SIMILAR PATTERNS OF AMINO ACIDS FOR 5ODI_G_ACTG702

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aun PR-5D

(Nicotiana
tabacum)
PF00314
(Thaumatin)
3 GLY A  48
THR A  50
ASN A 106
None
0.54A 5odiG-1aunA:
undetectable
5odiG-1aunA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli)
PF00224
(PK)
PF02887
(PK_C)
3 GLY A 454
THR A 461
ASN A 463
None
0.68A 5odiG-1e0tA:
0.2
5odiG-1e0tA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE


(Desulfovibrio
gigas)
PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B)
3 GLY A 281
THR A 283
ASN A 253
None
0.53A 5odiG-1e5dA:
6.6
5odiG-1e5dA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN


(Influenza C
virus)
PF02710
(Hema_HEFG)
PF03996
(Hema_esterase)
3 GLY A 172
THR A 170
ASN A 176
None
0.70A 5odiG-1flcA:
0.5
5odiG-1flcA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnz BARK AGGLUTININ I,
POLYPEPTIDE A


(Robinia
pseudoacacia)
PF00139
(Lectin_legB)
3 GLY A  88
THR A 214
ASN A 224
None
0.71A 5odiG-1fnzA:
undetectable
5odiG-1fnzA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5g TRYPAREDOXIN II

(Crithidia
fasciculata)
PF13905
(Thioredoxin_8)
3 GLY A  29
THR A  31
ASN A  63
None
0.68A 5odiG-1i5gA:
1.4
5odiG-1i5gA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfl ASPARTATE RACEMASE

(Pyrococcus
horikoshii)
PF01177
(Asp_Glu_race)
3 GLY A 193
THR A 124
ASN A  83
None
0.62A 5odiG-1jflA:
5.8
5odiG-1jflA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))


(Homo sapiens)
PF01336
(tRNA_anti-codon)
PF16900
(REPA_OB_2)
3 GLY A 260
THR A 279
ASN A 281
None
0.70A 5odiG-1jmcA:
undetectable
5odiG-1jmcA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mex FAB 29G12 HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 GLY H  65
THR H  68
ASN H  82
None
0.63A 5odiG-1mexH:
undetectable
5odiG-1mexH:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o73 TRYPAREDOXIN

(Trypanosoma
brucei)
PF13905
(Thioredoxin_8)
3 GLY A  28
THR A  30
ASN A  62
None
0.64A 5odiG-1o73A:
undetectable
5odiG-1o73A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcv OSMOTIN

(Nicotiana
tabacum)
PF00314
(Thaumatin)
3 GLY A  47
THR A  49
ASN A 105
None
0.48A 5odiG-1pcvA:
undetectable
5odiG-1pcvA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmo MANNOSE BINDING
LECTIN, FRIL
MANNOSE BINDING
LECTIN, FRIL


(Lablab
purpureus;
Lablab
purpureus)
PF00139
(Lectin_legB)
PF00139
(Lectin_legB)
3 GLY A  87
THR E 227
ASN E 234
None
0.48A 5odiG-1qmoA:
undetectable
5odiG-1qmoA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT


(Escherichia
coli)
PF00161
(RIP)
3 GLY A 102
THR A 104
ASN A  87
None
0.55A 5odiG-1r4pA:
undetectable
5odiG-1r4pA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA


(Drosophila
melanogaster)
PF08445
(FR47)
3 GLY A 143
THR A 145
ASN A 302
None
0.59A 5odiG-1sqhA:
undetectable
5odiG-1sqhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE


(Neisseria
gonorrhoeae)
PF01128
(IspD)
3 GLY A  89
THR A  85
ASN A  77
None
0.66A 5odiG-1vgwA:
3.3
5odiG-1vgwA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wno CHITINASE

(Aspergillus
fumigatus)
PF00704
(Glyco_hydro_18)
3 GLY A 272
THR A 233
ASN A 229
None
0.69A 5odiG-1wnoA:
1.8
5odiG-1wnoA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wod MODA

