SIMILAR PATTERNS OF AMINO ACIDS FOR 5NWV_A_ACAA18_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		5 GLY A 231
SER A 230
GLU A 353
GLU A 348
GLU A 347
 None
 1.30A 5nwvA-1dcuA:
0.0		 5nwvA-1dcuA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzp STAPHYLOCOCCAL
ACCESSORY REGULATOR
A

(Staphylococcus
aureus) 		no annotation 5 LEU D  53
SER D  33
GLU D  45
GLU D  50
LEU D  40
 None
 1.22A 5nwvA-1fzpD:
0.2		 5nwvA-1fzpD:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		5 GLY A 159
SER A 160
LYS A 158
LEU A 166
GLU A 162
 None
 1.30A 5nwvA-1hqsA:
0.0		 5nwvA-1hqsA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  31
GLY A  13
SER A  14
GLU A  23
LEU A  19
 None
 1.26A 5nwvA-1hygA:
0.0		 5nwvA-1hygA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlx AGGLUTININ

(Amaranthus
caudatus) 		PF07468
(Agglutinin) 		5 GLY A 172
LYS A 173
ASN A 170
LEU A 294
GLU A 295
 None
 1.30A 5nwvA-1jlxA:
0.0		 5nwvA-1jlxA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khu SMAD1

(Homo sapiens) 		PF03166
(MH2) 		5 LEU A 440
GLY A 442
ASN A 385
GLU A 387
LEU A 392
 None
 1.09A 5nwvA-1khuA:
0.0		 5nwvA-1khuA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 GLY A 301
LYS A 303
GLU A 264
GLU A 262
LEU A 261
 None
 1.31A 5nwvA-1kkrA:
0.0		 5nwvA-1kkrA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 LEU A 311
LYS A 303
ASN A 362
LEU A 364
LEU A 835
 None
 1.22A 5nwvA-1kqfA:
0.0		 5nwvA-1kqfA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mho S-100 PROTEIN

(Bos taurus) 		PF00036
(EF-hand_1)
PF01023
(S_100) 		5 SER A  30
GLU A  39
GLU A  34
LEU A  35
GLU A  31
 None
None
None
None
CA  A  90 (-2.1A)
 1.13A 5nwvA-1mhoA:
0.1		 5nwvA-1mhoA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE

(Bacillus
subtilis) 		PF05448
(AXE1) 		5 LEU C  59
GLY C 114
LYS C  87
GLU C 162
LEU C 161
 None
 1.16A 5nwvA-1odtC:
undetectable		 5nwvA-1odtC:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		5 LEU A  69
GLY A  72
LYS A 106
LEU A 108
LEU A 124
 None
 1.34A 5nwvA-1p5sA:
undetectable		 5nwvA-1p5sA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1v DEK PROTEIN

(Homo sapiens) 		PF08766
(DEK_C) 		5 SER A 335
ASN A 337
GLU A 339
LEU A 338
LEU A 333
 None
 1.33A 5nwvA-1q1vA:
undetectable		 5nwvA-1q1vA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Bacillus
subtilis) 		PF05690
(ThiG) 		5 LEU A 270
GLY A 254
GLU A 244
LEU A 243
LEU A 239
 None
 1.26A 5nwvA-1tygA:
undetectable		 5nwvA-1tygA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 LYS A 162
ASN A 163
GLU A 165
LEU A 164
LEU A 145
 None
 1.16A 5nwvA-1xeuA:
undetectable		 5nwvA-1xeuA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		5 GLY A 691
SER A 692
ASN A 618
GLU A 619
LEU A 620
 None
 1.10A 5nwvA-1z45A:
undetectable		 5nwvA-1z45A:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE

(Plasmodium
yoelii) 		PF00202
(Aminotran_3) 		5 GLU A 187
GLU A 185
LEU A 184
GLU A 182
LEU A 181
 None
 1.08A 5nwvA-1z7dA:
undetectable		 5nwvA-1z7dA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9i INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE-4

