SIMILAR PATTERNS OF AMINO ACIDS FOR 5NZY_A_CE3A1102_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE


(Trifolium
repens)
PF00232
(Glyco_hydro_1)
4 ASN A 398
THR A 252
ILE A 395
GLY A 322
None
0.99A 5nzyA-1cbgA:
1.4
5nzyA-1cbgA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egz ENDOGLUCANASE Z

(Dickeya
chrysanthemi)
PF00150
(Cellulase)
4 PHE A 113
THR A 190
ILE A 130
GLY A 166
None
0.96A 5nzyA-1egzA:
1.4
5nzyA-1egzA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0b CELLULASE

(Rhodothermus
marinus)
PF01670
(Glyco_hydro_12)
4 ASN A  42
PHE A  43
THR A  89
ILE A  62
None
0.88A 5nzyA-1h0bA:
undetectable
5nzyA-1h0bA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE


(Pseudomonas sp.
CF600)
PF00682
(HMGL-like)
PF07836
(DmpG_comm)
4 THR A  15
GLN A 272
ILE A  23
GLY A  19
None
0.89A 5nzyA-1nvmA:
0.0
5nzyA-1nvmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB


(Escherichia
coli)
PF08501
(Shikimate_dh_N)
4 THR A  93
GLN A  26
ILE A  10
GLY A  65
None
0.97A 5nzyA-1o9bA:
2.2
5nzyA-1o9bA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT


(Paracoccus
denitrificans)
PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII)
4 ARG A 254
GLN A 242
ILE A 243
GLY A 253
None
0.94A 5nzyA-1pbyA:
undetectable
5nzyA-1pbyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvp CELLULASE

(Pseudoalteromonas
haloplanktis)
PF00150
(Cellulase)
4 PHE A 115
THR A 192
ILE A 132
GLY A 168
None
0.98A 5nzyA-1tvpA:
2.7
5nzyA-1tvpA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvt TRANSACTIVATOR
PROTEIN


(Equine
infectious
anemia virus)
PF00539
(Tat)
4 ASN A  58
GLN A  66
ILE A  65
GLY A  68
None
0.98A 5nzyA-1tvtA:
undetectable
5nzyA-1tvtA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III


(Cucumaria
echinata)
PF00652
(Ricin_B_lectin)
4 PHE A 144
GLN A 142
ILE A 122
GLY A 124
None
None
None
CA  A1002 (-4.3A)
0.94A 5nzyA-1vclA:
undetectable
5nzyA-1vclA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vki HYPOTHETICAL PROTEIN
ATU3699


(Agrobacterium
fabrum)
PF04073
(tRNA_edit)
4 PHE A  15
THR A 107
ILE A 112
GLY A 110
None
0.98A 5nzyA-1vkiA:
0.9
5nzyA-1vkiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE


(Escherichia
virus T4)
PF11440
(AGT)
4 ASN A1095
THR A1130
ILE A1093
GLY A1126
None
0.95A 5nzyA-1xv5A:
undetectable
5nzyA-1xv5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN


(Listeria
monocytogenes)
PF01717
(Meth_synt_2)
4 ASN A  43
THR A  18
ILE A  41
GLY A  20
None
0.99A 5nzyA-1ypxA:
2.5
5nzyA-1ypxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
4 ASN A 451
ARG A 580
ILE A 450
GLY A 581
None
0.99A 5nzyA-1z8lA:
undetectable
5nzyA-1z8lA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2


(Homo sapiens)
PF02893
(GRAM)
PF06602
(Myotub-related)
4 ASN A 523
ARG A 528
GLN A 526
GLY A 529
None
0.98A 5nzyA-1zsqA:
undetectable
5nzyA-1zsqA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 THR A 135
GLN A 169
ILE A   4
GLY A   6
None
0.70A 5nzyA-2ag1A:
3.3
5nzyA-2ag1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjo ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN
OHRB


(Bacillus
subtilis)
PF02566
(OsmC)
4 ASN A  43
ARG A  14
ILE A  29
GLY A  13
None
0.90A 5nzyA-2bjoA:
undetectable
5nzyA-2bjoA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwa ENDOGLUCANASE

(Rhodothermus
marinus)
PF01670
(Glyco_hydro_12)
4 ASN A  42
PHE A  43
THR A  89
ILE A  62
None
0.84A 5nzyA-2bwaA:
undetectable
5nzyA-2bwaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czy PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3B


