SIMILAR PATTERNS OF AMINO ACIDS FOR 5OHH_A_ACTA307

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans) 		PF00561
(Abhydrolase_1) 		4 HIS A  27
HIS A  92
LEU A  81
THR A  82
 None
 1.19A 5ohhA-1a88A:
undetectable		 5ohhA-1a88A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		4 HIS B1812
HIS B1790
LEU B1837
THR B1836
 CYG  B1769 ( 4.9A)
None
None
None
 1.15A 5ohhA-1a9xB:
undetectable		 5ohhA-1a9xB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 HIS A 466
VAL A 248
LEU A 464
THR A 462
 None
 1.30A 5ohhA-1bbuA:
undetectable		 5ohhA-1bbuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		4 HIS A  83
VAL A  86
LEU A 100
THR A  75
 None
 1.35A 5ohhA-1j0aA:
undetectable		 5ohhA-1j0aA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
HIS A  96
LEU A 198
THR A 200
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
 1.22A 5ohhA-1jd0A:
36.2		 5ohhA-1jd0A:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
 0.24A 5ohhA-1jd0A:
36.2		 5ohhA-1jd0A:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		4 HIS A  92
HIS A  94
LEU A 176
THR A 178
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
AZI  A 305 (-4.2A)
AZI  A 305 ( 4.2A)
 1.17A 5ohhA-1kopA:
29.7		 5ohhA-1kopA:
32.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		5 HIS A  92
HIS A 111
VAL A 123
LEU A 176
THR A 177
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
 0.30A 5ohhA-1kopA:
29.7		 5ohhA-1kopA:
32.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 HIS A 113
HIS A  49
VAL A 253
THR A 196
 None
 1.07A 5ohhA-1o12A:
undetectable		 5ohhA-1o12A:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
HIS A  96
LEU A 198
THR A 200
 ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
 1.22A 5ohhA-1rj6A:
36.6		 5ohhA-1rj6A:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 601 ( 3.3A)
ZN  A 601 ( 3.2A)
None
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
 0.23A 5ohhA-1rj6A:
36.6		 5ohhA-1rj6A:
36.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry7 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 HIS B 290
VAL B 306
LEU B 340
THR B 338
 None
 1.36A 5ohhA-1ry7B:
undetectable		 5ohhA-1ry7B:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
HIS A  96
LEU A 198
THR A 200
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
 1.27A 5ohhA-1urtA:
37.4		 5ohhA-1urtA:
46.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
 0.32A 5ohhA-1urtA:
37.4		 5ohhA-1urtA:
46.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		4 HIS A 115
HIS A 117
LEU A 216
THR A 218
 ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ACY  A 279 (-4.3A)
ACY  A 279 ( 4.9A)
 1.29A 5ohhA-1y7wA:
25.6		 5ohhA-1y7wA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		5 HIS A 115
HIS A 135
VAL A 153
LEU A 216
THR A 217
 ZN  A 283 ( 3.2A)
ZN  A 283 ( 3.1A)
None
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
 0.20A 5ohhA-1y7wA:
25.6		 5ohhA-1y7wA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Methanothermobacter
thermautotrophicus) 		PF00710
(Asparaginase) 		4 HIS A 175
VAL A 173
LEU A 187
THR A 183
 None
 1.25A 5ohhA-2d6fA:
undetectable		 5ohhA-2d6fA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 HIS A 107
VAL A  77
LEU A 179
THR A 180
 GOL  A2003 ( 3.0A)
None
None
None
 1.25A 5ohhA-2elcA:
undetectable		 5ohhA-2elcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 HIS A 163
VAL A 162
LEU A 411
THR A  51
 None
 1.23A 5ohhA-2hgsA:
undetectable		 5ohhA-2hgsA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.16A 5ohhA-2it4A:
42.5		 5ohhA-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE

(Lactobacillus
plantarum) 		PF01643
(Acyl-ACP_TE) 		4 HIS A  15
VAL A  81
LEU A  33
THR A  32
 None
 0.95A 5ohhA-2ownA:
undetectable		 5ohhA-2ownA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		4 HIS A  73
HIS A  99
VAL A  97
THR A  62
 None
FE  A 278 (-3.1A)
None
None
 0.82A 5ohhA-2p17A:
undetectable		 5ohhA-2p17A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdg SUPERANTIGEN-LIKE
PROTEIN 11

