SIMILAR PATTERNS OF AMINO ACIDS FOR 5OS7_A_ACTA402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a79 TRNA ENDONUCLEASE

(Methanocaldococcus
jannaschii) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		3 HIS A 125
SER A 126
LYS A 156
 SO4  A   1 (-3.9A)
SO4  A   1 (-2.4A)
SO4  A   1 (-3.1A)
 0.81A 5os7A-1a79A:
undetectable		 5os7A-1a79A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		3 HIS A 554
SER A 555
LYS A 557
 ANP  A   1 (-4.7A)
ANP  A   1 (-4.1A)
ANP  A   1 (-2.6A)
 0.61A 5os7A-1d2nA:
0.0		 5os7A-1d2nA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 HIS A 549
SER A 550
LYS A 555
 None
 1.27A 5os7A-1d6mA:
0.0		 5os7A-1d6mA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 HIS A 840
SER A 852
LYS A 854
 None
 1.26A 5os7A-1f4hA:
undetectable		 5os7A-1f4hA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 HIS A 289
SER A 292
LYS A 297
 None
 1.41A 5os7A-1kcxA:
0.0		 5os7A-1kcxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox) 		3 HIS D  96
SER D 294
LYS D 297
 None
 1.46A 5os7A-1mtyD:
0.0		 5os7A-1mtyD:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nun FIBROBLAST GROWTH
FACTOR RECEPTOR 2
ISOFORM 2

(Homo sapiens) 		PF07679
(I-set) 		3 HIS B 213
SER B 215
LYS B 176
 None
 1.44A 5os7A-1nunB:
undetectable		 5os7A-1nunB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Haemophilus
influenzae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 HIS A 118
SER A 121
LYS A 125
 None
 1.50A 5os7A-1pquA:
0.2		 5os7A-1pquA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0v TRNA-INTRON
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		3 HIS A 257
SER A 258
LYS A 287
 None
 0.78A 5os7A-1r0vA:
0.0		 5os7A-1r0vA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3i PROBABLE CYSTEINE
DESULFURASE

(Synechocystis
sp.) 		PF00266
(Aminotran_5) 		3 HIS A 230
SER A  38
LYS A  40
 PLP  A 600 (-4.0A)
None
None
 1.06A 5os7A-1t3iA:
undetectable		 5os7A-1t3iA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9m PROBABLE
PYRIDOXAMINE
5'-PHOSPHATE OXIDASE

(Pseudomonas
aeruginosa) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 HIS A  82
SER A  85
LYS A  87
 None
FMN  A 250 (-3.5A)
FMN  A 250 (-2.7A)
 1.32A 5os7A-1t9mA:
1.2		 5os7A-1t9mA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlj HYPOTHETICAL UPF0130
PROTEIN SSO0622

(Sulfolobus
solfataricus) 		PF02676
(TYW3) 		3 HIS A  75
SER A  51
LYS A 181
 SO4  A 502 (-3.8A)
None
None
 1.32A 5os7A-1tljA:
undetectable		 5os7A-1tljA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ty9 PHENAZINE
BIOSYNTHESIS PROTEIN
PHZG

(Pseudomonas
fluorescens) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 HIS A  90
SER A  93
LYS A  95
 None
FMN  A 251 (-3.4A)
FMN  A 251 (-2.6A)
 1.29A 5os7A-1ty9A:
undetectable		 5os7A-1ty9A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE BETA
SUBUNIT