(Mus musculus) 		no annotation 5 GLY A  31
LYS A  33
LYS A  34
LEU A  71
LEU A  70
 None
 1.30A 5nwvA-2a9iA:
undetectable		 5nwvA-2a9iA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 GLY A 771
ASN A 823
GLU A 822
GLU A 798
GLU A 817
 None
 1.32A 5nwvA-2b3xA:
undetectable		 5nwvA-2b3xA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7u CHARYBDIN

(Drimia maritima) 		PF00161
(RIP) 		5 GLY A 107
GLU A  95
LEU A 111
GLU A 109
LEU A  92
 None
 1.30A 5nwvA-2b7uA:
undetectable		 5nwvA-2b7uA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		no annotation 5 GLY A 177
SER A 194
GLU A 286
LEU A 287
LEU A 198
 None
 1.19A 5nwvA-2be1A:
undetectable		 5nwvA-2be1A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d81 PHB DEPOLYMERASE

(Talaromyces
funiculosus) 		PF10503
(Esterase_phd) 		5 LEU A 204
GLY A 206
SER A 207
LEU A 228
LEU A 209
 None
 1.28A 5nwvA-2d81A:
undetectable		 5nwvA-2d81A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk5 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE

(Homo sapiens) 		PF05158
(RNA_pol_Rpc34) 		5 LYS A  55
ASN A  59
GLU A  61
GLU A  22
LEU A  57
 None
 1.26A 5nwvA-2dk5A:
undetectable		 5nwvA-2dk5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LYS A 265
GLU A 267
GLU A 269
LEU A 270
LEU A 273
 None
 1.15A 5nwvA-2eklA:
undetectable		 5nwvA-2eklA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fep CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF13377
(Peripla_BP_3) 		5 GLY A 125
GLU A 104
GLU A 106
LEU A 107
LEU A 110
 None
 0.96A 5nwvA-2fepA:
undetectable		 5nwvA-2fepA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi0 CONSERVED DOMAIN
PROTEIN

(Streptococcus
pneumoniae) 		PF08984
(DUF1858) 		5 LEU A  52
GLY A  55
SER A  56
LYS A  57
GLU A  31
 None
 1.15A 5nwvA-2fi0A:
undetectable		 5nwvA-2fi0A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K

(Homo sapiens) 		PF00481
(PP2C) 		5 LEU A 285
GLY A 198
LEU A 194
GLU A 200
LEU A 156
 None
 1.21A 5nwvA-2iq1A:
undetectable		 5nwvA-2iq1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		5 GLY A  64
ASN A  41
GLU A  40
LEU A  37
LEU A  34
 None
 1.30A 5nwvA-2jh9A:
undetectable		 5nwvA-2jh9A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgl MESODERM DEVELOPMENT
CANDIDATE 2

(Mus musculus) 		PF10185
(Mesd) 		5 LEU A 102
GLY A 100
LYS A  72
GLU A  64
LEU A  67
 None
 1.31A 5nwvA-2kglA:
undetectable		 5nwvA-2kglA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mdr DOUBLE-STRANDED
RNA-SPECIFIC
ADENOSINE DEAMINASE

(Homo sapiens) 		PF00035
(dsrm) 		5 GLY A 717
ASN A 796
GLU A 795
LEU A 792
LEU A 789
 None
 0.75A 5nwvA-2mdrA:
undetectable		 5nwvA-2mdrA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Pseudomonas
aeruginosa) 		PF01242
(PTPS) 		5 LEU A  93
LYS A   5
GLU A   2
LEU A   3
GLU A  99
 None
 1.30A 5nwvA-2obaA:
undetectable		 5nwvA-2obaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLY A 337
GLU A 156
LEU A 123
GLU A 125
LEU A 126
 None
 1.31A 5nwvA-2pajA:
undetectable		 5nwvA-2pajA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD

(Aquifex
aeolicus) 		PF00005
(ABC_tran) 		5 ASN A  72
GLU A  73
GLU A  75
LEU A  76
LEU A  79
 None
EDO  A 232 ( 4.5A)
None
EDO  A 233 ( 4.9A)
EDO  A 233 ( 4.1A)
 1.32A 5nwvA-2pclA:
undetectable		 5nwvA-2pclA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pql D7R4 PROTEIN