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 HIS A 140
HIS A 145
VAL A 194
THR A 117
 None
 1.34A 5ohhA-2rdgA:
undetectable		 5ohhA-2rdgA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzr POLYPROTEIN

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 HIS 2  64
VAL 2 202
LEU 2  83
THR 2  85
 None
 1.25A 5ohhA-2wzr2:
undetectable		 5ohhA-2wzr2:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		4 HIS A 235
VAL A 232
LEU A 260
THR A 262
 None
 1.32A 5ohhA-2ykfA:
undetectable		 5ohhA-2ykfA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H

(Homo sapiens) 		PF00179
(UQ_con) 		4 HIS A  42
VAL A  55
LEU A 120
THR A 121
 None
 1.30A 5ohhA-2z5dA:
undetectable		 5ohhA-2z5dA:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
HIS A  96
LEU A 198
THR A 200
 ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
None
None
 1.16A 5ohhA-2zncA:
30.8		 5ohhA-2zncA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
None
None
ZN  A   1 ( 4.7A)
 0.29A 5ohhA-2zncA:
30.8		 5ohhA-2zncA:
32.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 HIS A 636
HIS A 617
VAL A 356
THR A 407
 None
 1.35A 5ohhA-2ztgA:
undetectable		 5ohhA-2ztgA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ah5 THYMIDYLATE SYNTHASE
THYX

(Helicobacter
pylori) 		PF02511
(Thy1) 		4 HIS A 237
HIS A 234
LEU A 196
THR A 195
 SO4  A  10 (-4.1A)
SO4  A  10 (-4.7A)
FAD  A 240 (-4.4A)
None
 0.96A 5ohhA-3ah5A:
undetectable		 5ohhA-3ah5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 HIS A 163
HIS A 165
LEU A 259
THR A 261
 ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
None
 1.27A 5ohhA-3b1bA:
25.4		 5ohhA-3b1bA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 HIS A 163
HIS A 182
VAL A 201
LEU A 259
THR A 260
 ZN  A 378 (-3.2A)
ZN  A 378 (-3.1A)
None
None
ZN  A 378 ( 4.5A)
 0.23A 5ohhA-3b1bA:
25.4		 5ohhA-3b1bA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ble CITRAMALATE SYNTHASE
FROM LEPTOSPIRA
INTERROGANS

(Leptospira
interrogans) 		PF00682
(HMGL-like) 		4 HIS A 207
HIS A 231
VAL A  13
LEU A  81
 ZN  A1003 ( 3.4A)
None
None
None
 1.20A 5ohhA-3bleA:
undetectable		 5ohhA-3bleA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  95
HIS A 120
VAL A 144
LEU A 199
THR A 200
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
 0.49A 5ohhA-3da2A:
45.5		 5ohhA-3da2A:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 111
HIS A 138
VAL A 161
LEU A 219
 MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
 0.67A 5ohhA-3fe4A:
30.3		 5ohhA-3fe4A:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 138
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.2A)
None
None
None
 0.75A 5ohhA-3fe4A:
30.3		 5ohhA-3fe4A:
34.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Burkholderia
pseudomallei) 		PF03740
(PdxJ) 		4 HIS A  19
VAL A 226
LEU A  23
THR A  22
 None
 1.08A 5ohhA-3gk0A:
undetectable		 5ohhA-3gk0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ius UNCHARACTERIZED
CONSERVED PROTEIN

(Ruegeria
pomeroyi) 		no annotation 4 HIS A 107
VAL A 112
LEU A 118
THR A 119
 None
 1.36A 5ohhA-3iusA:
undetectable		 5ohhA-3iusA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k25 SLR1438 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF01263
(Aldose_epim) 		4 HIS A 141
VAL A  40
LEU A 227
THR A 288
 None
 0.81A 5ohhA-3k25A:
undetectable		 5ohhA-3k25A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl2 PUTATIVE
ISOCHORISMATASE

