SIMILAR PATTERNS OF AMINO ACIDS FOR 5OH1_A_EF2A202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE


(Escherichia
coli)
PF00982
(Glyco_transf_20)
4 PRO A 158
PHE A  88
TRP A  85
TYR A 265
None
1.43A 5oh1A-1gz5A:
undetectable
5oh1A-1gz5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE


(Saccharomyces
cerevisiae)
PF00343
(Phosphorylase)
4 PRO A 229
PHE A 228
TRP A 155
TYR A 157
None
1.46A 5oh1A-1ygpA:
0.0
5oh1A-1ygpA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg9 ADP-RIBOSYL CYCLASE
1


(Mus musculus)
PF02267
(Rib_hydrolayse)
4 ASN A 187
PRO A 188
PHE A  97
TRP A  53
None
1.34A 5oh1A-2eg9A:
undetectable
5oh1A-2eg9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8g CAPSID

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 PRO A 299
PHE A 636
TRP A 617
TYR A 343
None
1.48A 5oh1A-2g8gA:
undetectable
5oh1A-2g8gA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2


(Saccharomyces
cerevisiae)
PF03198
(Glyco_hydro_72)
PF07983
(X8)
4 ASN A 141
PRO A 145
PHE A 189
TYR A 155
None
1.25A 5oh1A-2w61A:
0.0
5oh1A-2w61A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale)
PF00232
(Glyco_hydro_1)
4 ASN A 190
PHE A 187
TRP A 144
TYR A 168
None
1.34A 5oh1A-3aivA:
0.0
5oh1A-3aivA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus)
PF00740
(Parvo_coat)
4 PRO A 310
PHE A 639
TRP A 620
TYR A 354
None
1.48A 5oh1A-3j4pA:
0.0
5oh1A-3j4pA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juu PORPHYRANASE B

(Zobellia
galactanivorans)
PF00722
(Glyco_hydro_16)
4 ASN A 261
PRO A 262
TRP A 260
TRP A 172
None
1.39A 5oh1A-3juuA:
0.0
5oh1A-3juuA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 PRO A 308
PHE A 638
TRP A 619
TYR A 352
None
1.42A 5oh1A-3kieA:
0.0
5oh1A-3kieA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
4 ASN A 319
PRO A 315
PHE A 670
TYR A 660
None
1.48A 5oh1A-3lppA:
undetectable
5oh1A-3lppA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 PRO A 309
PHE A 638
TRP A 619
TYR A 353
None
1.43A 5oh1A-3ng9A:
undetectable
5oh1A-3ng9A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE


(Cytophaga
hutchinsonii)
PF01494
(FAD_binding_3)
4 PRO A  50
PHE A  89
TRP A  99
TRP A 101
None
1.20A 5oh1A-3nixA:
undetectable
5oh1A-3nixA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B)
PF00740
(Parvo_coat)
4 PRO A 299
PHE A 627
TRP A 608
TYR A 343
None
1.50A 5oh1A-3nttA:
undetectable
5oh1A-3nttA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
4 PRO A  69
PHE A  70
TRP A 350
TYR A 948
None
1.40A 5oh1A-3ogrA:
undetectable
5oh1A-3ogrA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 PRO A 311
PHE A 640
TRP A 621
TYR A 355
None
1.38A 5oh1A-3ra2A:
undetectable
5oh1A-3ra2A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 PRO A 309
PHE A 638
TRP A 619
TYR A 353
None
1.44A 5oh1A-3shmA:
undetectable
5oh1A-3shmA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A)
PF00740
(Parvo_coat)
4 PRO A 310
PHE A 638
TRP A 619
TYR A 354
None
1.43A 5oh1A-3ux1A:
undetectable
5oh1A-3ux1A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE


(Streptomyces
avermitilis)
PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C)
4 PRO A 628
TRP A 347
TRP A 380
TYR A 350
None
1.31A 5oh1A-3w5nA:
undetectable
5oh1A-3w5nA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION


(Staphylothermus
marinus)
PF00128
(Alpha-amylase)
4 ASN A 338
PRO A 339
PHE A 344
TYR A 423
None
1.16A 5oh1A-4aeeA:
undetectable
5oh1A-4aeeA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE


(Bacteroides
plebeius)
no annotation 4 ASN A 317
PRO A 274
PHE A 319
TYR A  49
None
IOD  A1704 ( 4.6A)
None
None
0.95A 5oh1A-4aw7A:
undetectable
5oh1A-4aw7A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus)
PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18)
5 ASN B 353
PRO B 354
TRP B 382
TRP B 388
TRP B 402
LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
0.46A 5oh1A-4ci2B:
16.0
5oh1A-4ci2B:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana)
PF00128
(Alpha-amylase)
4 PRO A 284
PHE A 278
TRP A 353
TYR A 351
None
1.46A 5oh1A-4gklA:
undetectable
5oh1A-4gklA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iov CAPSID PROTEIN VP1

