SIMILAR PATTERNS OF AMINO ACIDS FOR 5OJ0_A_9WTA801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 SER A 719
ASN A 715
GLN A 739
SER A 726
THR A 728
 None
 1.47A 5oj0A-1bf2A:
undetectable		 5oj0A-1bf2A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cy9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac) 		5 ASN A 326
GLN A 402
THR A 288
GLY A 281
GLN A 354
 None
 1.27A 5oj0A-1cy9A:
undetectable		 5oj0A-1cy9A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dzb SCFV FRAGMENT 1F9

(Mus musculus) 		PF07686
(V-set) 		5 SER A 272
GLN A 290
SER A 263
GLY A 264
THR A 252
 None
 1.26A 5oj0A-1dzbA:
undetectable		 5oj0A-1dzbA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e25 EXTENDED-SPECTRUM
BETA-LACTAMASE PER-1

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 TRP A 105
SER A 130
ASN A 132
THR A 216
GLY A 236
 None
SO4  A 500 (-2.6A)
None
SO4  A 500 ( 4.0A)
SO4  A 500 (-3.5A)
 1.30A 5oj0A-1e25A:
8.7		 5oj0A-1e25A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3r FV ANTIBODY FRAGMENT

(Rattus
norvegicus) 		PF07686
(V-set) 		5 GLN B 165
THR B 189
SER B 205
GLY B 206
THR B 207
 None
 1.38A 5oj0A-1f3rB:
undetectable		 5oj0A-1f3rB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 SER A  84
GLN A 175
GLY A 242
THR A 241
GLN A 236
 None
 1.28A 5oj0A-1fcpA:
undetectable		 5oj0A-1fcpA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 ASN A 397
SER A 548
GLY A 549
THR A 550
GLN A 552
 None
 1.18A 5oj0A-1k25A:
48.9		 5oj0A-1k25A:
88.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 GLN A 447
GLN A 452
SER A 548
GLY A 549
THR A 550
 None
 0.50A 5oj0A-1k25A:
48.9		 5oj0A-1k25A:
88.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		5 ASN B 457
GLN B 380
THR B 481
GLY B 385
THR B 384
 None
 1.25A 5oj0A-1k5sB:
undetectable		 5oj0A-1k5sB:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ASN B 417
SER B 319
SER B 503
GLY B 447
THR B 448
 None
 1.31A 5oj0A-1m2vB:
undetectable		 5oj0A-1m2vB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		5 SER A 135
GLN A 388
THR A 105
GLY A 149
THR A 150
 None
 1.26A 5oj0A-1ocmA:
undetectable		 5oj0A-1ocmA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ASN A 417
SER A 319
SER A 503
GLY A 447
THR A 448
 None
 1.34A 5oj0A-1pd1A:
undetectable		 5oj0A-1pd1A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M) 		5 SER A 209
GLN A 183
GLY A 213
THR A 214
GLN A 181
 None
 1.42A 5oj0A-1t98A:
undetectable		 5oj0A-1t98A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ARG A 157
GLN A 167
THR A 141
GLY A 150
THR A 151
 None
 1.33A 5oj0A-1xkhA:
undetectable		 5oj0A-1xkhA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ARG B 465
GLN B 424
GLY B 416
THR B 417
GLN B 467
 None
 1.23A 5oj0A-2amcB:
2.8		 5oj0A-2amcB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azp HYPOTHETICAL PROTEIN
PA1268

(Pseudomonas
aeruginosa) 		PF05544
(Pro_racemase) 		5 ASN A  80
SER A 234
THR A  11
GLY A 237
THR A 238
 None
 1.07A 5oj0A-2azpA:
undetectable		 5oj0A-2azpA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 ARG B 413
SER B 428
ASN B 430
THR B 543
GLY B 559
THR B 560
 None
CL  B 704 (-3.4A)
None
CL  B 704 ( 4.8A)
CL  B 704 ( 4.0A)
CL  B 704 ( 4.8A)
 1.14A 5oj0A-2c6wB:
26.5		 5oj0A-2c6wB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 TRP B 411
SER B 428
ASN B 430
GLY B 559
THR B 560
 None
CL  B 704 (-3.4A)
None
CL  B 704 ( 4.0A)
CL  B 704 ( 4.8A)
 1.24A 5oj0A-2c6wB:
26.5		 5oj0A-2c6wB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdp BETA-AGARASE 1

