SIMILAR PATTERNS OF AMINO ACIDS FOR 5ODQ_D_ACTD202_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		3 HIS A 187
GLU A 186
TRP A 183
 None
 0.95A 5odqD-1jkmA:
2.3		 5odqD-1jkmA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 HIS A 224
GLU A 185
TRP A 186
 None
 1.02A 5odqD-1mlzA:
undetectable		 5odqD-1mlzA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3p LECTIN PAL

(Pterocarpus
angolensis) 		PF00139
(Lectin_legB) 		3 HIS A  57
GLU A 209
TRP A 210
 None
 1.19A 5odqD-1n3pA:
undetectable		 5odqD-1n3pA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odu PUTATIVE
ALPHA-L-FUCOSIDASE

(Thermotoga
maritima) 		PF01120
(Alpha_L_fucos) 		3 HIS A 129
GLU A  66
TRP A  67
 FUL  A1448 (-4.0A)
FUL  A1448 (-3.3A)
FUL  A1448 (-4.1A)
 1.13A 5odqD-1oduA:
undetectable		 5odqD-1oduA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 HIS A 110
GLU A  90
TRP A  88
 None
None
NHE  A 354 (-4.5A)
 1.12A 5odqD-1q1qA:
2.7		 5odqD-1q1qA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE

(Homo sapiens) 		PF00435
(Spectrin) 		3 HIS A1113
GLU A1109
TRP A1076
 None
 1.16A 5odqD-1s35A:
undetectable		 5odqD-1s35A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli) 		PF00485
(PRK) 		3 HIS A1118
GLU A1117
TRP A1115
 None
 1.19A 5odqD-1sq5A:
undetectable		 5odqD-1sq5A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ui1 URACIL-DNA
GLYCOSYLASE

(Thermus
thermophilus) 		PF03167
(UDG) 		3 HIS A 146
GLU A 144
TRP A 145
 None
 1.20A 5odqD-1ui1A:
2.8		 5odqD-1ui1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Escherichia
coli) 		PF00581
(Rhodanese) 		3 HIS A  14
GLU A  13
TRP A  10
 None
 0.64A 5odqD-1urhA:
undetectable		 5odqD-1urhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcc DNA TOPOISOMERASE I

(Vaccinia virus) 		PF09266
(VirDNA-topo-I_N) 		3 HIS A  33
GLU A  29
TRP A  50
 None
 0.95A 5odqD-1vccA:
undetectable		 5odqD-1vccA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		3 HIS A 183
GLU A 187
TRP A 188
 None
 0.79A 5odqD-1vcjA:
undetectable		 5odqD-1vcjA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq7 50S RIBOSOMAL
PROTEIN L30P

(Haloarcula
marismortui) 		PF00327
(Ribosomal_L30) 		3 HIS W  87
GLU W  86
TRP W  83
 None
 0.99A 5odqD-1vq7W:
undetectable		 5odqD-1vq7W:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 HIS A 240
GLU A 132
TRP A 235
 None
 1.21A 5odqD-1w1kA:
undetectable		 5odqD-1w1kA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		PF06052
(3-HAO) 		3 HIS A  17
GLU A  16
TRP A  13
 None
 0.86A 5odqD-1yfyA:
undetectable		 5odqD-1yfyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		3 HIS A 520
GLU A 521
TRP A 678
 None
 1.11A 5odqD-1zjkA:
undetectable		 5odqD-1zjkA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a87 THIOREDOXIN
REDUCTASE

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		3 HIS A 318
GLU A 317
TRP A 314
 None
 0.93A 5odqD-2a87A:
2.6		 5odqD-2a87A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 HIS A 541
GLU A 537
TRP A 583
 None
 1.09A 5odqD-2cvtA:
2.0		 5odqD-2cvtA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dax PROTEIN C21ORF6

(Homo sapiens) 		PF05773
(RWD) 		3 HIS A 135
GLU A 134
TRP A 131
 None
 0.87A 5odqD-2daxA:
undetectable		 5odqD-2daxA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		3 HIS A 459
GLU A 458
TRP A 455
 None
 1.05A 5odqD-2e3zA:
undetectable		 5odqD-2e3zA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE

(Enterococcus
faecalis) 		PF00294
(PfkB) 		3 HIS A 233
GLU A 218
TRP A 219
 None
 1.17A 5odqD-2f02A:
3.2		 5odqD-2f02A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb4 THIOPURINE
S-METHYLTRANSFERASE

(Mus musculus) 		PF05724
(TPMT) 		3 HIS A  41
GLU A  70
TRP A 145
 None
 1.18A 5odqD-2gb4A:
undetectable		 5odqD-2gb4A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 HIS A 138
GLU A 104
TRP A 134
 None
 1.14A 5odqD-2nlxA:
undetectable		 5odqD-2nlxA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN

(Paramecium
bursaria
Chlorella virus
1) 		PF05637
(Glyco_transf_34) 		3 HIS A 126
GLU A  72
TRP A  73
 None
 1.12A 5odqD-2p6wA:
undetectable		 5odqD-2p6wA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7n LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Mus musculus) 		PF00041
(fn3) 		3 HIS A 175
GLU A 186
TRP A 187
 None
 1.09A 5odqD-2q7nA:
undetectable		 5odqD-2q7nA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		3 HIS A 297
GLU A 296
TRP A 293
 None
 1.12A 5odqD-2radA:
undetectable		 5odqD-2radA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 HIS A 476
GLU A 475
TRP A 472
 None
 0.99A 5odqD-2va8A:
undetectable		 5odqD-2va8A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 HIS A 615
GLU A 613
TRP A 419
 None
 1.04A 5odqD-2wanA:
undetectable		 5odqD-2wanA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Brugia malayi) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 HIS A 403
GLU A 402
TRP A 399
 None
 1.05A 5odqD-2xgtA:
undetectable		 5odqD-2xgtA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ysr DEP
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00610
(DEP) 		3 HIS A  80
GLU A  83
TRP A  89
 None
 0.91A 5odqD-2ysrA:
undetectable		 5odqD-2ysrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Pyrococcus
horikoshii) 		PF09488
(Osmo_MPGsynth) 		3 HIS A 201
GLU A 305
TRP A 202
 None
 1.05A 5odqD-2zu8A:
1.9		 5odqD-2zu8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		3 HIS A 193
GLU A 189
TRP A 170
 None
 0.91A 5odqD-3bdzA:
undetectable		 5odqD-3bdzA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF08241
(Methyltransf_11) 		3 HIS A  63
GLU A  62
TRP A  59
 EDO  A 249 (-4.3A)
None
None
 0.70A 5odqD-3bkwA:
2.8		 5odqD-3bkwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czb PUTATIVE
TRANSGLYCOSYLASE

(Caulobacter
vibrioides) 		PF03562
(MltA)
PF06725
(3D) 		3 HIS A 275
GLU A 274
TRP A 271
 None
 1.11A 5odqD-3czbA:
undetectable		 5odqD-3czbA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhx METHIONINE IMPORT
ATP-BINDING PROTEIN
METN

(Escherichia
coli) 		PF09383
(NIL) 		3 HIS A  88
GLU A  87
TRP A  84
 None
 0.89A 5odqD-3dhxA:
undetectable		 5odqD-3dhxA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqv CULLIN-5

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 HIS C1763
GLU C1762
TRP C1759
 None
 0.75A 5odqD-3dqvC:
undetectable		 5odqD-3dqvC:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		3 HIS A 117
GLU A 116
TRP A 113
 None
 0.95A 5odqD-3fmcA:
3.2		 5odqD-3fmcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfk REGULATORY PROTEIN
SPX