(Mus musculus)
PF02671
(PAH)
4 PHE A  58
ARG A  78
ILE A  61
GLY A  74
None
0.83A 5nzyA-2czyA:
undetectable
5nzyA-2czyA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B


(Streptococcus
pneumoniae)
PF00905
(Transpeptidase)
4 THR B 667
GLN B 705
ILE B 711
GLY B 713
None
0.91A 5nzyA-2fffB:
undetectable
5nzyA-2fffB:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN


(Homo sapiens)
PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2)
4 ASN A 379
THR A 387
GLN A 357
ILE A 356
None
0.97A 5nzyA-2gjxA:
undetectable
5nzyA-2gjxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA


(Homo sapiens)
no annotation 4 ASN I 379
THR I 387
GLN I 357
ILE I 356
None
0.94A 5nzyA-2gk1I:
undetectable
5nzyA-2gk1I:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jch PENICILLIN-BINDING
PROTEIN 1B


(Streptococcus
pneumoniae)
PF00905
(Transpeptidase)
PF00912
(Transgly)
4 THR A 667
GLN A 705
ILE A 711
GLY A 713
None
0.92A 5nzyA-2jchA:
undetectable
5nzyA-2jchA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7e TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 14


(Saccharomyces
cerevisiae)
PF03366
(YEATS)
4 ASN A 123
GLN A 119
ILE A 120
GLY A  97
None
0.98A 5nzyA-2l7eA:
undetectable
5nzyA-2l7eA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfe E3 UBIQUITIN-PROTEIN
LIGASE HECW2


(Homo sapiens)
PF16562
(HECW_N)
4 ASN A 110
THR A 116
ILE A 121
GLY A 119
None
0.93A 5nzyA-2lfeA:
undetectable
5nzyA-2lfeA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2op6 HEAT SHOCK 70 KDA
PROTEIN D


(Caenorhabditis
elegans)
PF00012
(HSP70)
4 ASN A 483
PHE A 484
ILE A 467
GLY A 427
None
1.00A 5nzyA-2op6A:
undetectable
5nzyA-2op6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p38 PROTEIN INVOLVED IN
RIBOSOMAL BIOGENESIS


(Pyrococcus
abyssi)
PF03657
(UPF0113)
4 ASN A 146
PHE A 153
ILE A 145
GLY A 126
None
0.89A 5nzyA-2p38A:
undetectable
5nzyA-2p38A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens)
PF00067
(p450)
4 PHE A 238
THR A 214
GLN A 234
GLY A 217
None
0.95A 5nzyA-2pg6A:
undetectable
5nzyA-2pg6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvz PRPF METHYLACONITATE
ISOMERASE


(Shewanella
oneidensis)
PF04303
(PrpF)
4 THR A 323
GLN A 141
ILE A 148
GLY A 108
EDO  A1005 (-3.1A)
None
None
EDO  A1005 (-3.8A)
0.98A 5nzyA-2pvzA:
undetectable
5nzyA-2pvzA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdx FERREDOXIN REDUCTASE

(Pseudomonas
aeruginosa)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 ARG A 190
THR A 181
GLN A 191
GLY A 189
SO4  A 401 (-4.0A)
SO4  A 401 (-3.1A)
None
None
0.85A 5nzyA-2qdxA:
undetectable
5nzyA-2qdxA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r47 UNCHARACTERIZED
PROTEIN MTH_862


(Methanothermobacter
thermautotrophicus)
PF09897
(DUF2124)
4 ASN A  52
THR A  69
GLN A  41
GLY A  72
None
0.95A 5nzyA-2r47A:
3.1
5nzyA-2r47A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA


(Aspergillus
nidulans)
PF05368
(NmrA)
4 PHE A 181
THR A 219
ILE A 152
GLY A 151
None
None
NAD  A1353 (-4.3A)
NAD  A1353 (-4.7A)
0.93A 5nzyA-2vutA:
undetectable
5nzyA-2vutA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE


(Staphylococcus
aureus)
PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N)
4 ARG A 188
THR A 189
ILE A   8
GLY A 187
None
0.89A 5nzyA-2wqdA:
1.6
5nzyA-2wqdA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I