(Saccharophagus
degradans) 		PF03422
(CBM_6) 		5 SER A  73
GLN A 101
SER A 124
GLY A  71
THR A  70
 None
 1.41A 5oj0A-2cdpA:
undetectable		 5oj0A-2cdpA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 ARG A 135
ASN A 136
SER A  65
GLY A  64
THR A  63
 None
 1.27A 5oj0A-2csdA:
undetectable		 5oj0A-2csdA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6a COLLAGEN ADHESIN

(Staphylococcus
aureus) 		PF05737
(Collagen_bind) 		5 SER A 274
GLN A 267
SER A 231
GLY A 228
THR A 229
 None
 1.44A 5oj0A-2f6aA:
undetectable		 5oj0A-2f6aA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		5 ARG A 249
ASN A 155
THR A 273
GLY A   8
GLN A 243
 None
None
None
ACY  A 500 ( 4.7A)
None
 1.36A 5oj0A-2qc3A:
undetectable		 5oj0A-2qc3A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		6 TRP A 424
SER A 443
ASN A 445
GLN A 519
THR A 600
GLY A 617
 None
 1.17A 5oj0A-2waeA:
29.9		 5oj0A-2waeA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsz RUVB-LIKE 1

(Homo sapiens) 		PF06068
(TIP49) 		5 SER A 317
GLN A 291
THR A 312
GLY A 306
GLN A 284
 None
 1.21A 5oj0A-2xszA:
undetectable		 5oj0A-2xszA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yl2 ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 SER A 284
GLN A 320
THR A 294
SER A 300
GLY A 299
 None
 1.43A 5oj0A-2yl2A:
undetectable		 5oj0A-2yl2A:
24.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 ARG B 372
ASN B 377
ASN B 397
SER B 548
GLY B 549
GLN B 552
 None
None
CDS  B 901 ( 3.0A)
CDS  B 901 ( 2.9A)
CDS  B 901 ( 3.4A)
CDS  B 901 ( 4.2A)
 1.34A 5oj0A-2z2mB:
49.5		 5oj0A-2z2mB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 ARG B 372
ASN B 377
ASN B 397
THR B 526
GLY B 549
GLN B 552
 None
None
CDS  B 901 ( 3.0A)
CDS  B 901 ( 4.1A)
CDS  B 901 ( 3.4A)
CDS  B 901 ( 4.2A)
 1.29A 5oj0A-2z2mB:
49.5		 5oj0A-2z2mB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 ARG B 372
ASN B 377
SER B 395
THR B 526
GLY B 549
 None
None
CDS  B 901 ( 3.2A)
CDS  B 901 ( 4.1A)
CDS  B 901 ( 3.4A)
 1.08A 5oj0A-2z2mB:
49.5		 5oj0A-2z2mB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 ARG B 372
ASN B 397
SER B 548
GLY B 549
THR B 550
GLN B 552
 None
CDS  B 901 ( 3.0A)
CDS  B 901 ( 2.9A)
CDS  B 901 ( 3.4A)
CDS  B 901 ( 3.6A)
CDS  B 901 ( 4.2A)
 1.39A 5oj0A-2z2mB:
49.5		 5oj0A-2z2mB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 ARG B 372
ASN B 397
THR B 526
GLY B 549
THR B 550
GLN B 552
 None
CDS  B 901 ( 3.0A)
CDS  B 901 ( 4.1A)
CDS  B 901 ( 3.4A)
CDS  B 901 ( 3.6A)
CDS  B 901 ( 4.2A)
 1.33A 5oj0A-2z2mB:
49.5		 5oj0A-2z2mB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 ARG B 372
SER B 395
THR B 526
GLY B 549
THR B 550
 None
CDS  B 901 ( 3.2A)
CDS  B 901 ( 4.1A)
CDS  B 901 ( 3.4A)
CDS  B 901 ( 3.6A)
 1.25A 5oj0A-2z2mB:
49.5		 5oj0A-2z2mB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 ASN B 377
ASN B 397
GLN B 447
SER B 548
GLY B 549
GLN B 552
 None
CDS  B 901 ( 3.0A)
None
CDS  B 901 ( 2.9A)
CDS  B 901 ( 3.4A)
CDS  B 901 ( 4.2A)
 1.34A 5oj0A-2z2mB:
49.5		 5oj0A-2z2mB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 ASN B 377
ASN B 397
GLN B 447
THR B 526
GLY B 549
GLN B 552
 None
CDS  B 901 ( 3.0A)
None
CDS  B 901 ( 4.1A)
CDS  B 901 ( 3.4A)
CDS  B 901 ( 4.2A)
 1.16A 5oj0A-2z2mB:
49.5		 5oj0A-2z2mB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 SER A 728
ASN A 756
GLN A 720
GLY A 711
THR A 714
 K  A 201 (-2.7A)
None
None
None
None
 1.46A 5oj0A-3c10A:
undetectable		 5oj0A-3c10A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvh 25-D1.16 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG L  67
GLN L  89
SER L  62
GLY L  63
THR L  51
 None
 1.07A 5oj0A-3cvhL:
undetectable		 5oj0A-3cvhL:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		5 ASN A 398
GLN A 415
THR A 576
GLY A 353
THR A 352
 None
 1.23A 5oj0A-3gf7A:
undetectable		 5oj0A-3gf7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrr INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 3