(Streptomyces
avermitilis) 		PF00857
(Isochorismatase) 		4 HIS A 211
VAL A  68
LEU A 177
THR A 178
 None
 0.94A 5ohhA-3kl2A:
undetectable		 5ohhA-3kl2A:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
HIS A  96
LEU A 198
THR A 200
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
 1.16A 5ohhA-3ml5A:
42.2		 5ohhA-3ml5A:
53.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
 0.28A 5ohhA-3ml5A:
42.2		 5ohhA-3ml5A:
53.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		4 HIS A 123
HIS A 125
LEU A 214
THR A 216
 ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
MLT  A   3 ( 4.2A)
MLT  A   3 (-2.8A)
 1.19A 5ohhA-3q31A:
23.8		 5ohhA-3q31A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		5 HIS A 123
HIS A 142
VAL A 154
LEU A 214
THR A 215
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.2A)
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
 0.35A 5ohhA-3q31A:
23.8		 5ohhA-3q31A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		4 HIS A 142
VAL A 144
LEU A 214
THR A 215
 ZN  A   1 ( 3.2A)
None
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
 1.16A 5ohhA-3q31A:
23.8		 5ohhA-3q31A:
27.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
HIS A 119
VAL A 142
THR A 198
 ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
None
ZN  A 261 ( 4.4A)
 0.31A 5ohhA-3uyqA:
41.2		 5ohhA-3uyqA:
58.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 HIS A 313
HIS A 333
LEU A  27
THR A  28
 None
 1.11A 5ohhA-3wiqA:
undetectable		 5ohhA-3wiqA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 HIS A 636
HIS A 617
VAL A 356
THR A 407
 None
 1.35A 5ohhA-3wqyA:
undetectable		 5ohhA-3wqyA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkb DEOXYURIDINE
TRIPHOSPHATASE

(Trypanosoma
brucei) 		PF08761
(dUTPase_2) 		4 HIS A  82
HIS A 209
VAL A 206
LEU A  17
 DUN  A 303 (-3.7A)
None
None
None
 1.25A 5ohhA-4dkbA:
undetectable		 5ohhA-4dkbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4erc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
23

(Homo sapiens) 		PF00782
(DSPc) 		4 HIS A  59
HIS A  38
VAL A  91
LEU A  56
 None
 1.35A 5ohhA-4ercA:
undetectable		 5ohhA-4ercA:
18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		4 HIS A  89
HIS A  91
LEU A 173
THR A 175
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
 1.20A 5ohhA-4g7aA:
28.9		 5ohhA-4g7aA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		5 HIS A  89
HIS A 108
VAL A 120
LEU A 173
THR A 174
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
 0.32A 5ohhA-4g7aA:
28.9		 5ohhA-4g7aA:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Escherichia
coli) 		PF02401
(LYTB) 		4 HIS A 124
VAL A 127
LEU A 169
THR A 168
 10D  A 402 (-4.0A)
None
None
10D  A 402 (-3.5A)
 0.90A 5ohhA-4h4cA:
undetectable		 5ohhA-4h4cA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		4 HIS A 253
VAL A 216
LEU A 225
THR A 248
 None
 1.14A 5ohhA-4mq0A:
undetectable		 5ohhA-4mq0A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mup AMIDOHYDROLASE

(Agrobacterium
fabrum) 		PF04909
(Amidohydro_2) 		4 HIS A 174
VAL A 220
LEU A 261
THR A 262
 None
 1.30A 5ohhA-4mupA:
undetectable		 5ohhA-4mupA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7b LYTB

(Plasmodium
falciparum) 		PF02401
(LYTB) 		4 HIS A 126
VAL A 129
LEU A 168
THR A 167
 SO4  A 402 (-4.1A)
None
None
SO4  A 402 (-3.4A)
 0.85A 5ohhA-4n7bA:
undetectable		 5ohhA-4n7bA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E

(Aeropyrum
pernix) 		PF01040
(UbiA) 		4 HIS A 128
VAL A 132
LEU A 113
THR A 114
 None
PHB  A 302 (-4.6A)
None
None
 1.19A 5ohhA-4od5A:
undetectable		 5ohhA-4od5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5n HYPOTHETICAL PROTEIN
CNAG_02591

(Cryptococcus
neoformans) 		no annotation 4 HIS A  29
VAL A  64
LEU A  71
THR A  22
 None
None
None
CD  A 101 (-2.8A)
 1.17A 5ohhA-4p5nA:
undetectable		 5ohhA-4p5nA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7w L-PROLINE
CIS-4-HYDROXYLASE

