SIMILAR PATTERNS OF AMINO ACIDS FOR 5O96_G_SAMG501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		5 LEU A 151
GLY A 146
LEU A 258
ARG A 264
THR A 267
 None
 1.03A 5o96G-1aqlA:
undetectable		 5o96G-1aqlA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axd GLUTATHIONE
S-TRANSFERASE I

(Zea mays) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A 156
GLY A 158
GLU A  91
VAL A  97
ALA A 164
 None
 1.00A 5o96G-1axdA:
undetectable		 5o96G-1axdA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 257
GLY A 256
GLY A 213
LEU A  74
THR A 259
 None
 1.02A 5o96G-1e5fA:
undetectable		 5o96G-1e5fA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU B1009
GLU B 690
LEU B 702
VAL B 697
ALA B 713
 None
 1.00A 5o96G-1gl9B:
2.2		 5o96G-1gl9B:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gw1 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		5 LEU A 241
GLY A 246
SER A 237
GLU A 190
ALA A 189
 None
 1.03A 5o96G-1gw1A:
undetectable		 5o96G-1gw1A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001

(Methanothermobacter
thermautotrophicus) 		PF02598
(Methyltrn_RNA_3) 		5 GLY A 218
ARG A 245
THR A 246
GLU A 247
ALA A 249
 None
 0.97A 5o96G-1k3rA:
13.3		 5o96G-1k3rA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		5 LEU A 433
GLY A 437
SER A 429
VAL A 447
GLU A 499
 None
 0.98A 5o96G-1lw3A:
undetectable		 5o96G-1lw3A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 250
GLY A 249
GLY A 207
LEU A  67
THR A 252
 None
 0.99A 5o96G-1n8pA:
undetectable		 5o96G-1n8pA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		8 LEU A 171
GLY A 195
GLY A 199
LEU A 218
ARG A 224
THR A 225
GLU A 226
ALA A 228
 None
 0.98A 5o96G-1nxzA:
22.1		 5o96G-1nxzA:
49.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		8 LEU A 171
GLY A 195
LEU A 218
VAL A 222
ARG A 224
THR A 225
GLU A 226
ALA A 228
 None
 0.87A 5o96G-1nxzA:
22.1		 5o96G-1nxzA:
49.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 LEU A 108
GLY A 156
THR A 158
GLU A 185
ALA A 183
 None
 0.87A 5o96G-1p88A:
undetectable		 5o96G-1p88A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdr HUMAN DISCS LARGE
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A 520
GLY A 488
GLU A 484
GLY A 486
ALA A 528
 None
 0.93A 5o96G-1pdrA:
undetectable		 5o96G-1pdrA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh1 COLICIN B

(Escherichia
coli) 		PF01024
(Colicin)
PF03515
(Cloacin) 		5 LEU A 110
GLY A 113
LEU A 106
GLU A 256
ALA A 121
 None
 1.02A 5o96G-1rh1A:
undetectable		 5o96G-1rh1A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 297
GLY A 301
LEU A 271
ARG A 280
ALA A 275
 None
 0.95A 5o96G-1tuoA:
undetectable		 5o96G-1tuoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue0 ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1) 		5 GLY A 316
GLY A 314
SER A 223
ARG A 266
GLU A 262
 None
 0.93A 5o96G-1ue0A:
undetectable		 5o96G-1ue0A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v47 ATP SULFURYLASE

(Thermus
thermophilus) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		6 LEU A  58
GLY A 126
VAL A  29
THR A  34
GLU A  36
ALA A  38
 None
 1.38A 5o96G-1v47A:
2.7		 5o96G-1v47A:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v6z HYPOTHETICAL PROTEIN
TTHA0657

(Thermus
thermophilus) 		PF04452
(Methyltrans_RNA) 		6 GLY A 181
GLU A 183
GLY A 185
SER A 203
LEU A 204
ALA A 214
 None
 0.84A 5o96G-1v6zA:
21.5		 5o96G-1v6zA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v6z HYPOTHETICAL PROTEIN
TTHA0657

