SIMILAR PATTERNS OF AMINO ACIDS FOR 5OAJ_E_TKTE601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b97 RESTRICTION
ENDONUCLEASE ECORV

(Escherichia
coli) 		PF09233
(Endonuc-EcoRV) 		4 TRP A 216
TYR A 230
TYR A 110
ARG A 115
 None
 1.48A 5oajD-1b97A:
0.0
5oajE-1b97A:
0.0		 5oajD-1b97A:
20.77
5oajE-1b97A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nez H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, TLA(C)
ALPHA CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TRP A 133
TYR A 123
PHE A  73
TYR A 152
 None
 1.36A 5oajD-1nezA:
0.0
5oajE-1nezA:
0.0		 5oajD-1nezA:
21.75
5oajE-1nezA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		4 CYH A 117
PHE A 137
TYR A  29
ARG A  27
 None
 0.94A 5oajD-1p75A:
0.0
5oajE-1p75A:
0.0		 5oajD-1p75A:
20.77
5oajE-1p75A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr1 BETA-GLUCOSIDASE A

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		4 GLU A 405
TRP A 326
CYH A 169
TYR A 296
 GOL  A2000 (-2.6A)
None
None
GOL  A2000 (-4.0A)
 1.46A 5oajD-1tr1A:
0.0
5oajE-1tr1A:
0.0		 5oajD-1tr1A:
22.31
5oajE-1tr1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		4 GLU A  27
TRP A 215
CYH A 101
PHE A 225
 None
 1.45A 5oajD-2a30A:
0.0
5oajE-2a30A:
0.0		 5oajD-2a30A:
18.75
5oajE-2a30A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf0 GTP-BINDING PROTEIN
DI-RAS1

(Homo sapiens) 		PF00071
(Ras) 		4 GLU A 159
CYH A 123
TYR A 155
PHE A 146
 None
 1.30A 5oajD-2gf0A:
0.0
5oajE-2gf0A:
0.0		 5oajD-2gf0A:
21.22
5oajE-2gf0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 GLU A 952
PHE A 727
TYR A 955
ARG A 762
 None
None
None
CL  A   5 (-3.6A)
 1.39A 5oajD-2zaiA:
0.0
5oajE-2zaiA:
0.0		 5oajD-2zaiA:
18.31
5oajE-2zaiA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 GLU A 237
CYH A 176
TYR A  58
ARG A 209
 None
ONL  A 800 (-1.6A)
GOL  A 805 (-4.5A)
ONL  A 800 ( 4.8A)
 1.13A 5oajD-3dlaA:
0.0
5oajE-3dlaA:
0.0		 5oajD-3dlaA:
17.38
5oajE-3dlaA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		4 GLU A 129
TRP A 273
TYR A 485
TYR A 270
 GAL  A 900 (-2.8A)
GAL  A 900 ( 4.9A)
None
None
 1.20A 5oajD-3thcA:
0.0
5oajE-3thcA:
0.0		 5oajD-3thcA:
16.80
5oajE-3thcA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmp OTU
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF02338
(OTU) 		4 GLU A 264
CYH A 278
TYR A 269
TYR A 181
 None
SEP  A 177 ( 4.8A)
SEP  A 177 ( 4.9A)
SEP  A 177 ( 4.1A)
 1.27A 5oajD-3tmpA:
undetectable
5oajE-3tmpA:
undetectable		 5oajD-3tmpA:
19.54
5oajE-3tmpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wn6 ALPHA-AMYLASE

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 GLU A  39
TRP A  43
PHE A 351
TYR A 347
 None
 0.93A 5oajD-3wn6A:
undetectable
5oajE-3wn6A:
undetectable		 5oajD-3wn6A:
18.02
5oajE-3wn6A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wov OLIGOSACCHARYL
TRANSFERASE

(Pyrococcus
abyssi) 		no annotation 4 GLU A 958
PHE A 735
TYR A 961
ARG A 770
 None
 1.46A 5oajD-3wovA:
undetectable
5oajE-3wovA:
undetectable		 5oajD-3wovA:
17.90
5oajE-3wovA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zth STU0660

