SIMILAR PATTERNS OF AMINO ACIDS FOR 5ODI_A_ACTA701_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ax8 OBESITY PROTEIN

(Homo sapiens) 		PF02024
(Leptin) 		3 LYS A   3
LYS A  94
SER A  93
 None
 0.86A 5odiA-1ax8A:
undetectable		 5odiA-1ax8A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		3 LYS A 357
LYS A 637
SER A 634
 None
 1.36A 5odiA-1biyA:
undetectable		 5odiA-1biyA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 LYS A 234
LYS A  13
SER A  14
 None
 1.09A 5odiA-1bxtA:
undetectable		 5odiA-1bxtA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		3 LYS A   1
LYS A 390
SER A 393
 GLN  A1106 (-4.9A)
None
None
 0.94A 5odiA-1ct9A:
undetectable		 5odiA-1ct9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA

(Enterococcus
faecium) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 LYS B 203
LYS B 133
SER B 134
 SO4  B1342 (-3.0A)
ADP  B 350 (-2.9A)
None
 1.27A 5odiA-1e4eB:
3.9		 5odiA-1e4eB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ejf PROGESTERONE
RECEPTOR P23

(Homo sapiens) 		PF04969
(CS) 		3 LYS A  91
LYS A  35
SER A  34
 None
 1.50A 5odiA-1ejfA:
undetectable		 5odiA-1ejfA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek0 PROTEIN (GTP-BINDING
PROTEIN YPT51)

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		3 LYS A  36
LYS A  20
SER A  21
 None
GNP  A 501 (-2.7A)
MG  A 601 ( 2.0A)
 1.45A 5odiA-1ek0A:
2.2		 5odiA-1ek0A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		3 LYS A 358
LYS A 322
SER A 323
 HC1  A 580 (-2.8A)
None
HC1  A 580 ( 3.8A)
 0.93A 5odiA-1fehA:
5.6		 5odiA-1fehA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gd6 LYSOZYME

(Bombyx mori) 		PF00062
(Lys) 		3 LYS A   1
LYS A  39
SER A  38
 None
 1.34A 5odiA-1gd6A:
undetectable		 5odiA-1gd6A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		3 LYS L 237
LYS L 201
SER L 202
 CYN  L 428 (-2.8A)
None
CYN  L 428 ( 3.8A)
 1.19A 5odiA-1hfeL:
2.0		 5odiA-1hfeL:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i77 CYTOCHROME C3

(Desulfovibrio
desulfuricans) 		PF02085
(Cytochrom_CIII) 		3 LYS A  71
LYS A  85
SER A  84
 None
 1.25A 5odiA-1i77A:
undetectable		 5odiA-1i77A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kag SHIKIMATE KINASE I

(Escherichia
coli) 		PF01202
(SKI) 		3 LYS A 121
LYS A  17
SER A  18
 None
 1.37A 5odiA-1kagA:
undetectable		 5odiA-1kagA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		3 LYS A   4
LYS A 188
SER A 191
 None
 1.23A 5odiA-1o60A:
undetectable		 5odiA-1o60A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus) 		PF01264
(Chorismate_synt) 		3 LYS A 186
LYS A 178
SER A 179
 None
 1.44A 5odiA-1q1lA:
undetectable		 5odiA-1q1lA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 LYS A 314
LYS A 321
SER A 322
 None
 1.36A 5odiA-1vkoA:
4.0		 5odiA-1vkoA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w45 ANNEXIN A8

(Homo sapiens) 		PF00191
(Annexin) 		3 LYS A 226
LYS A 233
SER A 234
 None
 1.01A 5odiA-1w45A:
undetectable		 5odiA-1w45A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx8 CALSENSIN

(Haemopis
marmorata) 		PF13499
(EF-hand_7) 		3 LYS A  15
LYS A  68
SER A  67
 None
 1.41A 5odiA-1yx8A:
undetectable		 5odiA-1yx8A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmz CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 LYS A   6
LYS A   1
SER A   3
 None
 1.31A 5odiA-1zmzA:
undetectable		 5odiA-1zmzA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aca PUTATIVE ADENYLATE
CYCLASE