(Anopheles
gambiae) 		PF01395
(PBP_GOBP) 		5 GLY A 103
ASN A  73
GLU A  75
LEU A  74
LEU A  57
 None
 1.32A 5nwvA-2pqlA:
undetectable		 5nwvA-2pqlA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		5 LEU A 244
GLY A 241
SER A 240
ASN A 308
LEU A 187
 None
ADP  A2001 (-3.2A)
None
ADP  A2001 (-3.3A)
None
 1.27A 5nwvA-2q2rA:
undetectable		 5nwvA-2q2rA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 251
GLY A 247
GLU A 275
LEU A 270
LEU A 368
 None
None
None
None
IBP  A1570 ( 4.4A)
 1.17A 5nwvA-2wd9A:
undetectable		 5nwvA-2wd9A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we3 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Human
gammaherpesvirus
4) 		PF00692
(dUTPase) 		5 LEU A 102
GLY A  62
GLU A  82
LEU A  83
LEU A 106
 None
None
None
DUT  A1257 ( 4.4A)
None
 1.23A 5nwvA-2we3A:
undetectable		 5nwvA-2we3A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Thermus
thermophilus) 		PF09488
(Osmo_MPGsynth) 		5 GLY A  75
SER A  74
GLU A  64
LEU A  69
GLU A  70
 None
None
GDD  A 400 (-3.7A)
None
None
 1.21A 5nwvA-2wvlA:
undetectable		 5nwvA-2wvlA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00535
(Glycos_transf_2) 		5 GLY A  47
GLU A  40
LEU A  41
GLU A  42
LEU A  77
 None
 1.30A 5nwvA-3cknA:
undetectable		 5nwvA-3cknA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e61 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR OF RIBOSE
OPERON

(Staphylococcus
saprophyticus) 		PF13377
(Peripla_BP_3) 		5 LEU A  61
GLY A 118
LYS A 138
LEU A  65
LEU A 108
 None
 1.23A 5nwvA-3e61A:
undetectable		 5nwvA-3e61A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		5 LEU A 107
GLY A 157
GLU A 398
LEU A 399
LEU A 163
 None
 1.05A 5nwvA-3e73A:
undetectable		 5nwvA-3e73A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME

(Klebsiella
pneumoniae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 279
SER A 107
LYS A 106
ASN A 282
GLU A 110
 None
 1.30A 5nwvA-3fcpA:
undetectable		 5nwvA-3fcpA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A 445
GLU A 425
LEU A 424
GLU A 422
LEU A 421
 None
 0.95A 5nwvA-3fxiA:
undetectable		 5nwvA-3fxiA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		5 LEU A4254
GLY A4253
SER A4252
LEU A4247
GLU A4248
 None
 1.21A 5nwvA-3g1nA:
undetectable		 5nwvA-3g1nA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)

(Homo sapiens) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		5 GLY B 115
SER B 113
LYS B  62
GLU B 120
LEU B 111
 None
 1.32A 5nwvA-3hhrB:
undetectable		 5nwvA-3hhrB:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 15

(Thermus
thermophilus) 		PF11497
(NADH_Oxid_Nqo15) 		5 GLY 7 100
LYS 7 101
GLU 7   6
LEU 7   9
GLU 7   8
 None
 1.27A 5nwvA-3i9v7:
undetectable		 5nwvA-3i9v7:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Helicobacter
pylori;
Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA)
PF03507
(CagA) 		5 LEU A 220
GLY A 211
LYS E 955
LEU A 258
LEU A 255
 None
 1.34A 5nwvA-3iecA:
undetectable		 5nwvA-3iecA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0o RIBOSOMAL PROTEIN
S15

(Oryctolagus
cuniculus) 		PF00203
(Ribosomal_S19) 		5 LEU S  24
GLY S  27
SER S  26
LEU S  33
GLU S  93
 None
 1.32A 5nwvA-3j0oS:
undetectable		 5nwvA-3j0oS:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		5 GLY A 417
GLU A 452
GLU A 422
LEU A 451
LEU A 425
 None
 1.26A 5nwvA-3j1cA:
undetectable		 5nwvA-3j1cA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 SER A1113
LYS A1111
GLU A1296
LEU A1295
GLU A1114
 None
 1.33A 5nwvA-3k9bA:
undetectable		 5nwvA-3k9bA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwl UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 5 LEU A 139
GLY A 140
ASN A 102
GLU A 104
LEU A 100
 None
 1.24A 5nwvA-3kwlA:
undetectable		 5nwvA-3kwlA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhn LIPOPROTEIN