(Klebsiella
oxytoca) 		PF02288
(Dehydratase_MU) 		3 HIS B 204
SER B 200
LYS B 135
 None
CNC  B2601 (-2.7A)
CNC  B2601 (-2.8A)
 1.26A 5os7A-1uc4B:
undetectable		 5os7A-1uc4B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epr POZ-, AT HOOK-, AND
ZINC
FINGER-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 3 HIS A 377
SER A 378
LYS A 381
 ZN  A 201 ( 3.1A)
None
None
 1.24A 5os7A-2eprA:
undetectable		 5os7A-2eprA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fji EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		PF06046
(Sec6) 		3 HIS 1 672
SER 1 673
LYS 1 675
 None
 0.43A 5os7A-2fji1:
undetectable		 5os7A-2fji1:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax) 		PF00215
(OMPdecase) 		3 HIS A 231
SER A 230
LYS A 224
 None
 1.12A 5os7A-2guuA:
undetectable		 5os7A-2guuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		3 HIS A  96
SER A  99
LYS A   2
 None
 1.11A 5os7A-2h29A:
undetectable		 5os7A-2h29A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l30 POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00645
(zf-PARP) 		3 HIS A  53
SER A  55
LYS A  59
 ZN  A 109 (-3.1A)
None
ZN  A 109 ( 4.8A)
 1.02A 5os7A-2l30A:
undetectable		 5os7A-2l30A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o74 OHCU DECARBOXYLASE

(Danio rerio) 		PF09349
(OHCU_decarbox) 		3 HIS A  53
SER A  49
LYS A 155
 None
 0.82A 5os7A-2o74A:
undetectable		 5os7A-2o74A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 HIS A  24
SER A 160
LYS A 162
 None
 1.28A 5os7A-2p4qA:
undetectable		 5os7A-2p4qA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		3 HIS A 527
SER A 115
LYS A 106
 None
 1.22A 5os7A-2qqpA:
undetectable		 5os7A-2qqpA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		3 HIS A 259
SER A  30
LYS A  20
 UFP  A 529 (-4.1A)
None
None
 0.95A 5os7A-2tddA:
undetectable		 5os7A-2tddA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		3 HIS A 654
SER A 655
LYS A 657
 None
 1.46A 5os7A-2vsaA:
undetectable		 5os7A-2vsaA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		3 HIS A 769
SER A 780
LYS A 326
 None
 1.35A 5os7A-2w20A:
1.8		 5os7A-2w20A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 HIS A 353
SER A 355
LYS A 368
 3ES  A1635 (-3.8A)
3ES  A1636 (-4.3A)
None
 1.02A 5os7A-2xy9A:
undetectable		 5os7A-2xy9A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 HIS A 331
SER A 333
LYS A 346
 3ES  A1611 (-3.8A)
3ES  A1611 (-4.4A)
None
 1.08A 5os7A-2xydA:
undetectable		 5os7A-2xydA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA
BENZENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas
putida;
Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		3 HIS A 228
SER A 230
LYS B  94
 None
 1.29A 5os7A-3eqqA:
undetectable		 5os7A-3eqqA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
furiosus) 		PF07969
(Amidohydro_3) 		3 HIS A 466
SER A  46
LYS A 483
 None
 1.21A 5os7A-3icjA:
undetectable		 5os7A-3icjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyj MAJOR CAPSID PROTEIN
L1

(Deltapapillomavirus
4) 		no annotation 3 HIS F  87
SER F 378
LYS F  30
 None
 1.21A 5os7A-3iyjF:
undetectable		 5os7A-3iyjF:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 3 HIS A 834
SER A 827
LYS A 843
 None
 1.35A 5os7A-3j3iA:
undetectable		 5os7A-3j3iA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv9 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		3 HIS A 255
SER A 259
LYS A 171
 None
 1.24A 5os7A-3jv9A:
undetectable		 5os7A-3jv9A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		3 HIS A 176
SER A 126
LYS A 256
 None
 1.50A 5os7A-3kk7A:
undetectable		 5os7A-3kk7A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		3 HIS A  93
SER A  96
LYS A 100
 None
 1.37A 5os7A-3lfvA:
undetectable		 5os7A-3lfvA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		3 HIS A  67
SER A  23
LYS A  21
 None
 1.31A 5os7A-3m1rA:
undetectable		 5os7A-3m1rA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		3 HIS A  75
SER A  78
LYS A  82
 None
 1.49A 5os7A-3o7wA:
undetectable		 5os7A-3o7wA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 HIS A 359
SER A 358
LYS A 386
 None
 1.32A 5os7A-3ojlA:
undetectable		 5os7A-3ojlA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3piv INTERFERON

