SIMILAR PATTERNS OF AMINO ACIDS FOR 5OEX_A_CUA603_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		4 LYS A 100
HIS A 128
HIS A  80
HIS A  79
 None
CUZ  A4801 (-3.2A)
CUZ  A4801 (-3.3A)
CUZ  A4801 (-3.2A)
 1.17A 5oexA-1fwxA:
26.8		 5oexA-1fwxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 4 LYS A 100
HIS A 128
HIS A  80
HIS A  79
 None
CUZ  A 801 (-3.1A)
CUZ  A 801 (-3.3A)
CUZ  A 801 (-3.3A)
 1.21A 5oexA-1qniA:
24.8		 5oexA-1qniA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcb 5-FORMYLTETRAHYDROFO
LATE CYCLO-LIGASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01812
(5-FTHF_cyc-lig) 		4 LYS A  -4
HIS A   0
HIS A  -1
HIS A  -3
 None
 1.15A 5oexA-2jcbA:
0.0		 5oexA-2jcbA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 4 LYS A 150
HIS A 178
HIS A 130
HIS A 129
 None
CUK  A 702 (-3.1A)
CUK  A 702 (-3.2A)
CUK  A 702 (-3.5A)
 1.25A 5oexA-3sbqA:
25.2		 5oexA-3sbqA:
23.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 4 LYS A 103
HIS A 135
HIS A 136
HIS A 528
 CU  A 602 (-2.2A)
CU  A 602 (-3.1A)
None
CU  A 602 (-3.0A)
 0.18A 5oexA-5f75A:
72.6		 5oexA-5f75A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 4 LYS A 103
HIS A 135
HIS A 136
HIS A 528
 CU  A 602 (-2.6A)
CU  A 602 ( 3.0A)
CU  A 603 (-4.5A)
CU  A 602 ( 3.0A)
 0.02A 5oexA-5oexA:
77.1		 5oexA-5oexA:
undetectable