(Escherichia
coli)
PF13531
(SBP_bac_11)
3 GLY A 229
THR A 231
ASN A  83
None
0.65A 5odiG-1wodA:
undetectable
5odiG-1wodA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzo HPCE

(Thermus
thermophilus)
PF01557
(FAA_hydrolase)
3 GLY A  44
THR A  42
ASN A  75
None
0.68A 5odiG-1wzoA:
undetectable
5odiG-1wzoA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN


(Homo sapiens)
PF00102
(Y_phosphatase)
3 GLY A 822
THR A 721
ASN A 818
None
0.67A 5odiG-1yguA:
undetectable
5odiG-1yguA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM


(Thermoplasma
acidophilum)
PF01729
(QRPTase_C)
3 GLY A  77
THR A  55
ASN A  53
None
0.63A 5odiG-1ytkA:
2.1
5odiG-1ytkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3q THAUMATIN-LIKE
PROTEIN


(Musa acuminata)
PF00314
(Thaumatin)
3 GLY A  46
THR A  48
ASN A 104
None
0.56A 5odiG-1z3qA:
undetectable
5odiG-1z3qA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)


(Escherichia
virus phiX174)
PF02306
(Phage_G)
3 GLY 2  52
THR 2 151
ASN 2 149
None
0.69A 5odiG-2bpa2:
undetectable
5odiG-2bpa2:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctx ALPHA-COBRATOXIN

(Naja naja)
PF00087
(Toxin_TOLIP)
3 GLY A  40
THR A  22
ASN A  63
None
0.67A 5odiG-2ctxA:
undetectable
5odiG-2ctxA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3r LECTIN ALPHA CHAIN

(Cratylia
argentea)
PF00139
(Lectin_legB)
3 GLY A 208
THR A  97
ASN A 104
None
0.60A 5odiG-2d3rA:
undetectable
5odiG-2d3rA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE


(Leuconostoc
mesenteroides)
PF00479
(G6PD_N)
PF02781
(G6PD_C)
3 GLY A 231
THR A 314
ASN A 312
None
0.64A 5odiG-2dpgA:
2.8
5odiG-2dpgA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdf LECTIN

(Dioclea
violacea)
PF00139
(Lectin_legB)
3 GLY A 209
THR A  97
ASN A 104
None
0.68A 5odiG-2gdfA:
undetectable
5odiG-2gdfA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h7z IRDITOXIN SUBUNIT B

(Boiga
irregularis)
PF00087
(Toxin_TOLIP)
3 GLY B  52
THR B  36
ASN B  75
None
0.60A 5odiG-2h7zB:
undetectable
5odiG-2h7zB:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuc ALKALINE PHOSPHATASE

(Antarctic
bacterium TAB5)
PF00245
(Alk_phosphatase)
3 GLY B 198
THR B 200
ASN B 195
None
0.71A 5odiG-2iucB:
undetectable
5odiG-2iucB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium)
PF01177
(Asp_Glu_race)
3 GLY A 187
THR A 121
ASN A  78
None
TLA  A1272 (-3.9A)
TLA  A1272 (-4.3A)
0.68A 5odiG-2jfwA:
4.3
5odiG-2jfwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium)
PF01177
(Asp_Glu_race)
3 GLY A 187
THR A 189
ASN A  78
None
None
TLA  A1272 (-4.3A)
0.53A 5odiG-2jfwA:
4.3
5odiG-2jfwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE


(Staphylococcus
aureus)
PF00294
(PfkB)
3 GLY A 106
THR A  87
ASN A   8
None
0.69A 5odiG-2jgvA:
5.4
5odiG-2jgvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jod PITUITARY ADENYLATE
CYCLASE-ACTIVATING
POLYPEPTIDE TYPE I
RECEPTOR


