SIMILAR PATTERNS OF AMINO ACIDS FOR 5NZY_A_CE3A1103_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 TYR A 358
ASP A 348
VAL A 146
GLY A 147
HEM  A3000 (-3.9A)
None
HEM  A3000 (-4.7A)
HEM  A3000 (-3.8A)
0.96A 5nzyA-1dgfA:
undetectable
5nzyA-1dgfA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus)
PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH)
4 THR A 260
GLN A 262
ASP A 165
GLY A 235
None
0.98A 5nzyA-1ee8A:
undetectable
5nzyA-1ee8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli)
PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 TYR A 217
GLN A 187
VAL A 180
GLY A 147
None
0.82A 5nzyA-1gvhA:
undetectable
5nzyA-1gvhA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7k CATALASE

(Proteus
mirabilis)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 TYR A 337
ASP A 327
VAL A 125
GLY A 126
HEM  A 600 (-3.8A)
None
HEM  A 600 (-4.9A)
HEM  A 600 (-3.8A)
0.98A 5nzyA-1h7kA:
undetectable
5nzyA-1h7kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE


(Escherichia
coli)
PF01791
(DeoC)
4 PRO A 179
TYR A 215
VAL A 206
GLY A 205
None
0.99A 5nzyA-1ktnA:
2.6
5nzyA-1ktnA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p33 PTERIDINE REDUCTASE
1


(Leishmania
tarentolae)
PF13561
(adh_short_C2)
4 THR A   5
PRO A   7
TYR A  31
VAL A 105
None
1.00A 5nzyA-1p33A:
undetectable
5nzyA-1p33A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc9 CYSTEINE-RICH
SECRETORY PROTEIN


(Trimeresurus
stejnegeri)
PF00188
(CAP)
PF08562
(Crisp)
4 THR A 157
PRO A 160
TYR A 161
VAL A  29
None
0.99A 5nzyA-1rc9A:
undetectable
5nzyA-1rc9A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg)
4 TYR A  72
ASP A 151
VAL A 143
GLY A 144
ADP  A 400 (-3.6A)
GLA  A 500 (-3.0A)
None
None
1.00A 5nzyA-1s4eA:
undetectable
5nzyA-1s4eA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 TYR A 337
ASP A 327
VAL A 125
GLY A 126
HEM  A 501 (-3.8A)
None
HEM  A 501 (-4.8A)
HEM  A 501 (-3.8A)
0.96A 5nzyA-1si8A:
undetectable
5nzyA-1si8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa)
PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel)
4 TYR A 379
ASP A 369
VAL A 163
GLY A 164
HDD  A1880 ( 4.0A)
None
HDD  A1880 ( 4.8A)
HDD  A1880 ( 3.9A)
0.88A 5nzyA-1sy7A:
undetectable
5nzyA-1sy7A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT
BIPHENYL DIOXYGENASE
SMALL SUBUNIT


(Rhodococcus
jostii)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B)
4 GLN B 175
ASP B 145
GLY A 371
ARG B  91
None
0.97A 5nzyA-1uliB:
undetectable
5nzyA-1uliB:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB


(Escherichia
coli)
PF00496
(SBP_bac_5)
4 THR A  17
ASP A 174
VAL A  11
GLY A  12
None
1.02A 5nzyA-1uqwA:
undetectable
5nzyA-1uqwA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE


(Plasmodium
falciparum)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 320
ASP A 234
VAL A 205
GLY A 204
NAD  A 501 (-3.8A)
ADN  A 502 (-2.8A)
None
None
0.83A 5nzyA-1v8bA:
2.3
5nzyA-1v8bA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wk9 VALYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00133
(tRNA-synt_1)
4 THR A 219
PRO A 217
TYR A 198
GLY A 195
TSB  A 999 (-3.8A)
None
None
None
0.77A 5nzyA-1wk9A:
undetectable
5nzyA-1wk9A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012


(Homo sapiens)
PF08925
(DUF1907)
4 PRO A  11
TYR A 196
VAL A  19
GLY A  18
None
0.95A 5nzyA-1xcrA:
undetectable
5nzyA-1xcrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY


(Enterococcus
faecalis)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 THR A 176
PRO A 178
TYR A 180
GLY A 121
None
0.90A 5nzyA-1yv9A:
3.1
5nzyA-1yv9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN


(Porphyromonas
gingivalis)
PF04371
(PAD_porph)
4 PRO A 290
TYR A 292
VAL A 322
GLY A 326
None
0.73A 5nzyA-1zbrA:
undetectable
5nzyA-1zbrA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1


(Saccharomyces
cerevisiae)
no annotation 4 THR A 283
GLN A 152
VAL A 356
GLY A 357
None
0.93A 5nzyA-2be1A:
undetectable
5nzyA-2be1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE


(Xanthobacter
autotrophicus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 THR A 446
TYR A 260
VAL A 470
GLY A 471
None
0.82A 5nzyA-2c3dA:
undetectable
5nzyA-2c3dA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE


(Pyrococcus
horikoshii)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg)
4 TYR A  70
ASP A 149
VAL A 141
GLY A 142
APW  A 402 (-3.8A)
GLA  A 401 (-3.1A)
None
None
1.03A 5nzyA-2dejA:
undetectable
5nzyA-2dejA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg2 APOLIPOPROTEIN A-I
BINDING PROTEIN


(Mus musculus)
PF03853
(YjeF_N)
4 THR A 222
PRO A 205
ASP A 188
GLY A 192
None
0.89A 5nzyA-2dg2A:
2.8
5nzyA-2dg2A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 TYR A 339
ASP A 329
VAL A 127
GLY A 128
HEM  A 550 (-3.8A)
None
HEM  A 550 (-4.8A)
HEM  A 550 (-3.9A)
0.97A 5nzyA-2iqfA:
undetectable
5nzyA-2iqfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 TYR A 339
ASP A 329
VAL A 127
GLY A 128
HEM  A 501 (-3.8A)
None
HEM  A 501 ( 4.8A)
HEM  A 501 (-3.7A)
0.93A 5nzyA-2j2mA:
undetectable
5nzyA-2j2mA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jer AGMATINE DEIMINASE

(Enterococcus
faecalis)
PF04371
(PAD_porph)
4 PRO A 317
TYR A 319
VAL A 349
GLY A 353
None
None
None
AGT  A 357 ( 3.8A)
0.86A 5nzyA-2jerA:
undetectable
5nzyA-2jerA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdr UNCHARACTERIZED
PROTEIN


(Nostoc
punctiforme)
PF14499
(DUF4437)
4 TYR A 133
ASP A 111
VAL A 218
GLY A 217
None
0.90A 5nzyA-2qdrA:
undetectable
5nzyA-2qdrA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhx PTERIDINE REDUCTASE
1


(Leishmania
major)
PF00106
(adh_short)
PF13561
(adh_short_C2)
4 THR A   5
PRO A   7
TYR A  31
VAL A 105
None
0.96A 5nzyA-2qhxA:
undetectable
5nzyA-2qhxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
4 THR A 494
PRO A 502
ASP A 547
GLY A 445
None
0.97A 5nzyA-2wk2A:
1.4
5nzyA-2wk2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1f MRNA
3'-END-PROCESSING
PROTEIN RNA15


(Saccharomyces
cerevisiae)
PF00076
(RRM_1)
4 PRO A  16
TYR A  93
ASP A  68
VAL A  76
None
1.04A 5nzyA-2x1fA:
undetectable
5nzyA-2x1fA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum)
PF07940
(Hepar_II_III)
PF16332
(DUF4962)
4 PRO A 185
GLN A 200
VAL A 259
GLY A 256
None
1.00A 5nzyA-3aflA:
undetectable
5nzyA-3aflA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei)
PF00232
(Glyco_hydro_1)
4 ASP A  60
VAL A 435
GLY A 434
ARG A 389
None
1.04A 5nzyA-3ahyA:
1.2
5nzyA-3ahyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 338
ASP A 252
VAL A 223
GLY A 222
NAD  A 550 (-4.1A)
ADN  A 500 (-2.7A)
None
None
0.91A 5nzyA-3ce6A:
2.8
5nzyA-3ce6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus)
PF00679
(EFG_C)
4 THR A 282
PRO A 284
VAL A 240
GLY A 239
None
0.97A 5nzyA-3e3xA:
undetectable
5nzyA-3e3xA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN


(Mycobacterium
avium)
PF00199
(Catalase)
4 TYR A  34
ASP A 208
GLY A  31
ARG A  63
None
None
None
HEM  A 501 (-3.6A)
0.95A 5nzyA-3e4wA:
undetectable
5nzyA-3e4wA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eje ACYL CARRIER PROTEIN