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		5 GLN A  98
GLN A 101
SER A 160
GLY A 156
THR A 155
 None
 1.47A 5oj0A-3jrrA:
undetectable		 5oj0A-3jrrA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		5 ARG A 135
ASN A 136
SER A  65
GLY A  64
THR A  63
 None
 1.38A 5oj0A-3m7dA:
undetectable		 5oj0A-3m7dA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mky PROTEIN SOPB

(Escherichia
coli) 		no annotation 5 ARG B 166
SER B 220
GLY B 221
THR B 199
GLN B 165
 None
 1.40A 5oj0A-3mkyB:
undetectable		 5oj0A-3mkyB:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ARG A 432
ASN A 430
GLY A 172
THR A 171
GLN A 396
 None
 1.26A 5oj0A-3qtpA:
undetectable		 5oj0A-3qtpA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ros NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00171
(Aldedh) 		5 SER A 384
ASN A 382
GLN A 406
SER A 432
GLY A 387
 None
 1.40A 5oj0A-3rosA:
undetectable		 5oj0A-3rosA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 SER A 390
ASN A 392
THR A 511
GLY A 527
THR A 528
 None
 1.13A 5oj0A-3ue3A:
34.3		 5oj0A-3ue3A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 SER A 281
ASN A 283
GLN A 339
GLY A 426
THR A 427
 IM2  A 800 (-3.0A)
IM2  A 800 (-3.3A)
None
IM2  A 800 (-3.4A)
IM2  A 800 (-4.0A)
 0.94A 5oj0A-3upnA:
31.3		 5oj0A-3upnA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		5 SER A 385
ASN A 383
GLN A 407
SER A 433
GLY A 388
 None
 1.37A 5oj0A-3vz0A:
undetectable		 5oj0A-3vz0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		5 SER A 385
ASN A 383
SER A 433
GLY A 388
THR A 410
 None
 1.09A 5oj0A-3vz0A:
undetectable		 5oj0A-3vz0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		5 ARG A  90
SER A  45
THR A  42
GLY A 243
THR A 240
 None
 1.39A 5oj0A-3wv4A:
undetectable		 5oj0A-3wv4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 SER A 104
ASN A 310
SER A  72
GLY A  71
THR A  70
 None
NAG  A 911 (-1.8A)
None
None
None
 1.22A 5oj0A-3zz1A:
undetectable		 5oj0A-3zz1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		5 ASN A 464
GLN A 521
SER A 598
GLY A 599
THR A 600
 None
 0.65A 5oj0A-4bl3A:
29.6		 5oj0A-4bl3A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		5 ASN A 464
THR A 582
SER A 598
GLY A 599
THR A 600
 None
 1.12A 5oj0A-4bl3A:
29.6		 5oj0A-4bl3A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6y BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		5 SER A 130
ASN A 132
THR A 216
GLY A 236
THR A 237
 PEG  A 307 (-2.4A)
PEG  A 307 (-3.1A)
PEG  A 307 ( 4.3A)
PEG  A 307 (-2.7A)
PEG  A 307 (-3.9A)
 1.22A 5oj0A-4c6yA:
7.6		 5oj0A-4c6yA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7p RALF

