SIMILAR PATTERNS OF AMINO ACIDS FOR 5OGC_B_TA1B601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6o TATD-RELATED
DEOXYRIBONUCLEASE

(Thermotoga
maritima) 		PF01026
(TatD_DNase) 		5 VAL A  36
LEU A 205
HIS A   6
PRO A  62
GLY A  92
 None
 1.23A 5ogcB-1j6oA:
1.1		 5ogcB-1j6oA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 LEU A  57
PHE A 342
ARG A  55
GLY A 392
LEU A 391
 None
 1.26A 5ogcB-1li7A:
2.9		 5ogcB-1li7A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6y S-ADENOSYL-METHYLTRA
NSFERASE MRAW

(Thermotoga
maritima) 		PF01795
(Methyltransf_5) 		5 VAL A 252
ASP A 249
GLU A 248
LEU A  20
GLY A 286
 None
 1.12A 5ogcB-1m6yA:
2.8		 5ogcB-1m6yA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE

(Equine
arteritis virus) 		PF05579
(Peptidase_S32) 		5 VAL A 133
PHE A  60
THR A  71
GLY A  13
LEU A  49
 None
 1.06A 5ogcB-1mbmA:
undetectable		 5ogcB-1mbmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 VAL A 330
LEU A 404
THR A 373
PRO A 410
GLY A 296
 None
FAD  A3005 (-4.6A)
None
None
None
 1.27A 5ogcB-1n5xA:
undetectable		 5ogcB-1n5xA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 VAL A 239
ASP A 240
PHE A 337
THR A 329
GLY A 293
 None
IFG  A 557 ( 4.7A)
None
None
None
 1.14A 5ogcB-1nowA:
2.1		 5ogcB-1nowA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 VAL A 245
LEU A 170
ARG A 430
GLY A 318
LEU A 342
 None
 1.26A 5ogcB-1pdzA:
undetectable		 5ogcB-1pdzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 VAL A  28
LEU A 213
SER A  32
GLY A  38
LEU A  37
 None
 1.27A 5ogcB-1pv9A:
undetectable		 5ogcB-1pv9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 GLU A 139
LEU A 302
SER A 107
GLY A 148
LEU A 150
 MG  A 600 ( 4.9A)
None
MG  A 600 ( 2.1A)
GLA  A 500 (-3.6A)
GLA  A 500 ( 4.4A)
 1.28A 5ogcB-1s4eA:
undetectable		 5ogcB-1s4eA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A   6
THR A   7
PRO A  47
GLY A  49
LEU A  46
 None
None
None
GOL  A3001 (-3.3A)
None
 1.23A 5ogcB-1v40A:
undetectable		 5ogcB-1v40A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 VAL A  76
ASP A  75
THR A  53
GLY A  67
LEU A  18
 None
 1.22A 5ogcB-1v43A:
undetectable		 5ogcB-1v43A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfr HYPOTHETICAL PROTEIN
AF1521

(Archaeoglobus
fulgidus) 		PF01661
(Macro) 		5 VAL A 168
LEU A 157
PHE A 137
THR A 155
PRO A 123
 None
 1.17A 5ogcB-2bfrA:
undetectable		 5ogcB-2bfrA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 ASP A  53
HIS A 233
SER A  67
THR A 136
LEU A  74
 None
MTV  A1479 (-3.7A)
None
None
None
 1.14A 5ogcB-2bihA:
undetectable		 5ogcB-2bihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 HIS A 233
SER A  67
THR A 136
PRO A  69
LEU A  74
 MTV  A1479 (-3.7A)
None
None
None
None
 1.15A 5ogcB-2bihA:
undetectable		 5ogcB-2bihA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 HIS A 233
SER A  67
THR A 136
PRO A  69
LEU A  74
 MTV  A1479 (-3.9A)
GOL  A 703 (-3.1A)
None
GOL  A 703 (-3.9A)
None
 1.11A 5ogcB-2biiA:
undetectable		 5ogcB-2biiA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		5 VAL A 161
LEU A  74
PRO A 152
GLY A 128
LEU A 127
 None
 1.14A 5ogcB-2e18A:
undetectable		 5ogcB-2e18A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fli RIBULOSE-PHOSPHATE
3-EPIMERASE

