SIMILAR PATTERNS OF AMINO ACIDS FOR 5OH1_C_9UQC202_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dyp KAPPA-CARRAGEENASE

(Pseudoalteromonas
carrageenovora) 		PF00722
(Glyco_hydro_16) 		4 ASN A 204
PRO A 197
GLU A 168
TRP A 232
 None
CL  A1307 (-4.6A)
CL  A1307 ( 4.3A)
None
 1.15A 5oh1C-1dypA:
undetectable		 5oh1C-1dypA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 NATURAL KILLER CELL
PROTEASE 1
ECOTIN

(Rattus
norvegicus;
Escherichia
coli) 		PF00089
(Trypsin)
PF03974
(Ecotin) 		4 ASN A 179
GLU A 169
PHE A 175
TYR D 100
 None
 1.22A 5oh1C-1fi8A:
undetectable		 5oh1C-1fi8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		4 ASN A  13
PRO A  14
PHE A 110
TYR A  68
 None
 1.24A 5oh1C-1fokA:
0.0		 5oh1C-1fokA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 GLU A 329
PHE A 203
TRP A 204
TRP A 205
 None
 1.45A 5oh1C-1hcyA:
0.0		 5oh1C-1hcyA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kjv MATURE ALPHA CHAIN
OF MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
ANTIGEN (HEAVY
CHAIN)

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ASN A  63
GLU A  58
TRP A  60
TYR A  45
 None
 1.38A 5oh1C-1kjvA:
0.0		 5oh1C-1kjvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		4 ASN A 202
PRO A 203
PHE A   5
TRP A 200
 None
 1.41A 5oh1C-1kyhA:
undetectable		 5oh1C-1kyhA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mij PROTEIN PROSPERO

(Drosophila
melanogaster) 		PF05044
(HPD) 		4 ASN A1348
GLU A1354
PHE A1351
TYR A1299
 None
 1.10A 5oh1C-1mijA:
undetectable		 5oh1C-1mijA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		4 ASN A 105
PHE A 103
TRP A 189
TYR A  33
 None
 1.30A 5oh1C-1ukcA:
0.0		 5oh1C-1ukcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ASN A 142
PRO A 143
GLU A 213
TYR A 117
 None
 1.09A 5oh1C-1vknA:
undetectable		 5oh1C-1vknA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		4 ASN A 122
PRO A 120
GLU A 107
TYR A 362
 NAG  A1781 ( 4.1A)
NAG  A1781 ( 3.9A)
NAG  A1781 ( 4.9A)
None
 1.43A 5oh1C-1w7cA:
0.5		 5oh1C-1w7cA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Escherichia
coli) 		PF08534
(Redoxin) 		4 PRO E 174
GLU E 170
TRP E 168
TYR E  89
 None
 1.44A 5oh1C-1z5yE:
undetectable		 5oh1C-1z5yE:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Escherichia
coli) 		PF08534
(Redoxin) 		4 PRO E 174
GLU E 171
TRP E 168
TYR E  89
 None
 1.42A 5oh1C-1z5yE:
undetectable		 5oh1C-1z5yE:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		4 PRO A 344
GLU A 137
TRP A  62
TYR A 104
 None
 1.11A 5oh1C-1zy9A:
undetectable		 5oh1C-1zy9A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1f THREONINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 ASN A  95
GLU A  60
PHE A  68
TYR A 103
 PLP  A 500 (-3.9A)
None
PLP  A 500 (-4.7A)
None
 1.49A 5oh1C-2d1fA:
undetectable		 5oh1C-2d1fA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gju 252AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		no annotation 4 ASN A  13
PRO A  15
GLU A  52
PHE A  14
 None
 1.48A 5oh1C-2gjuA:
undetectable		 5oh1C-2gjuA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 ASN A 116
PRO A 117
GLU A 133
TYR A  47
 None
 0.98A 5oh1C-2gmiA:
undetectable		 5oh1C-2gmiA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m8x UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF07705
(CARDB) 		4 PRO A 447
GLU A 457
TRP A 503
TYR A 484
 None
 1.48A 5oh1C-2m8xA:
undetectable		 5oh1C-2m8xA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2l OUTER MEMBRANE
PROTEIN X

(Yersinia pestis) 		PF13505
(OMP_b-brl) 		4 ASN A  25
PRO A  26
TRP A 148
TYR A 137
 None
 1.42A 5oh1C-2n2lA:
undetectable		 5oh1C-2n2lA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsg HYPOTHETICAL PROTEIN
CGL3021

