SIMILAR PATTERNS OF AMINO ACIDS FOR 5OS8_A_ACTA402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		5 LYS A  77
ARG A  80
ARG A 155
LEU A 178
ASN A 189
 None
 0.29A 5os8A-1m2pA:
48.4		 5os8A-1m2pA:
75.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7a SIALIC ACID-BINDING
IG-LIKE LECTIN 8

(Homo sapiens) 		PF07686
(V-set) 		4 LYS A 116
ARG A 109
ARG A  70
ASN A  67
 None
 1.39A 5os8A-2n7aA:
0.0		 5os8A-2n7aA:
16.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		5 LYS X  78
ARG X  81
ARG X 156
LEU X 179
ASN X 190
 None
 0.92A 5os8A-3e3bX:
46.5		 5os8A-3e3bX:
84.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER

(Homo sapiens) 		PF00069
(Pkinase)
PF08332
(CaMKII_AD) 		4 LYS A  56
ARG A  59
ARG A 134
LEU A 159
 None
 1.30A 5os8A-3soaA:
23.3		 5os8A-3soaA:
23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ARG A  81
ARG A 194
LEU A 217
ASN A 228
 None
 0.33A 5os8A-4jr7A:
44.7		 5os8A-4jr7A:
56.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LYS E  77
ARG E  80
ARG E 155
LEU E 178
ASN E 189
 None
 0.48A 5os8A-4md8E:
50.2		 5os8A-4md8E:
98.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 LYS A  57
ARG A  60
ARG A 135
LEU A 160
 None
None
None
TPO  B 787 ( 4.7A)
 0.95A 5os8A-5hu3A:
27.0		 5os8A-5hu3A:
25.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LYS A  77
ARG A  80
ARG A 155
LEU A 178
ASN A 189
 None
 0.37A 5os8A-5movA:
52.0		 5os8A-5movA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LYS A  81
ARG A  84
ARG A 159
LEU A 182
ASN A 193
 ATP  A 403 (-3.4A)
SO4  A 401 (-2.8A)
SO4  A 401 (-3.0A)
None
SO4  A 401 (-3.7A)
 0.49A 5os8A-5xvuA:
46.6		 5os8A-5xvuA:
62.80