(Mesorhizobium
japonicum) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		4 HIS A 234
VAL A 236
LEU A 205
THR A 204
 None
 0.86A 5ohhA-4p7wA:
undetectable		 5ohhA-4p7wA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
HIS A  96
LEU A 198
THR A 200
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
 1.21A 5ohhA-4qk3A:
40.3		 5ohhA-4qk3A:
58.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
 0.18A 5ohhA-4qk3A:
40.3		 5ohhA-4qk3A:
58.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
VAL A 121
LEU A 198
THR A 199
 ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
 1.09A 5ohhA-4qk3A:
40.3		 5ohhA-4qk3A:
58.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 119
VAL A 121
LEU A 198
THR A 199
 ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
 1.08A 5ohhA-4qk3A:
40.3		 5ohhA-4qk3A:
58.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		4 HIS A 112
HIS A 114
LEU A 197
THR A 199
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.23A 5ohhA-4uovA:
30.4		 5ohhA-4uovA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		5 HIS A 112
HIS A 131
VAL A 143
LEU A 197
THR A 198
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 0.41A 5ohhA-4uovA:
30.4		 5ohhA-4uovA:
34.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 HIS A 182
HIS A 281
VAL A 118
THR A 307
 ADP  A 801 (-3.6A)
ADP  A 801 (-3.8A)
None
None
 1.18A 5ohhA-4woeA:
undetectable		 5ohhA-4woeA:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		4 HIS A  89
HIS A  91
LEU A 173
THR A 175
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
 1.20A 5ohhA-4x5sA:
29.1		 5ohhA-4x5sA:
34.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		5 HIS A  89
HIS A 108
VAL A 120
LEU A 173
THR A 174
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
 0.35A 5ohhA-4x5sA:
29.1		 5ohhA-4x5sA:
34.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		5 HIS A 110
HIS A 129
VAL A 141
LEU A 190
THR A 191
 ZN  A 301 (-3.3A)
ZN  A 301 ( 3.1A)
None
None
ZN  A 301 (-4.3A)
 0.48A 5ohhA-4xfwA:
26.4		 5ohhA-4xfwA:
28.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		4 HIS A 129
VAL A 131
LEU A 190
THR A 191
 ZN  A 301 ( 3.1A)
None
None
ZN  A 301 (-4.3A)
 1.22A 5ohhA-4xfwA:
26.4		 5ohhA-4xfwA:
28.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 HIS A 160
HIS A 162
LEU A 253
THR A 255
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
2HP  A 402 (-3.4A)
2HP  A 402 (-3.6A)
 1.18A 5ohhA-4xixA:
25.6		 5ohhA-4xixA:
30.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 HIS A 160
HIS A 179
VAL A 192
LEU A 253
THR A 254
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
 0.27A 5ohhA-4xixA:
25.6		 5ohhA-4xixA:
30.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 HIS A 179
VAL A 181
LEU A 253
THR A 254
 ZN  A 401 ( 3.1A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
 1.05A 5ohhA-4xixA:
25.6		 5ohhA-4xixA:
30.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		4 HIS A 165
HIS A 167
LEU A 251
THR A 253
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
BCT  A 402 (-3.8A)
BCT  A 402 ( 4.4A)
 1.27A 5ohhA-4xz5A:
29.2		 5ohhA-4xz5A:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		5 HIS A 165
HIS A 184
VAL A 196
LEU A 251
THR A 252
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
 0.19A 5ohhA-4xz5A:
29.2		 5ohhA-4xz5A:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
HIS A  96
LEU A 198
THR A 200
 ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 (-3.6A)
GOL  A 303 ( 3.5A)
 1.24A 5ohhA-5cjfA:
36.2		 5ohhA-5cjfA:
37.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 (-3.2A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
 0.24A 5ohhA-5cjfA:
36.2		 5ohhA-5cjfA:
37.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		4 HIS A 625
VAL A 581
LEU A 685
THR A 692
 None
 1.28A 5ohhA-5csaA:
undetectable		 5ohhA-5csaA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF03740
(PdxJ) 		4 HIS A  23
VAL A 230
LEU A  27
THR A  26
 None
 1.07A 5ohhA-5dlcA:
undetectable		 5ohhA-5dlcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5d PEPTIDE DEFORMYLASE