(Escherichia
coli)
PF00550
(PP-binding)
4 THR A  84
ASP A  55
VAL A  37
GLY A  32
None
0.96A 5nzyA-3ejeA:
undetectable
5nzyA-3ejeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
BIPHENYL DIOXYGENASE
SUBUNIT BETA


(Comamonas
testosteroni)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B)
4 GLN B 174
ASP B 144
GLY A 379
ARG B  90
None
1.04A 5nzyA-3gzyB:
undetectable
5nzyA-3gzyB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE


(Pseudomonas
putida)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
4 THR A 158
TYR A 127
ASP A 114
GLY A 165
None
0.90A 5nzyA-3h8fA:
2.6
5nzyA-3h8fA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus)
PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 TYR A 118
GLN A 375
GLY A  46
ARG A  45
None
1.04A 5nzyA-3ho8A:
undetectable
5nzyA-3ho8A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE


(Bacillus
subtilis)
PF01593
(Amino_oxidase)
4 TYR A 177
GLN A 192
VAL A 448
GLY A 449
None
None
FAD  A 600 (-4.4A)
FAD  A 600 ( 3.7A)
0.85A 5nzyA-3i6dA:
undetectable
5nzyA-3i6dA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb5 MAJOR CAPSID PROTEIN

(Propionibacterium
virus PA6)
no annotation 4 THR A 146
ASP A 121
VAL A 178
GLY A 177
None
1.04A 5nzyA-3jb5A:
undetectable
5nzyA-3jb5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C


(Saccharomyces
cerevisiae)
PF00106
(adh_short)
4 THR A 128
GLN A 170
VAL A 118
GLY A 119
None
GOL  A 256 (-3.8A)
None
None
1.04A 5nzyA-3kzvA:
2.2
5nzyA-3kzvA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE


(Ehrlichia
chaffeensis)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
4 THR A 225
TYR A 342
GLN A 149
GLY A 366
None
None
UNX  A 426 ( 4.3A)
None
1.01A 5nzyA-3lp8A:
undetectable
5nzyA-3lp8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2


(Homo sapiens)
PF00850
(Hist_deacetyl)
4 TYR A 157
ASP A 109
VAL A 101
GLY A 102
None
0.73A 5nzyA-3maxA:
1.6
5nzyA-3maxA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE


(Brucella
abortus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 312
ASP A 226
VAL A 197
GLY A 196
NAD  A 550 (-4.0A)
ADN  A 500 ( 2.6A)
None
None
0.90A 5nzyA-3n58A:
2.5
5nzyA-3n58A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2


(Homo sapiens)
no annotation 4 THR B 430
ASP B 478
VAL B 546
GLY B 545
None
0.80A 5nzyA-3nr8B:
undetectable
5nzyA-3nr8B:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0h GLUTATHIONE
REDUCTASE


(Bartonella
henselae)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 THR A 333
PRO A 335
TYR A 337
VAL A 315
None
0.77A 5nzyA-3o0hA:
undetectable
5nzyA-3o0hA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator)
no annotation 4 TYR B 219
GLN B 189
VAL B 182
GLY B 149
None
0.82A 5nzyA-3ozvB:
undetectable
5nzyA-3ozvB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A


(Thermotoga
maritima)
PF00005
(ABC_tran)
4 THR A 836
GLN A 812
GLY A 468
ARG A 472
None
0.86A 5nzyA-3pihA:
undetectable
5nzyA-3pihA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE


(Vibrio cholerae)
PF00579
(tRNA-synt_1b)
4 TYR A  39
ASP A  34
VAL A  72
GLY A  71
None
0.73A 5nzyA-3sz3A:
undetectable
5nzyA-3sz3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE


(Sphaerobacter
thermophilus)
PF00583
(Acetyltransf_1)
4 PRO A 293
TYR A 296
VAL A 249
GLY A 250
None
0.84A 5nzyA-3tt2A:
undetectable
5nzyA-3tt2A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A


(Mycobacterium
tuberculosis)
PF00905
(Transpeptidase)
4 THR A 314
PRO A 365
GLY A 306
ARG A 388
None
0.98A 5nzyA-3upnA:
undetectable
5nzyA-3upnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE


(Agrobacterium
fabrum)
PF13407
(Peripla_BP_4)
4 THR A 310
GLN A 256
VAL A 111
GLY A 112
None
1.02A 5nzyA-3uugA:
undetectable
5nzyA-3uugA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)


(Mycobacterium
avium)
PF13561
(adh_short_C2)
4 THR A 171
ASP A 130
VAL A 181
GLY A 180
None
0.84A 5nzyA-3uveA:
undetectable
5nzyA-3uveA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcr PUTATIVE KDPG
(2-KETO-3-DEOXY-6-PH
OSPHOGLUCONATE)
ALDOLASE


(Oleispira
antarctica)
PF01081
(Aldolase)
4 THR A  47
ASP A  82
VAL A  66
GLY A  67
None
1.04A 5nzyA-3vcrA:
undetectable
5nzyA-3vcrA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
4 TYR A 325
GLN A 280
ASP A 311
GLY A 352
None
0.88A 5nzyA-3vi3A:
undetectable
5nzyA-3vi3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY


(Thermobifida
fusca)
PF09481
(CRISPR_Cse1)
4 PRO A 290
GLN A 308
VAL A 193
GLY A 192
None
0.81A 5nzyA-3wvoA:
undetectable
5nzyA-3wvoA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxf UNCHARACTERIZED
PROTEIN


(Danio rerio)
PF00443
(UCH)
4 THR A 724
PRO A 766
VAL A 842
GLY A 843
None
1.02A 5nzyA-3wxfA:
undetectable
5nzyA-3wxfA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zth STU0660

(Streptococcus
thermophilus)
PF16813
(Cas_St_Csn2)
4 THR A 285
PRO A 284
TYR A 278
VAL A 316
None
1.02A 5nzyA-3zthA:
undetectable
5nzyA-3zthA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II)
4 TYR A  33
ASP A 189
VAL A 267
GLY A 266
None
0.94A 5nzyA-3zzuA:
undetectable
5nzyA-3zzuA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 TYR A 389
ASP A 379
VAL A 173
GLY A 174
HEM  A1715 (-3.7A)
None
HEM  A1715 (-4.8A)
HEM  A1715 (-3.8A)
0.91A 5nzyA-4aj9A:
undetectable
5nzyA-4aj9A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 TYR A 369
ASP A 359
VAL A 157
GLY A 158
HEM  A 537 (-4.2A)
None
HEM  A 537 (-4.9A)
HEM  A 537 (-4.0A)
0.91A 5nzyA-4cabA:
undetectable
5nzyA-4cabA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL


(Homo sapiens)
PF00753
(Lactamase_B)
4 ASP A 146
VAL A 205
GLY A 187
ARG A 209
None
1.02A 5nzyA-4chlA:
6.4
5nzyA-4chlA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csi CELLULASE

(Humicola grisea)
PF00840
(Glyco_hydro_7)
4 PRO A 408
ASP A 180
VAL A 105
GLY A 106
None
0.96A 5nzyA-4csiA:
undetectable
5nzyA-4csiA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN


(Rhizobium etli)
PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2)
4 THR A 294
PRO A 296
ASP A  88
GLY A 307
None
0.96A 5nzyA-4dvjA:
3.4
5nzyA-4dvjA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
4 TYR A  27
GLN A  21
VAL A  42
GLY A  51
None
NA  A 602 ( 4.5A)
None
None
0.98A 5nzyA-4e1jA:
undetectable
5nzyA-4e1jA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e37 CATALASE

(Pseudomonas
aeruginosa)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 TYR A 338
ASP A 328
VAL A 126
GLY A 127
HEM  A 500 (-4.0A)
None
HEM  A 500 (-4.9A)
HEM  A 500 (-3.8A)
0.97A 5nzyA-4e37A:
undetectable
5nzyA-4e37A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6w CLBP PEPTIDASE

(Escherichia
coli)
PF00144
(Beta-lactamase)
4 THR A 147
ASP A 192
VAL A 105
GLY A 102
None
0.94A 5nzyA-4e6wA:
undetectable
5nzyA-4e6wA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcy THIAMINASE-I

(Naegleria
gruberi)
no annotation 4 PRO A 126
TYR A 246
VAL A 217
GLY A 220
None
0.93A 5nzyA-4hcyA:
undetectable
5nzyA-4hcyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1)
PF03970
(Herpes_UL37_1)
4 ASP A 315
VAL A 290
GLY A 289
ARG A 285
None
1.03A 5nzyA-4k70A:
undetectable
5nzyA-4k70A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9x CELL DEATH PROTEIN 4

