SIMILAR PATTERNS OF AMINO ACIDS FOR 5OF1_B_SALB301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aw1 TRIOSEPHOSPHATE
ISOMERASE

(Moritella
marina) 		PF00121
(TIM) 		4 ALA A 164
VAL A 207
PHE A 115
ILE A 196
 None
 1.03A 5of1B-1aw1A:
0.0		 5of1B-1aw1A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		4 ALA A 220
VAL A 218
PHE A 121
ILE A 116
 None
 1.01A 5of1B-1brtA:
undetectable		 5of1B-1brtA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by8 PROTEIN
(PROCATHEPSIN K)

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 ALA A 132
VAL A 230
PHE A 171
ILE A 212
 None
 1.05A 5of1B-1by8A:
undetectable		 5of1B-1by8A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci5 PROTEIN (LYMPHOCYTE
FUNCTION-ASSOCIATED
ANTIGEN 3(CD58))

(Homo sapiens) 		no annotation 4 ALA A  45
VAL A  35
PHE A  43
ILE A  64
 None
 1.03A 5of1B-1ci5A:
undetectable		 5of1B-1ci5A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 ALA A 127
VAL A 131
PHE A  21
ILE A  16
 None
 0.85A 5of1B-1crzA:
0.0		 5of1B-1crzA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwv INVASIN

(Yersinia
pseudotuberculosis) 		PF02369
(Big_1)
PF07979
(Intimin_C)
PF09134
(Invasin_D3) 		4 ALA A 671
VAL A 673
PHE A 691
ILE A 622
 None
 1.04A 5of1B-1cwvA:
0.0		 5of1B-1cwvA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehi D-ALANINE:D-LACTATE
LIGASE

(Leuconostoc
mesenteroides) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ALA A  30
LYS A 330
PHE A 323
ILE A 338
 None
 0.96A 5of1B-1ehiA:
0.0		 5of1B-1ehiA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00355
(Rieske) 		4 ALA B 118
VAL B 121
PHE B  25
ILE B 125
 None
 0.85A 5of1B-1g8kB:
0.0		 5of1B-1g8kB:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8a ENDO-1,4-BETA-XYLANA
SE A

(Thermotoga
maritima) 		PF06452
(CBM9_1) 		4 ALA A 131
VAL A  54
PHE A 116
ILE A 150
 None
 1.02A 5of1B-1i8aA:
1.1		 5of1B-1i8aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 ALA A 397
VAL A 423
LYS A 446
ILE A 441
 None
 1.01A 5of1B-1kxhA:
undetectable		 5of1B-1kxhA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogp SULFITE OXIDASE

(Arabidopsis
thaliana) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 ALA A 353
VAL A 351
PHE A 339
ILE A 343
 None
 0.78A 5of1B-1ogpA:
undetectable		 5of1B-1ogpA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ALA A  46
VAL A  50
PHE A  90
ILE A  94
 None
 0.96A 5of1B-1svdA:
undetectable		 5of1B-1svdA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t11 TRIGGER FACTOR

(Vibrio cholerae) 		PF00254
(FKBP_C)
PF05697
(Trigger_N)
PF05698
(Trigger_C) 		4 ALA A 231
VAL A 215
PHE A 177
ILE A 195
 None
 1.01A 5of1B-1t11A:
undetectable		 5of1B-1t11A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmh TRIOSEPHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00121
(TIM) 		4 ALA A 164
VAL A 207
PHE A 115
ILE A 196
 None
 1.04A 5of1B-1tmhA:
undetectable		 5of1B-1tmhA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wk0 KIAA0970 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		4 ALA A  97
VAL A  62
PHE A 116
ILE A  84
 None
 0.90A 5of1B-1wk0A:
undetectable		 5of1B-1wk0A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xne HYPOTHETICAL PROTEIN
PF0469

(Pyrococcus
furiosus) 		PF04266
(ASCH) 		4 ALA A  49
VAL A  51
PHE A  43
ILE A  35
 None
 0.77A 5of1B-1xneA:
undetectable		 5of1B-1xneA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 ALA A1166
VAL A1249
PHE A1149
ILE A1252
 None
 1.01A 5of1B-2bruA:
undetectable		 5of1B-2bruA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cas CANINE PARVOVIRUS
EMPTY CAPSID (STRAIN
D) VIRAL PROTEIN 2

(Carnivore
protoparvovirus
1) 		PF00740
(Parvo_coat) 		4 ALA A 114
VAL A 112
PHE A 141
ILE A 145
 None
 1.01A 5of1B-2casA:
2.8		 5of1B-2casA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dng EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4H