(Vibrio
parahaemolyticus) 		PF01928
(CYTH) 		3 LYS A 176
LYS A  78
SER A  61
 None
PO4  A 304 (-3.8A)
None
 0.97A 5odiA-2acaA:
undetectable		 5odiA-2acaA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 LYS A 225
LYS A 357
SER A 356
 GDC  A1376 (-2.7A)
FMT  A1390 (-3.0A)
GDC  A1376 (-2.7A)
 1.35A 5odiA-2c5aA:
4.4		 5odiA-2c5aA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs2 POLY [ADP-RIBOSE]
POLYMERASE-1

(Homo sapiens) 		PF00645
(zf-PARP) 		3 LYS A  87
LYS A  10
SER A   9
 None
 1.06A 5odiA-2cs2A:
undetectable		 5odiA-2cs2A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LYS A 340
LYS A 262
SER A 263
 ANP  A2901 ( 4.3A)
None
None
 1.26A 5odiA-2db3A:
undetectable		 5odiA-2db3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eje GENERAL
TRANSCRIPTION FACTOR
II-I

(Homo sapiens) 		PF02946
(GTF2I) 		3 LYS A   1
LYS A  15
SER A  14
 None
 1.32A 5odiA-2ejeA:
undetectable		 5odiA-2ejeA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hql HYPOTHETICAL PROTEIN
MG376 HOMOLOG

(Mycoplasma
pneumoniae) 		PF11506
(DUF3217) 		3 LYS A  82
LYS A  77
SER A  78
 None
 1.40A 5odiA-2hqlA:
undetectable		 5odiA-2hqlA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2
MYOTROPHIN

(Gallus gallus;
Mus musculus) 		PF01115
(F_actin_cap_B)
PF12796
(Ank_2) 		3 LYS C 611
LYS B 442
SER B 441
 None
 1.40A 5odiA-2kxpC:
undetectable		 5odiA-2kxpC:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkn AH
RECEPTOR-INTERACTING
PROTEIN

(Homo sapiens) 		PF00254
(FKBP_C) 		3 LYS A  69
LYS A 103
SER A 104
 None
 1.15A 5odiA-2lknA:
undetectable		 5odiA-2lknA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwj TRANSCRIPTIONAL
REGULATOR, CARD
FAMILY

(Myxococcus
xanthus) 		PF02559
(CarD_CdnL_TRCF) 		3 LYS A  13
LYS A 143
SER A 146
 None
 0.88A 5odiA-2lwjA:
undetectable		 5odiA-2lwjA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m7z CD63-LIKE PROTEIN
SM-TSP-2

(Schistosoma
mansoni) 		PF00335
(Tetraspannin) 		3 LYS A   9
LYS A  79
SER A  78
 None
 1.43A 5odiA-2m7zA:
undetectable		 5odiA-2m7zA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf2 MRNA INTERFERASE
MAZF

(Staphylococcus
aureus) 		PF02452
(PemK_toxin) 		3 LYS A  77
LYS A 110
SER A 107
 None
 1.24A 5odiA-2mf2A:
undetectable		 5odiA-2mf2A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		3 LYS A 188
LYS A 152
SER A 153
 SF4  A 501 (-3.7A)
None
None
 1.17A 5odiA-2n0sA:
3.9		 5odiA-2n0sA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		3 LYS A 292
LYS A 325
SER A 326
 None
 1.34A 5odiA-2pq6A:
3.8		 5odiA-2pq6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LYS A 216
LYS A 262
SER A 263
 None
 1.27A 5odiA-2ptzA:
undetectable		 5odiA-2ptzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf5 CELL SHAPE
DETERMINING PROTEIN
MREC

(Streptococcus
pneumoniae) 		PF04085
(MreC) 		3 LYS A 127
LYS A 158
SER A 157
 None
 1.43A 5odiA-2qf5A:
undetectable		 5odiA-2qf5A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		3 LYS A  69
LYS A 230
SER A 208
 ATP  A1002 (-3.0A)
None
ATP  A1002 (-4.8A)
 1.00A 5odiA-2qxlA:
undetectable		 5odiA-2qxlA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v25 MAJOR CELL-BINDING
FACTOR

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		3 LYS A 160
LYS A 185
SER A 186
 None
 1.43A 5odiA-2v25A:
undetectable		 5odiA-2v25A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LYS A 377
LYS A 410
SER A 414
 None
 1.43A 5odiA-2va8A:
undetectable		 5odiA-2va8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 LYS A 689
LYS A 719
SER A 722
 None
 1.36A 5odiA-2wghA:
2.4		 5odiA-2wghA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		3 LYS A 731
LYS A 115
SER A 113
 None
 1.23A 5odiA-2ww8A:
4.6		 5odiA-2ww8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9j LIPOPROTEIN PRGK

