SIMILAR PATTERNS OF AMINO ACIDS FOR 5NZW_A_9F2A1102

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		5 HIS A 147
HIS A 149
HIS A 152
HIS A 234
ASP A 255
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.1A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.3A)
ZN  A 401 ( 2.2A)
 0.30A 5nzwA-1p9eA:
5.8		 5nzwA-1p9eA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)

(Homo sapiens) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 HIS A  54
HIS A  56
HIS A  59
HIS A 110
ASP A 134
 ZN  A 261 ( 3.4A)
ZN  A 261 ( 3.3A)
ZN  A 262 ( 3.3A)
ZN  A 261 (-3.3A)
ZN  A 262 ( 2.4A)
 0.30A 5nzwA-1qh5A:
6.5		 5nzwA-1qh5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		5 HIS A 110
HIS A 112
HIS A 115
ASP A 228
HIS A 253
 FE  A 401 (-3.5A)
FE  A 401 ( 3.3A)
FE  A 402 (-3.3A)
FE  A 402 (-2.5A)
PC  A 501 (-3.6A)
 0.68A 5nzwA-1wraA:
7.6		 5nzwA-1wraA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkp HYPOTHETICAL PROTEIN
BA1088

(Bacillus
anthracis) 		PF12706
(Lactamase_B_2) 		6 HIS A  59
HIS A  61
HIS A  64
HIS A 134
ASP A 155
HIS A 189
 ZN  A 245 (-3.3A)
ZN  A 245 (-3.1A)
ZN  A 246 (-3.2A)
ZN  A 245 (-3.3A)
ZN  A 246 ( 2.4A)
None
 0.46A 5nzwA-1zkpA:
10.1		 5nzwA-1zkpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztc HYPOTHETICAL PROTEIN
TM0894

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		5 HIS A  69
HIS A  71
HIS A  74
HIS A 140
ASP A 162
 NI  A 302 (-3.3A)
NI  A 302 (-3.2A)
NI  A 301 (-3.4A)
NI  A 302 (-3.4A)
NI  A 301 ( 2.3A)
 0.32A 5nzwA-1ztcA:
2.1		 5nzwA-1ztcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		5 HIS A 104
HIS A 106
HIS A 109
HIS A 169
ASP A 191
 ZN  A 252 (-3.3A)
ZN  A 252 ( 3.2A)
ZN  A 251 (-3.2A)
ZN  A 252 (-3.3A)
ZN  A 251 ( 2.4A)
 0.42A 5nzwA-2a7mA:
5.8		 5nzwA-2a7mA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904

(Enterococcus
faecalis) 		PF12706
(Lactamase_B_2) 		6 HIS A  92
HIS A  94
HIS A  97
ASP A 189
TYR A 261
HIS A 382
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.3A)
ZN  A 602 ( 2.5A)
None
None
 1.41A 5nzwA-2az4A:
6.4		 5nzwA-2az4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904

(Enterococcus
faecalis) 		PF12706
(Lactamase_B_2) 		6 HIS A  92
HIS A  94
HIS A  97
HIS A 167
ASP A 189
HIS A 382
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 602 ( 2.5A)
None
 0.27A 5nzwA-2az4A:
6.4		 5nzwA-2az4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904

(Enterococcus
faecalis) 		PF12706
(Lactamase_B_2) 		5 HIS A  97
HIS A 404
HIS A  92
ASP A 189
HIS A 167
 ZN  A 602 (-3.3A)
ZN  A 602 (-3.5A)
ZN  A 601 (-3.4A)
ZN  A 602 ( 2.5A)
ZN  A 601 (-3.4A)
 1.13A 5nzwA-2az4A:
6.4		 5nzwA-2az4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904

(Enterococcus
faecalis) 		PF12706
(Lactamase_B_2) 		5 HIS A 167
HIS A  92
HIS A 382
ASP A 189
HIS A 404
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
None
ZN  A 602 ( 2.5A)
ZN  A 602 (-3.5A)
 1.09A 5nzwA-2az4A:
6.4		 5nzwA-2az4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		5 HIS A  85
HIS A  87
HIS A  90
ASP A 203
HIS A 228
 ZN  A1550 (-3.3A)
ZN  A1550 ( 3.1A)
ZN  A1549 (-3.2A)
ZN  A1549 (-2.3A)
PC  A1541 (-3.9A)
 0.71A 5nzwA-2bibA:
7.4		 5nzwA-2bibA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbn RIBONUCLEASE Z

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		6 HIS A  64
HIS A  66
HIS A  69
HIS A 141
ASP A 212
HIS A 248
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 ( 2.3A)
None
 0.34A 5nzwA-2cbnA:
12.0		 5nzwA-2cbnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbn RIBONUCLEASE Z

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		5 HIS A 141
HIS A  64
HIS A 248
ASP A 212
HIS A 270
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
None
ZN  A 402 ( 2.3A)
ZN  A 402 (-3.3A)
 0.91A 5nzwA-2cbnA:
12.0		 5nzwA-2cbnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7y TRNASE Z

