SIMILAR PATTERNS OF AMINO ACIDS FOR 5OEX_A_CUA604

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 HIS A 132
HIS A 147
HIS A 130
 None
ZN  A  28 (-3.1A)
None
 0.83A 5oexA-1do5A:
undetectable		 5oexA-1do5A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		3 HIS A 376
HIS A 437
HIS A  79
 CUZ  A4801 (-3.3A)
CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.2A)
 0.50A 5oexA-1fwxA:
26.8		 5oexA-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcd HISACTOPHILIN

(Dictyostelium
discoideum) 		PF06268
(Fascin) 		3 HIS A  91
HIS A  89
HIS A  88
 None
 0.97A 5oexA-1hcdA:
undetectable		 5oexA-1hcdA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 193
HIS A 194
HIS A 198
 None
CU  A 665 (-3.0A)
CU  A 665 (-3.1A)
 0.95A 5oexA-1hcyA:
undetectable		 5oexA-1hcyA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 103
HIS A 980
HIS A 163
 CU  A1051 (-3.3A)
CU  A1050 (-3.0A)
CU  A1050 (-3.3A)
 0.97A 5oexA-1kcwA:
undetectable		 5oexA-1kcwA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 356
HIS A 361
HIS A 545
 None
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.68A 5oexA-1loxA:
undetectable		 5oexA-1loxA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		3 HIS A 175
HIS A  77
HIS A 186
 None
 0.98A 5oexA-1qf6A:
undetectable		 5oexA-1qf6A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 3 HIS A 376
HIS A 437
HIS A  79
 CUZ  A 801 (-3.3A)
CUZ  A 801 (-3.0A)
CUZ  A 801 (-3.3A)
 0.46A 5oexA-1qniA:
24.8		 5oexA-1qniA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3n HYPOTHETICAL PROTEIN
MJ0936

(Methanocaldococcus
jannaschii) 		PF12850
(Metallophos_2) 		3 HIS A 120
HIS A  99
HIS A 100
 MN  A 503 (-3.6A)
None
None
 0.96A 5oexA-1s3nA:
undetectable		 5oexA-1s3nA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		3 HIS A 741
HIS A 737
HIS A 825
 MG  A2123 (-3.0A)
IBM  A2111 ( 4.8A)
None
 1.00A 5oexA-1sojA:
undetectable		 5oexA-1sojA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tke THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF02824
(TGS)
PF07973
(tRNA_SAD) 		3 HIS A 175
HIS A  77
HIS A 186
 None
SER  A 500 (-4.0A)
None
 0.90A 5oexA-1tkeA:
undetectable		 5oexA-1tkeA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to5 SUPEROXIDE DISMUTASE

(Schistosoma
mansoni) 		PF00080
(Sod_Cu) 		3 HIS A  47
HIS A  62
HIS A  45
 CU  A 712 (-3.4A)
ZN  A 711 ( 3.1A)
CU  A 712 (-3.3A)
 0.93A 5oexA-1to5A:
undetectable		 5oexA-1to5A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE

(Moorella
thermoacetica) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		3 HIS A  86
HIS A  81
HIS A 148
 FEO  A 501 (-3.1A)
FEO  A 501 (-3.3A)
FEO  A 501 (-2.8A)
 0.95A 5oexA-1ycgA:
undetectable		 5oexA-1ycgA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF01522
(Polysacc_deac_1) 		3 HIS A 301
HIS A  20
HIS A  18
 None
None
EDO  A 309 (-4.3A)
 0.96A 5oexA-1z7aA:
undetectable		 5oexA-1z7aA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		3 HIS A  11
HIS A  66
HIS A 133
 ZN  A 401 (-3.2A)
P33  A 501 (-4.0A)
ZN  A 402 (-3.1A)
 0.95A 5oexA-1zzmA:
undetectable		 5oexA-1zzmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4h SELENOPROTEIN SEP15

(Drosophila
melanogaster) 		PF08806
(Sep15_SelM) 		3 HIS A  60
HIS A  58
HIS A  56
 None
 0.99A 5oexA-2a4hA:
undetectable		 5oexA-2a4hA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		3 HIS A  62
HIS A  85
HIS A  60
 CU  A 402 ( 3.4A)
ZN  A 400 (-3.2A)
CU  A 402 ( 3.3A)
 0.94A 5oexA-2apsA:
undetectable		 5oexA-2apsA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B) 		3 HIS A 128
HIS A  72
HIS A  74
 FE2  A 300 (-3.4A)
FE2  A 300 (-3.3A)
None
 1.02A 5oexA-2gcuA:
undetectable		 5oexA-2gcuA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		3 HIS A 388
HIS A 315
HIS A 317
 None
 0.95A 5oexA-2gv8A:
undetectable		 5oexA-2gv8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5i UPF0249 PROTEIN
EF_3048

