SIMILAR PATTERNS OF AMINO ACIDS FOR 5OG9_A_TESA503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		5 LEU A  51
LEU A 103
ILE A  21
LEU A  14
ALA A  43
 PO4  A 701 ( 4.9A)
PO4  A 701 (-4.9A)
None
None
None
 1.30A 5og9A-13pkA:
undetectable		 5og9A-13pkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		5 VAL A  13
ILE A  92
LEU A 200
PRO A  18
ALA A 209
 None
 1.39A 5og9A-1ekqA:
undetectable		 5og9A-1ekqA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		5 LEU A 267
VAL A 262
LEU A 259
ILE A 208
ALA A 233
 None
 1.23A 5og9A-1f6dA:
0.0		 5og9A-1f6dA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU B 722
VAL B 299
ILE A  40
LEU B 214
MET C   1
 None
None
FES  A1908 ( 4.4A)
FES  A1907 ( 4.3A)
None
 1.36A 5og9A-1ffvB:
0.0		 5og9A-1ffvB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		5 LEU A 285
VAL A 483
LEU A 461
LEU A 226
ALA A 478
 None
None
None
FAD  A1031 (-3.8A)
None
 1.37A 5og9A-1h7wA:
0.3		 5og9A-1h7wA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD

(Escherichia
coli) 		PF00005
(ABC_tran) 		5 LEU C  31
LEU C  29
ILE C  56
LEU C  16
MET C   5
 None
 1.33A 5og9A-1l7vC:
0.0		 5og9A-1l7vC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 184
VAL A 170
LEU A 160
ILE A 146
MET A 265
 None
 1.35A 5og9A-1ml4A:
0.0		 5og9A-1ml4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 287
LEU A 276
MET A 388
ALA A 225
MET A 259
 None
IH5  A 600 (-4.0A)
IH5  A 600 (-3.8A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
 1.30A 5og9A-1navA:
undetectable		 5og9A-1navA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 VAL X 103
LEU X   6
ILE X 112
LEU X  44
ALA X  91
 None
 1.28A 5og9A-1r6bX:
undetectable		 5og9A-1r6bX:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU B 143
ILE B  81
LEU B 171
PRO B  77
ALA B  67
 None
 1.20A 5og9A-1umbB:
undetectable		 5og9A-1umbB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU B 142
ILE B  80
LEU B 170
PRO B  76
ALA B  66
 None
 1.20A 5og9A-1w85B:
undetectable		 5og9A-1w85B:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw5 PEPTIDYL PROLYL
CIS/TRANS ISOMERASE

(Candida
albicans) 		PF00397
(WW)
PF00639
(Rotamase) 		5 VAL A  70
LEU A 136
ILE A 164
LEU A 103
ALA A 152
 None
 1.32A 5og9A-1yw5A:
undetectable		 5og9A-1yw5A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
NS-129) 		PF01266
(DAO) 		5 LEU A 218
VAL A 214
LEU A 209
ILE A 327
PRO A 331
 None
 1.14A 5og9A-1zovA:
undetectable		 5og9A-1zovA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 VAL A  46
LEU A  40
ILE A  62
LEU A  52
ALA A  16
 None
 1.36A 5og9A-2ag8A:
undetectable		 5og9A-2ag8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djk PROTEIN
DISULFIDE-ISOMERASE

(Humicola
insolens) 		PF13848
(Thioredoxin_6) 		5 LEU A  72
LEU A  74
ILE A  29
LEU A  26
ALA A  62
 None
 1.38A 5og9A-2djkA:
undetectable		 5og9A-2djkA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 LEU X  95
VAL X 161
LEU X 164
ILE X  76
ALA X 135
 None
 1.20A 5og9A-2f6hX:
1.4		 5og9A-2f6hX:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 LEU A 303
LEU A 299
LEU A   7
ALA A 271
MET A 267
 None
 1.37A 5og9A-2gahA:
undetectable		 5og9A-2gahA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig3 GROUP III TRUNCATED
HAEMOGLOBIN