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		6 HIS A  48
HIS A  50
HIS A  53
HIS A 134
ASP A 190
HIS A 222
 ZN  A1302 (-3.5A)
ZN  A1302 (-3.4A)
ZN  A1301 (-3.3A)
ZN  A1302 (-3.7A)
ZN  A1301 ( 2.3A)
None
 0.41A 5nzwA-2e7yA:
12.1		 5nzwA-2e7yA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7y TRNASE Z

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		5 HIS A  53
HIS A 244
HIS A  48
ASP A 190
HIS A 134
 ZN  A1301 (-3.3A)
ZN  A1301 (-3.1A)
ZN  A1302 (-3.5A)
ZN  A1301 ( 2.3A)
ZN  A1302 (-3.7A)
 1.18A 5nzwA-2e7yA:
12.1		 5nzwA-2e7yA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7y TRNASE Z

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		5 HIS A 134
HIS A  48
HIS A 222
ASP A 190
HIS A 244
 ZN  A1302 (-3.7A)
ZN  A1302 (-3.5A)
None
ZN  A1301 ( 2.3A)
ZN  A1301 (-3.1A)
 0.96A 5nzwA-2e7yA:
12.1		 5nzwA-2e7yA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis) 		PF12706
(Lactamase_B_2) 		5 HIS A  63
HIS A  68
HIS A 140
ASP A 211
HIS A 247
 None
ZN  A 401 (-3.4A)
None
ZN  A 401 (-2.6A)
None
 0.40A 5nzwA-2fk6A:
12.2		 5nzwA-2fk6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis) 		PF12706
(Lactamase_B_2) 		5 HIS A 140
HIS A  63
HIS A 247
ASP A 211
HIS A 269
 None
None
None
ZN  A 401 (-2.6A)
ZN  A 401 (-3.6A)
 1.01A 5nzwA-2fk6A:
12.2		 5nzwA-2fk6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		7 HIS A  71
HIS A  73
HIS A  76
HIS A 158
ASP A 179
TYR A 207
HIS A 396
 ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
ZN  A 481 (-2.5A)
None
SO4  A 491 (-4.0A)
 0.61A 5nzwA-2i7tA:
16.4		 5nzwA-2i7tA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		5 HIS A  76
HIS A 418
HIS A  71
ASP A 179
HIS A 158
 ZN  A 481 (-3.4A)
ZN  A 481 ( 3.4A)
ZN  A 482 (-3.5A)
ZN  A 481 (-2.5A)
ZN  A 482 ( 3.3A)
 0.96A 5nzwA-2i7tA:
16.4		 5nzwA-2i7tA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		5 HIS A 158
HIS A  71
HIS A 396
ASP A 179
HIS A 418
 ZN  A 482 ( 3.3A)
ZN  A 482 (-3.5A)
SO4  A 491 (-4.0A)
ZN  A 481 (-2.5A)
ZN  A 481 ( 3.4A)
 1.02A 5nzwA-2i7tA:
16.4		 5nzwA-2i7tA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyp BETA-LACTAMASE II

(Bacillus cereus) 		PF00753
(Lactamase_B) 		5 HIS A  86
HIS A  88
HIS A  91
HIS A 149
ASP A 168
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 302 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 302 ( 2.3A)
 0.61A 5nzwA-2nypA:
4.1		 5nzwA-2nypA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p18 GLYOXALASE II

(Leishmania
infantum) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 HIS A  76
HIS A  78
HIS A  81
HIS A 139
ASP A 164
 ZN  A 302 (-3.4A)
ZN  A 302 ( 3.2A)
ZN  A 301 (-3.3A)
ZN  A 302 ( 3.2A)
ZN  A 301 (-2.5A)
 0.31A 5nzwA-2p18A:
6.0		 5nzwA-2p18A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q42 PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 2

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 HIS A  54
HIS A  56
HIS A  59
HIS A 112
ASP A 131
 ZN  A 700 (-3.2A)
ZN  A 700 (-3.2A)
FE  A 701 (-3.1A)
ZN  A 700 (-3.3A)
FE  A 701 ( 2.4A)
 0.32A 5nzwA-2q42A:
2.2		 5nzwA-2q42A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 HIS A  53
HIS A  55
HIS A  58
HIS A 110
ASP A 127
 FE  A 253 (-3.3A)
FE  A 253 (-3.2A)
FE  A 252 (-3.2A)
FE  A 253 (-3.2A)
FE  A 252 ( 2.3A)
 0.30A 5nzwA-2qedA:
undetectable		 5nzwA-2qedA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2d ZN-DEPENDENT
HYDROLASES

