SIMILAR PATTERNS OF AMINO ACIDS FOR 5NWW_A_ACAA18_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN

(Thermococcus
litoralis) 		PF01547
(SBP_bac_1) 		3 LYS A 347
TRP A 261
SER A 346
 CL  A 414 (-3.0A)
None
None
 1.18A 5nwwA-1eu8A:
0.0		 5nwwA-1eu8A:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		3 LYS A 108
TRP A  89
SER A 105
 None
 1.28A 5nwwA-1fc9A:
0.0		 5nwwA-1fc9A:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		3 LYS A 253
TRP A 254
SER A 256
 None
 1.39A 5nwwA-1khwA:
undetectable		 5nwwA-1khwA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 LYS A 396
TRP A 243
SER A 398
 None
 1.12A 5nwwA-1ksiA:
0.0		 5nwwA-1ksiA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		3 LYS A 348
TRP A 336
SER A 346
 None
 1.28A 5nwwA-1l0qA:
0.0		 5nwwA-1l0qA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 LYS A 248
TRP A  69
SER A 251
 None
 1.20A 5nwwA-1lnlA:
0.0		 5nwwA-1lnlA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhm S-ADENOSYLMETHIONINE
DECARBOXYLASE

(Solanum
tuberosum) 		PF01536
(SAM_decarbox) 		3 LYS A 164
TRP A 165
SER A 119
 None
 1.38A 5nwwA-1mhmA:
0.0		 5nwwA-1mhmA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpz OBTUSTATIN

(Macrovipera
lebetina) 		no annotation 3 LYS A  21
TRP A  20
SER A  26
 None
 1.04A 5nwwA-1mpzA:
undetectable		 5nwwA-1mpzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nex CDC4 PROTEIN

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12937
(F-box-like) 		3 LYS B 724
TRP B 365
SER B 744
 None
 1.39A 5nwwA-1nexB:
0.0		 5nwwA-1nexB:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ssf TRANSFORMATION
RELATED PROTEIN 53
BINDING PROTEIN 1

(Mus musculus) 		PF09038
(53-BP1_Tudor) 		3 LYS A  17
TRP A  18
SER A  20
 None
 1.37A 5nwwA-1ssfA:
undetectable		 5nwwA-1ssfA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl5 UNKNOWN CONSERVED
PROTEIN BH2331

(Bacillus
halodurans) 		PF08241
(Methyltransf_11) 		3 LYS A 174
TRP A 173
SER A 176
 None
 1.33A 5nwwA-1vl5A:
undetectable		 5nwwA-1vl5A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae) 		PF00232
(Glyco_hydro_1) 		3 LYS A 285
TRP A 283
SER A 276
 None
 1.09A 5nwwA-1wcgA:
undetectable		 5nwwA-1wcgA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wt9 ANTICOAGULANT
PROTEIN-B

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		3 LYS B  70
TRP B  72
SER B  69
 None
 1.15A 5nwwA-1wt9B:
undetectable		 5nwwA-1wt9B:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzh CYTOCHROME C
PEROXIDASE

(Rhodobacter
capsulatus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 LYS A 267
TRP A 269
SER A 265
 None
 0.85A 5nwwA-1zzhA:
undetectable		 5nwwA-1zzhA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima) 		PF03537
(Glyco_hydro_114) 		3 LYS A 103
TRP A 102
SER A 105
 None
 1.03A 5nwwA-2aamA:
undetectable		 5nwwA-2aamA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cof PROTEIN KIAA1914

(Homo sapiens) 		PF00169
(PH) 		3 LYS A  23
TRP A  22
SER A  24
 None
 1.34A 5nwwA-2cofA:
undetectable		 5nwwA-2cofA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu9 HISTONE CHAPERONE
CIA1

(Schizosaccharomyces
pombe) 		PF04729
(ASF1_hist_chap) 		3 LYS A 140
TRP A 142
SER A 139
 None
 1.20A 5nwwA-2cu9A:
undetectable		 5nwwA-2cu9A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dnp RNA-BINDING PROTEIN
14

(Homo sapiens) 		PF00076
(RRM_1) 		3 LYS A  80
TRP A  79
SER A 147
 None
 1.30A 5nwwA-2dnpA:
undetectable		 5nwwA-2dnpA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erv HYPOTHETICAL PROTEIN
PAER03002360