(Homo sapiens)
PF02793
(HRM)
3 GLY A  70
THR A  98
ASN A  96
None
0.69A 5odiG-2jodA:
undetectable
5odiG-2jodA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN


(Canavalia rosea)
PF00139
(Lectin_legB)
3 GLY A 209
THR A  97
ASN A 104
None
0.65A 5odiG-2ow4A:
undetectable
5odiG-2ow4A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg2 CHOLOYLGLYCINE
HYDROLASE


(Clostridium
perfringens)
PF02275
(CBAH)
3 GLY A  96
THR A  98
ASN A 125
None
0.65A 5odiG-2rg2A:
undetectable
5odiG-2rg2A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Mycolicibacterium
smegmatis)
PF02542
(YgbB)
3 GLY A 141
THR A 133
ASN A 104
None
CDP  A1158 (-2.7A)
None
0.67A 5odiG-2uzhA:
undetectable
5odiG-2uzhA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl7 XPD

(Sulfurisphaera
tokodaii)
PF06733
(DEAD_2)
PF13307
(Helicase_C_2)
3 GLY A  26
THR A  28
ASN A 337
None
0.58A 5odiG-2vl7A:
2.2
5odiG-2vl7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa)
PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc)
3 GLY A1700
THR A1698
ASN A1722
NAP  A3001 (-4.0A)
None
None
0.60A 5odiG-2vz9A:
undetectable
5odiG-2vz9A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE


(Paraburkholderia
xenovorans)
PF00378
(ECH_1)
3 GLY A 177
THR A 521
ASN A 115
BME  A 601 (-3.7A)
None
None
0.68A 5odiG-2w3pA:
2.1
5odiG-2w3pA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME


(Escherichia
coli)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
3 GLY A  59
THR A  24
ASN A  22
None
0.68A 5odiG-2wskA:
2.5
5odiG-2wskA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis)
PF00248
(Aldo_ket_red)
3 GLY A  30
THR A  54
ASN A  60
NA7  A1284 ( 3.8A)
None
None
0.69A 5odiG-2wzmA:
undetectable
5odiG-2wzmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE


(Aquifex
aeolicus)
PF00586
(AIRS)
PF02769
(AIRS_C)
3 GLY A 296
THR A 169
ASN A 202
None
0.71A 5odiG-2zauA:
undetectable
5odiG-2zauA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis)
no annotation 3 GLY A 186
THR A 141
ASN A 175
RAM  A 641 ( 4.4A)
None
None
0.68A 5odiG-2zuxA:
undetectable
5odiG-2zuxA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE


(Pseudomonas
putida)
PF00202
(Aminotran_3)
3 GLY X  63
THR X  61
ASN X 292
None
0.63A 5odiG-3a8uX:
undetectable
5odiG-3a8uX:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE


(Desulfitobacterium
hafniense)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 GLY A 175
THR A 214
ASN A 212
None
0.66A 5odiG-3db2A:
undetectable
5odiG-3db2A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1


(Homo sapiens)
PF00586
(AIRS)
PF02769
(AIRS_C)
3 GLY A 322
THR A 200
ASN A 248
None
0.69A 5odiG-3fd5A:
undetectable
5odiG-3fd5A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7m XYLANASE INHIBITOR
TL-XI


(Triticum
aestivum)
PF00314
(Thaumatin)
3 GLY A  50
THR A  52
ASN A 108
None
0.45A 5odiG-3g7mA:
undetectable
5odiG-3g7mA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus)
PF01766
(Birna_VP2)
3 GLY A 339
THR A 236
ASN A 234
None
0.70A 5odiG-3ideA:
undetectable
5odiG-3ideA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8f POLIOVIRUS RECEPTOR

(Homo sapiens)
PF07686
(V-set)
PF08205
(C2-set_2)
3 GLY 7 216
THR 7 239
ASN 7 237
NAG  7 513 (-3.8A)
None
NAG  7 513 (-1.9A)
0.59A 5odiG-3j8f7:
undetectable
5odiG-3j8f7:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9f POLIOVIRUS RECEPTOR