(Danio rerio) 		PF00143
(Interferon) 		3 HIS A  90
SER A  93
LYS A  97
 None
 1.17A 5os7A-3pivA:
undetectable		 5os7A-3pivA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmc UNCHARACTERIZED
PROTEIN
PXO2-61/BXB0075/GBAA
_PXO2_0075

(Bacillus
anthracis) 		PF09385
(HisK_N) 		3 HIS A 129
SER A 130
LYS A  68
 None
IOD  A 413 (-3.2A)
IOD  A 413 (-2.6A)
 1.44A 5os7A-3pmcA:
undetectable		 5os7A-3pmcA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4

(Homo sapiens) 		PF04130
(Spc97_Spc98) 		3 HIS A 415
SER A 455
LYS A 457
 None
 0.63A 5os7A-3ripA:
undetectable		 5os7A-3ripA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		3 HIS A 227
SER A 229
LYS A 106
 None
 1.42A 5os7A-4c1oA:
0.5		 5os7A-4c1oA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1

(Mytilus
galloprovincialis) 		PF00092
(VWA) 		3 HIS A 380
SER A 383
LYS A 387
 None
 1.48A 5os7A-4cn8A:
undetectable		 5os7A-4cn8A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 HIS A 289
SER A 292
LYS A 297
 None
 1.24A 5os7A-4cnsA:
undetectable		 5os7A-4cnsA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 HIS A 289
SER A 292
LYS A 297
 None
 1.38A 5os7A-4cntA:
undetectable		 5os7A-4cntA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gsl AUTOPHAGY-RELATED
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF03986
(Autophagy_N)
PF03987
(Autophagy_act_C)
PF10381
(Autophagy_C) 		3 HIS C 232
SER C 230
LYS C 183
 None
 1.32A 5os7A-4gslC:
1.5		 5os7A-4gslC:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE

(Burkholderia
lata) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 HIS A  80
SER A  83
LYS A  85
 None
FMN  A 301 (-3.4A)
FMN  A 301 (-1.9A)
 1.39A 5os7A-4hmwA:
0.9		 5os7A-4hmwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k73 L,D-TRANSPEPTIDASE

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		3 HIS A 244
SER A 197
LYS A 209
 None
 1.49A 5os7A-4k73A:
undetectable		 5os7A-4k73A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb8 URICASE

(unclassified
Mammalia) 		PF01014
(Uricase) 		3 HIS A 104
SER A  53
LYS A  55
 None
 1.49A 5os7A-4mb8A:
undetectable		 5os7A-4mb8A:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 HIS E 276
SER E 277
LYS E 279
 None
 0.32A 5os7A-4md8E:
43.4		 5os7A-4md8E:
93.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		3 HIS B 417
SER B 419
LYS B 421
 None
 0.99A 5os7A-4ov6B:
undetectable		 5os7A-4ov6B:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		3 HIS A 240
SER A  48
LYS A  50
 LLP  A 241 ( 3.7A)
LLP  A 241 ( 3.2A)
LLP  A 241 ( 4.9A)
 1.08A 5os7A-4q76A:
undetectable		 5os7A-4q76A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		3 HIS A 240
SER A  48
LYS A 242
 LLP  A 241 ( 3.7A)
LLP  A 241 ( 3.2A)
LLP  A 241 ( 3.5A)
 1.06A 5os7A-4q76A:
undetectable		 5os7A-4q76A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		3 HIS A 485
SER A 265
LYS A 240
 None
 1.35A 5os7A-4qyjA:
undetectable		 5os7A-4qyjA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		3 HIS A 205
SER A 207
LYS A  84
 None
 1.42A 5os7A-4rhhA:
undetectable		 5os7A-4rhhA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2