(Streptococcus
pyogenes) 		PF00834
(Ribul_P_3_epim) 		5 ASP A 176
THR A 213
PRO A   8
GLY A 198
LEU A 201
 DX5  A1901 ( 2.6A)
None
None
DX5  A1901 (-3.4A)
None
 0.97A 5ogcB-2fliA:
3.1		 5ogcB-2fliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 VAL A 206
ASP A 207
PHE A 305
THR A 297
GLY A 261
 None
 1.05A 5ogcB-2gjxA:
undetectable		 5ogcB-2gjxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 5 VAL I 206
ASP I 207
PHE I 305
THR I 297
GLY I 261
 None
NGT  A  21 (-3.8A)
None
None
None
 1.09A 5ogcB-2gk1I:
undetectable		 5ogcB-2gk1I:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk3 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07090
(GATase1_like) 		5 GLU A 131
LEU A  90
THR A  87
GLY A 129
LEU A 125
 None
 1.29A 5ogcB-2gk3A:
2.6		 5ogcB-2gk3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 VAL A 287
GLU A 282
LEU A 231
GLY A 300
LEU A 278
 None
 1.13A 5ogcB-2jjmA:
4.7		 5ogcB-2jjmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASP A 140
LEU A 241
SER A 196
ARG A  98
LEU A 164
 None
 1.21A 5ogcB-2ldxA:
5.7		 5ogcB-2ldxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2

(Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		5 GLU A1525
SER A1636
THR A1643
GLY A1570
LEU A1573
 ZN  A6001 (-2.3A)
ZN  A6001 ( 4.5A)
None
GOL  A7007 ( 3.7A)
None
 1.15A 5ogcB-2oo4A:
undetectable		 5ogcB-2oo4A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osa N-CHIMAERIN

(Homo sapiens) 		PF00620
(RhoGAP) 		5 VAL A 404
LEU A 394
PHE A 422
ARG A 281
LEU A 343
 None
 1.14A 5ogcB-2osaA:
undetectable		 5ogcB-2osaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyr UPF0341 PROTEIN YHIQ

(Shigella
flexneri) 		PF04445
(SAM_MT) 		5 GLU A 138
PHE A 104
ARG A 112
GLY A 141
LEU A 143
 None
 1.22A 5ogcB-2oyrA:
2.2		 5ogcB-2oyrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR

(Pseudomonas
putida) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		5 LEU A 199
PHE A  97
THR A 197
GLY A 173
LEU A 174
 None
 1.01A 5ogcB-2uxoA:
undetectable		 5ogcB-2uxoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl1 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 VAL A 587
LEU A 709
HIS A 739
SER A 728
THR A 707
 None
None
None
None
SCN  A1778 ( 4.7A)
 1.11A 5ogcB-2wl1A:
undetectable		 5ogcB-2wl1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 VAL A 477
GLU A 461
LEU A 721
ARG A 517
LEU A 483
 None
 1.25A 5ogcB-2xe4A:
2.9		 5ogcB-2xe4A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 VAL D 369
GLU D 375
SER D 378
GLY D 327
LEU D 349
 None
 1.28A 5ogcB-2ynmD:
undetectable		 5ogcB-2ynmD:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE

(Nonomuraea
recticatena) 		PF00067
(p450) 		5 VAL A 304
ASP A 303
GLU A 302
GLY A 314
LEU A 299
 None
 1.30A 5ogcB-2z36A:
undetectable		 5ogcB-2z36A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 VAL A 245
LEU A 170
ARG A 428
GLY A 316
LEU A 340
 None
 1.29A 5ogcB-3b97A:
undetectable		 5ogcB-3b97A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9j XANTHINE OXIDASE