(Shewanella
oneidensis) 		PF04170
(NlpE) 		5 GLY A 107
SER A 108
LYS A 109
ASN A  49
LEU A  51
 None
None
SO4  A   1 ( 4.8A)
None
None
 1.21A 5nwvA-3lhnA:
undetectable		 5nwvA-3lhnA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG

(Haemophilus
influenzae) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 GLY A 179
SER A 180
LYS A 181
GLU A 135
LEU A 136
 None
 1.25A 5nwvA-3lykA:
undetectable		 5nwvA-3lykA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		5 GLY A 315
SER A 316
LYS A 317
GLU A 115
GLU A  58
 None
 1.19A 5nwvA-3nixA:
undetectable		 5nwvA-3nixA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		5 LEU A 395
GLY A 398
LYS A 400
GLU A 379
LEU A 378
 None
None
None
EDO  A   7 (-3.8A)
None
 1.18A 5nwvA-3puaA:
undetectable		 5nwvA-3puaA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ren GLYCOSYL HYDROLASE,
FAMILY 8

(Clostridium
perfringens) 		PF01270
(Glyco_hydro_8) 		5 GLY A 185
LYS A 186
ASN A 183
LEU A 114
LEU A 118
 None
 1.23A 5nwvA-3renA:
undetectable		 5nwvA-3renA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		5 SER A  90
LYS A  89
GLU A 318
GLU A 313
LEU A 308
 None
 1.15A 5nwvA-3sgzA:
undetectable		 5nwvA-3sgzA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Campylobacter
jejuni) 		PF00290
(Trp_syntA) 		5 GLY A 172
SER A 170
LYS A 177
GLU A 180
LEU A 184
 None
 1.15A 5nwvA-3thaA:
undetectable		 5nwvA-3thaA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A 147
GLY A  99
SER A  98
LEU A  37
LEU A  46
 None
 1.08A 5nwvA-3ujgA:
undetectable		 5nwvA-3ujgA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2i PEPTIDYL-TRNA
HYDROLASE

(Burkholderia
thailandensis) 		PF01195
(Pept_tRNA_hydro) 		5 GLY A 107
LYS A 105
ASN A  86
GLU A  87
LEU A  89
 None
 1.14A 5nwvA-3v2iA:
undetectable		 5nwvA-3v2iA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 GLY A 180
LYS A 253
GLU A 280
LEU A 255
GLU A 247
 None
 1.13A 5nwvA-3v8uA:
undetectable		 5nwvA-3v8uA:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7

(Mus musculus) 		PF00957
(Synaptobrevin)
PF13774
(Longin) 		5 GLY A  48
GLU A 152
GLU A 155
LEU A 154
LEU A 146
 None
 1.34A 5nwvA-4b93A:
undetectable		 5nwvA-4b93A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ASN A 253
GLU A 250
LEU A 251
GLU A 248
LEU A 355
 None
 0.89A 5nwvA-4c02A:
undetectable		 5nwvA-4c02A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 GLY B 468
ASN B 449
GLU B 356
LEU B 357
GLU B 358
 None
NAG  B3452 (-3.1A)
None
None
None
 1.30A 5nwvA-4cakB:
undetectable		 5nwvA-4cakB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL

(Homo sapiens) 		PF00481
(PP2C) 		5 LEU A 285
GLY A 198
LEU A 194
GLU A 200
LEU A 156
 None
 1.19A 5nwvA-4da1A:
undetectable		 5nwvA-4da1A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 5 GLY A 342
SER A 355
GLU A 376
LEU A 375
LEU A 378
 None
 1.34A 5nwvA-4ecoA:
undetectable		 5nwvA-4ecoA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 LEU A 335
GLU A 510
GLU A 370
LEU A 369
LEU A 460
 None
 1.22A 5nwvA-4eqvA:
undetectable		 5nwvA-4eqvA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eto PROTEIN S100-A4