(Enterococcus
faecalis) 		PF04794
(YdjC) 		3 HIS A  63
HIS A 129
HIS A 130
 None
 0.70A 5oexA-2i5iA:
undetectable		 5oexA-2i5iA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT
TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri;
Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS)
PF02332
(Phenol_Hydrox) 		3 HIS A 163
HIS A 159
HIS B  17
 None
 0.92A 5oexA-2incA:
undetectable		 5oexA-2incA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpw LAMIN-B1

(Homo sapiens) 		PF00932
(LTD) 		3 HIS A   6
HIS A   4
HIS A   3
 None
 0.91A 5oexA-2kpwA:
undetectable		 5oexA-2kpwA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m8e SLEEPING BEAUTY
TRANSPOSASE

(synthetic
construct) 		PF13384
(HTH_23) 		3 HIS A  50
HIS A  51
HIS A  56
 None
 0.95A 5oexA-2m8eA:
undetectable		 5oexA-2m8eA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaa R.MVAI

(Kocuria varians) 		PF15515
(MvaI_BcnI) 		3 HIS A 100
HIS A 225
HIS A 223
 None
 0.93A 5oexA-2oaaA:
undetectable		 5oexA-2oaaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		3 HIS A  76
HIS A 200
HIS A 227
 FE  A1001 (-3.5A)
FE  A1001 (-3.3A)
None
 0.93A 5oexA-2p4zA:
undetectable		 5oexA-2p4zA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 HIS A 246
HIS A 248
HIS A 285
 None
ZN  A 493 (-3.2A)
ZN  A 493 (-3.5A)
 0.77A 5oexA-2pajA:
undetectable		 5oexA-2pajA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2peb PUTATIVE DIOXYGENASE

(Nostoc
punctiforme) 		PF08883
(DOPA_dioxygen) 		3 HIS A  51
HIS A  14
HIS A  84
 UNL  A 201 (-4.0A)
ZN  A 200 ( 3.1A)
ZN  A 200 ( 3.4A)
 0.99A 5oexA-2pebA:
undetectable		 5oexA-2pebA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		3 HIS A 119
HIS A  87
HIS A 127
 None
 1.00A 5oexA-2pkgA:
undetectable		 5oexA-2pkgA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		3 HIS A  22
HIS A 234
HIS A 177
 ZN  A 272 (-3.6A)
ZN  A 272 (-3.2A)
ZN  A 274 (-3.1A)
 1.02A 5oexA-2pw6A:
undetectable		 5oexA-2pw6A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q78 UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		no annotation 3 HIS A   0
HIS A  -1
HIS A  -3
 MLC  A 200 (-3.9A)
None
None
 0.80A 5oexA-2q78A:
undetectable		 5oexA-2q78A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		3 HIS A 472
HIS A 244
HIS A 240
 None
 0.55A 5oexA-2qr4A:
undetectable		 5oexA-2qr4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 HIS A 653
HIS A 496
HIS A 497
 None
 0.95A 5oexA-2vdcA:
undetectable		 5oexA-2vdcA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 HIS M 494
HIS M 668
HIS M 670
 None
 0.81A 5oexA-2w4gM:
undetectable		 5oexA-2w4gM:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		3 HIS A   9
HIS A  39
HIS A  75
 None
SO4  A1289 (-4.1A)
None
 0.83A 5oexA-2yb4A:
undetectable		 5oexA-2yb4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvy CHEMOTAXIS PROTEIN
MOTB

(Salmonella
enterica) 		PF00691
(OmpA) 		3 HIS A 280
HIS A 277
HIS A 278
 None
 0.97A 5oexA-2zvyA:
undetectable		 5oexA-2zvyA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens) 		PF01522
(Polysacc_deac_1) 		3 HIS A 301
HIS A  20
HIS A  18
 None
 0.96A 5oexA-3cl6A:
undetectable		 5oexA-3cl6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		3 HIS A  14
HIS A  40
HIS A   8
 ZN  A 301 (-3.5A)
ZN  A 301 (-3.5A)
FE  A 311 (-3.4A)
 0.97A 5oexA-3dcpA:
undetectable		 5oexA-3dcpA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1p PROTEIN PHNP