(Pseudomonas
aeruginosa) 		PF09411
(PagL) 		3 LYS A  57
TRP A  48
SER A  89
 None
 1.04A 5nwwA-2ervA:
undetectable		 5nwwA-2ervA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		3 LYS A 404
TRP A 409
SER A 400
 None
 1.25A 5nwwA-2f9qA:
undetectable		 5nwwA-2f9qA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 LYS A 648
TRP A 650
SER A 706
 None
 1.32A 5nwwA-2iukA:
undetectable		 5nwwA-2iukA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LYS A 192
TRP A 258
SER A 189
 None
 1.30A 5nwwA-2j2mA:
undetectable		 5nwwA-2j2mA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpz NAPHTHALENE
1,2-DIOXYGENASE
SYSTEM FERREDOXIN
SUBUNIT

(Pseudomonas
putida) 		PF00355
(Rieske) 		3 LYS A   1
TRP A   4
SER A 103
 None
 0.92A 5nwwA-2qpzA:
undetectable		 5nwwA-2qpzA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		3 LYS A  92
TRP A  90
SER A  93
 None
 1.37A 5nwwA-2tddA:
undetectable		 5nwwA-2tddA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v72 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		3 LYS A  39
TRP A  40
SER A  17
 None
GAL  A1140 (-3.5A)
None
 1.40A 5nwwA-2v72A:
undetectable		 5nwwA-2v72A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Pisum sativum) 		PF01652
(IF4E) 		3 LYS A 131
TRP A 132
SER A 178
 None
 1.28A 5nwwA-2wmcA:
undetectable		 5nwwA-2wmcA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 LYS A 922
TRP A 878
SER A 851
 None
None
GD9  A2058 ( 4.5A)
 1.23A 5nwwA-2y3aA:
undetectable		 5nwwA-2y3aA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		3 LYS A 190
TRP A 196
SER A 187
 None
 1.34A 5nwwA-2yevA:
undetectable		 5nwwA-2yevA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		3 LYS A 503
TRP A 504
SER A 508
 None
 1.31A 5nwwA-3ayxA:
undetectable		 5nwwA-3ayxA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b13 DEDICATOR OF
CYTOKINESIS PROTEIN
2

(Homo sapiens) 		PF06920
(DHR-2) 		3 LYS A1252
TRP A1253
SER A1254
 None
 1.40A 5nwwA-3b13A:
undetectable		 5nwwA-3b13A:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuc PROTEIN OF UNKNOWN
FUNCTION WITH A FIC
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF02661
(Fic) 		3 LYS A  12
TRP A  13
SER A  15
 None
 0.99A 5nwwA-3cucA:
undetectable		 5nwwA-3cucA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		3 LYS A 470
TRP A 471
SER A 469
 None
 1.17A 5nwwA-3e0gA:
undetectable		 5nwwA-3e0gA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		3 LYS A 251
TRP A 250
SER A 253
 None
 1.21A 5nwwA-3gbzA:
undetectable		 5nwwA-3gbzA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goh ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Shewanella
oneidensis) 		PF08240
(ADH_N) 		3 LYS A  92
TRP A  55
SER A  90
 None
 1.14A 5nwwA-3gohA:
undetectable		 5nwwA-3gohA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hei EPHRIN-A1

(Homo sapiens) 		PF00812
(Ephrin) 		3 LYS B 103
TRP B  90
SER B 105
 None
 1.16A 5nwwA-3heiB:
undetectable		 5nwwA-3heiB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hty HYPOTHETICAL PROTEIN
BT_0869

(Bacteroides
thetaiotaomicron) 		PF12702
(Lipocalin_3) 		3 LYS A  44
TRP A  64
SER A  28
 None
 1.22A 5nwwA-3htyA:
undetectable		 5nwwA-3htyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo sapiens) 		PF09817
(Zwilch) 		3 LYS B 530
TRP B 531
SER B 549
 None
 1.33A 5nwwA-3if8B:
undetectable		 5nwwA-3if8B:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		3 LYS A 480
TRP A 490
SER A 479
 None
None
FAD  A 541 ( 4.0A)
 1.05A 5nwwA-3js8A:
undetectable		 5nwwA-3js8A:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1u BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		3 LYS A 190
TRP A 193
SER A 214
 EDO  A 405 (-2.7A)
EDO  A 403 ( 4.3A)
None
 1.27A 5nwwA-3k1uA:
undetectable		 5nwwA-3k1uA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k77 DNA REPAIR PROTEIN
XRCC1