(Legionella
pneumophila) 		PF01369
(Sec7) 		5 SER A  86
ASN A 122
GLN A 120
GLN A 121
GLY A  90
 None
 1.33A 5oj0A-4c7pA:
undetectable		 5oj0A-4c7pA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ARG A 589
THR A 356
SER A 560
GLY A 559
THR A 558
 None
 1.16A 5oj0A-4c7vA:
undetectable		 5oj0A-4c7vA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2o PER-2 BETA-LACTAMASE

(Citrobacter
freundii) 		PF13354
(Beta-lactamase2) 		5 SER A 130
ASN A 132
THR A 216
GLY A 236
THR A 237
 None
 1.27A 5oj0A-4d2oA:
6.3		 5oj0A-4d2oA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 ARG A  45
SER A 161
GLY A 156
THR A 155
GLN A 189
 None
CL  A 302 ( 4.8A)
CL  A 302 (-3.5A)
CL  A 302 (-4.6A)
None
 1.42A 5oj0A-4elxA:
undetectable		 5oj0A-4elxA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		5 ASN A 128
ASN A 308
GLN A 329
SER A 179
GLY A 178
 None
 1.45A 5oj0A-4frxA:
undetectable		 5oj0A-4frxA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 ARG A 135
ASN A 136
SER A  65
GLY A  64
THR A  63
 None
 1.22A 5oj0A-4gfjA:
undetectable		 5oj0A-4gfjA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA

(Vibrio
parahaemolyticus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 GLN A 331
GLN A 351
GLY A  13
THR A  14
GLN A 352
 None
AGS  A 501 (-3.9A)
None
None
None
 1.30A 5oj0A-4j9vA:
undetectable		 5oj0A-4j9vA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PROTEIN M TD

(Mycoplasma
genitalium) 		no annotation 5 SER M 276
ASN M 300
SER M 272
GLY M 273
THR M 297
 None
 1.44A 5oj0A-4nzrM:
2.1		 5oj0A-4nzrM:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 GLN A 287
THR A 244
SER A 316
GLY A 315
THR A 314
 None
 1.38A 5oj0A-4o9xA:
undetectable		 5oj0A-4o9xA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 SER A 520
ASN A 522
THR A 680
GLY A 697
THR A 698
 2U4  A 901 (-3.6A)
2U4  A 901 (-2.9A)
2U4  A 901 (-4.1A)
2U4  A 901 (-3.7A)
2U4  A 901 (-3.8A)
 1.03A 5oj0A-4oonA:
16.8		 5oj0A-4oonA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ASN A 363
GLN A 422
THR A 486
GLY A 502
THR A 503
 None
None
CA  A 601 ( 4.7A)
CA  A 601 ( 4.2A)
None
 0.92A 5oj0A-4ovdA:
35.7		 5oj0A-4ovdA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 SER A 361
GLN A 422
THR A 486
GLY A 502
THR A 503
 CA  A 601 ( 3.8A)
None
CA  A 601 ( 4.7A)
CA  A 601 ( 4.2A)
None
 1.19A 5oj0A-4ovdA:
35.7		 5oj0A-4ovdA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pot VP1

(Human
polyomavirus 9) 		PF00718
(Polyoma_coat) 		5 ASN A 276
SER A 143
GLY A 144
THR A 145
GLN A 133
 NGC  A 407 (-3.5A)
None
None
None
NGC  A 407 (-4.3A)
 1.42A 5oj0A-4potA:
undetectable		 5oj0A-4potA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9z UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		5 SER A  40
GLN A  25
GLN A  26
GLY A  36
GLN A  95
 None
 1.46A 5oj0A-4r9zA:
undetectable		 5oj0A-4r9zA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		5 SER A 737
ASN A 739
THR A 876
GLY A 892
THR A 893
 NXU  A1001 (-3.2A)
NXU  A1001 (-3.5A)
NXU  A1001 (-4.0A)
NXU  A1001 (-3.4A)
NXU  A1001 (-3.9A)
 1.03A 5oj0A-4ra7A:
31.1		 5oj0A-4ra7A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon) 		5 ASN A 326
GLN A 402
THR A 288
GLY A 281
GLN A 354
 None
 1.26A 5oj0A-4rulA:
undetectable		 5oj0A-4rulA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woq N-ACETYLNEURAMINATE
LYASE