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 VAL B 330
LEU B 404
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.6A)
None
None
None
 1.23A 5ogcB-3b9jB:
undetectable		 5ogcB-3b9jB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdn PHEROMONE-BINDING
PROTEIN ASP1

(Apis mellifera) 		PF01395
(PBP_GOBP) 		5 VAL A  65
ASP A  66
GLU A  67
GLY A  72
LEU A  74
 CL  A 120 ( 4.4A)
None
None
None
None
 1.10A 5ogcB-3cdnA:
undetectable		 5ogcB-3cdnA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3df7 PUTATIVE ATP-GRASP
SUPERFAMILY PROTEIN

(Archaeoglobus
fulgidus) 		PF02655
(ATP-grasp_3) 		5 ASP A 110
LEU A 132
ARG A 130
PRO A 140
GLY A 158
 None
 1.29A 5ogcB-3df7A:
undetectable		 5ogcB-3df7A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 533
ASP A 534
LEU A 621
ARG A 614
GLY A 537
 None
None
None
None
TDM  A 700 (-3.6A)
 1.11A 5ogcB-3e9yA:
undetectable		 5ogcB-3e9yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2

(Burkholderia
pseudomallei) 		PF00464
(SHMT) 		5 VAL A 310
LEU A  36
THR A 369
ARG A 366
GLY A 316
 None
 1.29A 5ogcB-3ecdA:
2.4		 5ogcB-3ecdA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eod PROTEIN HNR

(Escherichia
coli) 		PF00072
(Response_reg) 		5 LEU A  83
PHE A 121
PRO A   4
GLY A  31
LEU A  30
 None
 1.10A 5ogcB-3eodA:
4.3		 5ogcB-3eodA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		5 VAL A 403
GLU A 404
THR A 227
ARG A 318
LEU A 325
 None
 1.26A 5ogcB-3hidA:
undetectable		 5ogcB-3hidA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 318
GLU A 320
SER A 330
PHE A 302
GLY A 236
 None
 1.28A 5ogcB-3krtA:
undetectable		 5ogcB-3krtA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE

(Streptococcus
mutans) 		PF01048
(PNP_UDP_1) 		5 GLU A  23
ARG A  98
PRO A  22
GLY A 104
LEU A 103
 None
 1.09A 5ogcB-3la8A:
4.0		 5ogcB-3la8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A 233
SER A 462
ARG A  44
GLY A  10
LEU A  15
 None
 1.23A 5ogcB-3nksA:
undetectable		 5ogcB-3nksA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 VAL B 330
LEU B 404
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
 1.24A 5ogcB-3ns1B:
undetectable		 5ogcB-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY

(Paenarthrobacter
aurescens) 		PF04198
(Sugar-bind) 		5 VAL A 247
ASP A 243
HIS A 269
THR A 301
GLY A 209
 None
 1.26A 5ogcB-3nzeA:
undetectable		 5ogcB-3nzeA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLU C 929
SER C 928
PHE C1271
THR C1301
ARG C1306
 None
 1.24A 5ogcB-3sr6C:
undetectable		 5ogcB-3sr6C:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uen DNA TOPOISOMERASE
2-BINDING PROTEIN 1

(Homo sapiens) 		PF12738
(PTCB-BRCT) 		5 ASP A 648
HIS A 694
PRO A 645
GLY A 672
LEU A 671
 None
 1.28A 5ogcB-3uenA:
undetectable		 5ogcB-3uenA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		5 VAL A 256
SER A 204
THR A 113
GLY A 307
LEU A  62
 None
 1.11A 5ogcB-3v7pA:
2.6		 5ogcB-3v7pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ASP A4352
LEU A4644
PRO A4289
GLY A4291
LEU A4290
 None
 1.25A 5ogcB-3vkgA:
undetectable		 5ogcB-3vkgA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 362
PHE A 416
ARG A 347
GLY A 300
LEU A 299
 None
 1.24A 5ogcB-4bc5A:
undetectable		 5ogcB-4bc5A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		5 VAL A 431
LEU A 562
THR A 558
PRO A 381
GLY A 452
 None
 1.19A 5ogcB-4db4A:
undetectable		 5ogcB-4db4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		5 VAL A 101
SER A 143
ARG A 231
GLY A  79
LEU A 217
 None
 1.11A 5ogcB-4eb5A:
undetectable		 5ogcB-4eb5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E