(Homo sapiens)
PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR)
4 ASN A 159
THR A 185
GLN A 189
GLY A 187
NAG  A 659 (-1.9A)
None
None
None
0.92A 5nzyA-2xrcA:
undetectable
5nzyA-2xrcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK


([Ruminococcus]
gnavus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
4 ARG A 203
GLN A 551
ILE A 550
GLY A 553
None
1.01A 5nzyA-2yfnA:
undetectable
5nzyA-2yfnA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2


(Homo sapiens)
PF04146
(YTH)
4 ASN A  20
GLN A  26
ILE A  23
GLY A  28
None
0.97A 5nzyA-2yu6A:
undetectable
5nzyA-2yu6A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN


(Yersinia pestis)
no annotation 5 ASN X  48
THR X   5
GLN X  44
ILE X  45
GLY X   6
None
1.26A 5nzyA-2z22X:
undetectable
5nzyA-2z22X:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zym SOLUTE-BINDING
PROTEIN


(Thermoactinomyces
vulgaris)
PF13416
(SBP_bac_8)
4 PHE A 189
THR A  90
ILE A 353
GLY A  86
None
0.92A 5nzyA-2zymA:
undetectable
5nzyA-2zymA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7m CELLULASE

(Rhodothermus
marinus)
PF01670
(Glyco_hydro_12)
4 ASN A  42
PHE A  43
THR A  80
ILE A  62
None
0.89A 5nzyA-3b7mA:
undetectable
5nzyA-3b7mA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae)
PF00806
(PUF)
4 THR A 650
GLN A 691
ILE A 690
GLY A 686
None
0.87A 5nzyA-3bwtA:
undetectable
5nzyA-3bwtA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli)
PF10672
(Methyltrans_SAM)
4 ASN A 322
GLN A 327
ILE A 326
GLY A 361
None
0.92A 5nzyA-3c0kA:
2.0
5nzyA-3c0kA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN


(Bifidobacterium
longum)
PF02541
(Ppx-GppA)
4 PHE A  78
THR A  95
ILE A  28
GLY A  24
None
SO4  A 344 ( 3.5A)
None
SO4  A 344 (-3.3A)
0.84A 5nzyA-3cerA:
undetectable
5nzyA-3cerA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 ASN A1249
PHE A1255
THR A  74
GLY A  71
None
None
ADP  A 502 (-4.0A)
ADP  A 502 (-3.3A)
0.90A 5nzyA-3cmtA:
2.5
5nzyA-3cmtA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 ASN A2249
PHE A2255
THR A1074
GLY A1071
None
None
ADP  A1502 (-3.9A)
ADP  A1502 (-3.4A)
0.90A 5nzyA-3cmtA:
2.5
5nzyA-3cmtA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 ASN A3249
PHE A3255
THR A2074
GLY A2071
None
None
ADP  A2502 (-3.8A)
ADP  A2502 (-3.4A)
0.90A 5nzyA-3cmtA:
2.5
5nzyA-3cmtA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 ASN A4249
PHE A4255
THR A3074
GLY A3071
None
None
ADP  A3502 (-3.7A)
ADP  A3502 (-3.4A)
0.90A 5nzyA-3cmtA:
2.5
5nzyA-3cmtA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 ASN A1249
PHE A1255
THR A  74
GLY A  71
None
None
ADP  A 502 (-3.9A)
ADP  A 502 (-3.0A)
0.92A 5nzyA-3cmuA:
undetectable
5nzyA-3cmuA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 ASN A2249
PHE A2255
THR A1074
GLY A1071
None
None
ADP  A1502 (-3.5A)
ADP  A1502 (-2.8A)
0.95A 5nzyA-3cmuA:
undetectable
5nzyA-3cmuA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 ASN A3249
PHE A3255
THR A2074
GLY A2071
None
None
ADP  A2502 (-3.9A)
ADP  A2502 (-2.8A)
1.01A 5nzyA-3cmuA:
undetectable
5nzyA-3cmuA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 ASN A4249
PHE A4255
THR A3074
GLY A3071
None
None
ADP  A3502 (-3.7A)
ADP  A3502 (-2.7A)
0.95A 5nzyA-3cmuA:
undetectable
5nzyA-3cmuA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 ASN A5249
PHE A5255
THR A4074
GLY A4071
None
None
ADP  A4502 (-3.8A)
ADP  A4502 (-2.8A)
0.95A 5nzyA-3cmuA:
undetectable
5nzyA-3cmuA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4b ALGK

