SIMILAR PATTERNS OF AMINO ACIDS FOR 5NWW_A_ACAA18_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awc PROTEIN (GA BINDING
PROTEIN ALPHA)

(Mus musculus) 		PF00178
(Ets) 		5 GLY A 361
GLN A 324
LEU A 326
GLU A 328
LEU A 329
 None
 0.79A 5nwwA-1awcA:
0.0		 5nwwA-1awcA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awc PROTEIN (GA BINDING
PROTEIN ALPHA)

(Mus musculus) 		PF00178
(Ets) 		5 GLY A 361
GLN A 324
LEU A 327
GLU A 328
LEU A 329
 None
 0.91A 5nwwA-1awcA:
0.0		 5nwwA-1awcA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		5 GLY A 277
ASN A 286
GLN A 289
LEU A 290
LEU A 395
 None
 1.23A 5nwwA-1cptA:
0.0		 5nwwA-1cptA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dux ETS-DOMAIN PROTEIN
ELK-1

(Homo sapiens) 		PF00178
(Ets) 		5 GLY C  47
GLN C   9
LEU C  11
LEU C  12
LEU C  14
 None
 0.79A 5nwwA-1duxC:
0.0		 5nwwA-1duxC:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0a DELTA CRYSTALLIN I

(Meleagris
gallopavo) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 LYS A 299
GLN A 138
LEU A 136
LEU A 137
LEU A 180
 None
 1.19A 5nwwA-1i0aA:
0.0		 5nwwA-1i0aA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q TRPG

(Serratia
marcescens) 		PF00117
(GATase) 		5 GLY B  36
GLN B  78
LEU B  53
LEU B  79
LEU B   5
 None
 1.27A 5nwwA-1i7qB:
0.0		 5nwwA-1i7qB:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 GLY S  43
SER S  39
GLN S  62
GLU S  45
LEU S  61
 None
 1.27A 5nwwA-1i84S:
0.3		 5nwwA-1i84S:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ic2 TROPOMYOSIN ALPHA
CHAIN, SKELETAL
MUSCLE

(Gallus gallus) 		PF12718
(Tropomyosin_1) 		5 GLN A  68
GLU A  69
LEU A  71
GLU A  72
LEU A  73
 None
 1.25A 5nwwA-1ic2A:
0.0		 5nwwA-1ic2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 GLN A 280
LEU A 282
LEU A 283
GLU A 284
LEU A 285
 None
 0.75A 5nwwA-1mc3A:
0.0		 5nwwA-1mc3A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdm C-ETS-1 PROTEIN

(Mus musculus) 		PF00178
(Ets) 		5 GLY B 376
GLN B 339
LEU B 341
GLU B 343
LEU B 344
 None
 0.88A 5nwwA-1mdmB:
0.0		 5nwwA-1mdmB:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdm C-ETS-1 PROTEIN

(Mus musculus) 		PF00178
(Ets) 		5 GLY B 376
GLN B 339
LEU B 342
GLU B 343
LEU B 344
 None
 1.16A 5nwwA-1mdmB:
0.0		 5nwwA-1mdmB:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  71
LYS A  77
LEU A 192
GLU A 145
LEU A 193
 STU  A 401 (-3.6A)
None
None
None
STU  A 401 (-4.7A)
 1.07A 5nwwA-1nxkA:
undetectable		 5nwwA-1nxkA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		5 SER A 313
LYS A 315
LEU A 370
LEU A 373
GLU A 374
 None
 1.20A 5nwwA-1pw4A:
undetectable		 5nwwA-1pw4A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		5 GLY A  45
SER A  46
LEU A  17
LEU A  21
GLU A  24
 None
 1.04A 5nwwA-1tzsA:
undetectable		 5nwwA-1tzsA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 5 GLY A  39
LYS A  41
ASN A 343
LEU A 333
GLU A 335
 None
 1.15A 5nwwA-1u5uA:
undetectable		 5nwwA-1u5uA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A  48
GLN A 117
GLU A 119
LEU A 115
LEU A 120
 None
 1.17A 5nwwA-1v9lA:
undetectable		 5nwwA-1v9lA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmi HYPOTHETICAL PROTEIN
PHS014