(Bacillus
subtilis) 		PF03960
(ArsC) 		3 HIS A  23
GLU A  22
TRP A  19
 None
 0.72A 5odqD-3gfkA:
undetectable		 5odqD-3gfkA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 HIS A 235
GLU A 234
TRP A 231
 None
 0.90A 5odqD-3h55A:
undetectable		 5odqD-3h55A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiu UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF05974
(DUF892) 		3 HIS A 150
GLU A 149
TRP A 146
 None
 0.99A 5odqD-3hiuA:
undetectable		 5odqD-3hiuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		3 HIS T 506
GLU T 459
TRP T 397
 None
 1.03A 5odqD-3icqT:
undetectable		 5odqD-3icqT:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 HIS A  62
GLU A  63
TRP A 295
 ZN  A 502 ( 3.3A)
None
ACY  A 504 ( 3.7A)
 1.17A 5odqD-3jv7A:
undetectable		 5odqD-3jv7A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13377
(Peripla_BP_3) 		3 HIS A 189
GLU A 127
TRP A 220
 None
None
ACT  A   1 (-3.6A)
 1.07A 5odqD-3kkeA:
5.6		 5odqD-3kkeA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Shewanella
frigidimarina) 		PF04952
(AstE_AspA) 		3 HIS A 119
GLU A 118
TRP A 115
 None
 0.96A 5odqD-3lwuA:
2.7		 5odqD-3lwuA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		3 HIS A  53
GLU A  52
TRP A  49
 None
 0.88A 5odqD-3m1mA:
undetectable		 5odqD-3m1mA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p56 RIBONUCLEASE H2
SUBUNIT A

(Homo sapiens) 		PF01351
(RNase_HII) 		3 HIS A 223
GLU A 222
TRP A 219
 None
 0.76A 5odqD-3p56A:
undetectable		 5odqD-3p56A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbw ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Pseudomonas
aeruginosa) 		PF03702
(AnmK) 		3 HIS A 249
GLU A 248
TRP A 245
 None
 0.42A 5odqD-3qbwA:
undetectable		 5odqD-3qbwA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp2 RAT MAST CELL
PROTEASE II

(Rattus rattus) 		PF00089
(Trypsin) 		3 HIS A  91
GLU A  92
TRP A 237
 None
 0.92A 5odqD-3rp2A:
undetectable		 5odqD-3rp2A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE

(Paraburkholderia
xenovorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 HIS A  63
GLU A  90
TRP A 297
 None
 0.98A 5odqD-3sn0A:
undetectable		 5odqD-3sn0A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 HIS A 551
GLU A 553
TRP A 513
 None
 1.20A 5odqD-3ttsA:
2.1		 5odqD-3ttsA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		3 HIS A  63
GLU A  59
TRP A  55
 None
 0.87A 5odqD-3wv4A:
undetectable		 5odqD-3wv4A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		3 HIS A  63
GLU A  59
TRP A  55
 None
 0.84A 5odqD-3wvnA:
undetectable		 5odqD-3wvnA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		3 HIS A  46
GLU A 109
TRP A 107
 None
 1.16A 5odqD-4bq4A:
undetectable		 5odqD-4bq4A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		3 HIS A 182
GLU A 186
TRP A 187
 None
 0.78A 5odqD-4cpnA:
undetectable		 5odqD-4cpnA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fog THYMIDYLATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00303
(Thymidylat_synt) 		3 HIS A  75
GLU A  74
TRP A  71
 None
 0.60A 5odqD-4fogA:
undetectable		 5odqD-4fogA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdl AUTOPHAGY PROTEIN 5

(Homo sapiens) 		PF04106
(APG5) 		3 HIS B 257
GLU B 256
TRP B 253
 None
 0.94A 5odqD-4gdlB:
undetectable		 5odqD-4gdlB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8

(Thermus
thermophilus) 		no annotation 3 HIS H 192
GLU H 191
TRP H 188
 None
 0.98A 5odqD-4he8H:
undetectable		 5odqD-4he8H:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		3 HIS A 215
GLU A 232
TRP A 192
 None
 1.20A 5odqD-4hesA:
undetectable		 5odqD-4hesA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvq 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		PF06052
(3-HAO) 		3 HIS A  17
GLU A  16
TRP A  13
 None
 0.60A 5odqD-4hvqA:
undetectable		 5odqD-4hvqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		3 HIS A 113
GLU A 112
TRP A 109
 None
UBD  A 402 (-4.7A)
None
 1.04A 5odqD-4j7mA:
undetectable		 5odqD-4j7mA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr4 HYPOTHETICAL PROTEIN

