 0.69A 5ospA-3il4A:
undetectable		 5ospA-3il4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 TYR B 248
ILE B 224
VAL B 201
ALA B 191
 None
 0.76A 5ospA-3jcmB:
undetectable		 5ospA-3jcmB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Marinobacter
hydrocarbonoclasticus) 		PF00365
(PFK) 		5 TYR A   8
VAL A  39
ILE A  36
VAL A  25
ALA A  29
 None
 1.12A 5ospA-3k2qA:
undetectable		 5ospA-3k2qA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE

(Mesorhizobium
loti) 		PF12697
(Abhydrolase_6) 		4 VAL A 222
ILE A 224
PRO A 133
ALA A 128
 None
 0.73A 5ospA-3kxpA:
undetectable		 5ospA-3kxpA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8d METHYLTRANSFERASE

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		5 TYR A  76
VAL A  57
ILE A 120
VAL A  51
ALA A 119
 None
 1.36A 5ospA-3l8dA:
undetectable		 5ospA-3l8dA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l93 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Yersinia pestis) 		PF01467
(CTP_transf_like) 		4 VAL A  87
ILE A  85
VAL A  32
ALA A   5
 None
 0.47A 5ospA-3l93A:
undetectable		 5ospA-3l93A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwb D-ALANINE--D-ALANINE
LIGASE

(Mycobacterium
tuberculosis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 VAL A  48
ILE A  46
VAL A 113
ALA A  14
 None
 0.64A 5ospA-3lwbA:
undetectable		 5ospA-3lwbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		4 VAL X 864
ILE X 866
VAL X 822
ALA X 938
 None
 0.72A 5ospA-3lxuX:
undetectable		 5ospA-3lxuX:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		4 VAL A 305
VAL A 250
PRO A 247
ALA A  82
 None
 0.67A 5ospA-3mc2A:
undetectable		 5ospA-3mc2A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzh PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
CRP/FNR-FAMILY)

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 VAL A  55
ILE A  57
VAL A  37
ALA A  93
 None
CMP  A 623 ( 4.1A)
None
None
 0.68A 5ospA-3mzhA:
undetectable		 5ospA-3mzhA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		4 VAL A  52
ILE A  54
VAL A 131
ALA A  96
 None
 0.69A 5ospA-3nfbA:
undetectable		 5ospA-3nfbA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nut PRECORRIN-3
METHYLASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		4 VAL A 197
ILE A 204
VAL A 222
ALA A 194
 SAH  A1501 (-3.9A)
None
SAH  A1501 ( 4.2A)
None
 0.68A 5ospA-3nutA:
undetectable		 5ospA-3nutA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 VAL A 256
ILE A 258
VAL A 226
ALA A 237
 None
 0.70A 5ospA-3op1A:
undetectable		 5ospA-3op1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owu STEROID
DELTA-ISOMERASE

(Pseudomonas
putida) 		PF12680
(SnoaL_2) 		4 VAL A  20
ILE A  17
VAL A  88
ALA A  68
 EQU  A 200 ( 4.9A)
None
None
None
 0.65A 5ospA-3owuA:
undetectable		 5ospA-3owuA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p54 ENVELOPE
GLYCOPROTEIN

(Japanese
encephalitis
virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 VAL A  65
ILE A  68
VAL A  91
ALA A 117
 None
 0.70A 5ospA-3p54A:
undetectable		 5ospA-3p54A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pea ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		4 VAL A  50
ILE A  52
VAL A   7
ALA A  16
 None
 0.61A 5ospA-3peaA:
undetectable		 5ospA-3peaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 VAL A  61
ILE A  59
VAL A  10
ALA A  34
 None
 0.58A 5ospA-3pk0A:
undetectable		 5ospA-3pk0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 126
ASP A 128
PRO A 129
ALA A 103
 None
 0.73A 5ospA-3pxlA:
undetectable		 5ospA-3pxlA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		4 VAL A 125
ILE A 123
PRO A 133
ALA A 130
 None
 0.64A 5ospA-3qm2A:
undetectable		 5ospA-3qm2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		4 VAL A 362
ILE A 364
VAL A 196
ALA A 354
 None
 0.55A 5ospA-3r75A:
undetectable		 5ospA-3r75A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr2 CYSTEINE SYNTHASE

(Mycobacterium
marinum) 		PF00291
(PALP) 		4 VAL A 177
ILE A 183
VAL A 240
ALA A 201
 None
 0.77A 5ospA-3rr2A:
undetectable		 5ospA-3rr2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 VAL A 235
ILE A 237
VAL A 340
ALA A 313
 None
 0.71A 5ospA-3rreA:
undetectable		 5ospA-3rreA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syq G PROTEIN-ACTIVATED
INWARD RECTIFIER
POTASSIUM CHANNEL 2

(Mus musculus) 		PF01007
(IRK) 		4 VAL A 264
ILE A 262
VAL A 308
ALA A 241
 None
 0.76A 5ospA-3syqA:
undetectable		 5ospA-3syqA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A 336
ILE A 338
VAL A   8
ALA A 180
 None
 0.68A 5ospA-3t6sA:
undetectable		 5ospA-3t6sA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 127
ASP A 129
PRO A 130
ALA A 104
 None
 0.75A 5ospA-3t6wA:
undetectable		 5ospA-3t6wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Campylobacter
jejuni) 		PF00290
(Trp_syntA) 		4 VAL A 201
ILE A 199
VAL A 217
ALA A 218
 None
 0.73A 5ospA-3thaA:
undetectable		 5ospA-3thaA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 VAL A 192
ILE A 194
VAL A 215
ALA A 203
 None
 0.75A 5ospA-3ti8A:
undetectable		 5ospA-3ti8A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqt D-ALANINE--D-ALANINE
LIGASE

(Coxiella
burnetii) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ILE A  53
VAL A  68
PRO A  64
ALA A  73
 None
 0.77A 5ospA-3tqtA:
undetectable		 5ospA-3tqtA:
22.96