(Mus musculus) 		PF00076
(RRM_1) 		4 ALA A  43
VAL A  45
PHE A  88
ILE A  57
 None
 0.83A 5of1B-2dngA:
undetectable		 5of1B-2dngA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 ALA A 385
VAL A 383
PHE A 399
ILE A 415
 None
None
None
K  A 501 (-4.9A)
 0.82A 5of1B-2fpqA:
undetectable		 5of1B-2fpqA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
carnosus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 ALA A 317
VAL A 321
PHE A 300
ILE A 293
 None
 0.98A 5of1B-2hroA:
undetectable		 5of1B-2hroA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j13 POLYSACCHARIDE
DEACETYLASE

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		4 ALA A  74
VAL A  72
PHE A  51
ILE A 215
 None
 1.04A 5of1B-2j13A:
undetectable		 5of1B-2j13A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2x HYPOTHETICAL PROTEIN

(Mesorhizobium
loti) 		PF13242
(Hydrolase_like) 		4 ALA A 116
VAL A  76
PHE A  93
ILE A  41
 None
 0.93A 5of1B-2o2xA:
undetectable		 5of1B-2o2xA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 308
VAL A 273
PHE A 127
ILE A 109
 None
 1.05A 5of1B-2ovlA:
undetectable		 5of1B-2ovlA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6d DIPHTHINE SYNTHASE

(Pyrococcus
horikoshii) 		PF00590
(TP_methylase) 		4 ALA A  32
VAL A  30
PHE A  34
ILE A  51
 None
 1.04A 5of1B-2p6dA:
undetectable		 5of1B-2p6dA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 ALA A 256
VAL A 318
PHE A 248
ILE A 236
 None
 1.05A 5of1B-2p82A:
undetectable		 5of1B-2p82A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9w MAL S 1 ALLERGENIC
PROTEIN

(Malassezia
sympodialis) 		no annotation 4 ALA A 274
VAL A 272
PHE A 306
ILE A 347
 None
 0.99A 5of1B-2p9wA:
undetectable		 5of1B-2p9wA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 ALA B 656
VAL B 658
LYS B 626
PHE B 622
 None
 0.95A 5of1B-2rhqB:
undetectable		 5of1B-2rhqB:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 ALA A 228
VAL A 226
PHE A 252
ILE A 514
 None
 0.85A 5of1B-2w92A:
3.6		 5of1B-2w92A:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnx GLYCOSIDE HYDROLASE,
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 ALA A  11
VAL A  43
LYS A 151
ILE A  48
 None
 1.06A 5of1B-2wnxA:
undetectable		 5of1B-2wnxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ALA A 108
VAL A 115
PHE A  16
ILE A  59
 None
 0.85A 5of1B-2xsgA:
undetectable		 5of1B-2xsgA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp. JT-ISH-224) 		PF11477
(PM0188) 		4 ALA A 385
VAL A 381
PHE A 357
ILE A 447
 None
 0.78A 5of1B-2z4tA:
undetectable		 5of1B-2z4tA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ALA A 658
VAL A 593
PHE A 559
ILE A 661
 None
 1.06A 5of1B-3a24A:
undetectable		 5of1B-3a24A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		4 ALA A 145
VAL A 174
PHE A 300
ILE A 292
 None
 0.90A 5of1B-3ailA:
undetectable		 5of1B-3ailA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6y GAMMA-INTERFERON-IND
UCIBLE PROTEIN
IFI-16

(Homo sapiens) 		PF02760
(HIN) 		5 ALA A  15
VAL A  12
LYS A  51
PHE A  30
ILE A  60
 None
 1.48A 5of1B-3b6yA:
undetectable		 5of1B-3b6yA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 ALA A 735
VAL A 731
PHE A 669
ILE A 762
 None
 0.99A 5of1B-3cmmA:
undetectable		 5of1B-3cmmA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		4 ALA A 242
VAL A 244
PHE A 226
ILE A 258
 None
 1.05A 5of1B-3cuxA:
undetectable		 5of1B-3cuxA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		4 ALA A 178
VAL A 159
PHE A 171
ILE A 182
 None
None
GOL  A 360 (-4.9A)
None
 0.98A 5of1B-3f0hA:
undetectable		 5of1B-3f0hA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 ALA A 228
VAL A 226
PHE A 252
ILE A 514
 None
 0.85A 5of1B-3gdbA:
4.0		 5of1B-3gdbA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwg ACETYLTRANSFERASE,
GNAT FAMILY