(Salmonella
enterica) 		PF01514
(YscJ_FliF) 		3 LYS Y  25
LYS Y  53
SER Y  51
 None
 1.36A 5odiA-2y9jY:
undetectable		 5odiA-2y9jY:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		3 LYS A 134
LYS A 152
SER A 153
 CSO  A 133 ( 3.3A)
None
CSO  A 133 ( 3.3A)
 1.45A 5odiA-3b8bA:
undetectable		 5odiA-3b8bA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs1 FLAGELLAR
CALCIUM-BINDING
PROTEIN

(Trypanosoma
cruzi) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		3 LYS A  59
LYS A  67
SER A  72
 None
CSX  A  66 ( 2.8A)
None
 1.08A 5odiA-3cs1A:
undetectable		 5odiA-3cs1A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Vibrio cholerae) 		PF00793
(DAHP_synth_1) 		3 LYS A   4
LYS A 188
SER A 191
 None
 1.22A 5odiA-3e9aA:
undetectable		 5odiA-3e9aA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edp LIN2111 PROTEIN

(Listeria
innocua) 		PF00392
(GntR)
PF07702
(UTRA) 		3 LYS A   5
LYS A  14
SER A  13
 None
 0.92A 5odiA-3edpA:
undetectable		 5odiA-3edpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1

(Homo sapiens) 		PF00616
(RasGAP) 		3 LYS A1088
LYS A1096
SER A1097
 None
 1.38A 5odiA-3fayA:
undetectable		 5odiA-3fayA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7c OCCLUDIN

(Homo sapiens) 		PF07303
(Occludin_ELL) 		3 LYS A 414
LYS A 506
SER A 505
 None
 1.06A 5odiA-3g7cA:
undetectable		 5odiA-3g7cA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gut TRANSCRIPTION FACTOR
P65

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		3 LYS A  28
LYS A  56
SER A  51
 None
 1.49A 5odiA-3gutA:
undetectable		 5odiA-3gutA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05916
(Sld5)
PF05916
(Sld5)
PF16922
(SLD5_C) 		3 LYS B   3
LYS D 150
SER D 149
 None
 1.22A 5odiA-3jc7B:
undetectable		 5odiA-3jc7B:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn3 PUTATIVE PERIPLASMIC
PROTEIN

(Wolinella
succinogenes) 		PF12849
(PBP_like_2) 		3 LYS A  61
LYS A 126
SER A 125
 None
 1.09A 5odiA-3kn3A:
undetectable		 5odiA-3kn3A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwl UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 3 LYS A 478
LYS A 365
SER A 366
 None
 1.23A 5odiA-3kwlA:
undetectable		 5odiA-3kwlA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 LYS A  38
LYS A 483
SER A 482
 None
 1.37A 5odiA-3lijA:
undetectable		 5odiA-3lijA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		3 LYS A   1
LYS A  80
SER A  81
 None
 0.68A 5odiA-3nbuA:
2.8		 5odiA-3nbuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF13614
(AAA_31) 		3 LYS A 228
LYS A 219
SER A 222
 None
 1.42A 5odiA-3pg5A:
undetectable		 5odiA-3pg5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		3 LYS A 136
LYS A 123
SER A 126
 None
 1.39A 5odiA-3q88A:
2.6		 5odiA-3q88A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 LYS A 200
LYS A 130
SER A 131
 None
ATP  A 400 (-3.0A)
None
 1.06A 5odiA-3se7A:
3.2		 5odiA-3se7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skq MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
38

(Saccharomyces
cerevisiae) 		PF07766
(LETM1) 		3 LYS A 232
LYS A 224
SER A 227
 None
 1.45A 5odiA-3skqA:
undetectable		 5odiA-3skqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v47 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		3 LYS C 362
LYS C 366
SER C 365
 None
 1.49A 5odiA-3v47C:
undetectable		 5odiA-3v47C:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjc GTPASE IMAP FAMILY
MEMBER 7

(Homo sapiens) 		PF04548
(AIG1) 		3 LYS A 173
LYS A 134
SER A 168
 None
 1.41A 5odiA-3zjcA:
2.1		 5odiA-3zjcA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		3 LYS A 267
LYS A 240
SER A 243
 None
 1.41A 5odiA-4a27A:
3.2		 5odiA-4a27A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av2 TYPE IV PILUS
BIOGENESIS AND
COMPETENCE PROTEIN
PILQ
PILP PROTEIN