(Thermus
thermophilus) 		PF04452
(Methyltrans_RNA) 		6 GLY A 181
GLY A 185
SER A 203
LEU A 204
GLU A 212
ALA A 214
 None
 0.79A 5o96G-1v6zA:
21.5		 5o96G-1v6zA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		8 GLY A 204
GLU A 206
GLY A 208
LEU A 227
ARG A 233
THR A 234
GLU A 235
ALA A 237
 None
 0.72A 5o96G-1vhkA:
20.4		 5o96G-1vhkA:
32.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		5 GLY A 232
GLU A 234
GLY A 237
SER A 251
ALA A 266
 SAM  A 301 (-3.2A)
None
SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.4A)
 0.92A 5o96G-1x7pA:
12.1		 5o96G-1x7pA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		6 LEU A 433
GLY A 437
SER A 429
VAL A 447
THR A 441
GLU A 499
 None
 1.16A 5o96G-1zsqA:
undetectable		 5o96G-1zsqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9h VOLTAGE-GATED
POTASSIUM CHANNEL

(Streptomyces
lividans) 		PF07885
(Ion_trans_2) 		5 LEU A  40
LEU A  36
VAL A  97
THR A  72
ALA A  73
 None
 0.99A 5o96G-2a9hA:
undetectable		 5o96G-2a9hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cpw CBL-INTERACTING
PROTEIN STS-1
VARIANT

(Homo sapiens) 		PF00627
(UBA) 		5 LEU A  27
GLY A  30
LEU A  23
VAL A  48
ALA A  36
 None
 1.02A 5o96G-2cpwA:
undetectable		 5o96G-2cpwA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 GLY A 107
SER A 142
LEU A 141
GLU A 162
ALA A 164
 None
 0.95A 5o96G-2eb0A:
undetectable		 5o96G-2eb0A:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		8 LEU A 161
GLY A 185
GLU A 187
GLY A 189
LEU A 208
ARG A 214
THR A 215
ALA A 218
 SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
None
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
None
SAH  A 300 ( 4.5A)
SAH  A 300 ( 3.6A)
 0.70A 5o96G-2egwA:
26.5		 5o96G-2egwA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		8 LEU A 161
GLY A 185
GLY A 189
LEU A 208
ARG A 214
THR A 215
GLU A 216
ALA A 218
 SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
None
SAH  A 300 ( 4.5A)
None
SAH  A 300 ( 3.6A)
 0.71A 5o96G-2egwA:
26.5		 5o96G-2egwA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z PROTEIN (CHEMOTAXIS
METHYLATION PROTEIN)

(Thermotoga
maritima) 		PF03975
(CheD) 		6 LEU C  24
GLY C  89
VAL C  30
THR C 124
GLU C 122
ALA C  87
 None
 1.44A 5o96G-2f9zC:
undetectable		 5o96G-2f9zC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo sapiens) 		PF00106
(adh_short) 		5 LEU A  50
GLY A  43
SER A  56
VAL A  34
ALA A  22
 None
 1.03A 5o96G-2hrbA:
2.3		 5o96G-2hrbA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx0 PUTATIVE DNA-BINDING
PROTEIN

(Salmonella
enterica) 		PF03479
(DUF296) 		5 LEU A  65
GLY A 104
LEU A  97
ARG A  55
THR A  62
 None
 0.95A 5o96G-2hx0A:
undetectable		 5o96G-2hx0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0i DISKS LARGE HOMOLOG
1

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 GLY A 482
GLY A 485
SER A 513
GLU A 525
ALA A 527
 None
 1.03A 5o96G-2i0iA:
undetectable		 5o96G-2i0iA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptg ENOYL-ACYL CARRIER
REDUCTASE