(Homo sapiens) 		PF01023
(S_100) 		5 GLY A  21
SER A  20
LYS A  26
ASN A  30
GLU A  33
 CA  A 101 ( 4.9A)
None
None
None
CA  A 101 (-2.2A)
 1.24A 5nwvA-4etoA:
undetectable		 5nwvA-4etoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3l BMAL1B

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		5 LEU B 125
GLY B 127
LEU B 147
GLU B 146
LEU B 142
 None
 1.10A 5nwvA-4f3lB:
undetectable		 5nwvA-4f3lB:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fib UNCHARACTERIZED
PROTEIN YDHK

(Bacillus
subtilis) 		PF07563
(DUF1541) 		5 GLY A  85
SER A  86
LYS A  83
LEU A 202
GLU A 204
 None
 1.29A 5nwvA-4fibA:
undetectable		 5nwvA-4fibA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4got METHIONINE-BINDING
LIPOPROTEIN METQ

(Bacillus
subtilis) 		PF03180
(Lipoprotein_9) 		5 LYS A  73
GLU A  92
GLU A  94
LEU A  91
LEU A 103
 None
 1.14A 5nwvA-4gotA:
undetectable		 5nwvA-4gotA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvo LMO2349 PROTEIN

(Listeria
monocytogenes) 		PF00497
(SBP_bac_3) 		5 GLY A  92
LYS A 112
LEU A 114
GLU A 232
LEU A 228
 None
 1.33A 5nwvA-4gvoA:
undetectable		 5nwvA-4gvoA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 422
LYS A 421
GLU A 411
LEU A 355
LEU A 410
 None
 1.16A 5nwvA-4isbA:
undetectable		 5nwvA-4isbA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhj MIF4G
DOMAIN-CONTAINING
PROTEIN B

(Danio rerio) 		PF02854
(MIF4G) 		5 LYS A 143
ASN A 144
GLU A 145
GLU A 147
LEU A 151
 None
 1.19A 5nwvA-4jhjA:
undetectable		 5nwvA-4jhjA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq8 SCA-FAMILY PROTEIN

(Rickettsia
rickettsii) 		PF12574
(120_Rick_ant) 		5 GLY A 255
SER A 256
GLU A 337
LEU A 293
GLU A 284
 None
 1.11A 5nwvA-4lq8A:
undetectable		 5nwvA-4lq8A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg4 PHOSPHONOMUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		5 GLY A  45
SER A  46
ASN A 112
LEU A  85
GLU A  86
 CL  A 301 (-3.4A)
None
None
None
None
 1.28A 5nwvA-4mg4A:
undetectable		 5nwvA-4mg4A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p94 CONSERVED FLAGELLAR
PROTEIN F

(Sulfolobus
acidocaldarius) 		no annotation 5 LEU A 123
ASN A  71
GLU A  70
LEU A  69
LEU A 132
 None
 1.24A 5nwvA-4p94A:
undetectable		 5nwvA-4p94A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 LEU A 111
GLY A 107
LYS A 136
GLU A 110
LEU A 145
 None
 1.34A 5nwvA-4qfeA:
undetectable		 5nwvA-4qfeA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		5 LEU A 304
GLY A 307
SER A 452
LEU A 408
LEU A 406
 None
 1.08A 5nwvA-4yj1A:
undetectable		 5nwvA-4yj1A:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 LEU A 120
GLY A 197
SER A 117
LYS A 116
LEU A 123
 None
 1.34A 5nwvA-4z3yA:
undetectable		 5nwvA-4z3yA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrm UDP-GLUCOSE
4-EPIMERASE

(Thermotoga
maritima) 		PF01370
(Epimerase) 		5 GLY A 162
LYS A 164
GLU A 102
LEU A 101
LEU A 154
 None
 1.24A 5nwvA-4zrmA:
undetectable		 5nwvA-4zrmA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 370
GLY A 366
GLU A 387
LEU A 386
GLU A 323
 None
 1.29A 5nwvA-5bz4A:
undetectable		 5nwvA-5bz4A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2j 4-OXALOCROTONATE
DECARBOXYLASE NAHK

