SIMILAR PATTERNS OF AMINO ACIDS FOR 5ODH_G_ACTG710

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1blk P55 BLK PROTEIN
TYROSINE KINASE

(Mus musculus) 		PF00017
(SH2) 		4 ARG A  82
ILE A  83
TYR A  95
ILE A  79
 None
 1.40A 5odhG-1blkA:
undetectable		 5odhG-1blkA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7y TRANSLATIONALLY
CONTROLLED TUMOR
PROTEIN

(Schizosaccharomyces
pombe) 		PF00838
(TCTP) 		4 ARG A  98
ILE A  95
TYR A  91
ILE A   8
 None
 1.34A 5odhG-1h7yA:
undetectable		 5odhG-1h7yA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 ARG A 904
ILE A 911
TYR A 922
ILE A 935
 None
 1.45A 5odhG-1hn0A:
0.0		 5odhG-1hn0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		4 ARG A 305
ILE A 302
TYR A  46
ILE A 298
 None
 1.42A 5odhG-1j1uA:
2.4		 5odhG-1j1uA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocy BACTERIOPHAGE T4
SHORT TAIL FIBRE

(Escherichia
virus T4) 		PF07484
(Collar)
PF14928
(S_tail_recep_bd) 		4 ARG A 382
ILE A 379
TYR A 375
ILE A 523
 None
 1.31A 5odhG-1ocyA:
undetectable		 5odhG-1ocyA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		4 ARG A 161
ILE A 137
TYR A  62
ILE A  60
 None
 1.30A 5odhG-1vblA:
0.0		 5odhG-1vblA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		4 ARG A 263
ILE A  34
TYR A  29
ILE A 178
 None
 1.44A 5odhG-1vgpA:
0.0		 5odhG-1vgpA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wir PROTEIN ARGININE
N-METHYLTRANSFERASE
3

(Mus musculus) 		no annotation 4 ARG A  65
ILE A  61
TYR A  57
ILE A  43
 None
 1.20A 5odhG-1wirA:
undetectable		 5odhG-1wirA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ARG A 181
ILE A 132
TYR A  25
ILE A  21
 None
 1.27A 5odhG-1y4uA:
0.0		 5odhG-1y4uA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		4 ARG B  97
ILE B  99
TYR B 104
ILE B 140
 HEM  B 200 (-4.1A)
HEM  B 200 (-3.7A)
HEM  B 200 (-3.4A)
None
 1.36A 5odhG-2d2nB:
undetectable		 5odhG-2d2nB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2evr COG0791: CELL
WALL-ASSOCIATED
HYDROLASES
(INVASION-ASSOCIATED
PROTEINS)

(Nostoc
punctiforme) 		PF00877
(NLPC_P60) 		4 ARG A 196
ILE A 201
TYR A 185
ILE A 203
 None
 1.43A 5odhG-2evrA:
undetectable		 5odhG-2evrA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghj 50S RIBOSOMAL
PROTEIN L20

(Aquifex
aeolicus) 		PF00453
(Ribosomal_L20) 		4 ARG A  56
ILE A  60
TYR A  74
ILE A  78
 None
 1.48A 5odhG-2ghjA:
undetectable		 5odhG-2ghjA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jn0 HYPOTHETICAL
LIPOPROTEIN YGDR

(Escherichia
coli) 		PF06004
(DUF903) 		4 ARG A  13
ILE A  15
TYR A  32
ILE A  42
 None
 1.21A 5odhG-2jn0A:
undetectable		 5odhG-2jn0A:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgq PROTEIN TM_1862

(Thermotoga
maritima) 		PF04055
(Radical_SAM) 		4 ARG A 167
ILE A 144
TYR A 197
ILE A 169
 None
 1.49A 5odhG-2qgqA:
4.3		 5odhG-2qgqA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 196
ILE A 197
TYR A 162
ILE A 171
 None
 1.47A 5odhG-3a2fA:
undetectable		 5odhG-3a2fA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		4 ARG A 203
ILE A 207
TYR A 345
ILE A 311
 None
 1.40A 5odhG-3c3jA:
3.0		 5odhG-3c3jA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NTF2-RELATED EXPORT
PROTEIN

(Caenorhabditis
elegans) 		PF02136
(NTF2) 		4 ARG B  35
ILE B  38
TYR B  42
ILE B  61
 PEG  B1003 (-3.8A)
None
None
None
 1.00A 5odhG-3nv0B:
undetectable		 5odhG-3nv0B:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2

(Saccharomyces
cerevisiae) 		PF10193
(Telomere_reg-2) 		4 ARG A 138
ILE A 139
TYR A 147
ILE A  98
 None
 1.43A 5odhG-3o4zA:
undetectable		 5odhG-3o4zA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oet ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 ARG A 280
ILE A 278
TYR A 274
ILE A   3
 None
 1.49A 5odhG-3oetA:
3.9		 5odhG-3oetA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT A
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli;
Escherichia
coli;
Escherichia
coli) 		PF00507
(Oxidored_q4)
no annotation
no annotation 		4 ARG J 160
ILE A 120
TYR A 116
ILE N  28
 None
 0.88A 5odhG-3rkoJ:
undetectable		 5odhG-3rkoJ:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		4 ARG A 121
ILE A 119
TYR A  50
ILE A 265
 CL  A 801 (-4.1A)
None
None
None
 1.20A 5odhG-3thcA:
2.3		 5odhG-3thcA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thf PROTEIN SHROOM