(Methylobacterium
extorquens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 306
GLU A 308
SER A 318
PHE A 289
GLY A 218
 None
None
None
None
NAP  A 502 (-3.4A)
 1.22A 5ogcB-4gi2A:
undetectable		 5ogcB-4gi2A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 ASP A 399
THR A 360
ARG A 259
GLY A 266
LEU A 347
 None
 1.27A 5ogcB-4grhA:
undetectable		 5ogcB-4grhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igv KIROLA

(Actinidia
deliciosa) 		PF00407
(Bet_v_1) 		5 VAL A 127
GLU A 129
PHE A  99
PRO A 130
LEU A 133
 None
 1.19A 5ogcB-4igvA:
undetectable		 5ogcB-4igvA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkm BETA-GLUCURONIDASE

(Clostridium
perfringens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 LEU A 391
PHE A 424
PRO A 413
GLY A 358
LEU A 359
 None
 1.08A 5ogcB-4jkmA:
undetectable		 5ogcB-4jkmA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 SER A  16
PHE A 149
THR A 146
PRO A  11
GLY A 103
 NAG  A 201 (-4.9A)
None
None
None
None
 1.28A 5ogcB-4jpkA:
undetectable		 5ogcB-4jpkA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Campylobacter
jejuni) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		5 VAL A 121
LEU A 169
PHE A 141
GLY A 113
LEU A 130
 None
 1.08A 5ogcB-4noiA:
undetectable		 5ogcB-4noiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qku HYDROLASE

(Burkholderia
cenocepacia) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		5 VAL A 134
ARG A  97
PRO A  48
GLY A  49
LEU A  59
 None
 1.26A 5ogcB-4qkuA:
undetectable		 5ogcB-4qkuA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A  37
THR A  88
ARG A  72
GLY A  31
LEU A  30
 None
 1.02A 5ogcB-4ubtA:
undetectable		 5ogcB-4ubtA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		5 LEU A 147
HIS A 125
SER A 132
ARG A 142
GLY A  84
 None
None
None
OOG  A1305 ( 4.8A)
None
 1.14A 5ogcB-4ur8A:
undetectable		 5ogcB-4ur8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		5 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
 None
 1.03A 5ogcB-4wisA:
undetectable		 5ogcB-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 ASP A 222
LEU A 408
ARG A 322
PRO A 334
LEU A 340
 None
 1.27A 5ogcB-4wlhA:
undetectable		 5ogcB-4wlhA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 ASP A 470
GLU A 473
PRO A 537
GLY A 539
LEU A 540
 None
 0.97A 5ogcB-4wxxA:
4.5		 5ogcB-4wxxA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 298
GLU A 300
SER A 310
PHE A 281
GLY A 209
 None
None
None
None
NAP  A 501 (-2.9A)
 1.24A 5ogcB-4y1bA:
2.8		 5ogcB-4y1bA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 VAL A 329
LEU A 403
THR A 372
PRO A 409
GLY A 295
 None
FAD  A3004 (-4.7A)
None
None
None
 1.27A 5ogcB-4yswA:
undetectable		 5ogcB-4yswA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn2 PSLG