(Homo sapiens) 		PF01834
(XRCC1_N) 		3 LYS A  32
TRP A  33
SER A 145
 None
 1.36A 5nwwA-3k77A:
undetectable		 5nwwA-3k77A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 LYS A 709
TRP A 708
SER A 711
 None
 1.05A 5nwwA-3la4A:
undetectable		 5nwwA-3la4A:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqj MLL1 PHD3-BROMO

(Homo sapiens) 		PF00628
(PHD) 		3 LYS A1773
TRP A1777
SER A1770
 None
 1.39A 5nwwA-3lqjA:
undetectable		 5nwwA-3lqjA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		3 LYS A 189
TRP A 190
SER A 188
 CL  A 603 ( 4.0A)
None
CL  A 603 (-3.2A)
 1.36A 5nwwA-3mx3A:
undetectable		 5nwwA-3mx3A:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		3 LYS A 105
TRP A 420
SER A 107
 EDO  A 452 (-3.3A)
None
None
 1.31A 5nwwA-3r0zA:
undetectable		 5nwwA-3r0zA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s48 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H

(Staphylococcus
aureus) 		PF05031
(NEAT) 		3 LYS A 157
TRP A 156
SER A  89
 None
 1.07A 5nwwA-3s48A:
undetectable		 5nwwA-3s48A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		3 LYS X 107
TRP X 422
SER X 109
 None
 1.34A 5nwwA-3ss7X:
undetectable		 5nwwA-3ss7X:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		3 LYS A 420
TRP A 419
SER A 397
 None
 1.34A 5nwwA-3syjA:
undetectable		 5nwwA-3syjA:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		3 LYS A  11
TRP A  50
SER A  53
 MG  A 500 (-3.1A)
None
None
 0.84A 5nwwA-3t5tA:
undetectable		 5nwwA-3t5tA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 167
TRP A 168
SER A 139
 None
 1.32A 5nwwA-3t9pA:
undetectable		 5nwwA-3t9pA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		3 LYS A 104
TRP A 103
SER A 129
 None
 1.35A 5nwwA-3tc2A:
undetectable		 5nwwA-3tc2A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v96 METALLOPROTEINASE
INHIBITOR 1

(Homo sapiens) 		PF00965
(TIMP) 		3 LYS A 157
TRP A 147
SER A 155
 PO4  A 202 (-4.0A)
None
None
 1.19A 5nwwA-3v96A:
undetectable		 5nwwA-3v96A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 LYS A4635
TRP A4671
SER A4636
 None
 1.21A 5nwwA-3vkgA:
undetectable		 5nwwA-3vkgA:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4u HEMOGLOBIN SUBUNIT
ZETA

(Homo sapiens) 		PF00042
(Globin) 		3 LYS A  71
TRP A  14
SER A  72
 None
 1.31A 5nwwA-3w4uA:
undetectable		 5nwwA-3w4uA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cz2 RAS-RELATED PROTEIN
RAB-32

(Homo sapiens) 		PF00071
(Ras) 		3 LYS A 119
TRP A 120
SER A 122
 None
 1.21A 5nwwA-4cz2A:
undetectable		 5nwwA-4cz2A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		3 LYS A 422
TRP A 425
SER A 449
 None
 1.32A 5nwwA-4exkA:
undetectable		 5nwwA-4exkA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc3 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H

(Staphylococcus
aureus) 		PF05031
(NEAT) 		3 LYS E  77
TRP E  76
SER E   9
 None
 1.29A 5nwwA-4fc3E:
undetectable		 5nwwA-4fc3E:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqj HEMAGGLUTININ

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		3 LYS A 269
TRP A 271
SER A 120
 None
 0.97A 5nwwA-4fqjA:
undetectable		 5nwwA-4fqjA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 LYS B 709
TRP B 708
SER B 711
 None
 1.06A 5nwwA-4g7eB:
undetectable		 5nwwA-4g7eB:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ged ASCORBATE PEROXIDASE

(Leishmania
major) 		PF00141
(peroxidase) 		3 LYS A 297
TRP A 144
SER A  34
 None
 0.98A 5nwwA-4gedA:
undetectable		 5nwwA-4gedA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		3 LYS A 115
TRP A 117
SER A 119
 None
 1.38A 5nwwA-4hsuA:
undetectable		 5nwwA-4hsuA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		3 LYS B 206
TRP B 205
SER B 182
 None
 1.10A 5nwwA-4hxeB:
undetectable		 5nwwA-4hxeB:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij2 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H

