SIMILAR PATTERNS OF AMINO ACIDS FOR 5OSP_A_ACTA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		4 ARG A  80
ARG A 155
LEU A 178
ASN A 189
 None
 0.31A 5ospA-1m2pA:
48.5		 5ospA-1m2pA:
74.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG X  81
ARG X 156
LEU X 179
ASN X 190
 None
 0.76A 5ospA-3e3bX:
46.6		 5ospA-3e3bX:
83.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ARG A  81
ARG A 194
LEU A 217
ASN A 228
 None
 0.34A 5ospA-4jr7A:
44.6		 5ospA-4jr7A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG E  80
ARG E 155
LEU E 178
ASN E 189
 None
 0.45A 5ospA-4md8E:
50.4		 5ospA-4md8E:
94.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A  80
ARG A 155
LEU A 178
ASN A 189
 None
 0.00A 5ospA-5movA:
52.2		 5ospA-5movA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE

(Brucella suis) 		PF00106
(adh_short) 		4 ARG A  16
ARG A 191
LEU A 149
ASN A 239
 None
 1.14A 5ospA-5tgdA:
0.0		 5ospA-5tgdA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ARG A  84
ARG A 159
LEU A 182
ASN A 193
 SO4  A 401 (-2.8A)
SO4  A 401 (-3.0A)
None
SO4  A 401 (-3.7A)
 0.34A 5ospA-5xvuA:
46.9		 5ospA-5xvuA:
61.65