(Pyrococcus
horikoshii) 		no annotation 5 GLU B  43
LEU B  44
LEU B  45
GLU B  46
LEU B  47
 None
 0.69A 5nwwA-1wmiB:
undetectable		 5nwwA-1wmiB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yo5 SAM POINTED DOMAIN
CONTAINING ETS
TRANSCRIPTION FACTOR

(Homo sapiens) 		PF00178
(Ets) 		5 GLY C 292
GLN C 253
LEU C 255
GLU C 257
LEU C 258
 None
 0.74A 5nwwA-1yo5C:
undetectable		 5nwwA-1yo5C:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 GLY A  11
SER A  14
LYS A  12
ASN A  49
LEU A  57
 None
 1.08A 5nwwA-1zaoA:
undetectable		 5nwwA-1zaoA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 119
LYS A 285
LEU A 289
GLU A 291
LEU A 292
 FAD  A4750 (-4.3A)
None
None
None
None
 1.24A 5nwwA-1zy8A:
undetectable		 5nwwA-1zy8A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		5 GLY B 489
LEU B 383
LEU B 384
GLU B 385
LEU B 386
 None
 0.98A 5nwwA-2afhB:
undetectable		 5nwwA-2afhB:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 GLY A 497
SER A 496
ASN A 278
GLU A  74
LEU A 259
 None
 1.14A 5nwwA-2b3oA:
undetectable		 5nwwA-2b3oA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 GLY A 153
SER A 154
ASN A 340
LEU A 342
LEU A  79
 None
 1.17A 5nwwA-2de2A:
undetectable		 5nwwA-2de2A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dxq ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF00583
(Acetyltransf_1) 		5 GLY A  60
LEU A  19
LEU A  20
GLU A  21
LEU A  22
 None
 0.95A 5nwwA-2dxqA:
undetectable		 5nwwA-2dxqA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 139
LYS A 125
LEU A 114
GLU A 113
LEU A 115
 None
 1.14A 5nwwA-2eq9A:
undetectable		 5nwwA-2eq9A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 GLY A 292
GLN A 336
LEU A 338
GLU A 340
LEU A 341
 None
 1.07A 5nwwA-2f31A:
undetectable		 5nwwA-2f31A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5d GNA33

(Neisseria
gonorrhoeae) 		PF03562
(MltA)
PF06725
(3D) 		5 GLY A 291
ASN A 317
GLN A 319
LEU A 321
GLU A 323
 None
 0.97A 5nwwA-2g5dA:
undetectable		 5nwwA-2g5dA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3j DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1

(Rattus
norvegicus) 		PF00035
(dsrm) 		5 GLN A  12
LEU A  10
LEU A  13
GLU A  63
LEU A  59
 None
G  B 277 ( 3.5A)
None
None
None
 1.25A 5nwwA-2l3jA:
undetectable		 5nwwA-2l3jA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1t PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		5 GLY A 249
LEU A  32
LEU A  33
GLU A  34
LEU A  35
 None
 0.95A 5nwwA-2q1tA:
undetectable		 5nwwA-2q1tA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 GLY A  52
SER A  53
LYS A  55
GLU A 174
LEU A 142
 None
None
None
PGE  A 332 (-3.0A)
None
 0.95A 5nwwA-2qcvA:
undetectable		 5nwwA-2qcvA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		5 GLY A  52
LEU A  79
LEU A  80
GLU A  81
LEU A 157
 None
 1.26A 5nwwA-2ww9A:
undetectable		 5nwwA-2ww9A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1

(Homo sapiens) 		PF01026
(TatD_DNase) 		5 GLY A  82
ASN A  88
LEU A  93
GLU A  95
LEU A  96
 None
 1.23A 5nwwA-2xioA:
undetectable		 5nwwA-2xioA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypr PROTEIN FEV

(Homo sapiens) 		PF00178
(Ets) 		5 GLY A  88
GLN A  51
LEU A  53
LEU A  54
LEU A  56
 None
 1.03A 5nwwA-2yprA:
undetectable		 5nwwA-2yprA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypr PROTEIN FEV