([Eubacterium]
rectale) 		no annotation 3 HIS A 240
GLU A 169
TRP A  98
 None
PO4  A 405 (-2.8A)
None
 1.15A 5odqD-4lr4A:
undetectable		 5odqD-4lr4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE

(Thermotoga
maritima) 		PF09861
(DUF2088) 		3 HIS A 315
GLU A 281
TRP A 283
 None
None
SO4  A 501 (-4.2A)
 0.96A 5odqD-4narA:
undetectable		 5odqD-4narA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE

(Alicyclobacillus
acidocaldarius) 		PF00016
(RuBisCO_large) 		3 HIS A 386
GLU A 385
TRP A 382
 None
 0.82A 5odqD-4nasA:
undetectable		 5odqD-4nasA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		3 HIS A 361
GLU A 360
TRP A 357
 None
 0.90A 5odqD-4ru0A:
2.5		 5odqD-4ru0A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u36 SEED LECTIN

(Vatairea
macrocarpa) 		PF00139
(Lectin_legB) 		3 HIS A  57
GLU A 201
TRP A 202
 None
 1.15A 5odqD-4u36A:
undetectable		 5odqD-4u36A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		3 HIS A 351
GLU A 350
TRP A 349
 None
 1.20A 5odqD-4wb0A:
undetectable		 5odqD-4wb0A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020

(Homo sapiens) 		PF08144
(CPL) 		3 HIS A 547
GLU A 550
TRP A 593
 None
 1.14A 5odqD-4wzwA:
undetectable		 5odqD-4wzwA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbz EVDO1

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		3 HIS A 307
GLU A  88
TRP A 122
 None
 1.10A 5odqD-4xbzA:
undetectable		 5odqD-4xbzA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynq THREE-PRIME REPAIR
EXONUCLEASE 1

(Mus musculus) 		no annotation 3 HIS A 222
GLU A 221
TRP A 218
 None
 0.83A 5odqD-4ynqA:
undetectable		 5odqD-4ynqA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		3 HIS A 191
GLU A 233
TRP A 166
 MN  A 603 (-3.4A)
MN  A 603 ( 2.7A)
None
 1.21A 5odqD-4zaaA:
undetectable		 5odqD-4zaaA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 3 HIS A1255
GLU A1326
TRP A1267
 None
 0.84A 5odqD-5b2oA:
undetectable		 5odqD-5b2oA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3r IMP-18

(Pseudomonas
aeruginosa) 		no annotation 3 HIS A  84
GLU A  83
TRP A  80
 None
 0.88A 5odqD-5b3rA:
undetectable		 5odqD-5b3rA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c17 MERB2

(Bacillus
megaterium) 		PF03243
(MerB) 		3 HIS A 184
GLU A 183
TRP A 180
 None
 0.80A 5odqD-5c17A:
undetectable		 5odqD-5c17A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8p MOCVNH3 VARIANT

(Magnaporthe
oryzae) 		PF01476
(LysM)
PF08881
(CVNH) 		3 HIS A 140
GLU A 139
TRP A  52
 None
 1.14A 5odqD-5c8pA:
undetectable		 5odqD-5c8pA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czy LEGIONELLA EFFECTOR
LEGAS4

(Legionella
pneumophila) 		PF00023
(Ank)
PF00856
(SET) 		3 HIS A 356
GLU A 355
TRP A 352
 None
 0.87A 5odqD-5czyA:
undetectable		 5odqD-5czyA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 HIS A 559
GLU A 561
TRP A 520
 None
 1.20A 5odqD-5e9aA:
2.0		 5odqD-5e9aA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		3 HIS A 253
GLU A 221
TRP A 198
 None
 0.77A 5odqD-5gkxA:
undetectable		 5odqD-5gkxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 HIS A 281
GLU A 280
TRP A 277
 None
 0.89A 5odqD-5hm5A:
undetectable		 5odqD-5hm5A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja4 TONSOKU-LIKE PROTEIN

(Homo sapiens) 		PF12796
(Ank_2) 		3 HIS D 567
GLU D 568
TRP D 563
 None
 1.11A 5odqD-5ja4D:
undetectable		 5odqD-5ja4D:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		3 HIS A 574
GLU A 571
TRP A 602
 G  X   2 ( 3.8A)
C  X  24 ( 4.2A)
None
 0.98A 5odqD-5jbgA:
undetectable		 5odqD-5jbgA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jt8 BLO T 1 ALLERGEN