(Agrobacterium
fabrum) 		PF00753
(Lactamase_B) 		5 HIS A 111
HIS A 113
HIS A 116
HIS A 191
ASP A 213
 ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
ZN  A 277 ( 3.2A)
ZN  A 278 ( 3.2A)
ZN  A 277 (-2.0A)
 0.45A 5nzwA-2r2dA:
5.0		 5nzwA-2r2dA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 HIS A  69
HIS A  71
HIS A  74
HIS A 159
ASP A 178
 FE2  A 402 (-3.4A)
FE2  A 402 ( 3.2A)
FE2  A 401 (-3.3A)
FE2  A 402 ( 3.3A)
FE2  A 401 (-2.5A)
 0.36A 5nzwA-2vw8A:
2.7		 5nzwA-2vw8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B) 		5 HIS A  56
HIS A  58
HIS A  61
HIS A 132
ASP A 151
 None
PG4  A1212 ( 3.7A)
ZN  A1211 (-3.3A)
None
ZN  A1211 (-2.4A)
 0.51A 5nzwA-2xf4A:
2.4		 5nzwA-2xf4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		7 HIS A 242
HIS A 244
HIS A 247
HIS A 329
ASP A 352
TYR A 380
HIS A 580
 ZN  A1638 (-3.2A)
ZN  A1638 (-3.0A)
ZN  A1639 (-3.3A)
ZN  A1638 (-3.5A)
ZN  A1639 ( 2.3A)
None
None
 0.40A 5nzwA-2xr1A:
13.1		 5nzwA-2xr1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 HIS A 242
HIS A 329
HIS A 247
THR A 602
HIS A 604
 ZN  A1638 (-3.2A)
ZN  A1638 (-3.5A)
ZN  A1639 (-3.3A)
None
ZN  A1639 (-3.3A)
 1.09A 5nzwA-2xr1A:
13.1		 5nzwA-2xr1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 HIS A 329
HIS A 242
HIS A 580
ASP A 352
HIS A 604
 ZN  A1638 (-3.5A)
ZN  A1638 (-3.2A)
None
ZN  A1639 ( 2.3A)
ZN  A1639 (-3.3A)
 0.96A 5nzwA-2xr1A:
13.1		 5nzwA-2xr1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		5 HIS A   9
HIS A   7
ASP A 248
TYR A 195
HIS A 191
 None
 1.14A 5nzwA-2yb4A:
undetectable		 5nzwA-2yb4A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		7 HIS A 242
HIS A 244
HIS A 247
HIS A 329
ASP A 352
TYR A 380
HIS A 579
 ZN  A1638 ( 3.2A)
ZN  A1638 ( 3.1A)
ZN  A1637 ( 3.2A)
ZN  A1638 ( 3.3A)
ZN  A1637 (-2.2A)
None
PO4  A1639 (-3.9A)
 0.38A 5nzwA-2ycbA:
22.4		 5nzwA-2ycbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 HIS A 329
HIS A 242
HIS A 579
ASP A 352
HIS A 603
 ZN  A1638 ( 3.3A)
ZN  A1638 ( 3.2A)
PO4  A1639 (-3.9A)
ZN  A1637 (-2.2A)
ZN  A1637 ( 3.2A)
 1.00A 5nzwA-2ycbA:
22.4		 5nzwA-2ycbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 HIS A 179
HIS A 181
HIS A 184
ASP A 310
HIS A 317
 ZN  A 701 (-3.3A)
ZN  A 701 ( 3.3A)
ZN  A 700 (-3.2A)
ZN  A 700 ( 2.6A)
SO4  A 801 (-4.3A)
 0.75A 5nzwA-2yheA:
2.7		 5nzwA-2yheA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN

(Thermus
thermophilus) 		PF00753
(Lactamase_B) 		5 HIS A  54
HIS A  56
HIS A  59
HIS A 125
ASP A 144
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.2A)
ZN  A 208 (-3.2A)
ZN  A 209 (-3.3A)
ZN  A 208 ( 2.5A)
 0.45A 5nzwA-2zwrA:
6.0		 5nzwA-2zwrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585

(Sulfurisphaera
tokodaii) 		PF00753
(Lactamase_B) 		5 HIS A  58
HIS A  60
HIS A  63
HIS A 148
ASP A 165
 ZN  A 262 (-3.4A)
ZN  A 262 (-3.3A)
ZN  A 263 (-3.4A)
ZN  A 262 (-3.3A)
ZN  A 263 ( 2.5A)
 0.31A 5nzwA-3adrA:
6.3		 5nzwA-3adrA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		7 HIS A 256
HIS A 258
HIS A 261
HIS A 344
ASP A 367
TYR A 395
HIS A 594
 ZN  A 662 (-3.4A)
ZN  A 662 ( 3.3A)
ZN  A 665 (-3.3A)
ZN  A 662 (-3.4A)
ZN  A 665 (-2.5A)
None
SO4  A 657 (-3.4A)
 0.43A 5nzwA-3af5A:
23.0		 5nzwA-3af5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 HIS A 256
HIS A 344
HIS A 261
THR A 616
HIS A 618
 ZN  A 662 (-3.4A)
ZN  A 662 (-3.4A)
ZN  A 665 (-3.3A)
None
ZN  A 665 ( 3.3A)
 1.12A 5nzwA-3af5A:
23.0		 5nzwA-3af5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 HIS A 261
HIS A 618
HIS A 256
ASP A 367
HIS A 344
 ZN  A 665 (-3.3A)
ZN  A 665 ( 3.3A)
ZN  A 662 (-3.4A)
ZN  A 665 (-2.5A)
ZN  A 662 (-3.4A)
 1.06A 5nzwA-3af5A:
23.0		 5nzwA-3af5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 HIS A 344
HIS A 256
HIS A 594
ASP A 367
HIS A 618
 ZN  A 662 (-3.4A)
ZN  A 662 (-3.4A)
SO4  A 657 (-3.4A)
ZN  A 665 (-2.5A)
ZN  A 665 ( 3.3A)
 1.05A 5nzwA-3af5A:
23.0		 5nzwA-3af5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE

(Staphylococcus
aureus) 		PF00753
(Lactamase_B) 		5 HIS A 108
HIS A 110
HIS A 113
HIS A 185
ASP A 206
 None
 0.46A 5nzwA-3eshA:
5.8		 5nzwA-3eshA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		5 HIS A 527
HIS A 180
TYR A 239
THR A 149
HIS A 241
 FE2  A 534 (-3.3A)
FE2  A 534 (-3.4A)
None
None
FE2  A 534 (-3.3A)
 1.13A 5nzwA-3fsnA:
undetectable		 5nzwA-3fsnA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1p PROTEIN PHNP

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		6 HIS A  76
HIS A  78
HIS A  81
HIS A 143
ASP A 164
HIS A 200
 MN  A 400 ( 3.4A)
MN  A 400 ( 3.3A)
MN  A 401 (-3.5A)
MN  A 400 ( 3.4A)
MN  A 401 (-2.1A)
MLT  A 500 (-4.1A)
 0.36A 5nzwA-3g1pA:
12.7		 5nzwA-3g1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1p PROTEIN PHNP

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		5 HIS A 143
HIS A  76
HIS A 200
ASP A 164
HIS A 222
 MN  A 400 ( 3.4A)
MN  A 400 ( 3.4A)
MLT  A 500 (-4.1A)
MN  A 401 (-2.1A)
MN  A 401 (-3.7A)
 0.93A 5nzwA-3g1pA:
12.7		 5nzwA-3g1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		5 HIS A 151
HIS A 121
HIS A 216
ASP A 237
HIS A 217
 FE  A 306 (-3.5A)
FE  A 306 (-3.4A)
FE  A 305 (-3.4A)
FE  A 306 (-2.8A)
FE  A 305 (-3.3A)
 1.05A 5nzwA-3hc1A:
undetectable		 5nzwA-3hc1A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		6 HIS A  59
HIS A  61
HIS A  64
HIS A 141
ASP A 162
TYR A 189
 ZN  A 453 (-3.6A)
ZN  A 453 (-3.4A)
ZN  A 452 (-3.5A)
ZN  A 453 (-3.3A)
ZN  A 452 ( 2.6A)
SO4  A 447 (-4.7A)
 0.51A 5nzwA-3ie1A:
20.9		 5nzwA-3ie1A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl7 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Parabacteroides
distasonis) 		PF13483
(Lactamase_B_3) 		5 HIS A  79
HIS A  81
HIS A  84
HIS A 146
ASP A 168
 ZN  A 302 (-3.5A)
ZN  A 302 (-3.4A)
ZN  A 303 (-3.4A)
ZN  A 302 (-3.3A)
ZN  A 303 ( 2.5A)
 0.36A 5nzwA-3kl7A:
12.0		 5nzwA-3kl7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl7 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Parabacteroides
distasonis) 		PF13483
(Lactamase_B_3) 		5 HIS A  84
HIS A 215
HIS A  79
ASP A 168
HIS A 146
 ZN  A 303 (-3.4A)
ZN  A 303 (-3.3A)
ZN  A 302 (-3.5A)
ZN  A 303 ( 2.5A)
ZN  A 302 (-3.3A)
 1.00A 5nzwA-3kl7A:
12.0		 5nzwA-3kl7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py6 BETA-LACTAMASE-LIKE

(Brucella
abortus) 		PF12706
(Lactamase_B_2) 		6 HIS A  86
HIS A  88
HIS A  91
HIS A 170
ASP A 188
HIS A 219
 MN  A 301 (-3.4A)
MN  A 301 ( 3.3A)
MN  A 300 (-3.4A)
MN  A 301 ( 3.4A)
MN  A 300 (-2.5A)
5GP  A 303 (-4.1A)
 0.29A 5nzwA-3py6A:
10.7		 5nzwA-3py6A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpc POSSIBLE
METAL-DEPENDENT
HYDROLASE