(Homo sapiens) 		PF01130
(CD36) 		3 HIS A 189
SER A 186
LYS A 181
 None
 1.15A 5os7A-4tw0A:
undetectable		 5os7A-4tw0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		3 HIS A 482
SER A 310
LYS A 308
 MG  A1645 (-3.2A)
TPO  A 307 ( 2.4A)
TPO  A 307 ( 2.9A)
 1.13A 5os7A-4uooA:
undetectable		 5os7A-4uooA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3) 		PF00303
(Thymidylat_synt) 		3 HIS A 244
SER A  45
LYS A  35
 BVP  A1001 (-3.8A)
None
None
 1.46A 5os7A-4xscA:
undetectable		 5os7A-4xscA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmk TELOMERE LENGTH
REGULATOR TAZ1

(Schizosaccharomyces
pombe) 		no annotation 3 HIS A 462
SER A 465
LYS A 469
 None
 1.20A 5os7A-4zmkA:
undetectable		 5os7A-4zmkA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdd STRUCTURAL
POLYPROTEIN, VP2

(Israeli acute
paralysis virus) 		PF00073
(Rhv) 		3 HIS C  61
SER C  62
LYS C  59
 None
 1.43A 5os7A-5cddC:
undetectable		 5os7A-5cddC:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 HIS A 495
SER A 496
LYS A 536
 None
 1.20A 5os7A-5ek8A:
undetectable		 5os7A-5ek8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		3 HIS A 129
SER A 171
LYS A 173
 None
 1.12A 5os7A-5eodA:
undetectable		 5os7A-5eodA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6h DH427 ANTIBODY LIGHT
CHAIN

(Macaca mulatta) 		no annotation 3 HIS L  41
SER L  42
LYS L 170
 None
 1.21A 5os7A-5f6hL:
undetectable		 5os7A-5f6hL:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		3 HIS H 109
SER H 108
LYS H   7
 None
 1.23A 5os7A-5fg9H:
undetectable		 5os7A-5fg9H:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE

(Xanthophyllomyces
dendrorhous) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 HIS A  99
SER A 109
LYS A 131
 None
NAG  A1107 ( 4.4A)
NAG  A1107 (-2.7A)
 0.90A 5os7A-5fkcA:
undetectable		 5os7A-5fkcA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icu COPC

(Methylosinus
trichosporium) 		PF04234
(CopC) 		3 HIS A 107
SER A 103
LYS A  23
 CU  A 201 (-3.0A)
None
CU  A 201 ( 4.2A)
 1.40A 5os7A-5icuA:
undetectable		 5os7A-5icuA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imw INTERMEDILYSIN

(Streptococcus
intermedius) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 HIS A 242
SER A 240
LYS A 246
 None
 1.02A 5os7A-5imwA:
undetectable		 5os7A-5imwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		3 HIS A 282
SER A 133
LYS A 130
 KCX  A 129 ( 4.1A)
KCX  A 129 ( 2.8A)
KCX  A 129 ( 3.1A)
 1.33A 5os7A-5j84A:
undetectable		 5os7A-5j84A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		3 HIS A 223
SER A  31
LYS A  33
 PLP  A 501 (-3.9A)
None
None
 1.06A 5os7A-5j8qA:
undetectable		 5os7A-5j8qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpq ES6

(Chaetomium
thermophilum) 		no annotation 3 HIS r  81
SER r  82
LYS r  64
 None
 1.31A 5os7A-5jpqr:
undetectable		 5os7A-5jpqr:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT

(Ovis aries) 		no annotation 3 HIS d 134
SER d 133
LYS d 149
 NDP  d 401 (-4.2A)
None
None
 0.73A 5os7A-5lnkd:
undetectable		 5os7A-5lnkd:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m48 REGULATOR OF TY1
TRANSPOSITION
PROTEIN 103

(Saccharomyces
cerevisiae) 		no annotation 3 HIS A 215
SER A 219
LYS A 146
 None
 1.01A 5os7A-5m48A:
undetectable		 5os7A-5m48A:
15.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 HIS A 276
SER A 277
LYS A 279
 None
 0.36A 5os7A-5movA:
50.7		 5os7A-5movA:
92.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S5, PUTATIVE
40S RIBOSOMAL
PROTEIN S16,
PUTATIVE