(Clostridioides
difficile) 		PF00701
(DHDPS) 		5 ASN A 250
GLN A 229
THR A 177
GLY A 217
THR A 219
 None
 1.39A 5oj0A-4woqA:
undetectable		 5oj0A-4woqA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ASN A 378
GLN A 436
SER A 521
GLY A 522
THR A 523
 None
 1.30A 5oj0A-4ye5A:
33.5		 5oj0A-4ye5A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 SER A 376
ASN A 378
GLN A 436
GLY A 522
THR A 523
 None
 1.05A 5oj0A-4ye5A:
33.5		 5oj0A-4ye5A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		5 TRP A 106
SER A 131
GLN A 169
THR A 215
GLY A 235
 None
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.3A)
 1.39A 5oj0A-4yfmA:
9.5		 5oj0A-4yfmA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		5 SER B 799
GLN B 348
SER B 820
GLY B 821
GLN B 311
 None
 1.40A 5oj0A-4zktB:
undetectable		 5oj0A-4zktB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 ASN A 255
SER A 314
SER A 330
GLY A 312
GLN A 272
 None
 0.94A 5oj0A-5c2vA:
undetectable		 5oj0A-5c2vA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f83 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 TRP A  99
SER A 125
THR A 211
GLY A 231
THR A 232
 IM2  A 301 ( 4.0A)
IM2  A 301 (-2.7A)
IM2  A 301 (-4.1A)
IM2  A 301 (-3.3A)
IM2  A 301 (-4.0A)
 1.23A 5oj0A-5f83A:
6.9		 5oj0A-5f83A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 5 ARG A  45
ASN A  43
THR A  69
GLY A 756
THR A 463
 None
 1.40A 5oj0A-5fkrA:
undetectable		 5oj0A-5fkrA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		5 ASN A 188
GLN A  88
SER A 267
GLY A 268
GLN A  89
 None
 1.46A 5oj0A-5gneA:
undetectable		 5oj0A-5gneA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0k UNCHARACTERIZED
PROTEIN

(Pedobacter
heparinus) 		PF16265
(DUF4918) 		5 ASN A  30
GLN A 165
SER A  20
GLY A  19
THR A  18
 None
 1.40A 5oj0A-5h0kA:
undetectable		 5oj0A-5h0kA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		6 ARG A 555
SER A 572
ASN A 574
THR A 682
GLY A 700
THR A 701
 None
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.3A)
AZR  A 902 (-4.3A)
 1.44A 5oj0A-5hlbA:
25.8		 5oj0A-5hlbA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 ARG A 135
ASN A 136
SER A  65
GLY A  64
THR A  63
 None
 1.24A 5oj0A-5hm5A:
undetectable		 5oj0A-5hm5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 SER A 579
GLN A 650
SER A 573
GLY A 574
THR A 535
 None
 1.42A 5oj0A-5ip9A:
undetectable		 5oj0A-5ip9A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ASN A 905
ASN A 982
THR A 605
SER A 651
GLY A 650
 None
 1.47A 5oj0A-5iy9A:
undetectable		 5oj0A-5iy9A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		5 ARG A  16
ASN A  14
THR A  40
GLY A 723
THR A 431
 None
 1.40A 5oj0A-5jwzA:
undetectable		 5oj0A-5jwzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ARG A 345
SER A 362
ASN A 364
THR A 483
GLY A 499
 None
 1.32A 5oj0A-5kshA:
34.9		 5oj0A-5kshA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1

(Mus musculus) 		PF01825
(GPS) 		5 SER A 357
GLN A 208
SER A 360
GLY A 359
GLN A 210
 None
None
None
GOL  A 907 (-3.7A)
None
 1.31A 5oj0A-5kvmA:
undetectable		 5oj0A-5kvmA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxb WISTERIA FLORIBUNDA
AGGLUTININ