(Staphylococcus
aureus) 		PF05031
(NEAT) 		3 LYS E 397
TRP E 396
SER E 329
 None
 1.29A 5nwwA-4ij2E:
undetectable		 5nwwA-4ij2E:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0v TEK TYROSINE KINASE
VARIANT

(Homo sapiens) 		PF00041
(fn3)
PF10430
(Ig_Tie2_1) 		3 LYS A  95
TRP A  88
SER A  94
 None
 1.35A 5nwwA-4k0vA:
undetectable		 5nwwA-4k0vA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 LYS C  57
TRP C  59
SER C  56
 None
 1.37A 5nwwA-4lccC:
undetectable		 5nwwA-4lccC:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr4 HYPOTHETICAL PROTEIN

([Eubacterium]
rectale) 		no annotation 3 LYS A 267
TRP A 268
SER A 374
 None
 1.29A 5nwwA-4lr4A:
undetectable		 5nwwA-4lr4A:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npr XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE GH12

(Aspergillus
niveus) 		PF01670
(Glyco_hydro_12) 		3 LYS A 104
TRP A 103
SER A 187
 None
 1.01A 5nwwA-4nprA:
undetectable		 5nwwA-4nprA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pib INCLUSION BODY
PROTEIN

(Burkholderia
thailandensis) 		PF12306
(PixA) 		3 LYS A 182
TRP A 183
SER A  50
 None
 1.38A 5nwwA-4pibA:
undetectable		 5nwwA-4pibA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ps6 INHIBITOR OF
VERTEBRATE LYSOZYME

(Pseudomonas
aeruginosa) 		PF08816
(Ivy) 		3 LYS A  55
TRP A  56
SER A  58
 None
 1.24A 5nwwA-4ps6A:
undetectable		 5nwwA-4ps6A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		3 LYS B  54
TRP B  53
SER B  55
 None
 1.21A 5nwwA-4rt6B:
undetectable		 5nwwA-4rt6B:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		3 LYS A1315
TRP A1316
SER A1314
 None
 1.29A 5nwwA-4w4tA:
undetectable		 5nwwA-4w4tA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 LYS A1093
TRP A1037
SER A1092
 None
 1.34A 5nwwA-5e02A:
undetectable		 5nwwA-5e02A:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4q CONTACTIN-3

(Mus musculus) 		PF00041
(fn3) 		3 LYS A 829
TRP A 828
SER A 831
 None
 1.15A 5nwwA-5e4qA:
undetectable		 5nwwA-5e4qA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus musculus) 		PF05175
(MTS) 		3 LYS A 273
TRP A 277
SER A 272
 None
 0.87A 5nwwA-5fulA:
undetectable		 5nwwA-5fulA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 LYS A 200
TRP A 194
SER A 198
 None
 1.33A 5nwwA-5gvaA:
undetectable		 5nwwA-5gvaA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii) 		PF16483
(Glyco_hydro_64) 		3 LYS A 181
TRP A 133
SER A 183
 None
 0.99A 5nwwA-5h9xA:
undetectable		 5nwwA-5h9xA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hot INTEGRASE

(Human
immunodeficiency
virus 1) 		PF00552
(IN_DBD_C)
PF00665
(rve) 		3 LYS A  56
TRP A  61
SER A  57
 None
 1.40A 5nwwA-5hotA:
undetectable		 5nwwA-5hotA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 LYS A 673
TRP A 677
SER A 671
 None
 1.19A 5nwwA-5ihrA:
undetectable		 5nwwA-5ihrA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 LYS A  47
TRP A 208
SER A  13
 None
 1.30A 5nwwA-5k8dA:
undetectable		 5nwwA-5k8dA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum) 		PF02353
(CMAS) 		3 LYS A 293
TRP A 295
SER A 335
 None
 1.26A 5nwwA-5kpgA:
undetectable		 5nwwA-5kpgA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6q H5AL

(Homo sapiens) 		PF07686
(V-set) 		3 LYS A  49
TRP A  33
SER A  30
 None
 1.06A 5nwwA-5l6qA:
undetectable		 5nwwA-5l6qA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 LYS A 404
TRP A 553
SER A 402
 None
 1.19A 5nwwA-5lm8A:
undetectable		 5nwwA-5lm8A:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m23 WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40) 		3 LYS A 120
TRP A 114
SER A 118
 None
 1.24A 5nwwA-5m23A:
undetectable		 5nwwA-5m23A:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m30 TYPE VI SECRETION
PROTEIN

