SIMILAR PATTERNS OF AMINO ACIDS FOR 5NY7_A_NCAA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642

(Pyrococcus
horikoshii) 		PF00795
(CN_hydrolase) 		5 GLU A  42
TYR A  48
LYS A 113
GLU A 120
LEU A 172
 None
None
None
None
ACT  A1301 (-4.3A)
 0.91A 5ny7A-1j31A:
34.2		 5ny7A-1j31A:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwt MAJOR STRUCTURAL
SUBUNIT OF
BUNDLE-FORMING PILUS

(Escherichia
coli) 		PF05307
(Bundlin) 		5 GLU A 139
LYS A 131
TYR A 155
ALA A 134
LEU A 100
 None
 1.27A 5ny7A-1zwtA:
0.0		 5ny7A-1zwtA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus) 		PF00795
(CN_hydrolase) 		5 GLU A  81
TYR A  87
LYS A 150
GLU A 166
TYR A 192
 None
 0.77A 5ny7A-2w1vA:
33.2		 5ny7A-2w1vA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)

(Pyrococcus
abyssi) 		PF00795
(CN_hydrolase) 		5 GLU A  42
TYR A  48
LYS A 113
GLU A 120
LEU A 172
 None
None
None
None
ACY  A3001 (-4.2A)
 0.85A 5ny7A-3ki8A:
33.9		 5ny7A-3ki8A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY

(Staphylococcus
aureus) 		PF00795
(CN_hydrolase) 		5 GLU A  41
TYR A  47
LYS A 110
GLU A 119
TYR A 147
 None
None
None
None
PEG  A 265 (-4.5A)
 1.05A 5ny7A-3p8kA:
32.6		 5ny7A-3p8kA:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jqn ALIPHATIC AMIDASE

(Nesterenkonia
sp. AN1) 		PF00795
(CN_hydrolase) 		8 GLU A  41
TYR A  47
LYS A 111
TYR A 115
GLU A 119
TYR A 146
GLU A 149
LEU A 171
 None
 0.23A 5ny7A-5jqnA:
48.4		 5ny7A-5jqnA:
99.62