(Homo sapiens) 		PF00178
(Ets) 		5 GLY A  88
LEU A  53
LEU A  54
GLU A  55
LEU A  56
 None
 0.94A 5nwwA-2yprA:
undetectable		 5nwwA-2yprA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLY A 362
LYS A 366
ASN A 479
LEU A 376
LEU A 435
 None
None
THM  A6510 ( 4.7A)
None
None
 1.12A 5nwwA-2z1aA:
undetectable		 5nwwA-2z1aA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 GLY A  70
SER A  73
LYS A  47
LEU A  61
LEU A  85
 None
 1.22A 5nwwA-2z63A:
undetectable		 5nwwA-2z63A:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcw TRANSCRIPTIONAL
REGULATOR, FNR/CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 GLY A 156
LEU A 126
LEU A 127
GLU A 128
LEU A 129
 None
 1.05A 5nwwA-2zcwA:
undetectable		 5nwwA-2zcwA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgf F26G19 FAB

(Mus musculus) 		no annotation 5 GLY H 104
GLN L  37
LEU L  36
GLU L  38
LEU H  45
 None
 1.22A 5nwwA-3bgfH:
undetectable		 5nwwA-3bgfH:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		5 GLY B   8
LEU B 115
LEU B 118
GLU B 119
LEU B 116
 None
 1.24A 5nwwA-3bt6B:
undetectable		 5nwwA-3bt6B:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 GLY A 722
ASN A 759
GLN A 763
LEU A 752
LEU A 745
 None
 1.22A 5nwwA-3bwtA:
undetectable		 5nwwA-3bwtA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 22 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 31 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04051
(TRAPP) 		5 GLY D  35
LEU B  98
LEU B  99
GLU B 100
LEU B 101
 None
 1.05A 5nwwA-3cueD:
undetectable		 5nwwA-3cueD:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3q TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Staphylococcus
epidermidis) 		PF01715
(IPPT) 		5 ASN A 228
GLN A 231
GLU A 229
LEU A 226
LEU A 252
 None
 1.24A 5nwwA-3d3qA:
undetectable		 5nwwA-3d3qA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3r CALCYPHOSIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 GLY A  73
SER A  74
GLU A  81
LEU A  83
LEU A  77
 None
CA  A 192 (-2.5A)
CA  A 192 (-2.3A)
None
None
 1.06A 5nwwA-3e3rA:
undetectable		 5nwwA-3e3rA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdf PROBABLE
NADP-DEPENDENT
MANNITOL
DEHYDROGENASE

(Cladosporium
herbarum) 		PF13561
(adh_short_C2) 		5 GLY A 153
SER A 154
GLN A  15
LEU A  16
LEU A  18
 None
 1.25A 5nwwA-3gdfA:
undetectable		 5nwwA-3gdfA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3r ADAPTER PROTEIN MECA
1

(Bacillus
subtilis) 		PF05389
(MecA) 		5 GLY 1 149
SER 1 150
ASN 1 177
LEU 1 179
LEU 1 182
 None
 1.17A 5nwwA-3j3r1:
undetectable		 5nwwA-3j3r1:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 214
LEU A 200
LEU A 201
GLU A 198
LEU A 199
 None
 1.06A 5nwwA-3mi9A:
undetectable		 5nwwA-3mi9A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 GLY B 612
SER B 535
ASN B 617
LEU B 628
GLU B 622
 None
 1.25A 5nwwA-3prxB:
undetectable		 5nwwA-3prxB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr3 MICROCIN IMMUNITY
PROTEIN MCCF

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		5 SER A  82
ASN A 210
LEU A 118
LEU A 119
LEU A 117
 None
 1.26A 5nwwA-3sr3A:
undetectable		 5nwwA-3sr3A:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A 285
SER A 288
LYS A 286
ASN A 253
GLN A 251
 None
 1.24A 5nwwA-3txxA:
undetectable		 5nwwA-3txxA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0f ENDONUCLEASE 8-LIKE
3

(Mus musculus) 		PF06831
(H2TH) 		5 GLY A 204
SER A 203
ASN A 197
LEU A 182
LEU A 178
 None
 1.23A 5nwwA-3w0fA:
undetectable		 5nwwA-3w0fA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		5 ASN A 376
GLN A 358
LEU A 374
LEU A 354
GLU A 359
 None
 1.21A 5nwwA-3w5fA:
undetectable		 5nwwA-3w5fA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wu1 PROTEIN C-ETS-1