(Drosophila
melanogaster) 		PF08687
(ASD2) 		4 ARG A1516
ILE A1520
TYR A1536
ILE A1540
 None
 1.27A 5odhG-3thfA:
undetectable		 5odhG-3thfA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		4 ARG A 387
ILE A 389
TYR A 397
ILE A 473
 None
 1.24A 5odhG-3vgfA:
undetectable		 5odhG-3vgfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 ARG A 592
ILE A 613
TYR A 608
ILE A 577
 None
 1.17A 5odhG-4ckbA:
undetectable		 5odhG-4ckbA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgk SHARK V-NAR ANTIBODY

(Squalus
acanthias) 		PF07686
(V-set) 		4 ARG C  73
ILE C  89
TYR C 100
ILE C  68
 None
 1.34A 5odhG-4hgkC:
undetectable		 5odhG-4hgkC:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu8 GH10 XYLANASE

(Globitermes
brachycerastes) 		PF00331
(Glyco_hydro_10)
PF02368
(Big_2) 		4 ARG A 266
ILE A 252
TYR A 298
ILE A 312
 None
 1.17A 5odhG-4hu8A:
1.7		 5odhG-4hu8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc0 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E RIMO

(Thermotoga
maritima) 		PF00919
(UPF0004)
PF04055
(Radical_SAM) 		4 ARG A 167
ILE A 144
TYR A 197
ILE A 169
 None
 1.43A 5odhG-4jc0A:
1.3		 5odhG-4jc0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		4 ARG B 277
ILE B 279
TYR B 291
ILE B 235
 None
 1.48A 5odhG-4k3jB:
undetectable		 5odhG-4k3jB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmu ENDO-1,4-BETA-XYLANA
SE A

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		4 ARG A 164
ILE A 156
TYR A 197
ILE A 211
 None
 1.49A 5odhG-4pmuA:
1.6		 5odhG-4pmuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsj CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF06470
(SMC_hinge) 		4 ARG A 627
ILE A 630
TYR A 643
ILE A 649
 None
 1.32A 5odhG-4rsjA:
undetectable		 5odhG-4rsjA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		4 ARG B 186
ILE B  76
TYR B  97
ILE B  78
 None
 1.24A 5odhG-4yg8B:
undetectable		 5odhG-4yg8B:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab) 		4 ARG B 265
ILE B 262
TYR B 231
ILE B 200
 None
 1.46A 5odhG-5bn4B:
2.8		 5odhG-5bn4B:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0n FAB CA33 HEAVY CHAIN

(Oryctolagus
cuniculus) 		no annotation 4 ARG H  65
ILE H  79
TYR H  90
ILE H  47
 None
 1.42A 5odhG-5c0nH:
undetectable		 5odhG-5c0nH:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g53 ADENOSINE RECEPTOR
A2A

(Homo sapiens) 		PF00001
(7tm_1) 		4 ARG A 291
ILE A 238
TYR A 197
ILE A 200
 None
 1.33A 5odhG-5g53A:
undetectable		 5odhG-5g53A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ARG A 778
ILE A 777
TYR A 410
ILE A 383
 None
 1.29A 5odhG-5i2gA:
undetectable		 5odhG-5i2gA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1

(Trypanosoma
brucei) 		PF00913
(Trypan_glycop) 		4 ARG A 331
ILE A 328
TYR A 353
ILE A  51
 None
 1.41A 5odhG-5ly9A:
undetectable		 5odhG-5ly9A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
26S PROTEASOME
REGULATORY SUBUNIT
RPN5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF01399
(PCI) 		4 ARG P 364
ILE P 360
TYR P 357
ILE O 341
 None
 1.46A 5odhG-5mpdP:
undetectable		 5odhG-5mpdP:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ARG A  70
ILE A 164
TYR A 166
ILE A 110
 None
 1.46A 5odhG-5n9xA:
3.9		 5odhG-5n9xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 ARG A 787
ILE A 786
TYR A 853
ILE A 889
 None
 1.47A 5odhG-5ngyA:
undetectable		 5odhG-5ngyA:
19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		4 ARG A 145
ILE A 170
TYR A 215
ILE A 317
 None
 0.38A 5odhG-5odrA:
63.9		 5odhG-5odrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9t PROTOCADHERIN GAMMA
B2-ALPHA C

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 ARG A 382
ILE A 412
TYR A 388
ILE A 385
 None
 1.49A 5odhG-5t9tA:
undetectable		 5odhG-5t9tA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4u MGC81300 PROTEIN

(Xenopus laevis) 		no annotation 4 ARG A 751
ILE A 623
TYR A 621
ILE A 746
 None
 1.49A 5odhG-5u4uA:
undetectable		 5odhG-5u4uA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S2

(Leishmania
donovani) 		no annotation 4 ARG B  83
ILE B 174
TYR B 178
ILE B  90
 None
 1.14A 5odhG-6az1B:
undetectable		 5odhG-6az1B:
17.43