(Campylobacter
jejuni) 		PF01152
(Bac_globin) 		5 LEU A  94
VAL A 105
ILE A 113
LEU A  87
MET A  57
 None
None
HEM  A 700 (-3.4A)
None
ACT  A 820 ( 3.7A)
 1.11A 5og9A-2ig3A:
undetectable		 5og9A-2ig3A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		5 LEU A 303
LEU A 299
ILE A 204
LEU A 263
ALA A 275
 None
 1.19A 5og9A-2obmA:
undetectable		 5og9A-2obmA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE

(Agrobacterium
fabrum) 		PF06559
(DCD) 		5 VAL A  67
ILE A 137
LEU A  46
PRO A  61
ALA A 131
 None
 1.29A 5og9A-2r9qA:
undetectable		 5og9A-2r9qA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wul GLUTAREDOXIN RELATED
PROTEIN 5

(Homo sapiens) 		PF00462
(Glutaredoxin) 		5 LEU A 125
VAL A  74
LEU A  77
PRO A  62
ALA A  87
 None
 1.37A 5og9A-2wulA:
undetectable		 5og9A-2wulA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x77 ADP-RIBOSYLATION
FACTOR

(Leishmania
major) 		PF00025
(Arf) 		5 LEU A  12
VAL A 170
LEU A   8
ILE A  92
LEU A 180
 None
 1.36A 5og9A-2x77A:
undetectable		 5og9A-2x77A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 270
VAL A 331
LEU A 334
ILE A 314
LEU A 261
 None
None
None
None
PCJ  A   1 ( 4.5A)
 1.26A 5og9A-2z81A:
undetectable		 5og9A-2z81A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		5 LEU X 189
VAL X 128
ILE X 204
LEU X 211
MET X 196
 None
 1.33A 5og9A-2zyvX:
undetectable		 5og9A-2zyvX:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 109
LEU A 354
ILE A 158
LEU A 215
ALA A 243
 None
HEM  A1430 ( 4.5A)
None
None
HEM  A1430 (-3.5A)
 1.39A 5og9A-3abbA:
31.4		 5og9A-3abbA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 121
VAL A 145
LEU A 148
ILE A 137
PRO A 167
 None
 1.01A 5og9A-3b2dA:
undetectable		 5og9A-3b2dA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		5 LEU A 429
VAL A 431
LEU A 438
ILE A 409
PRO A 377
 None
 1.36A 5og9A-3bwsA:
undetectable		 5og9A-3bwsA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 LEU A  90
VAL A  98
LEU A  35
ILE A 106
ALA A 100
 None
 1.09A 5og9A-3fydA:
undetectable		 5og9A-3fydA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		5 LEU A 215
VAL A 234
LEU A 239
ALA A 300
MET A 244
 None
 1.15A 5og9A-3gd9A:
undetectable		 5og9A-3gd9A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 LEU A  90
VAL A  98
LEU A  35
ILE A 106
ALA A 100
 None
None
None
SAM  A 300 ( 4.4A)
None
 1.11A 5og9A-3gryA:
undetectable		 5og9A-3gryA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		5 LEU A 301
VAL A  63
LEU A  66
ILE A 102
LEU A 304
 None
 1.32A 5og9A-3hc1A:
1.9		 5og9A-3hc1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 LEU A 487
LEU A 491
ILE A 361
LEU A 173
PRO A 183
 None
 1.11A 5og9A-3hq2A:
0.8		 5og9A-3hq2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxl UNCHARACTERIZED
PROTEIN DSY3957

(Desulfitobacterium
hafniense) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 LEU A 205
LEU A 212
ILE A  41
LEU A  74
ALA A 187
 None
 1.36A 5og9A-3hxlA:
undetectable		 5og9A-3hxlA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Staphylococcus
aureus) 		PF00698
(Acyl_transf_1) 		5 LEU A  40
VAL A 111
ILE A  32
MET A  48
LEU A  45
 None
 1.01A 5og9A-3im9A:
undetectable		 5og9A-3im9A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l23 SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		5 VAL A 305
LEU A  48
MET A 310
ALA A 324
MET A  72
 None
 1.04A 5og9A-3l23A:
undetectable		 5og9A-3l23A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lza PUTATIVE SNOAL-LIKE
POLYKETIDE CYCLASE

