SIMILAR PATTERNS OF AMINO ACIDS FOR 5ODC_G_ACTG704_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		4 PRO B 145
GLN B 147
LYS B 322
GLN B  64
 None
 1.24A 5odcA-1ccwB:
undetectable
5odcG-1ccwB:
1.2		 5odcA-1ccwB:
21.20
5odcG-1ccwB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		4 PRO A 326
ALA A 328
GLN A 420
GLN A 237
 None
 1.47A 5odcA-1fbwA:
undetectable
5odcG-1fbwA:
undetectable		 5odcA-1fbwA:
20.96
5odcG-1fbwA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Escherichia
coli) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 PRO A  45
ALA A  43
GLN A  39
GLN A  42
 None
 0.97A 5odcA-1t4bA:
2.2
5odcG-1t4bA:
2.3		 5odcA-1t4bA:
19.42
5odcG-1t4bA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PRO A 401
ALA A 399
GLN A 425
GLN A 455
 None
 1.46A 5odcA-2ihtA:
3.1
5odcG-2ihtA:
1.8		 5odcA-2ihtA:
22.78
5odcG-2ihtA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 PRO A 238
ALA A 215
GLN A 241
GLN A 216
 None
 0.98A 5odcA-2qk4A:
4.8
5odcG-2qk4A:
4.8		 5odcA-2qk4A:
22.86
5odcG-2qk4A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 PRO A 233
ALA A 210
GLN A 236
GLN A 211
 None
 1.05A 5odcA-2xd4A:
4.2
5odcG-2xd4A:
3.6		 5odcA-2xd4A:
23.24
5odcG-2xd4A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		4 PRO A 274
ALA A 276
LYS A  84
GLN A 277
 None
None
EB4  A1300 ( 2.5A)
None
 1.20A 5odcA-2xuzA:
4.4
5odcG-2xuzA:
3.6		 5odcA-2xuzA:
18.50
5odcG-2xuzA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		4 PRO A 284
ALA A 188
GLN A 315
GLN A 190
 None
 1.34A 5odcA-2yh0A:
undetectable
5odcG-2yh0A:
undetectable		 5odcA-2yh0A:
14.83
5odcG-2yh0A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN
LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus;
Prochlorococcus
marinus) 		PF00142
(Fer4_NifH)
PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		4 ALA A 162
GLN D 101
LYS A 134
GLN D 103
 None
GOL  D1532 (-3.3A)
GOL  D1532 (-4.0A)
None
 1.20A 5odcA-2ynmA:
1.7
5odcG-2ynmA:
1.6		 5odcA-2ynmA:
19.38
5odcG-2ynmA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		4 PRO 1 301
ALA 1 289
GLN 1 420
GLN 1 288
 None
 1.47A 5odcA-3i9v1:
2.0
5odcG-3i9v1:
1.1		 5odcA-3i9v1:
23.69
5odcG-3i9v1:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl7 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Parabacteroides
distasonis) 		PF13483
(Lactamase_B_3) 		4 PRO A 187
ALA A 199
GLN A 190
GLN A 198
 None
 1.40A 5odcA-3kl7A:
2.2
5odcG-3kl7A:
2.4		 5odcA-3kl7A:
16.64
5odcG-3kl7A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9i TRYPTOPHANYL-TRNA
SYNTHETASE

(Yersinia pestis) 		PF00579
(tRNA-synt_1b) 		4 PRO A 271
ALA A 275
GLN A 268
GLN A 276
 None
 1.36A 5odcA-3n9iA:
undetectable
5odcG-3n9iA:
undetectable		 5odcA-3n9iA:
17.92
5odcG-3n9iA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		4 PRO A  81
GLN A  58
LYS A  52
GLN A  10
 None
 1.01A 5odcA-3odmA:
2.0
5odcG-3odmA:
1.8		 5odcA-3odmA:
22.86
5odcG-3odmA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN
LYMPHOCYTE ANTIGEN
86

(Mus musculus;
Mus musculus) 		PF13855
(LRR_8)
PF02221
(E1_DerP2_DerF2) 		4 PRO A 112
ALA A 110
GLN C 119
GLN A 134
 None
 1.48A 5odcA-3t6qA:
undetectable
5odcG-3t6qA:
undetectable		 5odcA-3t6qA:
20.90
5odcG-3t6qA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bp8 OLIGOPEPTIDASE B