(Eimeria tenella) 		PF13561
(adh_short_C2) 		5 GLY A 115
GLY A 113
SER A 327
ARG A 372
ALA A 374
 None
 1.01A 5o96G-2ptgA:
2.3		 5o96G-2ptgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		6 LEU A 108
GLY A 156
LEU A 182
THR A 158
GLU A 185
ALA A 183
 None
 1.50A 5o96G-2qfqA:
undetectable		 5o96G-2qfqA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmm UPF0217 PROTEIN
AF_1056

(Archaeoglobus
fulgidus) 		PF04013
(Methyltrn_RNA_2) 		5 LEU A 221
GLY A 242
GLY A 246
LEU A 265
GLU A 273
 SAM  A 301 (-4.3A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.4A)
None
 0.77A 5o96G-2qmmA:
11.2		 5o96G-2qmmA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmm UPF0217 PROTEIN
AF_1056

(Archaeoglobus
fulgidus) 		PF04013
(Methyltrn_RNA_2) 		5 LEU A 221
GLY A 242
GLY A 246
SER A 264
LEU A 265
 SAM  A 301 (-4.3A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
 1.03A 5o96G-2qmmA:
11.2		 5o96G-2qmmA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 GLY A  95
GLY A  55
SER A 174
VAL A 177
ALA A 113
 None
 0.91A 5o96G-2x58A:
undetectable		 5o96G-2x58A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		6 GLY A 244
LEU A 174
VAL A 167
THR A 212
GLU A 202
ALA A 203
 A5A  A 801 (-4.0A)
None
None
A5A  A 801 (-3.4A)
None
None
 1.48A 5o96G-2ztgA:
undetectable		 5o96G-2ztgA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350

(Thermus
thermophilus) 		PF00582
(Usp) 		5 LEU A 115
GLY A  15
LEU A 113
THR A   7
ALA A   6
 LEU  A 115 ( 0.6A)
GLY  A  15 ( 0.0A)
LEU  A 113 ( 0.6A)
THR  A   7 ( 0.8A)
ALA  A   6 ( 0.0A)
 1.03A 5o96G-3ab7A:
undetectable		 5o96G-3ab7A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1

(Mycobacterium
tuberculosis) 		PF00296
(Bac_luciferase) 		5 LEU A  68
GLY A  62
SER A  34
VAL A  37
ALA A  24
 None
 1.00A 5o96G-3b4yA:
4.4		 5o96G-3b4yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE

(Lactobacillus
plantarum) 		PF01261
(AP_endonuc_2) 		5 LEU A 251
GLY A 249
GLY A 247
VAL A 271
THR A 244
 None
 1.04A 5o96G-3cnyA:
undetectable		 5o96G-3cnyA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d02 PUTATIVE LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		5 GLY A  49
GLY A  47
LEU A  59
VAL A  32
ALA A 277
 None
 1.03A 5o96G-3d02A:
3.2		 5o96G-3d02A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmc NTF2-LIKE PROTEIN

(Trichormus
variabilis) 		PF12680
(SnoaL_2) 		5 LEU A  36
SER A 121
VAL A  54
GLU A  61
ALA A  59
 None
 0.97A 5o96G-3dmcA:
undetectable		 5o96G-3dmcA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8y SUSD/RAGB-ASSOCIATED
ESTERASE-LIKE
PROTEIN