(Shewanella
denitrificans) 		PF12680
(SnoaL_2) 		5 LEU A 138
VAL A 142
ILE A  33
LEU A  44
MET A  99
 None
 1.35A 5og9A-3lzaA:
undetectable		 5og9A-3lzaA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onm TRANSCRIPTIONAL
REGULATOR LRHA

(Yersinia
pseudotuberculosis) 		PF03466
(LysR_substrate) 		5 LEU A 118
LEU A 114
ILE A 102
LEU A 128
ALA A 152
 None
 1.30A 5og9A-3onmA:
undetectable		 5og9A-3onmA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os7 GALACTOSE
MUTAROTASE-LIKE
PROTEIN

(Clostridium
acetobutylicum) 		PF01263
(Aldose_epim) 		5 LEU A  73
VAL A  40
LEU A  52
LEU A  76
PRO A  55
 None
 1.23A 5og9A-3os7A:
undetectable		 5og9A-3os7A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Campylobacter
jejuni) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		5 LEU A 115
LEU A  94
LEU A 164
PRO A 125
ALA A 126
 None
 1.08A 5og9A-3pfiA:
undetectable		 5og9A-3pfiA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxb PUTATIVE XYLOSE
ISOMERASE

(Rhodospirillum
rubrum) 		PF01261
(AP_endonuc_2) 		5 LEU A  20
VAL A  11
LEU A  39
MET A 283
LEU A  28
 None
 1.20A 5og9A-3qxbA:
undetectable		 5og9A-3qxbA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tij NUPC FAMILY PROTEIN

(Vibrio cholerae) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		6 LEU A 382
VAL A 160
LEU A 159
MET A 168
LEU A 173
ALA A 148
 None
 1.27A 5og9A-3tijA:
undetectable		 5og9A-3tijA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnl SHIKIMATE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF08501
(Shikimate_dh_N) 		5 LEU A 151
VAL A  94
LEU A  93
ILE A 157
MET A 118
 None
 1.30A 5og9A-3tnlA:
undetectable		 5og9A-3tnlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Coxiella
burnetii) 		PF01590
(GAF) 		5 LEU A  60
ILE A  77
LEU A  68
PRO A  93
ALA A  92
 None
PO4  A 169 (-3.6A)
None
None
None
 1.16A 5og9A-3trcA:
undetectable		 5og9A-3trcA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 555
VAL A 374
LEU A 375
LEU A 385
PRO A 535
 None
 1.35A 5og9A-3u4aA:
undetectable		 5og9A-3u4aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Roseiflexus sp.
RS-1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A  40
ILE A  90
MET A 100
LEU A  97
ALA A 111
 None
 1.16A 5og9A-3u9iA:
undetectable		 5og9A-3u9iA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 LEU A 303
LEU A 424
ILE A 314
MET A 253
LEU A 257
 None
 1.33A 5og9A-3x1lA:
1.2		 5og9A-3x1lA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a39 METALLO-CARBOXYPEPTI
DASE

(Pseudomonas
aeruginosa) 		PF00246
(Peptidase_M14) 		5 VAL A 105
ILE A  23
LEU A  56
PRO A 100
MET A   1
 None
 1.35A 5og9A-4a39A:
undetectable		 5og9A-4a39A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2p CYTOCHROME P450
107B1 (P450CVIIB1)

(Streptomyces
himastatinicus) 		PF00067
(p450) 		5 LEU A 360
LEU A 273
MET A 125
LEU A 124
PRO A 282
 None
None
None
None
HEM  A 401 (-3.9A)
 1.35A 5og9A-4e2pA:
30.9		 5og9A-4e2pA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A  52
VAL A  31
ILE A 127
LEU A  70
ALA A  14
 None
 1.15A 5og9A-4epaA:
undetectable		 5og9A-4epaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5g AMINO ACID ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		5 LEU A 239
LEU A  42
ILE A 247
ALA A  75
MET A  72
 None
 1.24A 5og9A-4h5gA:
undetectable		 5og9A-4h5gA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyl STAGE II SPORULATION
PROTEIN