(Colwellia
psychrerythraea) 		PF00583
(Acetyltransf_1) 		4 ALA A  97
VAL A  57
PHE A 270
ILE A  91
 None
 1.05A 5of1B-3iwgA:
undetectable		 5of1B-3iwgA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke6 PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF07228
(SpoIIE)
PF13581
(HATPase_c_2) 		4 ALA A 508
VAL A 505
PHE A 445
ILE A 438
 None
 1.00A 5of1B-3ke6A:
undetectable		 5of1B-3ke6A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks7 PUTATIVE PUTATIVE
PNGASE F

(Bacteroides
fragilis) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 ALA A 409
VAL A 407
PHE A 387
ILE A 391
 None
 0.95A 5of1B-3ks7A:
2.3		 5of1B-3ks7A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ALA A  41
VAL A  73
PHE A  57
ILE A  49
 None
 0.95A 5of1B-3oeeA:
undetectable		 5of1B-3oeeA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ALA A 624
VAL A 622
PHE A 626
ILE A 634
 None
 0.89A 5of1B-3ogrA:
4.1		 5of1B-3ogrA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toj SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2

(Homo sapiens) 		PF00622
(SPRY) 		4 ALA A 318
VAL A 316
PHE A 484
ILE A 300
 None
 0.77A 5of1B-3tojA:
1.5		 5of1B-3tojA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ALA A 584
VAL A 578
LYS A 590
ILE A 538
 None
 1.02A 5of1B-3wmeA:
undetectable		 5of1B-3wmeA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjx EPSILON-TOXIN

(Clostridium
perfringens) 		PF03318
(ETX_MTX2) 		4 ALA A 181
VAL A 179
PHE A 105
ILE A 169
 BOG  A1297 ( 3.9A)
BOG  A1297 (-4.9A)
BOG  A1297 (-3.9A)
None
 0.99A 5of1B-3zjxA:
undetectable		 5of1B-3zjxA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 4 ALA A  39
VAL A  37
PHE A 400
ILE A 427
 None
 0.90A 5of1B-4a7kA:
undetectable		 5of1B-4a7kA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzg ALDOSE 1-EPIMERASE

(Bacillus
subtilis) 		PF01263
(Aldose_epim) 		4 ALA A 143
VAL A 145
PHE A 170
ILE A 174
 None
 1.00A 5of1B-4bzgA:
undetectable		 5of1B-4bzgA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxh ELONGATION FACTOR 1A

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ALA A 328
VAL A 388
PHE A 410
ILE A 358
 None
 1.04A 5of1B-4cxhA:
undetectable		 5of1B-4cxhA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ALA A 380
VAL A 384
PHE A 476
ILE A 394
 None
 0.57A 5of1B-4d5gA:
undetectable		 5of1B-4d5gA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ALA A 104
VAL A 106
PHE A  13
ILE A  67
 None
 0.91A 5of1B-4dnsA:
undetectable		 5of1B-4dnsA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx8 KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens) 		PF16705
(NUDIX_5) 		4 ALA H 159
LYS H  95
PHE H  97
ILE H 112
 None
BR  H 301 (-3.2A)
None
None
 0.92A 5of1B-4dx8H:
undetectable		 5of1B-4dx8H:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		4 ALA A 517
VAL A 515
PHE A 603
ILE A 499
 None
 1.04A 5of1B-4etpA:
undetectable		 5of1B-4etpA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 ALA A 272
VAL A 248
PHE A  43
ILE A 121
 None
 1.02A 5of1B-4g1cA:
undetectable		 5of1B-4g1cA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbo E7

(Thermobifida
fusca) 		PF03067
(LPMO_10) 		4 ALA A 191
VAL A 189
PHE A 221
ILE A 136
 None
 0.92A 5of1B-4gboA:
undetectable		 5of1B-4gboA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		4 ALA A 463
VAL A 467
PHE A 450
ILE A 372
 HEM  A 601 (-3.5A)
None
HEM  A 601 (-4.1A)
None
 0.92A 5of1B-4i8vA:
undetectable		 5of1B-4i8vA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Influenza A
virus;
Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		4 ALA A 220
VAL A 218
PHE A 121
ILE A 116
 None
 0.98A 5of1B-4iq4A:
undetectable		 5of1B-4iq4A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbm INTERFERON-INDUCIBLE
PROTEIN AIM2