(Caenorhabditis
elegans)
PF00619
(CARD)
PF00931
(NB-ARC)
4 THR A 332
PRO A 330
VAL A 290
GLY A 159
None
ATP  A 602 (-4.6A)
None
None
1.03A 5nzyA-4m9xA:
3.2
5nzyA-4m9xA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B


(Homo sapiens;
Mus musculus)
PF00027
(cNMP_binding)
PF00071
(Ras)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
4 THR R  65
GLN R  63
ASP E 796
GLY E 720
None
0.97A 5nzyA-4mh0R:
undetectable
5nzyA-4mh0R:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzw GLUTATHIONE
S-TRANSFERASE


(Streptococcus
sanguinis)
PF02798
(GST_N)
PF13410
(GST_C_2)
4 TYR A  45
GLN A 259
VAL A -12
GLY A -13
None
0.82A 5nzyA-4mzwA:
undetectable
5nzyA-4mzwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens)
PF08389
(Xpo1)
4 GLN B 682
ASP B 723
VAL B 708
GLY B 712
None
1.05A 5nzyA-4ol0B:
undetectable
5nzyA-4ol0B:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2


(Saccharomyces
cerevisiae)
PF00929
(RNase_T)
PF13423
(UCH_1)
4 THR A 516
GLN A 521
VAL A 533
GLY A 551
None
0.84A 5nzyA-4q8hA:
undetectable
5nzyA-4q8hA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfw ACYL-COA
THIOESTERASE II


(Yersinia pestis)
PF13622
(4HBT_3)
4 THR A 120
PRO A 122
TYR A 179
GLN A 264
None
1.04A 5nzyA-4qfwA:
undetectable
5nzyA-4qfwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF01964
(ThiC_Rad_SAM)
4 THR A 261
GLN A 287
VAL A 280
GLY A 281
None
0.99A 5nzyA-4s28A:
undetectable
5nzyA-4s28A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsh SURFACE PROTEIN
ADHESIN


(Streptococcus
mutans)
PF16364
(Antigen_C)
no annotation
4 THR B1160
PRO B1159
GLN B1312
GLY A  57
None
0.97A 5nzyA-4tshB:
undetectable
5nzyA-4tshB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yme SENSORY BOX/GGDEF
FAMILY PROTEIN


(Caulobacter
vibrioides)
PF00990
(GGDEF)
4 PRO A 503
TYR A 502
VAL A 397
GLY A 401
None
0.95A 5nzyA-4ymeA:
undetectable
5nzyA-4ymeA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH


(Synechocystis
sp. PCC 6803)
PF02514
(CobN-Mg_chel)
PF11965
(DUF3479)
4 TYR A 699
ASP A 739
VAL A 747
GLY A 748
None
0.84A 5nzyA-4zhjA:
undetectable
5nzyA-4zhjA:
15.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN


(Homo sapiens)
PF07522
(DRMBL)
PF12706
(Lactamase_B_2)
6 THR A 700
PRO A 702
TYR A 704
GLN A 718
ASP A 736
VAL A1018
None
0.59A 5nzyA-5ahrA:
47.6
5nzyA-5ahrA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN


(Homo sapiens)
PF07522
(DRMBL)
PF12706
(Lactamase_B_2)
6 THR A 700
PRO A 702
TYR A 704
GLN A 718
VAL A1018
GLY A1019
None
0.57A 5nzyA-5ahrA:
47.6
5nzyA-5ahrA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN


(Homo sapiens)
PF07522
(DRMBL)
PF12706
(Lactamase_B_2)
5 THR A 700
PRO A 702
VAL A1018
GLY A1019
ARG A1024
None
0.61A 5nzyA-5ahrA:
47.6
5nzyA-5ahrA:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK


(Drosophila
melanogaster)
PF00069
(Pkinase)
4 PRO A 152
TYR A 189
VAL A 221
GLY A 220
None
1.03A 5nzyA-5awmA:
undetectable
5nzyA-5awmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5y DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Colwellia
psychrerythraea)
PF01791
(DeoC)
4 PRO A 178
TYR A 212
VAL A 203
GLY A 202
None
1.02A 5nzyA-5c5yA:
2.1
5nzyA-5c5yA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3q DYNAMIN-1,DYNAMIN-1