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		3 HIS A 143
HIS A 200
HIS A 222
 MN  A 400 ( 3.4A)
MLT  A 500 (-4.1A)
MN  A 401 (-3.7A)
 0.99A 5oexA-3g1pA:
undetectable		 5oexA-3g1pA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		3 HIS A  57
HIS A 170
HIS A 196
 ZN  A 256 (-3.5A)
ZN  A 256 (-3.6A)
None
 0.89A 5oexA-3h3eA:
undetectable		 5oexA-3h3eA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 HIS B 693
HIS B 994
HIS B 995
 None
 0.98A 5oexA-3hkzB:
undetectable		 5oexA-3hkzB:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3s ALTRONATE HYDROLASE

(Shigella
flexneri) 		PF08666
(SAF) 		3 HIS A  78
HIS A  76
HIS A  42
 None
 0.93A 5oexA-3k3sA:
undetectable		 5oexA-3k3sA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgz CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Rhodopseudomonas
palustris) 		PF07883
(Cupin_2) 		3 HIS A 116
HIS A  82
HIS A  80
 MN  A   1 (-3.5A)
MN  A   1 (-3.4A)
None
 0.99A 5oexA-3kgzA:
undetectable		 5oexA-3kgzA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 156
HIS A 158
HIS A 164
 None
 0.91A 5oexA-3kw8A:
undetectable		 5oexA-3kw8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf9 4E10_D0_1IS1A_001_C
(T161)

(synthetic
construct) 		PF01765
(RRF) 		3 HIS A 119
HIS A 117
HIS A 116
 None
 0.82A 5oexA-3lf9A:
undetectable		 5oexA-3lf9A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 109
HIS A  66
HIS A 398
 CU  A1501 (-3.2A)
CU  A1501 ( 3.0A)
CU  A1502 ( 2.9A)
 1.02A 5oexA-3pxlA:
undetectable		 5oexA-3pxlA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1j PHD FINGER PROTEIN
20

(Homo sapiens) 		PF02820
(MBT) 		3 HIS A  32
HIS A  46
HIS A  52
 None
 0.97A 5oexA-3q1jA:
undetectable		 5oexA-3q1jA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi3 HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		3 HIS A 256
HIS A 252
HIS A 296
 ZN  A 534 (-3.3A)
PDB  A 600 (-4.6A)
None
 1.02A 5oexA-3qi3A:
undetectable		 5oexA-3qi3A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2u METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00753
(Lactamase_B) 		3 HIS A 119
HIS A  56
HIS A  58
 FE  A 443 (-3.4A)
FE  A 443 (-3.6A)
None
 0.98A 5oexA-3r2uA:
undetectable		 5oexA-3r2uA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		3 HIS A 356
HIS A 361
HIS A 545
 None
FE2  A   1 ( 3.4A)
FE2  A   1 (-3.3A)
 0.77A 5oexA-3rdeA:
undetectable		 5oexA-3rdeA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsn SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2

(Homo sapiens) 		no annotation 3 HIS A  52
HIS A  57
HIS A  58
 None
 0.88A 5oexA-3rsnA:
undetectable		 5oexA-3rsnA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 3 HIS A 433
HIS A 494
HIS A 129
 CUK  A 702 (-3.1A)
CUK  A 702 (-3.3A)
CUK  A 702 (-3.5A)
 0.53A 5oexA-3sbqA:
25.2		 5oexA-3sbqA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		3 HIS A 164
HIS A 160
HIS A 204
 HIS  A 164 (-1.0A)
HIS  A 160 ( 1.0A)
HIS  A 204 ( 1.0A)
 1.00A 5oexA-3sl5A:
undetectable		 5oexA-3sl5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  92
HIS A  90
HIS A 146
 None
 1.01A 5oexA-3t9wA:
undetectable		 5oexA-3t9wA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		3 HIS A 227
HIS A 173
HIS A 177
 None
ZN  A 231 (-3.2A)
ZN  A 231 (-3.2A)
 0.97A 5oexA-3te7A:
undetectable		 5oexA-3te7A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		3 HIS A 529
HIS A 525
HIS A 567
 ZN  A 772 (-3.5A)
C1L  A   1 (-4.1A)
None
 1.01A 5oexA-3ui7A:
undetectable		 5oexA-3ui7A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		3 HIS A 372
HIS A 368
HIS A 413
 ZN  A 702 (-3.3A)
None
None
 0.98A 5oexA-3v94A:
undetectable		 5oexA-3v94A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A 632
HIS A 633
HIS A 491
 None
CUO  A9002 (-3.3A)
CUO  A9002 (-3.4A)
 0.97A 5oexA-4bedA:
undetectable		 5oexA-4bedA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL

(Homo sapiens) 		PF00753
(Lactamase_B) 		3 HIS A 135
HIS A  79
HIS A  81
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
 0.99A 5oexA-4chlA:
undetectable		 5oexA-4chlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR

(Thermoproteus
tenax) 		no annotation 3 HIS A  58
HIS A  48
HIS A  49
 None
 0.73A 5oexA-4csoA:
undetectable		 5oexA-4csoA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 HIS A 492
HIS A 666
HIS A 668
 None
 0.97A 5oexA-4db1A:
undetectable		 5oexA-4db1A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Burkholderia
pseudomallei) 		PF00753
(Lactamase_B) 		3 HIS A 143
HIS A  68
HIS A  70
 CA  A 301 (-3.6A)
CA  A 301 (-3.5A)
None
 1.01A 5oexA-4efzA:
undetectable		 5oexA-4efzA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8q BUTYROPHILIN
SUBFAMILY 3 MEMBER
A2

(Homo sapiens) 		PF07686
(V-set) 		3 HIS A 214
HIS A 211
HIS A 212
 None
 0.87A 5oexA-4f8qA:
undetectable		 5oexA-4f8qA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 HIS A 300
HIS A 301
HIS A 291
 None
 0.81A 5oexA-4ggaA:
9.2		 5oexA-4ggaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		3 HIS A 660
HIS A 656
HIS A 700
 ZN  A1001 (-3.4A)
None
None
 1.02A 5oexA-4htzA:
undetectable		 5oexA-4htzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 3 HIS A  38
HIS A  37
HIS A  29
 None
 0.59A 5oexA-4iegA:
undetectable		 5oexA-4iegA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu2 CELL-WALL ANCHORING
PROTEIN

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin) 		3 HIS A   7
HIS A   5
HIS A   4
 SO4  A 305 (-3.6A)
None
None
 0.96A 5oexA-4iu2A:
undetectable		 5oexA-4iu2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00814
(Peptidase_M22) 		3 HIS A 175
HIS A 149
HIS A 145
 ZN  A 601 (-4.8A)
ZN  A 601 (-4.3A)
ZN  A 601 (-3.4A)
 0.96A 5oexA-4k25A:
undetectable		 5oexA-4k25A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 HIS A 300
HIS A 301
HIS A 291
 None
 0.76A 5oexA-4n14A:
9.6		 5oexA-4n14A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntc GLIT

(Aspergillus
fumigatus) 		PF07992
(Pyr_redox_2) 		3 HIS A  56
HIS A  63
HIS A  54
 None
 0.81A 5oexA-4ntcA:
undetectable		 5oexA-4ntcA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oci CALMODULIN, PUTATIVE

(Entamoeba
histolytica) 		PF00036
(EF-hand_1)
PF13833
(EF-hand_8) 		3 HIS A 146
HIS A 145
HIS A 141
 None
 0.96A 5oexA-4ociA:
undetectable		 5oexA-4ociA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		3 HIS A 492
HIS A 666
HIS A 668
 None
 0.97A 5oexA-4p7hA:
undetectable		 5oexA-4p7hA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida) 		PF00753
(Lactamase_B) 		3 HIS A 149
HIS A  74
HIS A  76
 FE  A 301 ( 3.5A)
FE  A 301 (-3.4A)
None
 1.01A 5oexA-4yslA:
undetectable		 5oexA-4yslA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 173
HIS A 272
HIS A 268
 None
ZN  A 402 (-3.4A)
ZN  A 402 (-3.5A)
 0.68A 5oexA-4zr0A:
undetectable		 5oexA-4zr0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 173
HIS A 272
HIS A 268
 None
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 0.76A 5oexA-4zr1A:
undetectable		 5oexA-4zr1A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 HIS A 576
HIS A 582
HIS A 586
 None
 0.94A 5oexA-5dkxA:
2.4		 5oexA-5dkxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8c UL31

(Suid
alphaherpesvirus
1) 		PF02718
(Herpes_UL31) 		3 HIS A 188
HIS A 190
HIS A 191
 ZN  A 300 (-3.2A)
None
None
 0.52A 5oexA-5e8cA:
undetectable		 5oexA-5e8cA:
19.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 3 HIS A 437
HIS A 482
HIS A 528
 None
None
CU  A 602 (-3.0A)
 0.20A 5oexA-5f75A:
72.6		 5oexA-5f75A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gja 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 2