(Trypanosoma
brucei) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 PRO A 588
ALA A 644
GLN A 699
GLN A 643
 None
 1.40A 5odcA-4bp8A:
4.2
5odcG-4bp8A:
undetectable		 5odcA-4bp8A:
22.08
5odcG-4bp8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 PRO A 193
ALA A 153
GLN A 255
GLN A 151
 None
 1.21A 5odcA-4dykA:
undetectable
5odcG-4dykA:
undetectable		 5odcA-4dykA:
22.47
5odcG-4dykA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gri GLUTAMATE--TRNA
LIGASE

(Borreliella
burgdorferi) 		PF00749
(tRNA-synt_1c) 		4 PRO A 450
ALA A 454
GLN A 484
LYS A 415
 None
 1.26A 5odcA-4griA:
undetectable
5odcG-4griA:
undetectable		 5odcA-4griA:
22.00
5odcG-4griA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		4 PRO A  33
ALA A  37
GLN A   6
GLN A   9
 None
 1.49A 5odcA-4kdsA:
undetectable
5odcG-4kdsA:
undetectable		 5odcA-4kdsA:
18.59
5odcG-4kdsA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kma GM14141P

(Drosophila
melanogaster) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		4 PRO A 122
GLN A 126
LYS A 110
GLN A 118
 None
 1.43A 5odcA-4kmaA:
undetectable
5odcG-4kmaA:
undetectable		 5odcA-4kmaA:
21.35
5odcG-4kmaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY

(Trichormus
variabilis) 		PF13458
(Peripla_BP_6) 		4 PRO A 328
ALA A 333
GLN A 302
GLN A 330
 None
 1.41A 5odcA-4rdcA:
7.4
5odcG-4rdcA:
5.2		 5odcA-4rdcA:
19.67
5odcG-4rdcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN

(Homo sapiens) 		PF10421
(OAS1_C) 		4 PRO A 309
ALA A 307
LYS A 187
GLN A 195
 None
None
CME  A 188 ( 1.1A)
CME  A 188 ( 4.4A)
 1.41A 5odcA-4xq7A:
undetectable
5odcG-4xq7A:
undetectable		 5odcA-4xq7A:
19.81
5odcG-4xq7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyd SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		4 PRO A 263
ALA A 161
GLN A 257
GLN A 159
 None
None
NAD  A 901 (-3.7A)
None
 1.34A 5odcA-5jydA:
1.9
5odcG-5jydA:
2.0		 5odcA-5jydA:
19.05
5odcG-5jydA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpq TRANSGLYCOSYLASE

(Neisseria
meningitidis) 		PF01464
(SLT)
PF14718
(SLT_L) 		4 PRO A 542
ALA A 539
GLN A 517
GLN A 538
 None
 1.11A 5odcA-5mpqA:
undetectable
5odcG-5mpqA:
undetectable		 5odcA-5mpqA:
22.55
5odcG-5mpqA:
22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		4 ALA A 556
GLN A 542
LYS A 545
GLN A 553
 None
 1.19A 5odcA-5odrA:
63.7
5odcG-5odrA:
64.1		 5odcA-5odrA:
100.00
5odcG-5odrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PRO A 248
ALA A 263
GLN A 269
GLN A 289
 None
 1.31A 5odcA-5vm1A:
undetectable
5odcG-5vm1A:
undetectable		 5odcA-5vm1A:
22.52
5odcG-5vm1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zc3 -

(-) 		no annotation 4 PRO B 472
ALA B 420
GLN B 479
GLN B 440
 None
 1.44A 5odcA-5zc3B:
undetectable
5odcG-5zc3B:
undetectable		 5odcA-5zc3B:
undetectable
5odcG-5zc3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 4 PRO A1211
ALA A1186
GLN A  72
GLN A1259
 None
None
SO4  A1403 (-3.1A)
None
 1.49A 5odcA-6apxA:
undetectable
5odcG-6apxA:
2.2		 5odcA-6apxA:
22.79
5odcG-6apxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 PRO C 159
ALA C 156
GLN C 148
GLN C 434
 None
 1.45A 5odcA-6fkhC:
2.8
5odcG-6fkhC:
3.1		 5odcA-6fkhC:
undetectable
5odcG-6fkhC:
undetectable