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		3 LYS A 145
TRP A 125
SER A 127
 None
 1.37A 5nwwA-5m30A:
undetectable		 5nwwA-5m30A:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me5 EUKARYOTIC
TRANSCRIPTION
INITIATION FACTOR 4E

(Cucumis melo) 		PF01652
(IF4E) 		3 LYS A 138
TRP A 139
SER A 185
 None
 1.30A 5nwwA-5me5A:
undetectable		 5nwwA-5me5A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me6 EUKARYOTIC
TRANSCRIPTION
INITIATION FACTOR 4E

(Cucumis melo) 		PF01652
(IF4E) 		3 LYS A 138
TRP A 139
SER A 185
 LYS  A 138 ( 0.0A)
TRP  A 139 ( 0.5A)
SER  A 185 ( 0.0A)
 1.13A 5nwwA-5me6A:
undetectable		 5nwwA-5me6A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myu TYPE VI SECRETION
SYSTEM PROTEIN IMPC

(Vibrio cholerae) 		PF05943
(VipB) 		3 LYS A 223
TRP A 224
SER A 226
 None
 1.12A 5nwwA-5myuA:
undetectable		 5nwwA-5myuA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 3 LYS A 487
TRP A 486
SER A 493
 None
 1.23A 5nwwA-5necA:
undetectable		 5nwwA-5necA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2

(Homo sapiens) 		PF01652
(IF4E) 		3 LYS A 134
TRP A 135
SER A 181
 None
 1.00A 5nwwA-5nvmA:
undetectable		 5nwwA-5nvmA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o03 NANOBODY (VHH)
NANO-32

(Norwalk virus) 		PF07686
(V-set) 		3 LYS C 120
TRP C 125
SER C 118
 None
 1.36A 5nwwA-5o03C:
undetectable		 5nwwA-5o03C:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 LYS T2827
TRP T2828
SER T2830
 None
 1.39A 5nwwA-5ojsT:
undetectable		 5nwwA-5ojsT:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svb ACETONE CARBOXYLASE
GAMMA SUBUNIT

(Xanthobacter
autotrophicus) 		PF08882
(Acetone_carb_G) 		3 LYS C  69
TRP C  70
SER C  67
 None
 1.30A 5nwwA-5svbC:
undetectable		 5nwwA-5svbC:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		3 LYS A 975
TRP A 973
SER A 978
 None
 1.24A 5nwwA-5u1sA:
undetectable		 5nwwA-5u1sA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urp TOXIN 2A

(Paenibacillus
larvae) 		no annotation 3 LYS A  23
TRP A  22
SER A  20
 None
 1.18A 5nwwA-5urpA:
undetectable		 5nwwA-5urpA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1

(Saccharomyces
cerevisiae) 		no annotation 3 LYS d 158
TRP d 159
SER d 161
 None
 0.62A 5nwwA-5wsgd:
undetectable		 5nwwA-5wsgd:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		3 LYS A  65
TRP A  66
SER A  68
 None
 1.30A 5nwwA-5xd0A:
undetectable		 5nwwA-5xd0A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN

(SFTS
phlebovirus) 		PF07243
(Phlebovirus_G1) 		3 LYS C 113
TRP C 141
SER C 115
 None
 1.15A 5nwwA-5y10C:
undetectable		 5nwwA-5y10C:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 3 LYS A 563
TRP A 594
SER A 562
 None
 1.38A 5nwwA-5z9sA:
undetectable		 5nwwA-5z9sA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S7E

(Leishmania
donovani) 		no annotation 3 LYS I 154
TRP I 143
SER I 185
 None
 1.28A 5nwwA-6az1I:
undetectable		 5nwwA-6az1I:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9z SULFATE TRANSPORTER
CYSZ

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		no annotation 3 LYS F 199
TRP F 201
SER F 198
 None
 1.03A 5nwwA-6d9zF:
undetectable		 5nwwA-6d9zF:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gzp NANOBODY

(Lama glama) 		no annotation 3 LYS A 100
TRP A 103
SER A 100
 None
 1.10A 5nwwA-6gzpA:
undetectable		 5nwwA-6gzpA:
undetectable