(Bacteroides
vulgatus) 		PF12715
(Abhydrolase_7) 		5 LEU A 378
GLY A 381
THR A 386
GLU A 389
ALA A 390
 None
 0.93A 5o96G-3g8yA:
undetectable		 5o96G-3g8yA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 GLY A  53
GLU A 146
GLY A  20
VAL A 168
ALA A 245
 None
RIB  A 305 (-2.6A)
None
None
None
 0.86A 5o96G-3go7A:
3.3		 5o96G-3go7A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		6 LEU A 100
GLU A  72
SER A  39
LEU A  38
GLU A  79
ALA A  77
 None
 1.45A 5o96G-3hl0A:
undetectable		 5o96G-3hl0A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1j OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00106
(adh_short) 		5 LEU A 180
GLU A 174
GLY A 175
LEU A 184
ALA A 192
 None
 1.00A 5o96G-3i1jA:
2.3		 5o96G-3i1jA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		5 LEU A 352
GLY A 350
GLY A 326
LEU A 402
ALA A 206
 None
 0.98A 5o96G-3i4jA:
undetectable		 5o96G-3i4jA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		5 LEU E 480
GLY E 482
GLU E 424
GLY E 426
LEU E 476
 None
ZN  E 996 ( 4.6A)
NHX  E 998 (-3.0A)
None
None
 0.92A 5o96G-3kdsE:
undetectable		 5o96G-3kdsE:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 LEU A1078
LEU A1083
ARG A1102
GLU A1114
ALA A1104
 None
 0.99A 5o96G-3kg7A:
undetectable		 5o96G-3kg7A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		5 GLY A 296
GLY A 292
SER A  65
ARG A 218
ALA A 220
 None
 1.03A 5o96G-3kl9A:
undetectable		 5o96G-3kl9A:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw2 PROBABLE R-RNA
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		PF04452
(Methyltrans_RNA) 		6 GLY A 196
SER A 218
ARG A 225
THR A 226
GLU A 227
ALA A 229
 ADN  A 300 (-3.2A)
ADN  A 300 (-3.6A)
None
ADN  A 300 (-4.1A)
None
ADN  A 300 (-3.4A)
 0.50A 5o96G-3kw2A:
26.3		 5o96G-3kw2A:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw2 PROBABLE R-RNA
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		PF04452
(Methyltrans_RNA) 		6 LEU A 219
SER A 218
ARG A 225
THR A 226
GLU A 227
ALA A 229
 ADN  A 300 (-4.1A)
ADN  A 300 (-3.6A)
None
ADN  A 300 (-4.1A)
None
ADN  A 300 (-3.4A)
 1.48A 5o96G-3kw2A:
26.3		 5o96G-3kw2A:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw2 PROBABLE R-RNA
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		PF04452
(Methyltrans_RNA) 		5 SER A 218
LEU A 219
ARG A 225
GLU A 227
ALA A 229
 ADN  A 300 (-3.6A)
ADN  A 300 (-4.1A)
None
None
ADN  A 300 (-3.4A)
 0.78A 5o96G-3kw2A:
26.3		 5o96G-3kw2A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 LEU A 163
GLU A  58
GLY A  54
SER A 164
ALA A 171
 None
 0.95A 5o96G-3m1lA:
2.8		 5o96G-3m1lA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n79 PDUT

(Salmonella
enterica) 		PF00936
(BMC) 		5 GLY A 133
GLY A 131
SER A  71
LEU A  72
ALA A 106
 None
 0.97A 5o96G-3n79A:
undetectable		 5o96G-3n79A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of7 REGULATOR OF
CHROMOSOME
CONDENSATION

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 GLY A 458
GLU A  58
GLY A  93
VAL A 462
ALA A 425
 None
 0.97A 5o96G-3of7A:
undetectable		 5o96G-3of7A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on3 KETO/OXOACID
FERREDOXIN
OXIDOREDUCTASE,
GAMMA SUBUNIT

(Geobacter
sulfurreducens) 		PF01558
(POR) 		5 LEU A  74
GLY A  11
GLU A  79
LEU A  95
THR A  77
 None
 1.01A 5o96G-3on3A:
2.0		 5o96G-3on3A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 6 LEU A 195
GLY A 215
GLY A 234
SER A 201
LEU A 202
VAL A 240
 None
CA  A 409 (-4.1A)
CA  A 410 (-4.0A)
None
None
None
 1.44A 5o96G-3p4gA:
undetectable		 5o96G-3p4gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 GLY A  18
GLY A  24
SER A 160
LEU A 181
VAL A 157
 NAD  A 277 (-3.4A)
None
None
None
None
 1.03A 5o96G-3pgxA:
2.7		 5o96G-3pgxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfo PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		5 GLY A  14
GLY A  44
THR A  16
GLU A  20
ALA A  18
 None
 0.97A 5o96G-3qfoA:
undetectable		 5o96G-3qfoA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhy BETA-LACTAMASE