(Pseudomonas
fluorescens)
no annotation 4 ARG A 208
THR A 210
GLN A 201
GLY A 205
None
0.98A 5nzyA-3e4bA:
undetectable
5nzyA-3e4bA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3erv PUTATIVE C39-LIKE
PEPTIDASE


(Bacillus
anthracis)
PF13529
(Peptidase_C39_2)
4 ASN A  95
THR A  75
ILE A 119
GLY A  71
None
None
EDO  A   1 (-3.9A)
None
0.95A 5nzyA-3ervA:
undetectable
5nzyA-3ervA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3es5 PUTATIVE CAPSID
PROTEIN


(Penicillium
stoloniferum
virus F)
no annotation 4 ARG A  97
GLN A  99
ILE A  98
GLY A  95
None
0.92A 5nzyA-3es5A:
undetectable
5nzyA-3es5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum)
no annotation 4 ASN A 236
THR A  73
ILE A 238
GLY A  74
None
0.96A 5nzyA-3gjyA:
undetectable
5nzyA-3gjyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE


(Yersinia pestis)
PF00425
(Chorismate_bind)
4 ARG A 134
THR A 139
GLN A  39
GLY A  34
None
0.69A 5nzyA-3gseA:
undetectable
5nzyA-3gseA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1


(Schizosaccharomyces
pombe)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
4 THR A1144
GLN A1140
ILE A1141
GLY A1281
None
0.94A 5nzyA-3h0gA:
undetectable
5nzyA-3h0gA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ico 6-PHOSPHOGLUCONOLACT
ONASE


(Mycobacterium
tuberculosis)
PF01182
(Glucosamine_iso)
4 THR A 233
GLN A 192
ILE A 191
GLY A 229
None
0.93A 5nzyA-3icoA:
2.2
5nzyA-3icoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE


(Streptococcus
pneumoniae)
PF00698
(Acyl_transf_1)
4 ASN A 268
PHE A 269
GLN A 262
ILE A 266
None
0.94A 5nzyA-3im8A:
undetectable
5nzyA-3im8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES6


(Plasmodium
falciparum)
PF01092
(Ribosomal_S6e)
4 PHE H  77
THR H  69
ILE H  64
GLY H  99
None
0.94A 5nzyA-3j7aH:
undetectable
5nzyA-3j7aH:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00171
(Aldedh)
4 ASN A 197
THR A 205
GLN A 200
GLY A  35
None
0.96A 5nzyA-3ju8A:
undetectable
5nzyA-3ju8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juu PORPHYRANASE B

(Zobellia
galactanivorans)
PF00722
(Glyco_hydro_16)
4 ASN A 168
GLN A 165
ILE A 166
GLY A 164
None
0.99A 5nzyA-3juuA:
undetectable
5nzyA-3juuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE


(Lactobacillus
brevis)
PF00348
(polyprenyl_synt)
4 THR A  55
GLN A 193
ILE A 197
GLY A 195
None
0.94A 5nzyA-3m9uA:
undetectable
5nzyA-3m9uA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mep UNCHARACTERIZED
PROTEIN ECA2234


(Pectobacterium
atrosepticum)
PF07081
(DUF1349)
4 PHE A  73
THR A 118
ILE A  96
GLY A 106
None
0.90A 5nzyA-3mepA:
undetectable
5nzyA-3mepA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
4 ARG A 204
GLN A 560
ILE A 559
GLY A 562
None
0.93A 5nzyA-3mi6A:
undetectable
5nzyA-3mi6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN


(Staphylococcus
aureus)
PF13468
(Glyoxalase_3)
4 PHE A  40
ARG A 264
ILE A 263
GLY A 265
None
0.80A 5nzyA-3p8aA:
undetectable
5nzyA-3p8aA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN


(Actinobacillus
pleuropneumoniae)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
4 ASN A 144
PHE A 200
ILE A 146
GLY A 286
None
1.00A 5nzyA-3pqsA:
undetectable
5nzyA-3pqsA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE


(Mycobacteroides
abscessus)
PF01182
(Glucosamine_iso)
4 THR A 234
GLN A 193
ILE A 192
GLY A 230
None
0.98A 5nzyA-3tx2A:
undetectable
5nzyA-3tx2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch)
4 ASN A 450
THR A 798
GLN A 759
GLY A 755
None
1.01A 5nzyA-4a4zA:
3.0
5nzyA-4a4zA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF01369
(Sec7)
PF16453
(IQ_SEC7_PH)
4 PHE A 413
ARG A 449
THR A 592
ILE A 452
None
0.98A 5nzyA-4c0aA:
undetectable
5nzyA-4c0aA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
cruzi)
PF00348
(polyprenyl_synt)
4 PHE A 321
THR A 208
GLN A 249
GLY A 243
None
IPE  A 405 ( 4.6A)
None
None
0.92A 5nzyA-4e1eA:
undetectable
5nzyA-4e1eA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB


(Geobacillus
stearothermophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
4 ARG A 203
GLN A 559
ILE A 558
GLY A 561
None
1.01A 5nzyA-4fnqA:
undetectable
5nzyA-4fnqA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j05 PHOSPHATE
TRANSPORTER


(Serendipita
indica)
PF00083
(Sugar_tr)
4 ASN A 431
PHE A 426
THR A 496
GLY A 492
PO4  A 600 (-3.1A)
None
None
None
0.86A 5nzyA-4j05A:
undetectable
5nzyA-4j05A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3


(Saccharomyces
cerevisiae)
PF05238
(CENP-N)
no annotation
4 ASN B 405
THR A 153
ILE B 409
GLY B 412
None
1.01A 5nzyA-4je3B:
undetectable
5nzyA-4je3B:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpw HEAVY CHAIN OF
ANTIBODY 12A21


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 ARG H  66
GLN H  68
ILE H  67
GLY H  65
None
1.00A 5nzyA-4jpwH:
undetectable
5nzyA-4jpwH:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE


(Leishmania
major)
PF00348
(polyprenyl_synt)
4 PHE A 321
THR A 208
GLN A 249
GLY A 243
None
IPE  A 401 ( 3.4A)
None
None
0.95A 5nzyA-4jzxA:
undetectable
5nzyA-4jzxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1c VACUOLAR CALCIUM ION
TRANSPORTER


(Saccharomyces
cerevisiae)
PF01699
(Na_Ca_ex)
4 ASN A  80
THR A 261
ILE A 256
GLY A 259
None
0.91A 5nzyA-4k1cA:
undetectable
5nzyA-4k1cA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC


([Bacillus]
selenitireducens)
PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N)
4 PHE A 666
THR A  45
ILE A  27
GLY A  30
None
0.96A 5nzyA-4ktpA:
undetectable
5nzyA-4ktpA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8j PUTATIVE EFFLUX
TRANSPORTER


(Bacteroides
eggerthii)
PF16576
(HlyD_D23)
4 ASN A  69
GLN A  66
ILE A  67
GLY A  65
None
0.90A 5nzyA-4l8jA:
undetectable
5nzyA-4l8jA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome)
PF00150
(Cellulase)
4 PHE A 112
THR A 190
ILE A 129
GLY A 165
None
0.96A 5nzyA-4m1rA:
undetectable
5nzyA-4m1rA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN


(Sebaldella
termitidis)
PF00977
(His_biosynth)
4 PHE A 247
THR A  32
ILE A 239
GLY A 258
None
GOL  A 307 (-3.6A)
None
GOL  A 307 (-3.6A)
1.00A 5nzyA-4ml9A:
undetectable
5nzyA-4ml9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4f INOSITOL
HEXAKISPHOSPHATE
KINASE


(Entamoeba
histolytica)
PF03770
(IPK)
4 PHE A 232
THR A  61
ILE A  64
GLY A  62
None
0.97A 5nzyA-4o4fA:
undetectable
5nzyA-4o4fA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS


(Homo sapiens)
PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
4 PHE A 802
THR A 819
ILE A 810
GLY A 813
None
1.01A 5nzyA-4pj3A:
2.1
5nzyA-4pj3A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2)
4 ASN P 212
ARG P 214
ILE P 213
GLY P 215
None
0.84A 5nzyA-4s2tP:
undetectable
5nzyA-4s2tP:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN


(Homo sapiens)
PF07522
(DRMBL)
PF12706
(Lactamase_B_2)
6 ASN A 938
PHE A 939
ARG A 960
THR A 962
ILE A 986
GLY A 988
None
0.60A 5nzyA-5ahrA:
47.6
5nzyA-5ahrA:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 ASN A 376
PHE A 379
THR A 369
GLY A 336
None
0.79A 5nzyA-5enyA:
2.1
5nzyA-5enyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta)
PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8)
4 ARG A 378
THR A 406
GLN A 323
GLY A 379
None
0.93A 5nzyA-5gmhA:
undetectable
5nzyA-5gmhA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Paraburkholderia
xenovorans)
PF00982
(Glyco_transf_20)
4 PHE A 286
ARG A 333
ILE A 330
GLY A 332
None
EDO  A 506 ( 3.1A)
None
None
0.96A 5nzyA-5hxaA:
undetectable
5nzyA-5hxaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2u CELLULASE

(soil metagenome)
PF00150
(Cellulase)
4 PHE A 123
THR A 200
ILE A 140
GLY A 175
None
0.93A 5nzyA-5i2uA:
2.2
5nzyA-5i2uA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik8 LAMININ SUBUNIT
ALPHA-2


(Mus musculus)
PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2)
4 PHE A2799
THR A2866
ILE A2848
GLY A2855
None
0.99A 5nzyA-5ik8A:
undetectable
5nzyA-5ik8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iku COLLAGENASE

(Hathewaya
histolytica)
PF04151
(PPC)
4 PHE A 815
THR A 836
ILE A 825
GLY A 852
None
1.00A 5nzyA-5ikuA:
undetectable
5nzyA-5ikuA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)


(Agrobacterium
fabrum)
PF13416
(SBP_bac_8)
4 ASN A 178
PHE A 179
GLN A 242
GLY A 241
None
0.99A 5nzyA-5l9sA:
undetectable
5nzyA-5l9sA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2m LLAMA NANOBODY VHH3

(Lama glama)
no annotation 4 ASN D  62
ARG D  55
ILE D  56
GLY D  40
ASN  D  62 ( 0.6A)
ARG  D  55 ( 0.6A)
ILE  D  56 ( 0.6A)
GLY  D  40 ( 0.0A)
0.92A 5nzyA-5m2mD:
undetectable
5nzyA-5m2mD:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE


(Fusobacterium
nucleatum)
PF00480
(ROK)
4 THR A 173
GLN A 240
ILE A 238
GLY A 236
None
1.01A 5nzyA-5nckA:
undetectable
5nzyA-5nckA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0x PUTATIVE FERRIC
REDUCTASE


(Cylindrospermum
stagnale)
PF08022
(FAD_binding_8)
PF08030
(NAD_binding_6)
4 ASN A 439
PHE A 438
THR A 523
GLY A 443
PEG  A 821 (-4.9A)
None
None
None
0.69A 5nzyA-5o0xA:
2.9
5nzyA-5o0xA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN


(Burkholderia
ambifaria)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ASN A 118
PHE A 142
THR A 180
GLY A 177
None
None
None
CIT  A 401 ( 4.8A)
0.98A 5nzyA-5tnxA:
2.2
5nzyA-5tnxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Paraburkholderia
xenovorans)
PF00982
(Glyco_transf_20)
4 PHE A 291
ARG A 338
ILE A 335
GLY A 337
None
0.96A 5nzyA-5v0tA:
undetectable
5nzyA-5v0tA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN


(Vibrio
vulnificus)
no annotation 4 PHE A3696
ARG A3629
ILE A3632
GLY A3628
PHE  A3696 ( 1.3A)
ARG  A3629 ( 0.6A)
ILE  A3632 ( 0.7A)
GLY  A3628 ( 0.0A)
0.99A 5nzyA-5w6lA:
undetectable
5nzyA-5w6lA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ces RAS-RELATED
GTP-BINDING PROTEIN
C


(Homo sapiens)
no annotation 4 ASN C 111
PHE C 112
THR C 137
GLY C 138
None
0.99A 5nzyA-6cesC:
undetectable
5nzyA-6cesC:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv0 SPIKE GLYCOPROTEIN

(Avian
coronavirus)
no annotation 4 PHE A 625
ARG A 873
ILE A 870
GLY A 872
None
0.94A 5nzyA-6cv0A:
undetectable
5nzyA-6cv0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1


(Saccharomyces
cerevisiae)
no annotation 4 ARG A1125
THR A1120
ILE A1126
GLY A1122
None
0.90A 5nzyA-6f42A:
undetectable
5nzyA-6f42A:
11.92