(Wisteria
floribunda) 		PF00139
(Lectin_legB) 		5 ASN A 111
SER A 243
THR A  65
GLY A 118
THR A 158
 None
 1.33A 5oj0A-5kxbA:
undetectable		 5oj0A-5kxbA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 SER A 130
ASN A 132
THR A 216
GLY A 236
THR A 237
 6YV  A 301 (-2.6A)
6YV  A 301 (-3.7A)
6YV  A 301 ( 4.2A)
6YV  A 301 ( 4.0A)
6YV  A 301 (-3.6A)
 1.23A 5oj0A-5ll7A:
7.3		 5oj0A-5ll7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)

(Helicobacter
pylori) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		6 ARG A 347
TRP A 349
SER A 366
THR A 498
GLY A 515
THR A 516
 None
 1.05A 5oj0A-5lp4A:
30.0		 5oj0A-5lp4A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 5 ARG A 220
SER A 301
THR A 119
SER A 277
GLY A 115
 None
 1.10A 5oj0A-5mg5A:
undetectable		 5oj0A-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S4
30S RIBOSOMAL
PROTEIN S5

(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis) 		PF00163
(Ribosomal_S4)
PF01479
(S4)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 SER D 200
ASN D  75
GLN D  77
GLY E 129
THR E 128
 A  A  12 ( 3.1A)
G  A  10 ( 4.1A)
None
None
G  A  10 ( 2.8A)
 1.39A 5oj0A-5o5jD:
undetectable		 5oj0A-5o5jD:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASN A 100
GLN A 448
SER A 453
GLY A 452
THR A 451
 None
 1.21A 5oj0A-5tc3A:
undetectable		 5oj0A-5tc3A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN

(Homo sapiens) 		PF00400
(WD40) 		5 ASN A  74
GLN A  20
THR A 174
GLY A 172
THR A 171
 None
 1.44A 5oj0A-5tf2A:
undetectable		 5oj0A-5tf2A:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tro PENICILLIN-BINDING
PROTEIN 1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 TRP A 351
ASN A 370
GLY A 515
THR A 516
GLN A 518
 None
 1.23A 5oj0A-5troA:
40.1		 5oj0A-5troA:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tro PENICILLIN-BINDING
PROTEIN 1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		6 TRP A 351
SER A 368
ASN A 370
GLN A 425
GLY A 515
THR A 516
 None
 1.14A 5oj0A-5troA:
40.1		 5oj0A-5troA:
31.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0r DH270.UCA1 LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG L  56
ASN L  62
SER L  17
GLN L  39
GLY L  15
 None
 1.31A 5oj0A-5u0rL:
undetectable		 5oj0A-5u0rL:
15.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		7 TRP A 381
ASN A 384
GLN A 453
GLN A 458
SER A 554
GLY A 555
THR A 556
 None
 1.27A 5oj0A-5u47A:
48.0		 5oj0A-5u47A:
50.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		7 TRP A 381
ASN A 384
GLN A 453
GLN A 458
THR A 532
GLY A 555
THR A 556
 None
 1.08A 5oj0A-5u47A:
48.0		 5oj0A-5u47A:
50.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		7 TRP A 381
ASN A 404
GLN A 453
GLN A 458
SER A 554
GLY A 555
THR A 556
 None
 0.99A 5oj0A-5u47A:
48.0		 5oj0A-5u47A:
50.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		7 TRP A 381
ASN A 404
GLN A 453
GLN A 458
THR A 532
GLY A 555
THR A 556
 None
 0.78A 5oj0A-5u47A:
48.0		 5oj0A-5u47A:
50.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		7 TRP A 381
SER A 402
ASN A 404
GLN A 458
THR A 532
GLY A 555
THR A 556
 None
 0.92A 5oj0A-5u47A:
48.0		 5oj0A-5u47A:
50.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujd SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNI

(Staphylococcus
pseudintermedius) 		no annotation 5 ASN A  95
SER A 155
SER A 151
GLY A 101
THR A 103
 None
 1.47A 5oj0A-5ujdA:
undetectable		 5oj0A-5ujdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgd GLUCOSE/GALACTOSE-BI
NDING LIPOPROTEIN

(Treponema
pallidum) 		no annotation 5 TRP A 280
SER A 277
ASN A 279
GLY A 211
THR A 212
 None
 1.05A 5oj0A-6bgdA:
undetectable		 5oj0A-6bgdA:
undetectable