(Trypanosoma
cruzi;
Trypanosoma
cruzi) 		no annotation
no annotation 		3 HIS r  65
SER r  63
LYS O   1
 None
 1.37A 5os7A-5optr:
undetectable		 5os7A-5optr:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovt BPH

(Thiobacillus
denitrificans) 		no annotation 3 HIS A 174
SER A 177
LYS A   1
 None
None
PO4  A 301 ( 4.1A)
 1.49A 5os7A-5ovtA:
undetectable		 5os7A-5ovtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud0 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Helicobacter
pylori) 		no annotation 3 HIS A 125
SER A 130
LYS A   4
 None
 1.41A 5os7A-5ud0A:
undetectable		 5os7A-5ud0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujc MMACHC-LIKE PROTEIN

(Caenorhabditis
elegans) 		PF16690
(MMACHC) 		3 HIS A  28
SER A  27
LYS A  12
 None
 1.30A 5os7A-5ujcA:
undetectable		 5os7A-5ujcA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 HIS A 289
SER A 292
LYS A 297
 None
 1.34A 5os7A-5uqcA:
undetectable		 5os7A-5uqcA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpr CYSTEINE DESULFURASE

(Elizabethkingia
anophelis) 		PF00266
(Aminotran_5) 		3 HIS A 224
SER A  32
LYS A  34
 LLP  A 225 ( 3.7A)
LLP  A 225 ( 3.3A)
LLP  A 225 ( 4.9A)
 1.01A 5os7A-5vprA:
undetectable		 5os7A-5vprA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpr CYSTEINE DESULFURASE

(Elizabethkingia
anophelis) 		PF00266
(Aminotran_5) 		3 HIS A 224
SER A  32
LYS A 226
 LLP  A 225 ( 3.7A)
LLP  A 225 ( 3.3A)
LLP  A 225 ( 3.5A)
 1.05A 5os7A-5vprA:
undetectable		 5os7A-5vprA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x89 ENDA-LIKE
PROTEIN,TRNA-SPLICIN
G ENDONUCLEASE

(Methanopyrus
kandleri) 		no annotation 3 HIS A 303
SER A 304
LYS A 334
 PO4  A 402 (-3.8A)
PO4  A 402 (-2.5A)
PO4  A 402 (-2.7A)
 1.02A 5os7A-5x89A:
undetectable		 5os7A-5x89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfl CATENIN ALPHA-2

(Mus musculus) 		no annotation 3 HIS A 387
SER A 391
LYS A 427
 None
 1.47A 5os7A-5xflA:
undetectable		 5os7A-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		no annotation 3 HIS C 672
SER C 673
LYS C 675
 None
 0.79A 5os7A-5yfpC:
undetectable		 5os7A-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z11 CD8 ALPHA CHAIN

(Ctenopharyngodon
idella) 		no annotation 3 HIS A  62
SER A  78
LYS A  80
 None
 1.22A 5os7A-5z11A:
undetectable		 5os7A-5z11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus) 		no annotation 3 HIS A 179
SER A 178
LYS A 176
 None
None
DMU  A 501 (-3.8A)
 1.36A 5os7A-6d0nA:
undetectable		 5os7A-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 HIS A1173
SER A1174
LYS A1170
 None
 0.73A 5os7A-6emkA:
0.4		 5os7A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 HIS A1828
SER A1829
LYS A1830
 None
 1.38A 5os7A-6emkA:
0.4		 5os7A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 3 HIS A1928
SER A1925
LYS A1968
 None
 1.48A 5os7A-6ez8A:
undetectable		 5os7A-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 3 HIS A 438
SER A 434
LYS A 400
 None
 0.97A 5os7A-6f3dA:
22.3		 5os7A-6f3dA:
undetectable