(Blomia
tropicalis) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 HIS A  44
GLU A  43
TRP A  40
 None
 1.08A 5odqD-5jt8A:
undetectable		 5odqD-5jt8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Homo sapiens) 		PF00076
(RRM_1)
PF08662
(eIF2A) 		3 HIS B 554
GLU B 553
TRP B 585
 None
 0.93A 5odqD-5k1hB:
undetectable		 5odqD-5k1hB:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k79 CYANOVIRIN-N DOMAIN
PROTEIN

(Cyanothece sp.
PCC 7424) 		PF08881
(CVNH) 		3 HIS A  97
GLU A  96
TRP A  50
 None
 1.14A 5odqD-5k79A:
undetectable		 5odqD-5k79A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRP46

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 HIS J 382
GLU J 346
TRP J 442
 None
 0.92A 5odqD-5lj3J:
undetectable		 5odqD-5lj3J:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 HIS A 611
GLU A 610
TRP A 607
 None
 0.82A 5odqD-5ltaA:
2.3		 5odqD-5ltaA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3c DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		no annotation 3 HIS A1053
GLU A1052
TRP A1049
 None
 1.15A 5odqD-5m3cA:
undetectable		 5odqD-5m3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 3 HIS A 433
GLU A 565
TRP A 497
 None
 1.12A 5odqD-5mqpA:
undetectable		 5odqD-5mqpA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myu TYPE VI SECRETION
SYSTEM PROTEIN IMPC

(Vibrio cholerae) 		PF05943
(VipB) 		3 HIS A 269
GLU A 270
TRP A 274
 None
 0.98A 5odqD-5myuA:
undetectable		 5odqD-5myuA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 3 HIS E 334
GLU E 258
TRP E 192
 None
 1.22A 5odqD-5n6yE:
undetectable		 5odqD-5n6yE:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL

(Bos taurus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 HIS A  94
GLU A  93
TRP A 262
 None
 0.90A 5odqD-5nmiA:
undetectable		 5odqD-5nmiA:
13.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D

(Methanothermococcus
thermolithotrophicus) 		PF02662
(FlpD) 		3 HIS D 104
GLU D 105
TRP D 106
 ACT  D 202 (-3.8A)
ACT  D 202 (-3.8A)
ACT  D 202 (-4.6A)
 0.18A 5odqD-5odrD:
29.0		 5odqD-5odrD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 HIS A 442
GLU A 439
TRP A 214
 None
 1.22A 5odqD-5t88A:
2.7		 5odqD-5t88A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 3 HIS A 366
GLU A 364
TRP A 165
 None
 1.11A 5odqD-5ww1A:
undetectable		 5odqD-5ww1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii;
Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 HIS A 787
GLU B 695
TRP B 512
 None
 1.10A 5odqD-5xogA:
undetectable		 5odqD-5xogA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		3 HIS A 880
GLU A 902
TRP A 872
 None
 1.14A 5odqD-5xvmA:
3.5		 5odqD-5xvmA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 3 HIS A 191
GLU A 190
TRP A 187
 None
 0.92A 5odqD-5yo8A:
undetectable		 5odqD-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 3 HIS A1719
GLU A1722
TRP A1831
 None
 1.15A 5odqD-5zalA:
undetectable		 5odqD-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 3 HIS A 962
GLU A 961
TRP A 958
 None
 0.77A 5odqD-6bv2A:
undetectable		 5odqD-6bv2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvp 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		no annotation 3 HIS A  17
GLU A  16
TRP A  13
 None
 0.79A 5odqD-6bvpA:
undetectable		 5odqD-6bvpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN

(Escherichia
coli;
Homo sapiens) 		no annotation 3 HIS R 211
GLU R 122
TRP R 126
 None
 1.13A 5odqD-6cmoR:
undetectable		 5odqD-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 3 HIS J 762
GLU J 740
TRP J 735
 None
 0.90A 5odqD-6fhsJ:
undetectable		 5odqD-6fhsJ:
undetectable