(Streptococcus
thermophilus) 		PF16813
(Cas_St_Csn2) 		4 GLU A 294
CYH A 223
PHE A 218
TYR A 215
 None
 1.39A 5oajD-3zthA:
undetectable
5oajE-3zthA:
undetectable		 5oajD-3zthA:
20.66
5oajE-3zthA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 GLU A 602
CYH A 962
CYH A 964
PHE A 987
 None
ZN  A1102 (-2.3A)
ZN  A1102 (-2.1A)
None
 1.41A 5oajD-4gl2A:
undetectable
5oajE-4gl2A:
undetectable		 5oajD-4gl2A:
15.68
5oajE-4gl2A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 CYH A 198
TYR A 388
PHE A 424
ARG A 321
 None
 1.29A 5oajD-4jrnA:
undetectable
5oajE-4jrnA:
undetectable		 5oajD-4jrnA:
20.16
5oajE-4jrnA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 TYR A 612
PHE A 644
TYR A 443
ARG A 439
 None
 1.39A 5oajD-4ka8A:
undetectable
5oajE-4ka8A:
undetectable		 5oajD-4ka8A:
16.57
5oajE-4ka8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0v EXONUCLEASE SUBUNIT
SBCD

(Escherichia
coli) 		PF00149
(Metallophos)
PF12320
(SbcD_C) 		4 GLU A 310
CYH A 249
PHE A  15
TYR A  16
 None
 1.43A 5oajD-4m0vA:
undetectable
5oajE-4m0vA:
undetectable		 5oajD-4m0vA:
21.11
5oajE-4m0vA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdf 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		4 GLU B 335
CYH B 169
TYR B 334
PHE B  23
 None
None
None
PO4  B 404 (-4.8A)
 1.48A 5oajD-4qdfB:
undetectable
5oajE-4qdfB:
undetectable		 5oajD-4qdfB:
18.81
5oajE-4qdfB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlx NITROREDUCTASE
FAMILY PROTEIN

(Lactobacillus
plantarum) 		PF00881
(Nitroreductase) 		4 GLU A 131
CYH A  51
TYR A 101
PHE A 137
 None
KTC  A 302 (-3.4A)
None
KTC  A 302 (-4.8A)
 1.33A 5oajD-4qlxA:
undetectable
5oajE-4qlxA:
undetectable		 5oajD-4qlxA:
18.49
5oajE-4qlxA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqe HOMOSPERMIDINE
SYNTHASE

(Blastochloris
viridis) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 GLU A 243
CYH A 264
TYR A 136
ARG A 318
 None
None
None
SO4  A 502 (-2.9A)
 1.25A 5oajD-4xqeA:
undetectable
5oajE-4xqeA:
undetectable		 5oajD-4xqeA:
19.83
5oajE-4xqeA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 GLU C 116
CYH C 576
CYH C  81
ARG C 501
 None
NFU  C 701 (-2.2A)
NFU  C 701 (-2.2A)
NFU  C 701 (-4.6A)
 1.05A 5oajD-5aa5C:
undetectable
5oajE-5aa5C:
undetectable		 5oajD-5aa5C:
17.18
5oajE-5aa5C:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 GLU A 850
PHE A 625
TYR A 853
ARG A 660
 None
 1.38A 5oajD-5azaA:
undetectable
5oajE-5azaA:
undetectable		 5oajD-5azaA:
14.68
5oajE-5azaA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLU A 471
TRP A 227
PHE A 550
TYR A 555
 None
 1.34A 5oajD-5c16A:
undetectable
5oajE-5c16A:
undetectable		 5oajD-5c16A:
18.50
5oajE-5c16A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja9 NANOBODY 6

(Lama glama) 		PF07686
(V-set) 		4 TRP A 108
PHE A  48
TYR A  38
ARG A  36
 None
EDO  A 202 ( 4.3A)
None
EDO  A 202 ( 3.9A)
 1.04A 5oajD-5ja9A:
undetectable
5oajE-5ja9A:
undetectable		 5oajD-5ja9A:
19.22
5oajE-5ja9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT
ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 GLU B 200
TYR B 201
PHE b 513
ARG b 237
 None
 1.41A 5oajD-5l9wB:
undetectable
5oajE-5l9wB:
undetectable		 5oajD-5l9wB:
16.27
5oajE-5l9wB:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojr -

(-) 		no annotation 4 CYH A 294
TYR A  44
PHE A 320
ARG A 278
 None
 1.50A 5oajD-5ojrA:
undetectable
5oajE-5ojrA:
undetectable		 5oajD-5ojrA:
undetectable
5oajE-5ojrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 GLU A 832
TYR A 824
PHE A 755
ARG A 751
 None
 1.21A 5oajD-5w21A:
undetectable
5oajE-5w21A:
undetectable		 5oajD-5w21A:
15.98
5oajE-5w21A:
15.98