(Haliangium
ochraceum) 		PF01740
(STAS) 		5 LEU A  63
LEU A  74
MET A  52
LEU A  20
ALA A  98
 None
 1.03A 5og9A-4hylA:
undetectable		 5og9A-4hylA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 LEU A  21
VAL A  50
LEU A  54
LEU A 244
ALA A  42
 None
 1.22A 5og9A-4lutA:
undetectable		 5og9A-4lutA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 237
VAL A 177
LEU A 239
PRO A 189
ALA A 188
 None
 1.28A 5og9A-4mrqA:
undetectable		 5og9A-4mrqA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 LEU D 467
VAL D  57
LEU D  60
ILE D 451
ALA D  64
 None
 1.35A 5og9A-4ngeD:
undetectable		 5og9A-4ngeD:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oic PROBABLE PROTEIN
PHOSPHATASE 2C 6

(Oryza sativa) 		PF00481
(PP2C) 		5 LEU B 228
LEU B 224
ILE B 371
PRO B 367
ALA B 296
 None
 1.02A 5og9A-4oicB:
undetectable		 5og9A-4oicB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onq DNA
METHYLTRANSFERASE

(Nicotiana
tabacum) 		PF00145
(DNA_methylase) 		5 LEU A 501
VAL A 473
ILE A 562
LEU A 505
PRO A 338
 None
 1.07A 5og9A-4onqA:
undetectable		 5og9A-4onqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		5 LEU A 171
MET A 179
LEU A 176
PRO A 120
ALA A  96
 None
 1.30A 5og9A-4oqfA:
undetectable		 5og9A-4oqfA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		5 LEU A 210
VAL A 218
LEU A 194
PRO A 243
ALA A 246
 None
 1.32A 5og9A-4p8sA:
undetectable		 5og9A-4p8sA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcv BDCA (YJGI)

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 LEU A  10
VAL A  81
ILE A  67
PRO A 110
ALA A 109
 None
 1.22A 5og9A-4pcvA:
undetectable		 5og9A-4pcvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 VAL A 178
LEU A 179
ILE A 256
PRO A 190
ALA A 176
 None
 1.16A 5og9A-4q0gA:
undetectable		 5og9A-4q0gA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpk PHOSPHOTRANSFERASE

(Brucella
abortus) 		PF10090
(HPTransfase) 		5 LEU A 186
VAL A   5
LEU A   3
LEU A  16
PRO A 170
 None
 1.30A 5og9A-4qpkA:
undetectable		 5og9A-4qpkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 LEU A 246
LEU A 196
ILE A 261
LEU A 254
MET A 181
 None
 1.19A 5og9A-4rbnA:
undetectable		 5og9A-4rbnA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN

(Sphingobium
chlorophenolicum) 		PF03466
(LysR_substrate) 		5 VAL A 275
LEU A 166
ILE A 101
LEU A 142
MET A 111
 None
 1.22A 5og9A-4rnsA:
undetectable		 5og9A-4rnsA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		5 LEU A 230
VAL A 278
LEU A 283
ILE A 270
ALA A 291
 None
 1.32A 5og9A-4wu0A:
0.8		 5og9A-4wu0A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		5 LEU A  89
VAL A  82
LEU A 114
MET A  16
LEU A  18
 None
 1.27A 5og9A-4y9sA:
undetectable		 5og9A-4y9sA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7e LMO1422 PROTEIN

(Listeria
monocytogenes) 		PF04069
(OpuAC) 		5 LEU A 432
LEU A 359
ILE A 407
LEU A 424
ALA A 368
 None
 1.23A 5og9A-4z7eA:
undetectable		 5og9A-4z7eA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8z UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 5 LEU A  71
ILE A 249
LEU A 199
PRO A 130
ALA A 158
 None
 1.06A 5og9A-4z8zA:
undetectable		 5og9A-4z8zA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN

(Homo sapiens) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 VAL A  35
LEU A  52
ILE A  88
MET A  75
ALA A   4
 None
 1.10A 5og9A-4ztdA:
undetectable		 5og9A-4ztdA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		5 LEU A  75
ILE A 163
LEU A 171
ALA A 191
MET A  68
 None
 0.99A 5og9A-4zz7A:
undetectable		 5og9A-4zz7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anp BA41

(Bizionia
argentinensis) 		PF04536
(TPM_phosphatase) 		5 LEU A  62
VAL A  78
LEU A  66
ILE A 123
LEU A  53
 None
 1.26A 5og9A-5anpA:
undetectable		 5og9A-5anpA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Thermoplasma
acidophilum) 		PF01884
(PcrB) 		5 LEU A   9
VAL A   4
LEU A   5
ILE A 199
MET A 127
 None
 1.23A 5og9A-5b69A:
undetectable		 5og9A-5b69A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdn DNA GYRASE SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		5 LEU A 209
VAL A 195
LEU A 198
ILE A 346
PRO A 165
 LEU  A 209 ( 0.6A)
VAL  A 195 ( 0.6A)
LEU  A 198 ( 0.6A)
ILE  A 346 ( 0.6A)
PRO  A 165 ( 1.1A)
 1.38A 5og9A-5cdnA:
3.6		 5og9A-5cdnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d66 UNCHARACTERIZED
PROTEIN

(Acinetobacter
baumannii) 		PF12796
(Ank_2) 		5 LEU A 127
LEU A 123
ILE A 160
PRO A 146
ALA A 147
 None
None
None
CL  A 301 ( 4.5A)
None
 1.13A 5og9A-5d66A:
undetectable		 5og9A-5d66A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 VAL A 413
LEU A 417
LEU A 497
PRO A 539
ALA A 528
 None
 1.30A 5og9A-5djwA:
undetectable		 5og9A-5djwA:
22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		5 LEU A  20
VAL A  26
LEU A  29
PRO A 329
ALA A 330
 None
 0.40A 5og9A-5e78A:
57.6		 5og9A-5e78A:
98.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		5 LEU A 101
LEU A  49
ILE A  62
LEU A 125
ALA A  40
 None
 1.33A 5og9A-5g5nA:
undetectable		 5og9A-5g5nA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		5 LEU A 785
VAL A 719
LEU A 748
PRO A 709
ALA A 722
 None
 1.13A 5og9A-5gsmA:
undetectable		 5og9A-5gsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hou CELLULAR TUMOR
ANTIGEN
P53,CREB-BINDING
PROTEIN FUSION
PROTEIN

(Homo sapiens;
Mus musculus) 		PF02135
(zf-TAZ)
PF08563
(P53_TAD) 		5 LEU A3361
LEU A3432
ILE A3415
MET A3387
LEU A3391
 None
 1.24A 5og9A-5houA:
undetectable		 5og9A-5houA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i9q 426C.TM4DV1-3 P120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 LEU A 259
LEU A 452
ILE A 394
LEU A 416
ALA A 341
 None
 1.31A 5og9A-5i9qA:
undetectable		 5og9A-5i9qA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 VAL B 730
LEU B 647
ILE B 714
PRO B 683
ALA B 684
 None
 1.14A 5og9A-5ldrB:
undetectable		 5og9A-5ldrB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF

(Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG)
PF13721
(SecD-TM1) 		5 LEU D 512
VAL D 516
ILE F 157
LEU D 567
ALA D 556
 None
 1.26A 5og9A-5mg3D:
undetectable		 5og9A-5mg3D:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpt CITRININ POLYKETIDE
SYNTHASE

(Monascus
purpureus) 		PF08242
(Methyltransf_12) 		5 LEU A2009
LEU A2005
ILE A2059
LEU A1979
ALA A1968
 None
 1.30A 5og9A-5mptA:
undetectable		 5og9A-5mptA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwa BIFUNCTIONAL EPOXIDE
HYDROLASE 2