(Xanthomonas
oryzae) 		PF01327
(Pep_deformylase) 		4 HIS A 135
VAL A 139
LEU A  80
THR A  78
 None
 1.35A 5ohhA-5e5dA:
undetectable		 5ohhA-5e5dA:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		4 HIS X  93
HIS X  95
LEU X 196
THR X 198
 ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
None
None
 1.15A 5ohhA-5eztX:
42.4		 5ohhA-5eztX:
58.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 HIS X  93
HIS X 118
VAL X 141
LEU X 196
THR X 197
 ZN  X 301 (-3.2A)
ZN  X 301 (-3.1A)
None
None
ZN  X 301 ( 4.4A)
 0.26A 5ohhA-5eztX:
42.4		 5ohhA-5eztX:
58.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		4 HIS H 111
VAL H 113
LEU H 225
THR H 214
 None
 1.03A 5ohhA-5g06H:
undetectable		 5ohhA-5g06H:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
HIS A  98
LEU A 181
THR A 183
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
 1.14A 5ohhA-5hpjA:
28.4		 5ohhA-5hpjA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
HIS A 115
VAL A 127
LEU A 181
THR A 182
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
 0.33A 5ohhA-5hpjA:
28.4		 5ohhA-5hpjA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		4 HIS A 115
VAL A 117
LEU A 181
THR A 182
 ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
 1.18A 5ohhA-5hpjA:
28.4		 5ohhA-5hpjA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  94
HIS A  96
LEU A 198
THR A 200
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.9A)
 1.15A 5ohhA-5jn9A:
31.6		 5ohhA-5jn9A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
 0.38A 5ohhA-5jn9A:
31.6		 5ohhA-5jn9A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB

(Chlamydomonas
reinhardtii) 		no annotation 4 HIS A 298
HIS A 180
LEU A 128
THR A 125
 None
ZN  A 500 (-3.3A)
None
None
 1.03A 5ohhA-5k5wA:
undetectable		 5ohhA-5k5wA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus;
Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		4 HIS C 242
VAL A 372
LEU A 460
THR C 246
 None
 1.33A 5ohhA-5n28C:
undetectable		 5ohhA-5n28C:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		4 HIS A 197
HIS A 248
LEU A 163
THR A 151
 FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
None
83D  A 602 (-3.5A)
 1.17A 5ohhA-5u8zA:
undetectable		 5ohhA-5u8zA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 4 HIS A 168
HIS A 219
LEU A 134
THR A 122
 FE  A 500 (-3.3A)
FE  A 500 (-3.2A)
None
None
 1.27A 5ohhA-5v2dA:
undetectable		 5ohhA-5v2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6t ENDO-1,4-BETA-MANNAN
ASE

(Eisenia fetida) 		no annotation 4 HIS A 278
VAL A 128
LEU A 238
THR A 237
 None
 1.27A 5ohhA-5y6tA:
undetectable		 5ohhA-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 4 HIS A 665
VAL A 715
LEU A 672
THR A 669
 None
 1.15A 5ohhA-6cg0A:
undetectable		 5ohhA-6cg0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0p PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii) 		no annotation 4 HIS A  61
HIS A  63
VAL A 103
THR A  68
 MN  A 303 ( 3.3A)
MN  A 303 (-3.4A)
None
MN  A 303 ( 4.9A)
 1.36A 5ohhA-6d0pA:
undetectable		 5ohhA-6d0pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 4 HIS A 117
HIS A 119
LEU A 201
THR A 203
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
None
 1.23A 5ohhA-6ekiA:
29.7		 5ohhA-6ekiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 5 HIS A 117
HIS A 136
VAL A 148
LEU A 201
THR A 202
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 (-4.4A)
 0.26A 5ohhA-6ekiA:
29.7		 5ohhA-6ekiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 4 HIS A  94
HIS A  96
LEU A 198
THR A 200
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.5A)
 1.23A 5ohhA-6fe1A:
32.9		 5ohhA-6fe1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 5 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
 0.38A 5ohhA-6fe1A:
32.9		 5ohhA-6fe1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 4 HIS A 181
VAL A 148
LEU A  27
THR A  24
 QPS  A 602 (-4.1A)
None
None
None
 0.88A 5ohhA-6gnfA:
undetectable		 5ohhA-6gnfA:
undetectable