(Homo sapiens)
PF08205
(C2-set_2)
3 GLY 8 216
THR 8 239
ASN 8 237
NAG  8 305 (-4.0A)
None
NAG  8 305 (-1.7A)
0.67A 5odiG-3j9f8:
undetectable
5odiG-3j9f8:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jca INTEGRASE

(Mouse mammary
tumor virus)
PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn)
3 GLY A 146
THR A 121
ASN A 123
None
0.65A 5odiG-3jcaA:
undetectable
5odiG-3jcaA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kls EXOTOXIN 1

(Staphylococcus
aureus)
PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB)
3 GLY X 187
THR X 227
ASN X 229
None
0.61A 5odiG-3klsX:
undetectable
5odiG-3klsX:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE


(Clostridioides
difficile)
PF06050
(HGD-D)
3 GLY A 211
THR A 286
ASN A 284
None
0.65A 5odiG-3o3oA:
5.2
5odiG-3o3oA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 IFN-ALPHA/BETA
BINDING PROTEIN C12R


(Ectromelia
virus)
PF00047
(ig)
PF13895
(Ig_2)
3 GLY B 242
THR B 300
ASN B 298
None
0.65A 5odiG-3oq3B:
undetectable
5odiG-3oq3B:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6


(Saccharomyces
cerevisiae)
PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD)
3 GLY A 758
THR A 820
ASN A 817
None
0.68A 5odiG-3psfA:
3.8
5odiG-3psfA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6


(Saccharomyces
cerevisiae)
PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD)
3 GLY A 758
THR A 820
ASN A 817
None
0.62A 5odiG-3psiA:
4.0
5odiG-3psiA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9f TRYPAREDOXIN

(Leishmania
major)
PF13905
(Thioredoxin_8)
3 GLY A  28
THR A  30
ASN A  62
None
0.60A 5odiG-3s9fA:
undetectable
5odiG-3s9fA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3a KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY B MEMBER
1A


(Mus musculus)
PF00059
(Lectin_C)
3 GLY A 182
THR A 184
ASN A 203
None
0.69A 5odiG-3t3aA:
undetectable
5odiG-3t3aA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE


(Escherichia
coli)
PF00586
(AIRS)
PF02769
(AIRS_C)
3 GLY A 303
THR A 177
ASN A 210
None
0.70A 5odiG-3u0oA:
undetectable
5odiG-3u0oA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcs ERYTHROAGGLUTININ

(Phaseolus
vulgaris)
PF00139
(Lectin_legB)
3 GLY A 108
THR A 234
ASN A 244
None
0.69A 5odiG-3wcsA:
undetectable
5odiG-3wcsA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs3 THAUMATIN-LIKE
PROTEIN


(Malus domestica)
PF00314
(Thaumatin)
3 GLY A  53
THR A  55
ASN A 113
None
ACT  A1227 (-3.1A)
None
0.49A 5odiG-3zs3A:
undetectable
5odiG-3zs3A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE


(Pseudomonas
aeruginosa)
PF00202
(Aminotran_3)
3 GLY A  64
THR A  62
ASN A 292
None
0.62A 5odiG-4b98A:
undetectable
5odiG-4b98A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE


(Trypanosoma
brucei)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
3 GLY A 123
THR A 390
ASN A 422
None
0.70A 5odiG-4bi9A:
undetectable
5odiG-4bi9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A)
PF02624
(YcaO)
3 GLY A 371
THR A 374
ASN A 220
None
0.54A 5odiG-4bs9A:
3.6
5odiG-4bs9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 GLY A  89
THR A 328
ASN A 330
None
0.71A 5odiG-4cabA:
undetectable
5odiG-4cabA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)


(Mycobacterium
tuberculosis)
PF07993
(NAD_binding_4)
3 GLY A 256
THR A 193
ASN A 158
None
0.63A 5odiG-4dqvA:
5.3
5odiG-4dqvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h20 HEAVY CHAIN OF FAB
FRAGMENT FROM THE
ANTI-RICIN
MONOCLONAL ANTIBODY
RAC18