(Pseudomonas
aeruginosa) 		PF00150
(Cellulase) 		5 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
 None
 1.16A 5ogcB-4zn2A:
undetectable		 5ogcB-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 VAL A 288
GLU A 283
LEU A 232
GLY A 301
LEU A 279
 None
GMT  A 401 (-3.6A)
None
None
None
 0.98A 5ogcB-5d01A:
3.1		 5ogcB-5d01A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		5 VAL A 345
ASP A 348
SER A 233
PRO A 421
LEU A 422
 None
 1.22A 5ogcB-5e84A:
undetectable		 5ogcB-5e84A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 256
ASP A 487
LEU A 374
THR A 373
GLY A 463
 None
FAD  A 601 (-4.6A)
None
None
None
 1.27A 5ogcB-5eb5A:
undetectable		 5ogcB-5eb5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 VAL A 182
ASP A 183
LEU A 284
GLY A 206
LEU A 219
 None
PLP  A 401 (-2.7A)
None
None
None
 1.17A 5ogcB-5f9sA:
3.0		 5ogcB-5f9sA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gha SULFUR TRANSFERASE
TTUA

(Thermus
thermophilus) 		PF01171
(ATP_bind_3) 		5 VAL A 108
ASP A 109
PHE A 288
GLY A 117
LEU A 121
 None
 1.29A 5ogcB-5ghaA:
undetectable		 5ogcB-5ghaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsi PUTATIVE
DECARBOXYLASE

(Lactobacillus
brevis) 		PF00282
(Pyridoxal_deC) 		5 VAL A 137
GLU A 134
HIS A 453
THR A 103
GLY A 401
 None
 1.22A 5ogcB-5hsiA:
undetectable		 5ogcB-5hsiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyd PROTEIN S100-Z

(Homo sapiens) 		PF01023
(S_100) 		5 GLU A  69
PHE A  16
ARG A  40
GLY A  32
LEU A  34
 None
 1.25A 5ogcB-5hydA:
undetectable		 5ogcB-5hydA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 608
ASP A 605
SER A 593
THR A 129
GLY A  18
 None
 1.28A 5ogcB-5i68A:
undetectable		 5ogcB-5i68A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkn PROTEIN FAM63A

(Homo sapiens) 		PF04424
(MINDY_DUB) 		5 PHE A 229
THR A 223
PRO A 138
GLY A 207
LEU A 208
 None
 1.02A 5ogcB-5jknA:
undetectable		 5ogcB-5jknA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		5 VAL A 422
ASP A 499
LEU A 489
HIS A 425
GLY A 470
 None
 1.14A 5ogcB-5jxlA:
undetectable		 5ogcB-5jxlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyj SPERM-EGG FUSION
PROTEIN JUNO

(Mus musculus) 		PF03024
(Folate_rec) 		5 VAL A 216
PHE A  96
THR A 187
GLY A 104
LEU A 103
 None
 1.14A 5ogcB-5jyjA:
undetectable		 5ogcB-5jyjA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 VAL A 289
HIS A 390
THR A 438
ARG A 402
GLY A 467
 TPO  A 285 ( 3.6A)
None
None
None
None
 1.29A 5ogcB-5k4pA:
undetectable		 5ogcB-5k4pA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		5 ASP A 113
GLU A  92
HIS A  80
GLY A  89
LEU A  38
 None
 1.29A 5ogcB-5l2pA:
4.5		 5ogcB-5l2pA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mf1 FUSION PROTEIN
HAP2/GCS1