(Corynebacterium
glutamicum) 		PF11716
(MDMPI_N) 		4 ASN A  93
PRO A  94
PHE A  35
TYR A  55
 None
 1.45A 5oh1C-2nsgA:
undetectable		 5oh1C-2nsgA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PRO A 452
GLU A 457
TRP A 462
TYR A 440
 None
 1.47A 5oh1C-2nyaA:
undetectable		 5oh1C-2nyaA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 ASN A 141
PRO A 145
PHE A 189
TYR A 155
 None
 1.05A 5oh1C-2w61A:
undetectable		 5oh1C-2w61A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 ASN A 141
PRO A 145
PHE A 189
TYR A 213
 None
 1.22A 5oh1C-2w61A:
undetectable		 5oh1C-2w61A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 ASN A 249
PRO A 250
GLU A 359
TRP A 282
 None
 1.46A 5oh1C-2xdqA:
undetectable		 5oh1C-2xdqA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 ASN A 171
PHE A 174
TRP A 623
TYR A 179
 None
 1.49A 5oh1C-2yevA:
undetectable		 5oh1C-2yevA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		4 ASN A 250
PRO A 251
GLU A  86
TYR A  81
 None
None
EPE  A 503 (-3.8A)
None
 1.19A 5oh1C-3b1eA:
undetectable		 5oh1C-3b1eA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqx GLYOXALASE-RELATED
ENZYME

(Fulvimarina
pelagi) 		PF00903
(Glyoxalase) 		4 ASN A 126
PRO A 127
GLU A  80
PHE A 125
 None
 1.34A 5oh1C-3bqxA:
undetectable		 5oh1C-3bqxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1n POU DOMAIN, CLASS 6,
TRANSCRIPTION FACTOR
1

(Homo sapiens) 		PF00046
(Homeobox)
PF00157
(Pou) 		4 ASN I 256
PRO I 257
GLU I 254
PHE I 253
 None
 1.12A 5oh1C-3d1nI:
undetectable		 5oh1C-3d1nI:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		4 GLU A 650
TRP A 550
TRP A 647
TYR A 230
 None
 1.37A 5oh1C-3d3lA:
undetectable		 5oh1C-3d3lA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 ASN A 224
GLU A 281
TRP A 245
TRP A 247
 None
 1.31A 5oh1C-3eqnA:
undetectable		 5oh1C-3eqnA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		4 PRO A 163
GLU A 466
PHE A 467
TYR A 138
 None
 1.49A 5oh1C-3i44A:
undetectable		 5oh1C-3i44A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ASN A 204
GLU A 268
PHE A 267
TYR A 245
 None
 1.28A 5oh1C-3jq1A:
undetectable		 5oh1C-3jq1A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1

(Homo sapiens) 		PF00899
(ThiF) 		4 ASN A 168
GLU A 313
PHE A 154
TYR A 164
 None
None
None
EDO  A 347 (-4.6A)
 1.25A 5oh1C-3kydA:
undetectable		 5oh1C-3kydA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpp BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 PRO G 942
GLU G1293
TRP G1096
TYR G1146
 None
 1.36A 5oh1C-3mppG:
undetectable		 5oh1C-3mppG:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		4 ASN A  43
PRO A  44
GLU A  34
PHE A  37
 None
 0.62A 5oh1C-3op7A:
undetectable		 5oh1C-3op7A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os7 GALACTOSE
MUTAROTASE-LIKE
PROTEIN

(Clostridium
acetobutylicum) 		PF01263
(Aldose_epim) 		4 ASN A 310
PRO A 309
PHE A 320
TYR A 284
 None
PG4  A 400 ( 4.9A)
None
PG4  A 344 (-4.4A)
 1.46A 5oh1C-3os7A:
undetectable		 5oh1C-3os7A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		4 ASN A 318
GLU A 300
PHE A 315
TYR A 198
 None
 1.46A 5oh1C-3pcoA:
2.2		 5oh1C-3pcoA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poj MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Rattus
norvegicus) 		PF00431
(CUB) 		4 PRO A 246
PHE A 240
TRP A 271
TYR A 187
 None
 1.39A 5oh1C-3pojA:
undetectable		 5oh1C-3pojA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3som METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN

(Homo sapiens) 		PF16690
(MMACHC) 		4 PRO A  56
PHE A 154
TRP A 157
TYR A 205
 None
 1.47A 5oh1C-3somA:
undetectable		 5oh1C-3somA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy6 FIMBRIAL PROTEIN
BF1861

(Bacteroides
fragilis) 		PF13149
(Mfa_like_1) 		4 ASN A 124
GLU A 232
PHE A 123
TYR A 215
 None
 1.32A 5oh1C-3sy6A:
undetectable		 5oh1C-3sy6A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 ASN A 474
PRO A 475
PHE A 376
TRP A 305
 None
 0.94A 5oh1C-3ummA:
undetectable		 5oh1C-3ummA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		4 ASN A 423
PRO A 424
GLU A 386
TYR A 397
 None
 1.24A 5oh1C-3vgfA:
undetectable		 5oh1C-3vgfA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 ASN A 242
GLU A 237
TRP A 239
TRP A 212
 None
 1.43A 5oh1C-3vwaA:
undetectable		 5oh1C-3vwaA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zw6 RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE 1,
CHLOROPLASTIC