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 GLY H  66
THR H  69
ASN H  84
None
0.68A 5odiG-4h20H:
undetectable
5odiG-4h20H:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC


(Homo sapiens)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
3 GLY A 471
THR A 407
ASN A 445
None
0.62A 5odiG-4hwtA:
2.2
5odiG-4hwtA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE


(Kluyveromyces
lactis)
PF01425
(Amidase)
3 GLY A 138
THR A 140
ASN A 122
None
0.57A 5odiG-4issA:
undetectable
5odiG-4issA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8r HEAVY CHAIN OF POM2
FAB


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 GLY B  65
THR B  68
ASN B  82
None
0.70A 5odiG-4j8rB:
undetectable
5odiG-4j8rB:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5h VVTL1

(Vitis vinifera)
PF00314
(Thaumatin)
3 GLY A  70
THR A  72
ASN A 128
None
0.56A 5odiG-4l5hA:
undetectable
5odiG-4l5hA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkm PUTATIVE SURFACE
ANCHORED PROTEIN


(Clostridium
perfringens)
no annotation 3 GLY A 231
THR A 229
ASN A 200
None
0.62A 5odiG-4mkmA:
undetectable
5odiG-4mkmA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n01 PERIPLASMIC BINDING
PROTEIN


(Veillonella
parvula)
PF01497
(Peripla_BP_2)
3 GLY A 314
THR A 317
ASN A 165
None
0.61A 5odiG-4n01A:
3.9
5odiG-4n01A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1


(Homo sapiens)
PF00282
(Pyridoxal_deC)
3 GLY A 521
THR A 519
ASN A 465
None
GOL  A 902 (-4.5A)
GOL  A 902 (-4.3A)
0.65A 5odiG-4q6rA:
undetectable
5odiG-4q6rA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Pseudarthrobacter
chlorophenolicus)
PF01547
(SBP_bac_1)
3 GLY A 117
THR A 115
ASN A 328
LB2  A 501 (-3.1A)
None
LB2  A 501 (-3.0A)
0.71A 5odiG-4r2fA:
undetectable
5odiG-4r2fA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvp SUPEROXIDE DISMUTASE

(Sedum alfredii)
PF00080
(Sod_Cu)
3 GLY A  39
THR A  41
ASN A 114
None
0.70A 5odiG-4rvpA:
undetectable
5odiG-4rvpA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE


(Pseudomonas sp.)
PF00202
(Aminotran_3)
3 GLY A  64
THR A  62
ASN A 292
None
0.59A 5odiG-4uhmA:
undetectable
5odiG-4uhmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii)
PF02624
(YcaO)
3 GLY A 364
THR A 367
ASN A 214
None
0.67A 5odiG-4v1uA:
3.7
5odiG-4v1uA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB


(Mycobacterium
tuberculosis)
no annotation 3 GLY A 126
THR A 124
ASN A 265
None
0.67A 5odiG-4xxnA:
undetectable
5odiG-4xxnA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y05 KINESIN-LIKE PROTEIN
KIF2C


(Homo sapiens)
PF00225
(Kinesin)
3 GLY A 339
THR A 335
ASN A 556
None
0.62A 5odiG-4y05A:
undetectable
5odiG-4y05A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2


(Ascophyllum
nodosum)
no annotation 3 GLY A  74
THR A  76
ASN A 158
None
0.65A 5odiG-5aa6A:
undetectable
5odiG-5aa6A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN


(Coprinopsis
cinerea)
PF03664
(Glyco_hydro_62)
3 GLY A 198
THR A 200
ASN A 190
None
0.68A 5odiG-5b6tA:
undetectable
5odiG-5b6tA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum)
PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2)
3 GLY A 345
THR A 347
ASN A 382
None
0.62A 5odiG-5bxpA:
4.1
5odiG-5bxpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej3 ENDO-1,4-BETA-XYLANA
SE B