(Pseudomonas
putida) 		no annotation 5 GLY A 124
GLU A 224
LEU A 219
GLU A 221
LEU A 218
 None
None
None
EDO  A 304 (-3.3A)
EDO  A 304 (-4.8A)
 1.14A 5nwvA-5d2jA:
undetectable		 5nwvA-5d2jA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		5 LEU A 301
GLY A 281
GLU A 290
LEU A 289
GLU A 288
 None
 1.27A 5nwvA-5ddbA:
undetectable		 5nwvA-5ddbA:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df6 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2) 		5 GLY A 133
SER A 134
LYS A 131
LEU A 136
LEU A 216
 None
None
UNX  A 305 ( 4.3A)
None
None
 1.12A 5nwvA-5df6A:
undetectable		 5nwvA-5df6A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7s LON PROTEASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C) 		5 GLY A 717
ASN A 739
GLU A 740
LEU A 743
LEU A 746
 None
 1.22A 5nwvA-5e7sA:
undetectable		 5nwvA-5e7sA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 LEU A 517
GLY A 492
GLU A 256
LEU A 259
LEU A 262
 None
 1.24A 5nwvA-5ficA:
undetectable		 5nwvA-5ficA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin)
PF06105
(Aph-1) 		5 GLY C   2
GLU A 667
GLU A 669
LEU A 670
LEU A 673
 None
 0.89A 5nwvA-5fn4C:
undetectable		 5nwvA-5fn4C:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 LEU A 517
GLY A 492
GLU A 256
LEU A 259
LEU A 262
 None
 1.21A 5nwvA-5hqnA:
undetectable		 5nwvA-5hqnA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		5 LEU A 519
GLY A 494
GLU A 258
LEU A 261
LEU A 264
 None
 1.21A 5nwvA-5i85A:
undetectable		 5nwvA-5i85A:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 GLY A 885
SER A 913
GLU A 938
LEU A 937
LEU A 940
 None
 1.22A 5nwvA-5irmA:
undetectable		 5nwvA-5irmA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA

(Bacillus
subtilis) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLY A 138
LYS A 140
GLU A 129
LEU A 132
GLU A 136
 None
 1.33A 5nwvA-5iufA:
undetectable		 5nwvA-5iufA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE

(Schistosoma
mansoni) 		PF00334
(NDK) 		5 LEU A 136
SER A 132
ASN A 128
GLU A 126
LEU A 129
 None
 1.18A 5nwvA-5kk8A:
undetectable		 5nwvA-5kk8A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU B 560
GLU B 575
LEU B 572
GLU B 568
LEU A 595
 None
 1.19A 5nwvA-5mkkB:
undetectable		 5nwvA-5mkkB:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 5 LEU A 410
GLY A 409
ASN A 380
GLU A 381
LEU A 379
 None
 1.31A 5nwvA-5mpmA:
undetectable		 5nwvA-5mpmA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 LEU A 673
LYS A 718
LYS A 681
GLU A 686
LEU A 685
 None
 1.13A 5nwvA-5ve8A:
undetectable		 5nwvA-5ve8A:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wml -

(-) 		no annotation 5 LEU A 315
GLY A 167
LYS A 169
LEU A 163
LEU A 318
 None
PMP  A 501 (-3.4A)
GLU  A 502 ( 2.3A)
None
None
 1.26A 5nwvA-5wmlA:
undetectable		 5nwvA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 5 LEU A 521
GLY A 524
LYS A 527
LEU A 401
LEU A 361
 None
 1.24A 5nwvA-5x9wA:
undetectable		 5nwvA-5x9wA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyk PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		no annotation 5 LEU E 170
GLY E 173
LYS E 176
GLU E 153
LEU E 152
 None
 1.19A 5nwvA-5xykE:
undetectable		 5nwvA-5xykE:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 5 GLY A 815
LYS A 814
ASN A 819
GLU A 670
LEU A 673
 None
 1.25A 5nwvA-6bhuA:
undetectable		 5nwvA-6bhuA:
1.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 5 LEU A 392
GLY A 394
LYS A 395
LYS A 396
LEU A 402
 None
 1.34A 5nwvA-6d6vA:
undetectable		 5nwvA-6d6vA:
21.25