SIMILAR PATTERNS OF AMINO ACIDS FOR 5O87_A_NCTA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 TYR A 181
TYR A 134
VAL A 440
MET A 444
ILE A 491
 None
 1.35A 5o87A-1jf5A:
0.0
5o87B-1jf5A:
0.0		 5o87A-1jf5A:
10.13
5o87B-1jf5A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 TRP G  68
VAL G 123
CYH G 104
VAL G 118
ILE G  65
 None
None
SF4  G 482 (-2.4A)
SF4  G 483 (-4.1A)
SF4  G 483 (-4.7A)
 1.35A 5o87A-2vdcG:
0.0
5o87B-2vdcG:
0.0		 5o87A-2vdcG:
10.04
5o87B-2vdcG:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 VAL A 149
TYR A 213
CYH A 215
VAL A 159
ILE A 207
 None
 1.18A 5o87A-3juxA:
0.0
5o87B-3juxA:
0.0		 5o87A-3juxA:
6.95
5o87B-3juxA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)

(Mycobacterium
tuberculosis) 		PF00857
(Isochorismatase) 		5 TYR A  41
VAL A 130
TYR A  34
VAL A 139
ILE A   6
 None
 0.93A 5o87A-3pl1A:
0.0
5o87B-3pl1A:
0.0		 5o87A-3pl1A:
19.13
5o87B-3pl1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 5 TYR A 248
VAL A 191
CYH A 308
VAL A 166
MET A 170
 None
None
GST  A 511 (-3.4A)
None
None
 1.32A 5o87A-3v1vA:
undetectable
5o87B-3v1vA:
undetectable		 5o87A-3v1vA:
11.11
5o87B-3v1vA:
11.11