(Streptomyces
lividans)
PF00457
(Glyco_hydro_11)
3 GLY A  32
THR A   2
ASN A  12
None
0.65A 5odiG-5ej3A:
undetectable
5odiG-5ej3A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6


(Homo sapiens)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
3 GLY B1049
THR B1041
ASN B1039
None
NAG  B1307 (-2.9A)
NAG  B1307 (-1.7A)
0.65A 5odiG-5gjeB:
undetectable
5odiG-5gjeB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae)
PF00890
(FAD_binding_2)
3 GLY A 254
THR A 252
ASN A  73
None
FAD  A 602 (-4.1A)
FAD  A 602 (-4.2A)
0.70A 5odiG-5glgA:
13.2
5odiG-5glgA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 GLY A 138
THR A 140
ASN A 122
None
0.58A 5odiG-5i8iA:
4.0
5odiG-5i8iA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN


(Leishmania
mexicana)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
3 GLY A 126
THR A 393
ASN A 425
None
0.63A 5odiG-5lnqA:
undetectable
5odiG-5lnqA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides)
PF00353
(HemolysinCabind)
3 GLY A 424
THR A 422
ASN A 451
None
0.69A 5odiG-5n8pA:
undetectable
5odiG-5n8pA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides)
PF00353
(HemolysinCabind)
3 GLY A 473
THR A 439
ASN A 435
None
0.70A 5odiG-5n8pA:
undetectable
5odiG-5n8pA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides)
PF00353
(HemolysinCabind)
3 GLY A 424
THR A 422
ASN A 451
None
0.69A 5odiG-5n97A:
undetectable
5odiG-5n97A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides)
PF00353
(HemolysinCabind)
3 GLY A 473
THR A 439
ASN A 435
None
0.71A 5odiG-5n97A:
undetectable
5odiG-5n97A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1)
no annotation 3 GLY B 148
THR B 125
ASN B 123
None
0.70A 5odiG-5nd1B:
undetectable
5odiG-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis)
no annotation 3 GLY A 221
THR A 223
ASN A  79
MG  A 610 ( 4.7A)
MG  A 610 ( 4.7A)
None
0.71A 5odiG-5odoA:
8.0
5odiG-5odoA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A


(Methanothermococcus
thermolithotrophicus)
PF07992
(Pyr_redox_2)
PF13187
(Fer4_9)
3 GLY A 141
THR A 143
ASN A 229
None
0.10A 5odiG-5odrA:
63.0
5odiG-5odrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v5s OUTER MEMBRANE
PROTEIN TOLC


(Escherichia
coli)
PF02321
(OEP)
3 GLY A  59
THR A 266
ASN A  61
None
0.60A 5odiG-5v5sA:
undetectable
5odiG-5v5sA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L


(Drosophila
melanogaster)
PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4)
3 GLY A 827
THR A 829
ASN A 859
None
0.59A 5odiG-5vkqA:
undetectable
5odiG-5vkqA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvm CADHERIN-23

(Homo sapiens)
no annotation 3 GLY A2215
THR A2174
ASN A2172
None
0.66A 5odiG-5vvmA:
undetectable
5odiG-5vvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5


(Rice dwarf
virus)
no annotation 3 GLY C 672
THR C 675
ASN C 700
None
0.69A 5odiG-5x6xC:
undetectable
5odiG-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwt THIOREDOXIN
REDUCTASE


(Francisella
tularensis)
no annotation 3 GLY A  97
THR A  82
ASN A  84
None
0.56A 5odiG-6bwtA:
18.8
5odiG-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE


(Methanothermococcus
thermolithotrophicus)
no annotation 3 GLY A  88
THR A 341
ASN A 375
None
0.71A 5odiG-6et9A:
undetectable
5odiG-6et9A:
undetectable