(Mus musculus) 		PF02760
(HIN) 		5 ALA A  11
VAL A   8
LYS A  48
PHE A  27
ILE A  57
 None
 1.50A 5of1B-4jbmA:
undetectable		 5of1B-4jbmA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1g PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Bacillus cereus) 		PF01522
(Polysacc_deac_1) 		4 ALA A 102
VAL A 100
PHE A  79
ILE A 243
 None
 0.92A 5of1B-4l1gA:
undetectable		 5of1B-4l1gA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		4 ALA A 183
VAL A 187
PHE A 174
ILE A 201
 None
 1.05A 5of1B-4m38A:
undetectable		 5of1B-4m38A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opw UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF10988
(DUF2807) 		4 ALA A 117
VAL A 140
PHE A  46
ILE A 132
 None
 0.97A 5of1B-4opwA:
undetectable		 5of1B-4opwA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 ALA A  97
VAL A 406
PHE A 336
ILE A 294
 1VE  A 501 (-3.1A)
None
1VE  A 501 (-3.9A)
None
 0.91A 5of1B-4oyaA:
undetectable		 5of1B-4oyaA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcv BDCA (YJGI)

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 ALA A 217
VAL A 213
PHE A   4
ILE A  22
 None
 0.99A 5of1B-4pcvA:
undetectable		 5of1B-4pcvA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 ALA A 410
VAL A 408
PHE A 388
ILE A 392
 None
 0.97A 5of1B-4qhbA:
2.2		 5of1B-4qhbA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF04146
(YTH) 		4 ALA A 355
VAL A 351
PHE A 357
ILE A 448
 None
 0.98A 5of1B-4r3iA:
undetectable		 5of1B-4r3iA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r84 SIALYLTRANSFERASE
0160

(Photobacterium
damselae) 		PF11477
(PM0188) 		4 ALA A 381
VAL A 377
PHE A 353
ILE A 443
 None
None
None
CSF  A 501 (-4.8A)
 0.78A 5of1B-4r84A:
undetectable		 5of1B-4r84A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN

(Sphingobium
chlorophenolicum) 		PF03466
(LysR_substrate) 		4 ALA A 201
VAL A 207
PHE A 231
ILE A 273
 None
 1.05A 5of1B-4rnsA:
undetectable		 5of1B-4rnsA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8n SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2

(Homo sapiens) 		PF00622
(SPRY) 		4 ALA A 318
VAL A 316
PHE A 484
ILE A 300
 None
 0.85A 5of1B-4x8nA:
2.2		 5of1B-4x8nA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 ALA A  68
LYS A  83
PHE A  37
ILE A 125
 None
 0.94A 5of1B-4xriA:
undetectable		 5of1B-4xriA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzy EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		no annotation 4 ALA A 116
VAL A 106
PHE A 335
ILE A 353
 None
 0.99A 5of1B-4yzyA:
undetectable		 5of1B-4yzyA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 ALA A 478
VAL A 476
PHE A 415
ILE A 384
 None
 0.75A 5of1B-4zm6A:
undetectable		 5of1B-4zm6A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0k LABDANE-RELATED
DITERPENE SYNTHASE

(Streptomyces
sp.) 		no annotation 4 ALA A 279
VAL A 222
PHE A  20
ILE A 304
 None
 1.06A 5of1B-5a0kA:
undetectable		 5of1B-5a0kA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix) 		4 ALA C 147
VAL C 153
PHE C 190
ILE C 234
 None
 0.93A 5of1B-5a53C:
undetectable		 5of1B-5a53C:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cag UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF17145
(DUF5119) 		4 ALA A 168
VAL A 166
PHE A 252
ILE A 264
 None
 0.70A 5of1B-5cagA:
undetectable		 5of1B-5cagA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eip YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		PF04146
(YTH) 		4 ALA A 407
VAL A 409
PHE A 395
ILE A 382
 None
 0.91A 5of1B-5eipA:
undetectable		 5of1B-5eipA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		4 ALA A 295
VAL A 293
PHE A 250
ILE A 345
 None
 0.81A 5of1B-5ek8A:
undetectable		 5of1B-5ek8A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		4 ALA A 183
VAL A 187
PHE A 174
ILE A 201
 None
 1.01A 5of1B-5ekuA:
undetectable		 5of1B-5ekuA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		4 ALA A 240
VAL A 242
PHE A 268
ILE A 288
 None
 1.00A 5of1B-5ey7A:
undetectable		 5of1B-5ey7A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf DNA REPAIR HELICASE
RAD25, SSL2

(Saccharomyces
cerevisiae) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 ALA 1 399
VAL 1 395
PHE 1 484
ILE 1 384
 None
 0.89A 5of1B-5fmf1:
undetectable		 5of1B-5fmf1:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ALA A  56
VAL A  58
PHE A  14
ILE A  69
 None
 1.01A 5of1B-5fxeA:
undetectable		 5of1B-5fxeA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		PF04146
(YTH) 		4 ALA A 407
VAL A 409
PHE A 395
ILE A 382
 None
 0.93A 5of1B-5h8aA:
undetectable		 5of1B-5h8aA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE

(Francisella
tularensis) 		PF01761
(DHQ_synthase) 		4 ALA A 189
VAL A 185
PHE A 296
ILE A 206
 None
 1.06A 5of1B-5hvnA:
undetectable		 5of1B-5hvnA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		4 ALA A 151
VAL A 180
PHE A 305
ILE A 297
 None
 0.91A 5of1B-5l2pA:
undetectable		 5of1B-5l2pA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd RAB SMALL MONOMERIC
GTPASE-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00071
(Ras) 		4 ALA C  81
VAL C  11
PHE C 106
ILE C 171
 None
 0.97A 5of1B-5lddC:
undetectable		 5of1B-5lddC:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L15,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00828
(Ribosomal_L27A) 		4 ALA N 214
VAL N 176
PHE N 217
ILE N 165
 None
 0.78A 5of1B-5mlcN:
undetectable		 5of1B-5mlcN:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6y PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Bacillus cereus) 		no annotation 4 ALA B 102
VAL B 100
PHE B  79
ILE B 243
 None
None
None
CL  B 318 ( 4.6A)
 0.99A 5of1B-5o6yB:
undetectable		 5of1B-5o6yB:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8m YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		no annotation 4 ALA A 407
VAL A 409
PHE A 395
ILE A 382
 None
 0.91A 5of1B-5o8mA:
undetectable		 5of1B-5o8mA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5of2 SPORE
COAT-ASSOCIATED
PROTEIN N

(Bacillus
subtilis) 		no annotation 4 ALA A  53
VAL A  55
PHE A  70
ILE A 198
 None
EDO  A 301 ( 3.5A)
None
None
 0.23A 5of1B-5of2A:
32.4		 5of1B-5of2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5of2 SPORE
COAT-ASSOCIATED
PROTEIN N

(Bacillus
subtilis) 		no annotation 4 VAL A  55
LYS A  68
PHE A  70
ILE A 198
 EDO  A 301 ( 3.5A)
None
None
None
 0.73A 5of1B-5of2A:
32.4		 5of1B-5of2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 4 ALA A 215
VAL A 158
PHE A 208
ILE A 117
 None
 1.01A 5of1B-5ogzA:
undetectable		 5of1B-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm GENERAL
TRANSCRIPTION AND
DNA REPAIR FACTOR
IIH HELICASE SUBUNIT
XPB

(Saccharomyces
cerevisiae) 		no annotation 4 ALA 7 399
VAL 7 395
PHE 7 484
ILE 7 384
 None
 0.80A 5of1B-5oqm7:
undetectable		 5of1B-5oqm7:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbk IMPORTIN SUBUNIT
ALPHA-3

(Homo sapiens) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 ALA A 158
VAL A 153
PHE A 162
ILE A 142
 None
 1.03A 5of1B-5tbkA:
undetectable		 5of1B-5tbkA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3s TWO-COMPONENT
INSECTICIDAL PROTEIN
16 KDA UNIT

(Alcaligenes
faecalis) 		PF06355
(Aegerolysin) 		4 ALA A  36
VAL A  33
PHE A  43
ILE A  24
 None
 1.06A 5of1B-5v3sA:
undetectable		 5of1B-5v3sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN

(Penicillium
rubens) 		no annotation 4 ALA A 125
VAL A 123
PHE A 129
ILE A 145
 None
 0.92A 5of1B-5w7mA:
undetectable		 5of1B-5w7mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo sapiens) 		no annotation 4 ALA A1794
VAL A1792
PHE A1690
ILE A1578
 None
 0.89A 5of1B-5wchA:
undetectable		 5of1B-5wchA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxl RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix) 		4 ALA A 147
VAL A 153
PHE A 190
ILE A 234
 None
 1.00A 5of1B-5wxlA:
undetectable		 5of1B-5wxlA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE

(Chromobacterium
sp. USM2) 		PF07167
(PhaC_N) 		4 ALA A 287
VAL A 215
PHE A 312
ILE A 296
 None
 1.03A 5of1B-5xavA:
undetectable		 5of1B-5xavA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT RPAC1

(Saccharomyces
cerevisiae) 		no annotation 4 ALA C  98
VAL C  96
PHE C  85
ILE C  92
 None
 0.95A 5of1B-6f42C:
undetectable		 5of1B-6f42C:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens) 		no annotation 4 ALA A 587
VAL A 585
PHE A 633
ILE A 581
 None
OLA  A4002 ( 4.3A)
OLA  A4004 (-4.8A)
None
 1.03A 5of1B-6ffhA:
undetectable		 5of1B-6ffhA:
16.88