(Homo sapiens)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
4 THR A 200
GLN A 284
VAL A 234
GLY A 233
None
0.98A 5nzyA-5d3qA:
undetectable
5nzyA-5d3qA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej2 CARVEOL
DEHYDROGENASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
4 THR A 175
ASP A 134
VAL A 185
GLY A 184
MPD  A 302 ( 4.2A)
None
None
None
0.82A 5nzyA-5ej2A:
undetectable
5nzyA-5ej2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE


(Thermus
thermophilus)
no annotation 4 THR C  59
ASP C 130
VAL C 126
ARG C 125
None
0.93A 5nzyA-5h9uC:
undetectable
5nzyA-5h9uC:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus)
no annotation 4 THR B 197
VAL B  99
GLY B 187
ARG B 136
None
0.98A 5nzyA-5hdfB:
undetectable
5nzyA-5hdfB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh3 OXYA PROTEIN

(Actinoplanes
teichomyceticus)
PF00067
(p450)
4 THR A 149
GLN A 115
VAL A 208
GLY A 207
HEM  A 401 ( 4.7A)
None
None
None
0.76A 5nzyA-5hh3A:
undetectable
5nzyA-5hh3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i84 PHOSPHATE-BINDING
PROTEIN PSTS


(Xanthomonas
citri)
PF12849
(PBP_like_2)
4 THR A 188
TYR A 217
VAL A 204
GLY A 198
PO4  A 403 ( 4.6A)
None
None
None
1.00A 5nzyA-5i84A:
undetectable
5nzyA-5i84A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2


(Saccharomyces
cerevisiae)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
4 THR B 549
PRO B 551
VAL B 585
GLY B 584
None
0.76A 5nzyA-5ip9B:
undetectable
5nzyA-5ip9B:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN


(Chaetomium
thermophilum)
no annotation 4 THR A1549
ASP A1759
VAL A1828
GLY A1842
None
0.96A 5nzyA-5nnlA:
undetectable
5nzyA-5nnlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE


(Ruminiclostridium
thermocellum)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
4 ASP A 621
VAL A 609
GLY A 610
ARG A 656
None
0.99A 5nzyA-5nz7A:
undetectable
5nzyA-5nz7A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2


(Homo sapiens)
PF03372
(Exo_endo_phos)
4 THR A 430
ASP A 478
VAL A 546
GLY A 545
None
0.79A 5nzyA-5okoA:
undetectable
5nzyA-5okoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnn PHOSPHATE-BINDING
PROTEIN PSTS


(Burkholderia
pseudomallei)
PF12849
(PBP_like_2)
4 THR A 184
TYR A 213
VAL A 200
GLY A 194
None
0.93A 5nzyA-5wnnA:
undetectable
5nzyA-5wnnA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 281
ASP A 195
VAL A 166
GLY A 165
NAD  A 500 (-4.0A)
ADN  A 501 (-2.7A)
None
None
0.85A 5nzyA-6aphA:
2.3
5nzyA-6aphA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE


(Bacillus
subtilis)
no annotation 4 THR A 305
PRO A 303
VAL A 223
GLY A 222
None
0.90A 5nzyA-6cgmA:
undetectable
5nzyA-6cgmA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d43 TRIOSEPHOSPHATE
ISOMERASE


(Homo sapiens)
no annotation 4 THR B 204
ASP B  36
VAL B  40
GLY B   9
None
0.91A 5nzyA-6d43B:
2.7
5nzyA-6d43B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eub ANGIOPOIETIN-RELATED
PROTEIN 4


(Homo sapiens)
no annotation 4 TYR A 244
ASP A 332
GLY A 361
ARG A 230
None
0.95A 5nzyA-6eubA:
undetectable
5nzyA-6eubA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-)
no annotation 4 THR B 298
ASP B 198
VAL B 169
GLY B 168
NAD  B 501 (-4.1A)
ADN  B 502 (-2.7A)
None
None
0.90A 5nzyA-6f3mB:
2.1
5nzyA-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-)
no annotation 4 THR A 279
ASP A 193
VAL A 164
GLY A 163
NAD  A 502 (-4.1A)
ADN  A 501 (-2.7A)
None
None
0.82A 5nzyA-6gbnA:
2.3
5nzyA-6gbnA:
undetectable