(Homo sapiens) 		PF00178
(Ets) 		5 GLY B 376
GLN B 339
LEU B 341
GLU B 343
LEU B 344
 None
 0.95A 5nwwA-3wu1B:
undetectable		 5nwwA-3wu1B:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wu1 PROTEIN C-ETS-1

(Homo sapiens) 		PF00178
(Ets) 		5 GLY B 376
GLN B 339
LEU B 342
GLU B 343
LEU B 344
 None
 1.11A 5nwwA-3wu1B:
undetectable		 5nwwA-3wu1B:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxb UNCHARACTERIZED
PROTEIN

(Gallus gallus) 		PF00106
(adh_short) 		5 GLY A 233
GLN A  24
LEU A  26
LEU A  27
LEU A  29
 None
 1.15A 5nwwA-3wxbA:
undetectable		 5nwwA-3wxbA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		5 GLY A 118
LEU A  13
LEU A  14
GLU A  15
LEU A  16
 None
 1.20A 5nwwA-3zgqA:
undetectable		 5nwwA-3zgqA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh2 L-LACTATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		6 GLY A  87
LYS A  88
ASN A  94
LEU A  98
LEU A  99
LEU A 101
 None
 1.42A 5nwwA-3zh2A:
undetectable		 5nwwA-3zh2A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii) 		PF16997
(Wap1) 		5 GLY A 399
LYS A 404
ASN A 407
LEU A 463
LEU A 467
 None
 1.28A 5nwwA-3zilA:
undetectable		 5nwwA-3zilA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emo SHARPIN

(Homo sapiens) 		PF16764
(Sharpin_PH) 		5 GLY A  34
GLN A  90
LEU A  99
LEU A  89
GLU A  88
 None
 1.03A 5nwwA-4emoA:
undetectable		 5nwwA-4emoA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3h ARGINASE (ROCF)

(Helicobacter
pylori) 		PF00491
(Arginase) 		5 GLY A  20
LYS A  19
GLN A 297
LEU A 299
LEU A 302
 None
 1.07A 5nwwA-4g3hA:
undetectable		 5nwwA-4g3hA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB
TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12

(Homo sapiens;
Oryctolagus
cuniculus) 		PF00229
(TNF)
PF07654
(C1-set)
PF07686
(V-set) 		5 SER L  52
LYS L  63
GLN T  28
GLU T  76
LEU T 134
 None
 1.24A 5nwwA-4ht1L:
undetectable		 5nwwA-4ht1L:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iri TRANSCRIPTIONAL
REGULATOR ERG

(Homo sapiens) 		PF00178
(Ets) 		6 GLY A 335
GLN A 298
LEU A 300
LEU A 301
GLU A 302
LEU A 303
 None
 0.78A 5nwwA-4iriA:
undetectable		 5nwwA-4iriA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		5 GLY A 150
LYS A1056
ASN A 144
LEU A 137
LEU A 162
 None
 1.22A 5nwwA-4kf7A:
undetectable		 5nwwA-4kf7A:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfv BETA-CATENIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF08216
(CTNNBL) 		5 ASN A 141
GLN A 144
LEU A 146
LEU A 147
LEU A 149
 None
 1.03A 5nwwA-4mfvA:
undetectable		 5nwwA-4mfvA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nss MYCOBACTERIAL
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A 104
SER A 106
LEU A  92
LEU A  97
LEU A  93
 None
 1.26A 5nwwA-4nssA:
undetectable		 5nwwA-4nssA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2

(Homo sapiens) 		PF08514
(STAG) 		5 GLN A 269
LEU A 267
LEU A 266
GLU A 265
LEU A 264
 None
 1.24A 5nwwA-4pjuA:
undetectable		 5nwwA-4pjuA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		5 GLY A1057
ASN A1062
LEU A1111
GLU A1127
LEU A1110
 None
 1.21A 5nwwA-4pk1A:
undetectable		 5nwwA-4pk1A:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q69 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 GLY A 239
GLU A 352
LEU A 349
LEU A 350
LEU A 372
 None
 0.98A 5nwwA-4q69A:
undetectable		 5nwwA-4q69A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 GLY A 331
SER A 332
ASN A 104
LEU A 102
LEU A  43
 None
 1.20A 5nwwA-4qyjA:
undetectable		 5nwwA-4qyjA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzh LIC12234