(Adeno-associated
virus)
PF00740
(Parvo_coat)
4 PRO A 299
PHE A 635
TRP A 616
TYR A 343
None
1.42A 5oh1A-4iovA:
undetectable
5oh1A-4iovA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
4 PRO A  69
PHE A  70
TRP A 350
TYR A 930
None
1.36A 5oh1A-4iugA:
undetectable
5oh1A-4iugA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7a UNCHARACTERIZED
PROTEIN


(Bacteroides
caccae)
PF15890
(Peptidase_Mx1)
4 ASN A  59
PRO A  60
TRP A  52
TYR A 297
None
1.29A 5oh1A-4l7aA:
undetectable
5oh1A-4l7aA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus)
PF00740
(Parvo_coat)
4 PRO A 310
PHE A 638
TRP A 619
TYR A 354
None
1.46A 5oh1A-4rsoA:
undetectable
5oh1A-4rsoA:
8.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense)
no annotation 7 ASN A  50
PRO A  51
PHE A  77
TRP A  79
TRP A  85
TRP A  99
TYR A 101
LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-4.4A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
LVY  A 151 (-4.7A)
0.16A 5oh1A-4v30A:
24.1
5oh1A-4v30A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE


(Aspergillus
flavus)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 ASN A 318
PHE A 414
TRP A 415
TYR A 337
LGC  A 602 ( 4.4A)
None
None
None
1.41A 5oh1A-4ynuA:
undetectable
5oh1A-4ynuA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2


(Rattus
norvegicus)
PF00431
(CUB)
PF07645
(EGF_CA)
4 PRO A 245
PHE A 239
TRP A 270
TYR A 186
None
1.39A 5oh1A-5ckmA:
undetectable
5oh1A-5ckmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]


(Candida
albicans)
PF00982
(Glyco_transf_20)
4 PRO A 175
PHE A 101
TRP A  98
TYR A 283
None
1.39A 5oh1A-5huuA:
undetectable
5oh1A-5huuA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Aspergillus
fumigatus)
PF00982
(Glyco_transf_20)
4 PRO A 183
PHE A 109
TRP A 106
TYR A 290
None
1.46A 5oh1A-5hvmA:
undetectable
5oh1A-5hvmA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens)
no annotation 5 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.56A 5oh1A-5hxbZ:
11.4
5oh1A-5hxbZ:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A


(Aspergillus
niger)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
4 PRO A  69
PHE A  70
TRP A 350
TYR A 932
None
1.40A 5oh1A-5ihrA:
undetectable
5oh1A-5ihrA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k50 L-THREONINE
3-DEHYDROGENASE


(Trypanosoma
brucei)
no annotation 4 PRO A1281
PHE A1123
TRP A1280
TYR A1144
None
None
None
GOL  A1402 ( 4.3A)
1.41A 5oh1A-5k50A:
undetectable
5oh1A-5k50A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK


(Gluconacetobacter
diazotrophicus)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
4 ASN B 440
PRO B 460
PHE B 459
TYR B 313
None
1.36A 5oh1A-5kohB:
undetectable
5oh1A-5kohB:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME


(Lysobacter sp.
XL1)
no annotation 4 ASN A  65
PRO A  64
PHE A  63
TYR A 198
NA  A 305 (-3.4A)
None
None
None
1.48A 5oh1A-5mrtA:
undetectable
5oh1A-5mrtA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae)
no annotation 4 ASN B 304
PRO B 273
PHE B 301
TYR B  74
None
1.43A 5oh1A-5swiB:
undetectable
5oh1A-5swiB:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Burkholderia
vietnamiensis)
PF00982
(Glyco_transf_20)
4 PRO A 160
PHE A  90
TRP A  87
TYR A 268
None
1.43A 5oh1A-5tvgA:
undetectable
5oh1A-5tvgA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Paraburkholderia
xenovorans)
PF00982
(Glyco_transf_20)
4 PRO A 168
PHE A  98
TRP A  95
TYR A 280
None
1.43A 5oh1A-5v0tA:
undetectable
5oh1A-5v0tA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znp SHORT LIFE FAMILY
PROTEIN


(Populus
trichocarpa)
no annotation 4 ASN A 134
PRO A 135
PHE A 124
TYR A  64
None
1.49A 5oh1A-5znpA:
undetectable
5oh1A-5znpA:
undetectable