(Bacillus
anthracis) 		PF13354
(Beta-lactamase2) 		5 LEU A  80
GLY A  78
LEU A 119
ARG A 128
ALA A 123
 None
 1.00A 5o96G-3qhyA:
undetectable		 5o96G-3qhyA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 285
GLU A  98
GLY A  96
LEU A  88
GLU A 292
 None
 0.91A 5o96G-3rcyA:
undetectable		 5o96G-3rcyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4w MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 285
GLU A  98
GLY A  96
LEU A  88
GLU A 292
 None
 0.94A 5o96G-3t4wA:
undetectable		 5o96G-3t4wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbx PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		5 GLU A  39
GLY A  67
SER A  51
VAL A  29
ALA A  44
 None
 1.01A 5o96G-3wbxA:
undetectable		 5o96G-3wbxA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiw GLYCOSYL HYDROLASE
FAMILY 88

(Pedobacter
heparinus) 		PF07470
(Glyco_hydro_88) 		6 LEU A 252
GLY A 254
GLU A 180
LEU A 316
GLU A 383
ALA A 315
 None
 1.32A 5o96G-3wiwA:
undetectable		 5o96G-3wiwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cng SPOU RRNA METHYLASE

(Sulfolobus
acidocaldarius) 		PF00588
(SpoU_methylase) 		5 GLY A 111
GLU A 113
GLY A 116
VAL A 139
ALA A 145
 SAH  A1157 (-3.1A)
None
SAH  A1157 ( 3.2A)
SAH  A1157 ( 4.3A)
SAH  A1157 ( 3.7A)
 0.93A 5o96G-4cngA:
13.0		 5o96G-4cngA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfc TRANSCRIPTION-REPAIR
-COUPLING FACTOR
UVRABC SYSTEM
PROTEIN A

(Escherichia
coli;
Escherichia
coli) 		PF14814
(UB2H)
no annotation 		6 LEU B 150
GLY A 166
VAL B 202
THR B 223
GLU B 226
ALA B 224
 None
 1.43A 5o96G-4dfcB:
undetectable		 5o96G-4dfcB:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Escherichia
coli) 		PF04452
(Methyltrans_RNA) 		6 LEU A 171
GLU A 196
LEU A 217
VAL A 221
ARG A 223
THR A 224
 None
 0.89A 5o96G-4e8bA:
31.7		 5o96G-4e8bA:
48.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 166
GLY A 167
GLY A 172
LEU A 250
VAL A 163
 None
EDO  A 407 (-3.8A)
CL  A 419 (-3.9A)
None
None
 0.93A 5o96G-4ej6A:
2.7		 5o96G-4ej6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4o HAPTOGLOBIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 LEU C 139
GLY C 297
GLY C 129
LEU C 190
THR C 141
 None
 0.99A 5o96G-4f4oC:
undetectable		 5o96G-4f4oC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwi ABC-TYPE
DIPEPTIDE/OLIGOPEPTI
DE/NICKEL TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		PF00005
(ABC_tran)
PF08352
(oligo_HPY) 		6 LEU B  10
GLY B 231
VAL B  13
THR B  49
GLU B  52
ALA B  53
 None
None
None
ATP  B 402 (-3.4A)
None
None
 1.25A 5o96G-4fwiB:
undetectable		 5o96G-4fwiB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gw9 BACTERIOPHYTOCHROME