(Nicotiana
tabacum) 		PF00004
(AAA) 		4 ASN A 130
PRO A 131
GLU A 121
PHE A 124
 None
 1.48A 5oh1C-3zw6A:
undetectable		 5oh1C-3zw6A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 ASN A 338
PRO A 339
PHE A 344
TYR A 423
 None
 1.19A 5oh1C-4aeeA:
undetectable		 5oh1C-4aeeA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 4 ASN A 317
PRO A 274
PHE A 319
TYR A  49
 None
IOD  A1704 ( 4.6A)
None
None
 1.08A 5oh1C-4aw7A:
undetectable		 5oh1C-4aw7A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		5 ASN B 353
PRO B 354
TRP B 382
TRP B 388
TRP B 402
 LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
 0.69A 5oh1C-4ci2B:
14.7		 5oh1C-4ci2B:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		4 ASN A 116
PRO A 117
GLU A 247
TYR A 212
 None
 1.25A 5oh1C-4jndA:
undetectable		 5oh1C-4jndA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		4 ASN A  67
GLU A  98
TRP A 158
TYR A  29
 None
 1.30A 5oh1C-4l22A:
undetectable		 5oh1C-4l22A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASN A 503
PRO A 504
PHE A 494
TYR A 265
 None
 1.49A 5oh1C-4ptfA:
undetectable		 5oh1C-4ptfA:
7.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 6 ASN A  50
PRO A  51
PHE A  77
TRP A  79
TRP A  99
TYR A 101
 LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-4.4A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.7A)
LVY  A 151 (-4.7A)
 1.00A 5oh1C-4v30A:
19.9		 5oh1C-4v30A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 5 PRO A  51
TRP A  79
TRP A  85
TRP A  99
TYR A 101
 LVY  A 151 (-4.4A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
LVY  A 151 (-4.7A)
 0.55A 5oh1C-4v30A:
19.9		 5oh1C-4v30A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ASN B  56
PRO B  78
PHE B  76
TYR B 131
 None
 1.43A 5oh1C-4z0xB:
undetectable		 5oh1C-4z0xB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 ASN A 465
PRO A 464
GLU A 462
PHE A 468
 None
 1.46A 5oh1C-5cslA:
undetectable		 5oh1C-5cslA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gv0 LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 1

(Mus musculus) 		PF01299
(Lamp) 		4 ASN A 248
PRO A 208
PHE A 344
TYR A 213
 None
 1.41A 5oh1C-5gv0A:
undetectable		 5oh1C-5gv0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.7A)
 0.76A 5oh1C-5hxbZ:
10.7		 5oh1C-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 5 PRO Z 352
GLU Z 377
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.61A 5oh1C-5hxbZ:
10.7		 5oh1C-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		4 ASN A1452
PRO A1453
GLU A1461
TYR A 997
 None
 1.42A 5oh1C-5jbeA:
undetectable		 5oh1C-5jbeA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 PRO B 128
GLU B 122
PHE B 129
TRP B 335
 None
 1.30A 5oh1C-5ldrB:
undetectable		 5oh1C-5ldrB:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 4 ASN A  65
PRO A  64
PHE A  63
TYR A 198
 NA  A 305 (-3.4A)
None
None
None
 1.13A 5oh1C-5mrtA:
undetectable		 5oh1C-5mrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF07361
(Cytochrom_B562) 		4 ASN A 179
PRO A 180
GLU A2048
TRP A 175
 None
 1.48A 5oh1C-5ndzA:
undetectable		 5oh1C-5ndzA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 4 ASN A 377
PRO A 378
TRP A 374
TYR A  56
 None
None
EDO  A 709 (-4.6A)
EDO  A 709 (-4.4A)
 1.15A 5oh1C-5ta1A:
undetectable		 5oh1C-5ta1A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 4 PRO A 222
GLU A 218
TRP A 220
TYR A 112
 None
 1.33A 5oh1C-5wmmA:
undetectable		 5oh1C-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsx CHITINASE

(Thermococcus
chitonophagus) 		no annotation 4 ASN A 521
GLU A 647
PHE A 470
TRP A 645
 None
 0.99A 5oh1C-5xsxA:
undetectable		 5oh1C-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 ASN A 563
GLU A 486
PHE A 560
TYR A 535
 None
 1.42A 5oh1C-6arxA:
undetectable		 5oh1C-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbd PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN D

(Sus scrofa) 		no annotation 4 ASN A 236
PRO A 235
PHE A 234
TYR A 228
 None
 1.39A 5oh1C-6bbdA:
undetectable		 5oh1C-6bbdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf


(;
) 		no annotation
no annotation 		4 GLU 7  96
PHE 7  91
TRP 8  47
TRP 8  50
 None
 1.41A 5oh1C-6cuf7:
undetectable		 5oh1C-6cuf7:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1d COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		no annotation 4 PRO A 256
PHE A 250
TRP A 281
TYR A 197
 None
 1.35A 5oh1C-6f1dA:
undetectable		 5oh1C-6f1dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 4 ASN D 101
PRO D  74
GLU D  46
TRP D  49
 None
 1.48A 5oh1C-6f45D:
undetectable		 5oh1C-6f45D:
undetectable