(Chlamydomonas
reinhardtii) 		PF10699
(HAP2-GCS1) 		5 ASP A 547
GLU A 546
LEU A 571
THR A 572
LEU A 543
 None
 1.25A 5ogcB-5mf1A:
undetectable		 5ogcB-5mf1A:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 6 ASP A  26
GLU A  27
LEU A 215
HIS A 227
PRO A 357
LEU A 360
 None
 1.08A 5ogcB-5mjsA:
54.6		 5ogcB-5mjsA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 VAL B  23
ASP B  26
GLU B  27
HIS B 229
SER B 236
 None
 1.11A 5ogcB-5n5nB:
55.1		 5ogcB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 VAL B  23
ASP B  26
GLU B  27
LEU B 217
HIS B 229
 None
 1.05A 5ogcB-5n5nB:
55.1		 5ogcB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 VAL B  23
ASP B  26
GLU B  27
SER B 236
LEU B 371
 None
 1.23A 5ogcB-5n5nB:
55.1		 5ogcB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
GLU B  27
HIS B 229
SER B 236
THR B 276
PRO B 360
GLY B 370
 None
 0.77A 5ogcB-5n5nB:
55.1		 5ogcB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
GLU B  27
LEU B 217
HIS B 229
THR B 276
PRO B 360
GLY B 370
 None
 0.70A 5ogcB-5n5nB:
55.1		 5ogcB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
GLU B  27
LEU B 217
THR B 276
PRO B 360
GLY B 370
LEU B 371
 None
 0.89A 5ogcB-5n5nB:
55.1		 5ogcB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
GLU B  27
SER B 236
THR B 276
PRO B 360
GLY B 370
LEU B 371
 None
 0.91A 5ogcB-5n5nB:
55.1		 5ogcB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
HIS B 229
SER B 236
PHE B 272
THR B 276
PRO B 360
GLY B 370
 None
 0.95A 5ogcB-5n5nB:
55.1		 5ogcB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
LEU B 217
HIS B 229
PHE B 272
THR B 276
PRO B 360
GLY B 370
 None
 0.83A 5ogcB-5n5nB:
55.1		 5ogcB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
LEU B 217
PHE B 272
THR B 276
PRO B 360
GLY B 370
LEU B 371
 None
 0.96A 5ogcB-5n5nB:
55.1		 5ogcB-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
SER B 236
PHE B 272
THR B 276
PRO B 360
GLY B 370
LEU B 371
 None
 1.04A 5ogcB-5n5nB:
55.1		 5ogcB-5n5nB:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 5 GLU A 345
PHE A 337
THR A  73
GLY A  80
LEU A  81
 None
 1.23A 5ogcB-5nbsA:
4.2		 5ogcB-5nbsA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 ASP A 275
LEU A 202
SER A 627
PHE A 197
LEU A 295
 None
 1.27A 5ogcB-5oljA:
3.2		 5ogcB-5oljA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		8 VAL B  23
ASP B  26
GLU B  27
LEU B 215
THR B 274
PRO B 358
GLY B 360
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
TA1  B 502 (-4.7A)
None
TA1  B 502 (-3.6A)
TA1  B 502 (-3.7A)
 1.01A 5ogcB-5w3jB:
54.6		 5ogcB-5w3jB:
75.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
GLU B  27
SER B 234
PRO B 358
GLY B 360
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 ( 4.9A)
None
TA1  B 502 (-3.6A)
TA1  B 502 (-3.7A)
 1.00A 5ogcB-5w3jB:
54.6		 5ogcB-5w3jB:
75.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wro ENOLASE

(Drosophila
melanogaster) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 VAL A 313
LEU A 238
ARG A 497
GLY A 385
LEU A 409
 None
 1.28A 5ogcB-5wroA:
undetectable		 5ogcB-5wroA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xww AMPHB

(Streptomyces
nodosus) 		no annotation 5 GLU A 433
LEU A 246
ARG A 236
GLY A 426
LEU A 428
 None
 1.12A 5ogcB-5xwwA:
undetectable		 5ogcB-5xwwA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 5 VAL A 132
ASP A  98
LEU A 156
PHE A 178
GLY A  84
 None
K  A 402 (-3.1A)
None
None
None
 1.27A 5ogcB-6b2wA:
undetectable		 5ogcB-6b2wA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1
PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 5 HIS B 384
SER B  62
THR B 150
ARG B 133
GLY A1187
 None
 1.06A 5ogcB-6f9nB:
undetectable		 5ogcB-6f9nB:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 5 GLU J 641
PHE J 698
ARG J 230
GLY J 656
LEU J 657
 None
 1.08A 5ogcB-6fhsJ:
undetectable		 5ogcB-6fhsJ:
11.39