SIMILAR PATTERNS OF AMINO ACIDS FOR 5NZ0_A_ZLDA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0i DNA LIGASE

(Escherichia
virus T7) 		PF01068
(DNA_ligase_A_M) 		5 TRP A 254
GLY A 267
ILE A 266
THR A 292
VAL A 295
 None
 0.75A 5nz0A-1a0iA:
0.0		 5nz0A-1a0iA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cz4 VCP-LIKE ATPASE

(Thermoplasma
acidophilum) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 GLY A  78
MET A  21
VAL A  85
ASN A 134
LEU A 149
 None
 1.34A 5nz0A-1cz4A:
undetectable		 5nz0A-1cz4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A  15
ILE A 241
TYR A 258
VAL A 358
LEU A 154
 None
 1.21A 5nz0A-1e5mA:
0.0		 5nz0A-1e5mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 GLY A 593
ILE A 591
MET A 624
THR A 636
LEU A 581
 None
 1.49A 5nz0A-1jqoA:
0.3		 5nz0A-1jqoA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		5 GLY A 283
TYR A 157
THR A 272
VAL A 274
LEU A  83
 None
 1.24A 5nz0A-1sdeA:
0.0		 5nz0A-1sdeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 GLY A 575
ILE A 574
TYR A 607
THR A 578
LEU A 217
 None
 1.03A 5nz0A-1su7A:
undetectable		 5nz0A-1su7A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 GLY A  49
ILE A  47
MET A 510
THR A 486
VAL A 469
 None
 1.32A 5nz0A-1tmoA:
0.0		 5nz0A-1tmoA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR

(Caenorhabditis
elegans) 		PF01833
(TIG)
PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 GLY A 356
ILE A 355
PHE A 347
TYR A 546
LEU A 286
 None
None
None
EDO  A  54 ( 4.6A)
None
 1.35A 5nz0A-1ttuA:
undetectable		 5nz0A-1ttuA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 GLY A 426
ILE A 445
THR A 458
VAL A 401
LEU A 161
 None
 1.43A 5nz0A-1vcjA:
undetectable		 5nz0A-1vcjA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		5 GLY A  78
ILE A  79
TYR A 256
VAL A 258
LEU A 114
 None
 1.42A 5nz0A-1wzaA:
0.0		 5nz0A-1wzaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuw GLUTAMATE RACEMASE 1

(Bacillus
subtilis) 		PF01177
(Asp_Glu_race) 		5 GLY A 184
ILE A 182
THR A 212
VAL A  18
LEU A 131
 None
 1.34A 5nz0A-1zuwA:
0.0		 5nz0A-1zuwA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 412
ILE A 413
PHE A 416
TYR A 446
VAL A 385
 None
 0.87A 5nz0A-2bc0A:
0.0		 5nz0A-2bc0A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		5 ILE A 201
TRP A 232
THR A 231
VAL A 271
ASN A 199
 None
 1.35A 5nz0A-2ddtA:
undetectable		 5nz0A-2ddtA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		5 ILE A 201
TRP A 232
TYR A 297
THR A 231
ASN A 199
 None
 1.36A 5nz0A-2ddtA:
undetectable		 5nz0A-2ddtA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36

(Canis lupus) 		PF03388
(Lectin_leg-like) 		5 TRP A 136
ILE A 159
TYR A 188
VAL A 147
LEU A 224
 None
 1.43A 5nz0A-2dupA:
undetectable		 5nz0A-2dupA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36

(Mus musculus) 		PF11605
(Vps36_ESCRT-II) 		5 TRP A  49
ILE A  48
THR A  39
VAL A  24
LEU A  11
 None
 1.29A 5nz0A-2dx5A:
undetectable		 5nz0A-2dx5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		5 TRP A 722
GLY A 725
ILE A 724
VAL A 422
LEU A 716
 FUL  A 900 ( 3.9A)
None
None
None
None
 1.18A 5nz0A-2eaeA:
1.8		 5nz0A-2eaeA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzm GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 GLY A 184
ILE A 182
THR A 212
VAL A  19
LEU A 131
 None
 1.34A 5nz0A-2gzmA:
undetectable		 5nz0A-2gzmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1z LMO0427 PROTEIN

(Listeria
monocytogenes) 		PF02302
(PTS_IIB) 		5 ILE A  46
TYR A  19
THR A  18
VAL A  15
LEU A  50
 None
 1.45A 5nz0A-2m1zA:
undetectable		 5nz0A-2m1zA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		5 GLY A 554
ILE A 556
THR A 426
VAL A 424
LEU A 375
 None
 1.14A 5nz0A-2o2cA:
1.1		 5nz0A-2o2cA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3o YYCI PROTEIN