(Homo sapiens) 		no annotation 5 VAL A  22
LEU A  23
LEU A  60
PRO A  17
ALA A  18
 None
None
8S9  A 302 (-4.8A)
8S9  A 302 (-4.3A)
None
 1.22A 5og9A-5mwaA:
undetectable		 5og9A-5mwaA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxp -

(-) 		no annotation 5 LEU A 210
LEU A 247
ILE A 173
LEU A 152
MET A 177
 ACT  A 401 ( 4.9A)
None
None
None
None
 1.36A 5og9A-5mxpA:
undetectable		 5og9A-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF05524
(PEP-utilisers_N) 		5 LEU A 212
LEU A 309
ILE A 276
LEU A 254
MET A 194
 None
 1.19A 5og9A-5t12A:
undetectable		 5og9A-5t12A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		5 LEU C 710
VAL C 904
ILE C 889
LEU C 876
PRO C 896
 None
 1.23A 5og9A-5tw1C:
undetectable		 5og9A-5tw1C:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 LEU A  90
VAL A2269
LEU A  55
ILE A2263
ALA A  15
 None
 1.20A 5og9A-5tzyA:
undetectable		 5og9A-5tzyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 LEU A 197
LEU A  34
ILE A 168
LEU A 212
ALA A 103
 None
 1.04A 5og9A-5ujsA:
undetectable		 5og9A-5ujsA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0t PROTEIN MSP1

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 VAL A 229
LEU A 223
ILE A 157
ALA A 181
MET A 177
 None
 1.25A 5og9A-5w0tA:
undetectable		 5og9A-5w0tA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn7 PUTATIVE RTX-TOXIN

(Vibrio
vulnificus) 		PF11647
(MLD) 		5 LEU A2808
LEU A2851
ILE A2803
LEU A2598
ALA A2874
 None
 1.16A 5og9A-5xn7A:
undetectable		 5og9A-5xn7A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 LEU A  32
LEU A  96
ILE A  18
LEU A  43
PRO A  88
 None
 1.28A 5og9A-5xsqA:
undetectable		 5og9A-5xsqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 552
LEU A 514
ILE A 586
LEU A 410
ALA A 425
 None
 1.33A 5og9A-5xxoA:
undetectable		 5og9A-5xxoA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica) 		no annotation 5 LEU A  40
VAL A  89
ILE A 256
LEU A 133
ALA A 123
 None
 1.33A 5og9A-5yhpA:
undetectable		 5og9A-5yhpA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 5 LEU A 106
VAL A 148
LEU A 151
ILE A 131
PRO A 161
 None
 1.07A 5og9A-6bk7A:
undetectable		 5og9A-6bk7A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blb HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 119
LEU A  98
LEU A 168
PRO A 129
ALA A 130
 None
 1.05A 5og9A-6blbA:
undetectable		 5og9A-6blbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blb HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 119
VAL A 126
LEU A 168
PRO A 129
ALA A 130
 None
 1.28A 5og9A-6blbA:
undetectable		 5og9A-6blbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 5 LEU A  45
VAL A  12
LEU A  15
ILE A  99
LEU A   4
 None
 1.36A 5og9A-6d46A:
undetectable		 5og9A-6d46A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 LEU A 292
ILE A 160
LEU A 188
ALA A 149
MET A 153
 None
 1.25A 5og9A-6et9A:
undetectable		 5og9A-6et9A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT

(Geobacillus
kaustophilus) 		no annotation 5 ILE A 210
MET A  20
LEU A  23
ALA A 159
MET A 164
 None
 1.17A 5og9A-6f6eA:
undetectable		 5og9A-6f6eA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE

(Thermotoga
maritima) 		no annotation 5 LEU B 243
LEU B 271
ILE B 259
LEU B 140
PRO B 289
 None
 1.17A 5og9A-6fpeB:
undetectable		 5og9A-6fpeB:
11.11