(Veillonella
parvula) 		PF12706
(Lactamase_B_2) 		5 HIS A  69
HIS A  71
HIS A  74
HIS A 129
ASP A 165
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.4A)
ZN  A 302 (-3.4A)
ZN  A 301 (-3.3A)
ZN  A 302 ( 2.5A)
 0.52A 5nzwA-3rpcA:
12.4		 5nzwA-3rpcA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpc POSSIBLE
METAL-DEPENDENT
HYDROLASE

(Veillonella
parvula) 		PF12706
(Lactamase_B_2) 		5 HIS A  74
HIS A 223
HIS A  69
ASP A 165
HIS A 129
 ZN  A 302 (-3.4A)
ZN  A 302 (-3.5A)
ZN  A 301 (-3.4A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.3A)
 1.05A 5nzwA-3rpcA:
12.4		 5nzwA-3rpcA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 HIS A  75
HIS A  80
HIS A 150
ASP A 172
HIS A 376
 ZN  A 600 (-4.8A)
ZN  A 600 (-3.6A)
None
ZN  A 600 (-2.4A)
None
 0.39A 5nzwA-3t3oA:
8.7		 5nzwA-3t3oA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 HIS A 150
HIS A  75
HIS A 376
ASP A 172
HIS A 398
 None
ZN  A 600 (-4.8A)
None
ZN  A 600 (-2.4A)
ZN  A 600 (-3.6A)
 0.93A 5nzwA-3t3oA:
8.7		 5nzwA-3t3oA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		5 HIS A  48
HIS A  50
HIS A  53
HIS A 108
ASP A 141
 NI  A 301 (-3.5A)
NI  A 301 (-3.3A)
NI  A 302 (-3.6A)
NI  A 301 (-3.4A)
NI  A 302 ( 2.5A)
 0.35A 5nzwA-3x2zA:
8.9		 5nzwA-3x2zA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x2z UPF0173
METAL-DEPENDENT
HYDROLASE TM_1162

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		5 HIS A  53
HIS A 190
HIS A  48
ASP A 141
HIS A 108
 NI  A 302 (-3.6A)
NI  A 302 (-3.6A)
NI  A 301 (-3.5A)
NI  A 302 ( 2.5A)
NI  A 301 (-3.4A)
 1.08A 5nzwA-3x2zA:
8.9		 5nzwA-3x2zA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		6 HIS A  74
HIS A  76
HIS A  79
HIS A 142
ASP A 164
HIS A 368
 ZN  A1557 (-3.0A)
ZN  A1557 (-3.2A)
ZN  A1556 (-3.2A)
ZN  A1557 (-3.3A)
ZN  A1556 ( 2.7A)
None
 0.33A 5nzwA-3zq4A:
8.4		 5nzwA-3zq4A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 HIS A  79
HIS A 390
HIS A  74
ASP A 164
HIS A 142
 ZN  A1556 (-3.2A)
ZN  A1556 (-3.4A)
ZN  A1557 (-3.0A)
ZN  A1556 ( 2.7A)
ZN  A1557 (-3.3A)
 1.11A 5nzwA-3zq4A:
8.4		 5nzwA-3zq4A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 HIS A 142
HIS A  74
HIS A 368
ASP A 164
HIS A 390
 ZN  A1557 (-3.3A)
ZN  A1557 (-3.0A)
None
ZN  A1556 ( 2.7A)
ZN  A1556 (-3.4A)
 0.90A 5nzwA-3zq4A:
8.4		 5nzwA-3zq4A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		6 HIS A  62
HIS A  64
HIS A  67
HIS A 182
ASP A 253
HIS A 291
 ZN  A1364 (-3.5A)
ZN  A1364 ( 3.2A)
ZN  A1363 (-3.4A)
ZN  A1364 ( 3.5A)
ZN  A1363 (-2.5A)
PO4  A1365 (-3.8A)
 0.30A 5nzwA-3zwfA:
10.2		 5nzwA-3zwfA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		5 HIS A  67
HIS A 313
HIS A  62
ASP A 253
HIS A 182
 ZN  A1363 (-3.4A)
ZN  A1363 ( 3.4A)
ZN  A1364 (-3.5A)
ZN  A1363 (-2.5A)
ZN  A1364 ( 3.5A)
 1.08A 5nzwA-3zwfA:
10.2		 5nzwA-3zwfA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		5 HIS A 182
HIS A  62
HIS A 291
ASP A 253
HIS A 313
 ZN  A1364 ( 3.5A)
ZN  A1364 (-3.5A)
PO4  A1365 (-3.8A)
ZN  A1363 (-2.5A)
ZN  A1363 ( 3.4A)
 0.97A 5nzwA-3zwfA:
10.2		 5nzwA-3zwfA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00753
(Lactamase_B) 		5 HIS A  77
HIS A  79
HIS A  82
HIS A 145
ASP A 164
 ZN  A1001 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1000 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1000 ( 2.3A)
 0.30A 5nzwA-4ad9A:
3.9		 5nzwA-4ad9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		5 HIS A  14
HIS A  12
ASP A 323
THR A 166
HIS A 251
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.6A)
ZN  A 401 (-2.8A)
None
None
 1.08A 5nzwA-4hjwA:
undetectable		 5nzwA-4hjwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keq 4-PYRIDOXOLACTONASE