(Bacillus
subtilis) 		PF09648
(YycI) 		5 GLY A 131
ILE A 128
MET A 167
THR A 188
LEU A 173
 None
 1.31A 5nz0A-2o3oA:
undetectable		 5nz0A-2o3oA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		5 GLY A  80
ILE A 245
THR A  83
VAL A  75
LEU A 222
 None
 1.38A 5nz0A-2pxjA:
undetectable		 5nz0A-2pxjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmj DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 GLY A 165
ILE A 164
THR A 139
VAL A 127
LEU A 219
 None
 1.04A 5nz0A-2vmjA:
undetectable		 5nz0A-2vmjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 GLY A 265
ILE A 266
TYR A 332
VAL A 295
ASN A 268
 None
 1.06A 5nz0A-3bgaA:
undetectable		 5nz0A-3bgaA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c02 AQUAGLYCEROPORIN

(Plasmodium
falciparum) 		PF00230
(MIP) 		5 GLY A  51
ILE A 177
TRP A  43
TYR A  44
LEU A 192
 None
GOL  A 662 ( 4.5A)
None
None
None
 1.42A 5nz0A-3c02A:
3.6		 5nz0A-3c02A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli) 		PF01274
(Malate_synthase) 		5 GLY A 443
ILE A 334
PHE A 333
VAL A 424
LEU A 371
 None
 1.06A 5nz0A-3cv2A:
undetectable		 5nz0A-3cv2A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1t TYPE I SITE-SPECIFIC
RESTRICTION-MODIFICA
TION SYSTEM, R
(RESTRICTION)
SUBUNIT

(Vibrio
vulnificus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF13588
(HSDR_N_2) 		5 GLY A 336
ILE A 308
TYR A 350
THR A 349
TRP A 322
 None
 1.42A 5nz0A-3h1tA:
undetectable		 5nz0A-3h1tA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 TYR B 984
THR A 645
VAL B 726
ASN A 723
LEU A 719
 None
 1.36A 5nz0A-3hkzB:
0.4		 5nz0A-3hkzB:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 GLY A 204
ILE A 169
PHE A 262
THR A 166
VAL A 165
 None
 1.39A 5nz0A-3oz6A:
undetectable		 5nz0A-3oz6A:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		10 TRP A 103
ILE A 107
PHE A 110
MET A 142
TYR A 148
THR A 149
VAL A 152
ASN A 179
LEU A 183
TRP A 207
 None
 0.55A 5nz0A-3qplA:
29.8		 5nz0A-3qplA:
91.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		5 TYR A 148
THR A 149
VAL A 152
LEU A 200
TRP A 207
 None
 1.46A 5nz0A-3qplA:
29.8		 5nz0A-3qplA:
91.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 GLY A 338
ILE A 337
THR A 427
ASN A 283
LEU A 258
 None
None
IM2  A 800 (-4.0A)
IM2  A 800 (-3.3A)
None
 1.41A 5nz0A-3upnA:
undetectable		 5nz0A-3upnA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		5 TRP A  63
ILE A  75
PHE A  37
TYR A 172
TRP A  76
 None
 1.21A 5nz0A-3x0uA:
2.0		 5nz0A-3x0uA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		5 GLY A 355
ILE A 356
TYR A 139
THR A 138
LEU A 149
 None
 0.91A 5nz0A-3zdnA:
undetectable		 5nz0A-3zdnA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		5 GLY A 429
ILE A 428
MET A 151
VAL A 205
LEU A 416
 None
 1.15A 5nz0A-3zmrA:
undetectable		 5nz0A-3zmrA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 GLY A 335
ILE A 336
PHE A 337
VAL A 280
LEU A 338
 None
None
CL  A1587 ( 4.9A)
None
None
 1.04A 5nz0A-3zo9A:
undetectable		 5nz0A-3zo9A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 TRP A 334
GLY A 335
ILE A 336
PHE A 337
VAL A 280
 None
None
None
CL  A1587 ( 4.9A)
None
 0.97A 5nz0A-3zo9A:
undetectable		 5nz0A-3zo9A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ano ESSB

(Geobacillus
thermodenitrificans) 		PF10140
(YukC) 		5 GLY A 126
ILE A 104
PHE A 105
VAL A  41
LEU A 141
 None
 1.46A 5nz0A-4anoA:
undetectable		 5nz0A-4anoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4beq ALANINE RACEMASE 2