(Neisseria
meningitidis;
Neisseria
meningitidis) 		PF03958
(Secretin_N)
PF07660
(STN)
PF04351
(PilP) 		3 LYS M 106
LYS A 387
SER A 349
 None
 1.39A 5odiA-4av2M:
undetectable		 5odiA-4av2M:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		3 LYS A 556
LYS A 578
SER A 577
 None
 1.49A 5odiA-4bzkA:
undetectable		 5odiA-4bzkA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 LYS A 576
LYS A   5
SER A   4
 None
 1.18A 5odiA-4c3hA:
undetectable		 5odiA-4c3hA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF01869
(BcrAD_BadFG) 		3 LYS A  59
LYS A 257
SER A 259
 None
 1.47A 5odiA-4ehtA:
undetectable		 5odiA-4ehtA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghn UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF03572
(Peptidase_S41) 		3 LYS A 302
LYS A 380
SER A 378
 None
 1.44A 5odiA-4ghnA:
undetectable		 5odiA-4ghnA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

([Candida]
glabrata) 		PF16796
(Microtub_bd) 		3 LYS A 436
LYS A 490
SER A 431
 None
 0.81A 5odiA-4gkpA:
undetectable		 5odiA-4gkpA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		3 LYS A 350
LYS A 358
SER A 438
 None
 1.47A 5odiA-4gl2A:
undetectable		 5odiA-4gl2A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		3 LYS A 274
LYS A 281
SER A 282
 None
 1.42A 5odiA-4infA:
1.5		 5odiA-4infA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6e MRNA-DECAPPING
ENZYME SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00293
(NUDIX) 		3 LYS A 209
LYS A 216
SER A 217
 None
 1.47A 5odiA-4k6eA:
undetectable		 5odiA-4k6eA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkn TRIOSEPHOSPHATE
ISOMERASE

(Chlamydomonas
reinhardtii) 		PF00121
(TIM) 		3 LYS A 253
LYS A 220
SER A 223
 None
 1.11A 5odiA-4mknA:
undetectable		 5odiA-4mknA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		3 LYS A 715
LYS A 778
SER A 779
 None
 1.48A 5odiA-4n78A:
undetectable		 5odiA-4n78A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1

(Homo sapiens;
Homo sapiens) 		PF00211
(Guanylate_cyc)
PF00211
(Guanylate_cyc) 		3 LYS B 593
LYS A 606
SER A 609
 None
 1.20A 5odiA-4ni2B:
undetectable		 5odiA-4ni2B:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		3 LYS A  70
LYS A 337
SER A 338
 None
 1.22A 5odiA-4p4sA:
undetectable		 5odiA-4p4sA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qei GLYCINE--TRNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 LYS A 143
LYS A 136
SER A 138
 None
 1.47A 5odiA-4qeiA:
3.0		 5odiA-4qeiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 LYS A 123
LYS A 100
SER A 101
 None
 1.48A 5odiA-4qmeA:
undetectable		 5odiA-4qmeA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0v FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		3 LYS A 228
LYS A 192
SER A 193
 CSO  A 169 (-2.9A)
None
CL  A 603 ( 3.8A)
 1.19A 5odiA-4r0vA:
2.0		 5odiA-4r0vA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		3 LYS A  51
LYS A  58
SER A  59
 None
 1.42A 5odiA-4rv3A:
2.4		 5odiA-4rv3A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xko HEAT SHOCK COGNATE
90 KDA PROTEIN

(Dictyostelium
discoideum) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 LYS A 143
LYS A  62
SER A  61
 None
 1.25A 5odiA-4xkoA:
undetectable		 5odiA-4xkoA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y99 TROPONIN I, CARDIAC
MUSCLE

(Homo sapiens) 		PF00992
(Troponin)
PF11636
(Troponin-I_N) 		3 LYS C  46
LYS C  40
SER C  39
 None
 1.15A 5odiA-4y99C:
undetectable		 5odiA-4y99C:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12862
(ANAPC5) 		3 LYS O  34
LYS O  27
SER O 208
 None
 1.49A 5odiA-5a31O:
undetectable		 5odiA-5a31O:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum) 		PF00026
(Asp) 		3 LYS A  46
LYS A  62
SER A  61
 None
 1.32A 5odiA-5bwyA:
undetectable		 5odiA-5bwyA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by1 NON-STRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		3 LYS A  65
LYS A   1
SER A   3
 None
 1.29A 5odiA-5by1A:
undetectable		 5odiA-5by1A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		3 LYS A 217
LYS A 243
SER A 246
 None
 1.35A 5odiA-5c65A:
undetectable		 5odiA-5c65A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3