(Mesorhizobium
japonicum) 		PF00753
(Lactamase_B) 		5 HIS A  96
HIS A  98
HIS A 101
HIS A 185
ASP A 207
 ZN  A 302 (-3.4A)
ZN  A 302 ( 3.2A)
ZN  A 301 (-3.2A)
ZN  A 302 (-3.3A)
ZN  A 301 ( 2.1A)
 0.50A 5nzwA-4keqA:
2.3		 5nzwA-4keqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le6 ORGANOPHOSPHORUS
HYDROLASE

(Pseudomonas
pseudoalcaligenes) 		PF00753
(Lactamase_B) 		5 HIS A 139
HIS A 141
HIS A 144
HIS A 226
ASP A 247
 ZN  A 405 (-3.3A)
ZN  A 405 ( 3.1A)
ZN  A 406 (-3.2A)
ZN  A 405 (-3.1A)
ZN  A 406 ( 2.3A)
 0.34A 5nzwA-4le6A:
2.4		 5nzwA-4le6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF02112
(PDEase_II) 		6 HIS A 128
HIS A 130
HIS A 133
HIS A 213
ASP A 244
HIS A 294
 ZN  A 403 (-3.4A)
ZN  A 403 ( 3.2A)
ZN  A 404 (-3.3A)
ZN  A 403 ( 3.3A)
ZN  A 404 (-2.4A)
G  A 402 (-3.6A)
 0.32A 5nzwA-4ojxA:
3.1		 5nzwA-4ojxA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF02112
(PDEase_II) 		6 HIS A 213
HIS A 128
HIS A 294
ASP A 244
THR A  16
HIS A 326
 ZN  A 403 ( 3.3A)
ZN  A 403 (-3.4A)
G  A 402 (-3.6A)
ZN  A 404 (-2.4A)
None
ZN  A 404 ( 3.3A)
 1.37A 5nzwA-4ojxA:
3.1		 5nzwA-4ojxA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		5 HIS A  98
HIS A  52
HIS A 171
ASP A 237
HIS A 172
 NI  A1001 (-3.4A)
NI  A1001 (-3.2A)
NI  A1002 (-3.3A)
NI  A1001 ( 2.7A)
NI  A1002 ( 3.3A)
 1.18A 5nzwA-4q2cA:
2.2		 5nzwA-4q2cA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		6 HIS A 185
HIS A 187
HIS A 190
HIS A 253
ASP A 284
HIS A 321
 ZN  A 501 (-3.6A)
ZN  A 501 ( 3.4A)
ZN  A 502 (-3.5A)
ZN  A 501 ( 3.5A)
ZN  A 502 (-2.5A)
3PE  A 503 (-3.8A)
 0.34A 5nzwA-4qn9A:
12.2		 5nzwA-4qn9A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		5 HIS A 253
HIS A 185
HIS A 321
ASP A 284
HIS A 343
 ZN  A 501 ( 3.5A)
ZN  A 501 (-3.6A)
3PE  A 503 (-3.8A)
ZN  A 502 (-2.5A)
ZN  A 502 ( 3.6A)
 1.02A 5nzwA-4qn9A:
12.2		 5nzwA-4qn9A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1

(Homo sapiens) 		PF00753
(Lactamase_B) 		5 HIS A 117
HIS A 119
HIS A 122
HIS A 172
ASP A 195
 FE  A1242 (-3.5A)
FE  A1242 (-3.4A)
FE  A1243 (-3.5A)
FE  A1242 (-3.4A)
FE  A1243 ( 2.4A)
 0.29A 5nzwA-4v0hA:
4.0		 5nzwA-4v0hA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuk PUTATIVE HYDROLASE

(Acinetobacter
sp. NBRC 100985) 		PF00753
(Lactamase_B) 		6 HIS A 155
HIS A 157
HIS A 160
HIS A 244
ASP A 265
HIS A 268
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 ( 2.5A)
None
 0.54A 5nzwA-4xukA:
3.3		 5nzwA-4xukA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		6 HIS A  84
HIS A  86
HIS A  89
HIS A 153
ASP A 175
HIS A 381
 ZN  A 601 (-3.5A)
ZN  A 601 (-3.1A)
ZN  A 602 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 602 ( 2.5A)
U5P  A 606 (-3.9A)
 0.29A 5nzwA-4xwtA:
7.9		 5nzwA-4xwtA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 HIS A 153
HIS A  84
HIS A 381
ASP A 175
HIS A 403
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.5A)
U5P  A 606 (-3.9A)
ZN  A 602 ( 2.5A)
ZN  A 602 (-3.2A)
 0.95A 5nzwA-4xwtA:
7.9		 5nzwA-4xwtA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 HIS A 153
HIS A 381
HIS A  84
THR A  35
HIS A  89
 ZN  A 601 (-3.4A)
U5P  A 606 (-3.9A)
ZN  A 601 (-3.5A)
None
ZN  A 602 (-3.3A)
 1.06A 5nzwA-4xwtA:
7.9		 5nzwA-4xwtA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo3 ACYLHOMOSERINE
LACTONASE