(Vibrio cholerae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 267
ILE A 278
VAL A 379
ASN A  80
LEU A  85
 None
 1.36A 5nz0A-4beqA:
undetectable		 5nz0A-4beqA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A 435
ILE A 461
MET A 471
TYR A 466
VAL A 480
 TPP  A 600 (-3.4A)
TPP  A 600 ( 4.7A)
None
TPP  A 600 (-3.6A)
None
 1.05A 5nz0A-4cokA:
undetectable		 5nz0A-4cokA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 GLY A 425
ILE A 444
THR A 457
VAL A 400
LEU A 160
 None
 1.50A 5nz0A-4cpnA:
undetectable		 5nz0A-4cpnA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 GLY A 252
ILE A 250
PHE A 254
ASN A 294
LEU A  75
 None
 1.47A 5nz0A-4gbrA:
2.2		 5nz0A-4gbrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljs PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		5 GLY A 236
ILE A 235
THR A 201
VAL A 202
LEU A 303
 None
 1.10A 5nz0A-4ljsA:
undetectable		 5nz0A-4ljsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 GLY A 343
ILE A 344
PHE A 345
VAL A 288
LEU A 346
 None
None
None
None
GOL  A 704 ( 4.6A)
 1.20A 5nz0A-4lxfA:
undetectable		 5nz0A-4lxfA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 TRP A 342
GLY A 343
ILE A 344
PHE A 345
VAL A 288
 None
 1.09A 5nz0A-4lxfA:
undetectable		 5nz0A-4lxfA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		5 GLY A  81
ILE A 246
THR A  84
VAL A  76
LEU A 223
 None
 1.37A 5nz0A-4lxlA:
undetectable		 5nz0A-4lxlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn0 BEROVIN

(Beroe
abyssicola) 		PF10591
(SPARC_Ca_bdg) 		5 GLY A  91
PHE A 110
VAL A  58
ASN A 107
TRP A 103
 None
 1.03A 5nz0A-4mn0A:
undetectable		 5nz0A-4mn0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb6 VP1

(Feline
calicivirus) 		PF00915
(Calici_coat) 		5 ILE A 623
PHE A 606
THR A 556
VAL A 367
LEU A 601
 None
 1.04A 5nz0A-4pb6A:
undetectable		 5nz0A-4pb6A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		5 GLY A 555
ILE A 557
THR A 427
VAL A 425
LEU A 376
 None
 1.06A 5nz0A-4qfhA:
undetectable		 5nz0A-4qfhA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrj PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
uniformis) 		PF10282
(Lactonase) 		5 GLY A  35
ILE A  45
TYR A  37
THR A  38
LEU A  96
 None
 1.45A 5nz0A-4qrjA:
undetectable		 5nz0A-4qrjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Weissella
paramesenteroides) 		PF13377
(Peripla_BP_3) 		5 GLY A  64
PHE A 121
TYR A  91
THR A  86
LEU A 123
 None
 1.29A 5nz0A-4rk6A:
undetectable		 5nz0A-4rk6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		5 GLY A  60
ILE A  61
VAL A 259
ASN A 125
LEU A 121
 None
 1.47A 5nz0A-4rslA:
undetectable		 5nz0A-4rslA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		5 GLY A 334
ILE A 332
TYR A 429
VAL A 437
LEU A 380
 None
None
SO4  A 881 (-4.5A)
None
None
 1.44A 5nz0A-4uqgA:
2.0		 5nz0A-4uqgA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		5 GLY A  17
ILE A  16
TYR A 154
VAL A 186
LEU A  41
 None
 1.23A 5nz0A-4uw2A:
undetectable		 5nz0A-4uw2A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		5 GLY A  82
ILE A 247
THR A  85
VAL A  77
LEU A 224
 None
 1.32A 5nz0A-4xdoA:
undetectable		 5nz0A-4xdoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxf FUCULOSE-1-PHOSPHATE
ALDOLASE

(Glaciozyma
antarctica) 		PF00596
(Aldolase_II) 		5 GLY A 123
ILE A 126
THR A  72
VAL A  84
LEU A 203
 None
 1.43A 5nz0A-4xxfA:
undetectable		 5nz0A-4xxfA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7p ALKALINE D-PEPTIDASE

(Bacillus cereus) 		PF00144
(Beta-lactamase) 		5 GLY A 297
ILE A 298
THR A 283
VAL A 284
LEU A 267
 None
 1.32A 5nz0A-4y7pA:
undetectable		 5nz0A-4y7pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y89 CARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 7

(Homo sapiens) 		PF07686
(V-set) 		5 GLY A  31
ILE A  93
VAL A  22
ASN A  99
LEU A  97
 None
 1.16A 5nz0A-4y89A:
undetectable		 5nz0A-4y89A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yco TRNA-DIHYDROURIDINE
SYNTHASE C