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		3 HIS A  42
HIS A  46
HIS A 214
 None
 1.02A 5oexA-5gjaA:
undetectable		 5oexA-5gjaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		3 HIS A 249
HIS A 250
HIS A 289
 None
 0.82A 5oexA-5gsmA:
undetectable		 5oexA-5gsmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 3 HIS A 426
HIS A 424
HIS A 485
 None
 0.77A 5oexA-5i5jA:
27.8		 5oexA-5i5jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 HIS A 768
HIS A 714
HIS A 712
 None
ZN  A1002 (-3.3A)
ZN  A1002 (-3.2A)
 0.96A 5oexA-5jjrA:
undetectable		 5oexA-5jjrA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 HIS Q 300
HIS Q 301
HIS Q 291
 None
 0.81A 5oexA-5lcwQ:
8.9		 5oexA-5lcwQ:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 HIS R 300
HIS R 301
HIS R 291
 None
 0.82A 5oexA-5lcwR:
4.1		 5oexA-5lcwR:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5los PIIN_05872

(Serendipita
indica) 		no annotation 3 HIS A  92
HIS A  31
HIS A  30
 ZN  A 201 (-3.3A)
ZN  A 201 (-3.6A)
None
 0.93A 5oexA-5losA:
undetectable		 5oexA-5losA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5los PIIN_05872

(Serendipita
indica) 		no annotation 3 HIS A  99
HIS A  24
HIS A  23
 None
 0.92A 5oexA-5losA:
undetectable		 5oexA-5losA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		3 HIS B  71
HIS B 589
HIS B 502
 None
CU  B 701 (-3.2A)
CU  B 701 (-3.2A)
 1.00A 5oexA-5lxzB:
8.3		 5oexA-5lxzB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		3 HIS A 227
HIS A 224
HIS A 404
 None
ZN  A 512 (-3.5A)
ZN  A 511 (-3.1A)
 0.92A 5oexA-5m8tA:
undetectable		 5oexA-5m8tA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5oex -

(-) 		no annotation 3 HIS A 437
HIS A 482
HIS A 528
 CU  A 604 (-3.3A)
CU  A 604 (-3.2A)
CU  A 602 ( 3.0A)
 0.01A 5oexA-5oexA:
77.1		 5oexA-5oexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ore OCTOPINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 3 HIS A 277
HIS A 280
HIS A 281
 None
 0.99A 5oexA-5oreA:
undetectable		 5oexA-5oreA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u87 PREPROALBUMIN PAWS1

(Helianthus
annuus) 		PF00234
(Tryp_alpha_amyl) 		3 HIS A  31
HIS A  35
HIS A  55
 None
 0.98A 5oexA-5u87A:
undetectable		 5oexA-5u87A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		3 HIS A 159
HIS A 143
HIS A 123
 None
EDO  A 509 ( 3.5A)
PO4  A 503 (-3.7A)
 0.73A 5oexA-5uamA:
14.3		 5oexA-5uamA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubv ATPASE DOMAIN OF
I-AAA PROTEASE

(Thermothelomyces
thermophila) 		no annotation 3 HIS A 185
HIS A 184
HIS A   9
 ADP  A 302 (-4.4A)
None
None
 0.92A 5oexA-5ubvA:
undetectable		 5oexA-5ubvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve3 BPPRF

(Paraburkholderia
phytofirmans) 		no annotation 3 HIS B 114
HIS B  58
HIS B  60
 FE  B 500 (-3.3A)
FE  B 500 (-3.3A)
None
 1.02A 5oexA-5ve3B:
undetectable		 5oexA-5ve3B:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 HIS B 721
HIS B 720
HIS B 723
 None
 1.02A 5oexA-5vniB:
undetectable		 5oexA-5vniB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 HIS A 512
HIS A 511
HIS A 509
 None
 0.86A 5oexA-5vocA:
undetectable		 5oexA-5vocA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 3 HIS A 545
HIS A 585
HIS A 584
 None
 0.87A 5oexA-5yy3A:
undetectable		 5oexA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z43 AMBP1

(Fischerella
ambigua) 		no annotation 3 HIS A 178
HIS A 175
HIS A 151
 None
 0.97A 5oexA-5z43A:
undetectable		 5oexA-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 3 HIS A 139
HIS A 137
HIS A  33
 CU  A 501 (-3.2A)
CU  A 501 (-3.1A)
CU  A 501 (-3.5A)
 1.00A 5oexA-6cxhA:
undetectable		 5oexA-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e12 -

(-) 		no annotation 3 HIS A  90
HIS A 124
HIS A 120
 None
None
OLA  A 301 (-3.8A)
 0.99A 5oexA-6e12A:
undetectable		 5oexA-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 3 HIS A 492
HIS A 666
HIS A 668
 None
 0.97A 5oexA-6fsaA:
undetectable		 5oexA-6fsaA:
undetectable