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 GLY A 131
LYS A 151
LEU A 176
LEU A 203
LEU A 179
 None
 1.22A 5nwwA-4tzhA:
undetectable		 5nwwA-4tzhA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 GLY A 449
LEU A 515
LEU A 516
GLU A 517
LEU A 518
 None
 0.92A 5nwwA-4u1rA:
undetectable		 5nwwA-4u1rA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		5 GLY A 344
ASN A 469
LEU A 408
GLU A 333
LEU A 405
 None
 1.14A 5nwwA-4uxvA:
undetectable		 5nwwA-4uxvA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwj PHOSPHOCARRIER
PROTEIN HPR

(Escherichia
coli) 		PF00381
(PTS-HPr) 		5 GLY B  67
SER B  31
GLN B   4
LEU B  77
GLU B  75
 None
 1.19A 5nwwA-4xwjB:
undetectable		 5nwwA-4xwjB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 GLY A 363
LYS A 365
GLN A 355
LEU A 403
LEU A 384
 None
 1.25A 5nwwA-4z0cA:
undetectable		 5nwwA-4z0cA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 5 LYS A 556
GLN A 572
LEU A 589
LEU A 575
LEU A 540
 None
 1.06A 5nwwA-4zuzA:
undetectable		 5nwwA-4zuzA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zy7 UNCHARACTERIZED
PROTEIN MSMEG_5817

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A 104
SER A 106
LEU A  92
LEU A  97
LEU A  93
 None
None
EDO  A 202 (-4.8A)
None
None
 1.23A 5nwwA-4zy7A:
undetectable		 5nwwA-4zy7A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		5 SER A 231
ASN A  86
GLN A  89
GLU A  90
LEU A  94
 None
 1.22A 5nwwA-5c9eA:
undetectable		 5nwwA-5c9eA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		5 SER A 231
ASN A  86
GLN A  89
LEU A  91
LEU A  94
 None
 1.20A 5nwwA-5c9eA:
undetectable		 5nwwA-5c9eA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LYS A 191
LEU A 235
LEU A 236
GLU A 233
LEU A 234
 None
 1.11A 5nwwA-5ci6A:
undetectable		 5nwwA-5ci6A:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		5 GLY A 257
GLN A 146
GLU A 147
LEU A 148
LEU A 151
 None
 0.94A 5nwwA-5dztA:
undetectable		 5nwwA-5dztA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8g FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR

(Homo sapiens) 		PF00178
(Ets) 		6 GLY A 322
GLN A 285
LEU A 287
LEU A 288
GLU A 289
LEU A 290
 None
 0.90A 5nwwA-5e8gA:
undetectable		 5nwwA-5e8gA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8g FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR

(Homo sapiens) 		PF00178
(Ets) 		6 GLY A 322
LYS A 327
LEU A 287
LEU A 288
GLU A 289
LEU A 290
 None
 1.39A 5nwwA-5e8gA:
undetectable		 5nwwA-5e8gA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY B 348
ASN B 246
GLN B 176
LEU B 179
LEU B 325
 None
 1.11A 5nwwA-5f38B:
undetectable		 5nwwA-5f38B:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5go2 PROTEIN AROA(G)

(Bacillus
subtilis) 		PF01817
(CM_2) 		5 GLN A  11
LEU A   9
LEU A   8
GLU A   7
LEU A   6
 None
 0.97A 5nwwA-5go2A:
undetectable		 5nwwA-5go2A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb0 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		no annotation 5 GLY B 938
LYS B 939
GLN B1033
LEU B1035
GLU B1037
 None
 1.05A 5nwwA-5hb0B:
undetectable		 5nwwA-5hb0B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM

(Pseudomonas
aeruginosa) 		PF01323
(DSBA) 		5 GLY A 124
LEU A 133
LEU A 134
GLU A 135
LEU A 136
 GLY  A 124 ( 0.0A)
LEU  A 133 ( 0.6A)
LEU  A 134 ( 0.6A)
GLU  A 135 ( 0.6A)
LEU  A 136 ( 0.6A)
 0.72A 5nwwA-5hfiA:
undetectable		 5nwwA-5hfiA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxg UNCHARACTERIZED
PROTEIN STM1697

(Salmonella
enterica) 		PF00563
(EAL) 		5 GLY A  80
ASN A  76
GLN A 104
LEU A 103
LEU A 124
 None
 1.00A 5nwwA-5hxgA:
undetectable		 5nwwA-5hxgA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 LYS A 153
LEU A 205
LEU A 206
GLU A 203
LEU A 204
 FMT  A 403 ( 4.1A)
None
None
None
None
 1.16A 5nwwA-5idnA:
undetectable		 5nwwA-5idnA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvt FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR

(Homo sapiens) 		PF00178
(Ets) 		6 GLY A 322
GLN A 285
LEU A 287
LEU A 288
GLU A 289
LEU A 290
 None
 0.82A 5nwwA-5jvtA:
undetectable		 5nwwA-5jvtA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvt FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR

(Homo sapiens) 		PF00178
(Ets) 		6 GLY A 322
LYS A 327
LEU A 287
LEU A 288
GLU A 289
LEU A 290
 None
 1.39A 5nwwA-5jvtA:
undetectable		 5nwwA-5jvtA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASN A 326
GLN A 375
LEU A 377
LEU A 374
GLU A 378
 None
 1.03A 5nwwA-5kbrA:
undetectable		 5nwwA-5kbrA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp0 FLAGELLAR PROTEIN
FLIT,FLAGELLUM-SPECI
FIC ATP SYNTHASE

(Salmonella
enterica) 		PF05400
(FliT) 		5 GLY A  28
GLN A  84
LEU A  86
GLU A  88
LEU A  89
 None
 0.93A 5nwwA-5kp0A:
undetectable		 5nwwA-5kp0A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 SER A 990
LEU A1076
LEU A1077
GLU A1078
LEU A1079
 None
 0.92A 5nwwA-5lpyA:
undetectable		 5nwwA-5lpyA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 SER A 990
LEU A1076
LEU A1077
GLU A1078
LEU A1079
 None
 0.89A 5nwwA-5lpzA:
undetectable		 5nwwA-5lpzA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npu ANC27

(synthetic
construct) 		no annotation 5 GLY A 390
SER A 392
ASN A 467
LEU A 531
LEU A 437
 TPP  A 602 ( 3.7A)
TPP  A 602 ( 4.5A)
None
None
None
 1.24A 5nwwA-5npuA:
undetectable		 5nwwA-5npuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui5 RNA POLYMERASE SIGMA
FACTOR RPON

(Aquifex
aeolicus) 		PF04552
(Sigma54_DBD)
PF04963
(Sigma54_CBD) 		5 GLY I 287
GLN I 340
GLU I 342
LEU I 338
LEU I 343
 None
 1.28A 5nwwA-5ui5I:
undetectable		 5nwwA-5ui5I:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhj 26S PROTEASOME
REGULATORY SUBUNIT 4

(Homo sapiens) 		PF00004
(AAA) 		5 GLN B 315
LEU B 313
LEU B 312
GLU B 311
LEU B 310
 None
 1.25A 5nwwA-5vhjB:
undetectable		 5nwwA-5vhjB:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		5 LYS A1410
LEU A1405
LEU A1404
GLU A1403
LEU A1402
 None
 1.25A 5nwwA-5xjyA:
undetectable		 5nwwA-5xjyA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Homo sapiens) 		no annotation 5 GLY A 240
LEU A 292
LEU A 293
GLU A 294
LEU A 295
 None
 0.97A 5nwwA-6d7tA:
undetectable		 5nwwA-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 GLN A2669
LEU A2671
LEU A2672
GLU A2673
LEU A2674
 None
 0.91A 5nwwA-6ez8A:
undetectable		 5nwwA-6ez8A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 GLY A 162
SER A 444
ASN A 439
LEU A 437
LEU A 453
 None
 1.22A 5nwwA-6f5dA:
undetectable		 5nwwA-6f5dA:
16.25