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF00989
(PAS)
PF01590
(GAF)
PF08446
(PAS_2) 		5 LEU A 157
LEU A 302
ARG A 142
GLU A 139
ALA A 137
 None
 1.00A 5o96G-4gw9A:
undetectable		 5o96G-4gw9A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20) 		5 LEU A 105
GLY A 162
GLY A 231
LEU A  12
GLU A 135
 None
None
None
None
ZN  A1002 (-2.0A)
 1.00A 5o96G-4h2kA:
undetectable		 5o96G-4h2kA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 LEU B 177
GLY B 175
GLY B 173
LEU B 251
ALA B 180
 None
 0.99A 5o96G-4hdsB:
3.2		 5o96G-4hdsB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 LEU M 312
GLY M 310
GLY M 376
LEU M  70
ARG M 452
 None
 0.86A 5o96G-4heaM:
undetectable		 5o96G-4heaM:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilt INTRADIOL
RING-CLEAVAGE
DIOXYGENASE

(Streptomyces
sp. SirexAA-E) 		PF00775
(Dioxygenase_C) 		5 LEU A 159
GLY A 221
SER A  97
LEU A  98
ARG A 172
 None
 0.89A 5o96G-4iltA:
undetectable		 5o96G-4iltA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilv INTRADIOL
RING-CLEAVAGE
DIOXYGENASE

(Streptomyces
sp. SirexAA-E) 		PF00775
(Dioxygenase_C) 		5 LEU A 159
GLY A 221
SER A  97
LEU A  98
ARG A 172
 None
 0.88A 5o96G-4ilvA:
undetectable		 5o96G-4ilvA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Sinorhizobium
meliloti) 		PF04452
(Methyltrans_RNA) 		5 GLY A 195
GLU A 197
GLY A 199
LEU A 219
ALA A 229
 None
 0.76A 5o96G-4j3cA:
18.0		 5o96G-4j3cA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Sinorhizobium
meliloti) 		PF04452
(Methyltrans_RNA) 		5 GLY A 195
GLY A 199
LEU A 219
ARG A 225
ALA A 229
 None
 0.99A 5o96G-4j3cA:
18.0		 5o96G-4j3cA:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		5 LEU A 124
GLY A 122
GLY A 120
ARG A 223
ALA A 127
 None
 0.85A 5o96G-4j7mA:
undetectable		 5o96G-4j7mA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01746
(tRNA_m1G_MT) 		5 LEU A 186
GLY A 206
LEU A 232
VAL A 245
THR A 248
 SAH  A 302 (-4.2A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.8A)
SAH  A 302 ( 3.9A)
SAH  A 302 ( 4.4A)
 0.92A 5o96G-4jwjA:
8.7		 5o96G-4jwjA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjz TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		5 GLY A 383
GLY A 200
LEU A 377
THR A 381
ALA A 379
 None
 0.96A 5o96G-4kjzA:
5.5		 5o96G-4kjzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		5 LEU A 336
GLY A 354
GLY A 350
LEU A  50
ALA A 331
 PLM  A 702 ( 4.7A)
None
PLM  A 704 ( 3.2A)
PLM  A 702 ( 4.1A)
PLM  A 702 (-3.6A)
 0.98A 5o96G-4kvlA:
undetectable		 5o96G-4kvlA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Mycobacterium
tuberculosis) 		PF04452
(Methyltrans_RNA) 		6 GLY A 199
GLU A 201
GLY A 203
ARG A 228
THR A 229
ALA A 232
 None
 1.16A 5o96G-4l69A:
27.3		 5o96G-4l69A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Mycobacterium
tuberculosis) 		PF04452
(Methyltrans_RNA) 		8 LEU A 175
GLY A 199
GLU A 201
GLY A 203
LEU A 222
VAL A 226
THR A 229
ALA A 232
 None
 0.72A 5o96G-4l69A:
27.3		 5o96G-4l69A:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg1 C9ORF114

(Homo sapiens) 		PF02598
(Methyltrn_RNA_3) 		6 GLY A 312
GLY A 316
ARG A 352
THR A 353
GLU A 354
ALA A 356
 SAH  A 401 (-3.1A)
SAH  A 401 (-3.3A)
None
SAH  A 401 (-4.3A)
None
SAH  A 401 (-3.4A)
 0.82A 5o96G-4rg1A:
11.8		 5o96G-4rg1A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF

(Escherichia
coli) 		PF04069
(OpuAC) 		5 LEU A 192
GLY A 212
SER A 193
LEU A 194
ALA A 205
 None
 1.03A 5o96G-4wepA:
undetectable		 5o96G-4wepA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN

(Homo sapiens) 		no annotation 5 LEU C 194
GLY C 352
GLY C 184
LEU C 245
THR C 196
 None
 1.01A 5o96G-4wjgC:
undetectable		 5o96G-4wjgC:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0l HAPTOGLOBIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU C 198
GLY C 356
GLY C 188
LEU C 249
THR C 200
 None
 0.94A 5o96G-4x0lC:
undetectable		 5o96G-4x0lC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0w YEAZ

(Pseudomonas
aeruginosa) 		PF00814
(Peptidase_M22) 		5 LEU A   7
GLY A  63
LEU A  39
ARG A  73
ALA A  75
 None
 1.03A 5o96G-4y0wA:
undetectable		 5o96G-4y0wA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		5 LEU A  47
GLY A  51
GLU A  23
GLY A  24
VAL A  55
 None
 1.03A 5o96G-4y9sA:
undetectable		 5o96G-4y9sA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5q CYTOCHROME P450
HYDROXYLASE

(Streptomyces
atroolivaceus) 		PF00067
(p450) 		6 LEU A 127
GLU A 371
GLY A 372
SER A 143
GLU A 364
ALA A 124
 None
 1.44A 5o96G-4z5qA:
undetectable		 5o96G-4z5qA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zf7 INTERLEUKIN 2

(Mustela
putorius) 		PF00715
(IL2) 		6 LEU A  95
GLU A  99
GLY A  97
LEU A  15
THR A  52
GLU A  50
 None
None
SO4  A 201 ( 3.5A)
None
None
None
 1.41A 5o96G-4zf7A:
undetectable		 5o96G-4zf7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris) 		PF00759
(Glyco_hydro_9) 		5 GLY A 223
GLU A 159
GLY A 158
LEU A 183
ALA A 165
 None
 0.97A 5o96G-4zg8A:
undetectable		 5o96G-4zg8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoh CARF

(Serratia sp.
ATCC 39006) 		PF03781
(FGE-sulfatase) 		5 LEU A 242
GLY A 232
GLY A 209
SER A 167
ALA A 153
 None
None
K  A1267 (-4.4A)
None
None
 0.95A 5o96G-5aohA:
undetectable		 5o96G-5aohA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1

(Saccharomyces
cerevisiae) 		PF04252
(RNA_Me_trans) 		5 LEU A  83
GLY A 106
LEU A 133
THR A 140
ALA A 143
 SAH  A 301 (-4.5A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.0A)
SAH  A 301 (-4.0A)
SAH  A 301 ( 4.0A)
 0.88A 5o96G-5c77A:
8.3		 5o96G-5c77A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus;
Influenza C
virus) 		PF00602
(Flu_PB1)
PF00604
(Flu_PB2) 		5 GLY C 399
GLY C 501
SER B 290
THR C 383
GLU C 378
 None
 0.96A 5o96G-5d9aC:
undetectable		 5o96G-5d9aC:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmx D-ALANINE--D-ALANINE
LIGASE

(Acinetobacter
baumannii) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A  36
GLY A  39
LEU A  32
ARG A  60
ALA A  42
 None
 0.89A 5o96G-5dmxA:
2.4		 5o96G-5dmxA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A 158
GLY A 160
GLU A  93
VAL A  99
ALA A 166
 None
 1.01A 5o96G-5f06A:
undetectable		 5o96G-5f06A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 LEU A  44
GLY A  49
SER A  41
LEU A  40
ARG A 242
 None
 1.03A 5o96G-5h7kA:
undetectable		 5o96G-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hf4 DISKS LARGE HOMOLOG
4

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 GLY A 330
GLY A 333
SER A 361
GLU A 373
ALA A 375
 None
 1.03A 5o96G-5hf4A:
undetectable		 5o96G-5hf4A:
17.48