(Escherichia
coli) 		PF01207
(Dus) 		5 TRP A 204
GLY A 224
ILE A 223
TRP A 276
TYR A 279
 None
FMN  A 401 (-3.6A)
None
None
C  D  17 ( 4.3A)
 1.46A 5nz0A-4ycoA:
undetectable		 5nz0A-4ycoA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhx RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN

(Grosmannia
penicillata) 		PF00961
(LAGLIDADG_1) 		5 GLY A  41
ILE A  23
PHE A  22
ASN A 136
LEU A 135
 None
 1.32A 5nz0A-4yhxA:
undetectable		 5nz0A-4yhxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A 162
THR A  31
VAL A  51
ASN A 147
LEU A 143
 None
 1.25A 5nz0A-4ynzA:
undetectable		 5nz0A-4ynzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135

(Acanthamoeba
polyphaga
mimivirus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 205
THR A 395
VAL A 394
ASN A 187
LEU A 198
 None
 1.22A 5nz0A-4z26A:
undetectable		 5nz0A-4z26A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2f CD166 ANTIGEN

(Homo sapiens) 		PF08205
(C2-set_2) 		5 TYR A  29
THR A 126
VAL A  31
LEU A 115
TRP A  56
 None
 1.04A 5nz0A-5a2fA:
undetectable		 5nz0A-5a2fA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 385
ILE A 420
TYR A 416
THR A 417
LEU A 438
 None
 1.47A 5nz0A-5bswA:
undetectable		 5nz0A-5bswA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn7 PROTEIN FAM179B

(Mus musculus) 		no annotation 5 GLY A 393
ILE A 395
PHE A 394
THR A 386
LEU A 417
 None
 1.39A 5nz0A-5dn7A:
undetectable		 5nz0A-5dn7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 5 GLY B 297
ILE B 295
PHE B 299
ASN B 339
LEU B  83
 None
 1.44A 5nz0A-5f8uB:
1.6		 5nz0A-5f8uB:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 GLY A 335
PHE A 327
THR A 139
VAL A 174
LEU A 112
 None
 1.37A 5nz0A-5h1cA:
undetectable		 5nz0A-5h1cA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 6 TRP A 321
GLY A 322
ILE A 323
PHE A 324
VAL A 267
LEU A 325
 None
 1.14A 5nz0A-5h2tA:
undetectable		 5nz0A-5h2tA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kte DIVALENT METAL
CATION TRANSPORTER
MNTH

(Deinococcus
radiodurans) 		PF01566
(Nramp) 		5 GLY A 324
MET A 150
THR A 157
VAL A 160
LEU A 374
 None
 0.94A 5nz0A-5kteA:
undetectable		 5nz0A-5kteA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		5 GLY A 389
ILE A 392
VAL A 285
LEU A 369
TRP A 396
 None
 1.29A 5nz0A-5lmcA:
undetectable		 5nz0A-5lmcA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT

(Homo sapiens) 		no annotation 5 GLY G  99
ILE G  34
TRP G 117
TYR G 116
VAL G   2
 None
 1.31A 5nz0A-5u0uG:
undetectable		 5nz0A-5u0uG:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
FV 24-60 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		no annotation
no annotation 		5 TRP A 244
GLY A  27
ILE A  25
TYR H  54
LEU A  19
 None
 1.36A 5nz0A-5u8qA:
undetectable		 5nz0A-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yid PLASMEPSIN II

(Plasmodium
falciparum) 		no annotation 5 GLY A 127
ILE A 125
PHE A  33
TYR A 102
VAL A 138
 None
K95  A 401 ( 4.7A)
None
None
None
 1.31A 5nz0A-5yidA:
undetectable		 5nz0A-5yidA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 5 GLY A 212
ILE A 211
THR A  80
LEU A 151
TRP A 154
 None
 1.03A 5nz0A-6cc4A:
1.9		 5nz0A-6cc4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccb GLYCOPROTEIN 120

(Human
immunodeficiency
virus 1) 		no annotation 5 GLY C 451
ILE C 449
THR C 256
VAL C 254
LEU C 390
 None
 1.48A 5nz0A-6ccbC:
undetectable		 5nz0A-6ccbC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqc SCFV OF 9C12
ANTIBODY

(Mus musculus) 		no annotation 5 GLY D 229
TRP D 237
TYR D 236
VAL D 132
LEU D 103
 None
 1.41A 5nz0A-6eqcD:
undetectable		 5nz0A-6eqcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6guo -

(-) 		no annotation 5 GLY A 294
ILE A 295
PHE A 161
TYR A 278
LEU A  56
 None
 1.27A 5nz0A-6guoA:
undetectable		 5nz0A-6guoA:
undetectable