(Chryseobacterium
sp. StRB126) 		PF00753
(Lactamase_B) 		6 HIS A 145
HIS A 147
HIS A 150
HIS A 237
ASP A 258
HIS A 261
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-2.3A)
C6L  A 403 (-3.8A)
 0.56A 5nzwA-4zo3A:
6.3		 5nzwA-4zo3A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo3 ACYLHOMOSERINE
LACTONASE

(Chryseobacterium
sp. StRB126) 		PF00753
(Lactamase_B) 		5 HIS A 237
HIS A 145
HIS A 261
ASP A 258
HIS A 305
 ZN  A 401 ( 3.2A)
ZN  A 401 (-3.3A)
C6L  A 403 (-3.8A)
ZN  A 402 (-2.3A)
ZN  A 402 ( 3.3A)
 0.95A 5nzwA-4zo3A:
6.3		 5nzwA-4zo3A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 349
HIS A 272
HIS A 271
HIS A 348
HIS A 244
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.7A)
 1.10A 5nzwA-4zr0A:
undetectable		 5nzwA-4zr0A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		6 HIS A  84
HIS A  86
HIS A  89
HIS A 151
ASP A 173
HIS A 377
 ZN  A1458 (-3.6A)
ZN  A1458 (-3.5A)
ZN  A1457 (-3.5A)
ZN  A1458 (-3.6A)
ZN  A1457 ( 2.7A)
G  E   1 ( 3.9A)
 0.38A 5nzwA-5a0tA:
9.1		 5nzwA-5a0tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 HIS A  89
HIS A 399
HIS A  84
ASP A 173
HIS A 151
 ZN  A1457 (-3.5A)
ZN  A1457 (-3.5A)
ZN  A1458 (-3.6A)
ZN  A1457 ( 2.7A)
ZN  A1458 (-3.6A)
 1.09A 5nzwA-5a0tA:
9.1		 5nzwA-5a0tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 HIS A 151
HIS A  84
HIS A 377
ASP A 173
HIS A 399
 ZN  A1458 (-3.6A)
ZN  A1458 (-3.6A)
G  E   1 ( 3.9A)
ZN  A1457 ( 2.7A)
ZN  A1457 (-3.5A)
 0.94A 5nzwA-5a0tA:
9.1		 5nzwA-5a0tA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aho 5' EXONUCLEASE
APOLLO

(Homo sapiens) 		PF07522
(DRMBL) 		6 HIS A  31
HIS A  33
HIS A  36
HIS A  99
ASP A 120
HIS A 276
 ZN  A1321 (-3.3A)
ZN  A1321 ( 3.2A)
ZN  A1320 ( 3.4A)
ZN  A1321 ( 3.4A)
ZN  A1320 (-2.5A)
TLA  A1319 ( 3.9A)
 0.24A 5nzwA-5ahoA:
20.8		 5nzwA-5ahoA:
35.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aho 5' EXONUCLEASE
APOLLO

(Homo sapiens) 		PF07522
(DRMBL) 		6 HIS A  31
HIS A  33
HIS A  36
HIS A  99
ASP A 120
THR A 257
 ZN  A1321 (-3.3A)
ZN  A1321 ( 3.2A)
ZN  A1320 ( 3.4A)
ZN  A1321 ( 3.4A)
ZN  A1320 (-2.5A)
TLA  A1322 (-3.3A)
 0.66A 5nzwA-5ahoA:
20.8		 5nzwA-5ahoA:
35.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN

(Homo sapiens) 		PF07522
(DRMBL)
PF12706
(Lactamase_B_2) 		9 HIS A 732
HIS A 734
ASP A 736
HIS A 737
HIS A 793
ASP A 815
TYR A 841
TYR A 879
HIS A 994
 ZN  A2041 (-3.4A)
ZN  A2041 (-3.1A)
None
ZN  A2041 ( 4.8A)
ZN  A2041 (-3.4A)
ZN  A2041 (-3.1A)
None
None
None
 0.58A 5nzwA-5ahrA:
20.3		 5nzwA-5ahrA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN

(Homo sapiens) 		PF07522
(DRMBL)
PF12706
(Lactamase_B_2) 		5 HIS A 793
HIS A 732
HIS A 994
ASP A 815
TYR A 879
 ZN  A2041 (-3.4A)
ZN  A2041 (-3.4A)
None
ZN  A2041 (-3.1A)
None
 1.05A 5nzwA-5ahrA:
20.3		 5nzwA-5ahrA:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11