(Mus musculus) 		PF02338
(OTU) 		3 LYS A 228
LYS A 148
SER A 149
 None
 0.96A 5odiA-5dq6A:
undetectable		 5odiA-5dq6A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica;
Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 LYS A 385
LYS D 413
SER D 414
 None
 1.07A 5odiA-5fl7A:
undetectable		 5odiA-5fl7A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 LYS A 247
LYS A 464
SER A 465
 None
 1.14A 5odiA-5gxdA:
3.3		 5odiA-5gxdA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7d DESIGNED THIOREDOXIN
DF106

(synthetic
construct) 		PF00085
(Thioredoxin) 		3 LYS A 103
LYS A  85
SER A  86
 None
 1.49A 5odiA-5j7dA:
2.6		 5odiA-5j7dA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqm PROTEIN UPS1,
MITOCHONDRIAL,MITOCH
ONDRIAL DISTRIBUTION
AND MORPHOLOGY
PROTEIN 35

(Saccharomyces
cerevisiae) 		PF04707
(PRELI)
PF05254
(UPF0203) 		3 LYS A 200
LYS A 187
SER A 189
 None
 1.46A 5odiA-5jqmA:
undetectable		 5odiA-5jqmA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6j NITROPHORIN-7

(Rhodnius
prolixus) 		no annotation 3 LYS A 185
LYS A 178
SER A 181
 None
 1.29A 5odiA-5m6jA:
undetectable		 5odiA-5m6jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbg GENERAL SECRETION
PATHWAY PROTEIN F

(Dickeya
dadantii) 		no annotation 3 LYS A 100
LYS A  64
SER A  66
 None
 1.34A 5odiA-5nbgA:
undetectable		 5odiA-5nbgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oh5 RIDL

(Legionella
pneumophila) 		no annotation 3 LYS A  83
LYS A  90
SER A  91
 None
 1.27A 5odiA-5oh5A:
undetectable		 5odiA-5oh5A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9

(Homo sapiens) 		PF00439
(Bromodomain) 		3 LYS A 202
LYS A 235
SER A 238
 None
 1.34A 5odiA-5twxA:
undetectable		 5odiA-5twxA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyh INTERAPTIN

(Legionella
pneumophila) 		no annotation 3 LYS B  83
LYS B  90
SER B  91
 None
 1.16A 5odiA-5wyhB:
undetectable		 5odiA-5wyhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2b SULFOTRANSFERASE

(Mus musculus) 		no annotation 3 LYS D  78
LYS D 230
SER D  69
 None
 1.39A 5odiA-5x2bD:
undetectable		 5odiA-5x2bD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x94 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2) 		3 LYS A  55
LYS A  35
SER A  36
 None
 1.33A 5odiA-5x94A:
undetectable		 5odiA-5x94A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bka NITRONATE
MONOOXYGENASE

(Cyberlindnera
mrakii) 		no annotation 3 LYS A 116
LYS A 329
SER A 330
 None
 1.47A 5odiA-6bkaA:
undetectable		 5odiA-6bkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP1

(Escherichia
virus N4) 		no annotation 3 LYS A 265
LYS A 228
SER A 173
 None
 1.42A 5odiA-6c2jA:
undetectable		 5odiA-6c2jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf6 TANKYRASE-1

(Mus musculus) 		no annotation 3 LYS A 497
LYS A 482
SER A 485
 None
 1.30A 5odiA-6cf6A:
undetectable		 5odiA-6cf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A1286
LYS A1278
SER A1282
 None
 1.42A 5odiA-6emkA:
undetectable		 5odiA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A1957
LYS A2060
SER A2065
 None
 1.39A 5odiA-6emkA:
undetectable		 5odiA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftx -

(-) 		no annotation 3 LYS W 696
LYS W 822
SER W 821
 None
 1.19A 5odiA-6ftxW:
undetectable		 5odiA-6ftxW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 3 LYS O  81
LYS O  87
SER O  88
 None
 1.34A 5odiA-6g2jO:
undetectable		 5odiA-6g2jO:
undetectable