(Methanocaldococcus
jannaschii) 		PF00149
(Metallophos) 		5 HIS A 158
HIS A 186
ASP A  49
TYR A  13
HIS A  10
 MG  A 402 (-4.2A)
MG  A 402 (-2.7A)
MG  A 402 ( 2.7A)
None
MG  A 401 (-3.5A)
 1.15A 5nzwA-5dnyA:
undetectable		 5nzwA-5dnyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A  95
HIS A 137
HIS A 396
HIS A 446
 CU  A1463 (-2.9A)
CU  A1463 (-4.1A)
CU  A1463 (-3.3A)
CU  A1463 ( 4.8A)
CU  A1465 (-3.3A)
 1.14A 5nzwA-5g3fA:
undetectable		 5nzwA-5g3fA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 HIS A  82
HIS A  87
HIS A 152
ASP A 174
HIS A 388
 None
None
None
A  C   2 ( 4.1A)
A  C   1 ( 4.3A)
 0.85A 5nzwA-5habA:
9.0		 5nzwA-5habA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH

(synthetic
construct) 		PF00753
(Lactamase_B) 		6 HIS A 114
HIS A 116
HIS A 119
HIS A 200
ASP A 221
HIS A 224
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 401 ( 2.4A)
None
 0.50A 5nzwA-5hifA:
5.5		 5nzwA-5hifA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH

(synthetic
construct) 		PF00753
(Lactamase_B) 		5 HIS A 200
HIS A 114
HIS A 224
ASP A 221
HIS A 268
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.4A)
None
ZN  A 401 ( 2.4A)
ZN  A 401 ( 3.2A)
 0.95A 5nzwA-5hifA:
5.5		 5nzwA-5hifA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		6 HIS A 540
HIS A 542
HIS A 545
HIS A 670
ASP A 699
HIS A 737
 ZN  A 901 (-3.4A)
ZN  A 901 ( 3.1A)
ZN  A 902 (-3.4A)
ZN  A 901 ( 3.5A)
ZN  A 902 (-2.3A)
PO4  A 903 (-4.3A)
 0.38A 5nzwA-5mtzA:
6.8		 5nzwA-5mtzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		5 HIS A 545
HIS A 759
HIS A 540
ASP A 699
HIS A 670
 ZN  A 902 (-3.4A)
ZN  A 902 ( 3.2A)
ZN  A 901 (-3.4A)
ZN  A 902 (-2.3A)
ZN  A 901 ( 3.5A)
 1.07A 5nzwA-5mtzA:
6.8		 5nzwA-5mtzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		5 HIS A 670
HIS A 540
HIS A 737
ASP A 699
HIS A 759
 ZN  A 901 ( 3.5A)
ZN  A 901 (-3.4A)
PO4  A 903 (-4.3A)
ZN  A 902 (-2.3A)
ZN  A 902 ( 3.2A)
 0.96A 5nzwA-5mtzA:
6.8		 5nzwA-5mtzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao1 BETA-LACTAMASE
DOMAIN PROTEIN

(Paraburkholderia
phymatum) 		PF00753
(Lactamase_B) 		5 HIS A  94
HIS A  96
HIS A  99
HIS A 205
ASP A 224
 CA  A 404 (-3.4A)
CA  A 404 (-3.2A)
CA  A 403 (-3.7A)
CA  A 404 (-3.3A)
CA  A 403 ( 2.2A)
 0.46A 5nzwA-6ao1A:
5.5		 5nzwA-6ao1A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 5 HIS A  67
HIS A  69
HIS A  72
HIS A 128
ASP A 164
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
ZN  A 302 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 302 ( 2.5A)
 0.51A 5nzwA-6brmA:
11.5		 5nzwA-6brmA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 5 HIS A  72
HIS A 221
HIS A  67
ASP A 164
HIS A 128
 ZN  A 302 (-3.3A)
ZN  A 302 (-3.4A)
ZN  A 301 (-3.4A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.3A)
 1.09A 5nzwA-6brmA:
11.5		 5nzwA-6brmA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch0 -

(-) 		no annotation 5 HIS C 118
HIS C 120
HIS C 123
HIS C 198
ASP C 220
 CO  C 302 (-3.3A)
CO  C 302 ( 3.1A)
CO  C 301 (-3.3A)
CO  C 302 ( 3.4A)
CO  C 301 (-2.1A)
 0.42A 5nzwA-6ch0C:
5.1		 5nzwA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e0s -

(-) 		no annotation 5 HIS A  91
HIS A  93
ASP A  95
HIS A  96
HIS A 169
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
ZN  A 302 (-4.2A)
ZN  A 301 (-3.4A)
 0.67A 5nzwA-6e0sA:
4.8		 5nzwA-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 HIS A 439
HIS A  91
HIS A 133
HIS A 437
HIS A 491
 EDO  A 602 (-3.8A)
EDO  A 602 ( 4.5A)
EDO  A 602 (-4.1A)
None
None
 1.06A 5nzwA-6evgA:
undetectable		 5nzwA-6evgA:
14.02