SIMILAR PATTERNS OF AMINO ACIDS FOR 5NWV_A_ACAA18

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		5 GLY A 231
SER A 230
GLU A 353
GLU A 348
GLU A 347
 None
 1.30A 5nwvA-1dcuA:
0.0		 5nwvA-1dcuA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzp STAPHYLOCOCCAL
ACCESSORY REGULATOR
A

(Staphylococcus
aureus) 		no annotation 5 LEU D  53
SER D  33
GLU D  45
GLU D  50
LEU D  40
 None
 1.22A 5nwvA-1fzpD:
0.2		 5nwvA-1fzpD:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		5 GLY A 159
SER A 160
LYS A 158
LEU A 166
GLU A 162
 None
 1.30A 5nwvA-1hqsA:
0.0		 5nwvA-1hqsA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyg L-LACTATE/MALATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  31
GLY A  13
SER A  14
GLU A  23
LEU A  19
 None
 1.26A 5nwvA-1hygA:
0.0		 5nwvA-1hygA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlx AGGLUTININ

(Amaranthus
caudatus) 		PF07468
(Agglutinin) 		5 GLY A 172
LYS A 173
ASN A 170
LEU A 294
GLU A 295
 None
 1.30A 5nwvA-1jlxA:
0.0		 5nwvA-1jlxA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khu SMAD1

(Homo sapiens) 		PF03166
(MH2) 		5 LEU A 440
GLY A 442
ASN A 385
GLU A 387
LEU A 392
 None
 1.09A 5nwvA-1khuA:
0.0		 5nwvA-1khuA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 GLY A 301
LYS A 303
GLU A 264
GLU A 262
LEU A 261
 None
 1.31A 5nwvA-1kkrA:
0.0		 5nwvA-1kkrA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 LEU A 311
LYS A 303
ASN A 362
LEU A 364
LEU A 835
 None
 1.22A 5nwvA-1kqfA:
0.0		 5nwvA-1kqfA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mho S-100 PROTEIN

(Bos taurus) 		PF00036
(EF-hand_1)
PF01023
(S_100) 		5 SER A  30
GLU A  39
GLU A  34
LEU A  35
GLU A  31
 None
None
None
None
CA  A  90 (-2.1A)
 1.13A 5nwvA-1mhoA:
0.1		 5nwvA-1mhoA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE

(Bacillus
subtilis) 		PF05448
(AXE1) 		5 LEU C  59
GLY C 114
LYS C  87
GLU C 162
LEU C 161
 None
 1.16A 5nwvA-1odtC:
undetectable		 5nwvA-1odtC:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		5 LEU A  69
GLY A  72
LYS A 106
LEU A 108
LEU A 124
 None
 1.34A 5nwvA-1p5sA:
undetectable		 5nwvA-1p5sA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1v DEK PROTEIN

(Homo sapiens) 		PF08766
(DEK_C) 		5 SER A 335
ASN A 337
GLU A 339
LEU A 338
LEU A 333
 None
 1.33A 5nwvA-1q1vA:
undetectable		 5nwvA-1q1vA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Bacillus
subtilis) 		PF05690
(ThiG) 		5 LEU A 270
GLY A 254
GLU A 244
LEU A 243
LEU A 239
 None
 1.26A 5nwvA-1tygA:
undetectable		 5nwvA-1tygA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 LYS A 162
ASN A 163
GLU A 165
LEU A 164
LEU A 145
 None
 1.16A 5nwvA-1xeuA:
undetectable		 5nwvA-1xeuA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		5 GLY A 691
SER A 692
ASN A 618
GLU A 619
LEU A 620
 None
 1.10A 5nwvA-1z45A:
undetectable		 5nwvA-1z45A:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE

(Plasmodium
yoelii) 		PF00202
(Aminotran_3) 		5 GLU A 187
GLU A 185
LEU A 184
GLU A 182
LEU A 181
 None
 1.08A 5nwvA-1z7dA:
undetectable		 5nwvA-1z7dA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9i INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE-4

(Mus musculus) 		no annotation 5 GLY A  31
LYS A  33
LYS A  34
LEU A  71
LEU A  70
 None
 1.30A 5nwvA-2a9iA:
undetectable		 5nwvA-2a9iA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 GLY A 771
ASN A 823
GLU A 822
GLU A 798
GLU A 817
 None
 1.32A 5nwvA-2b3xA:
undetectable		 5nwvA-2b3xA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7u CHARYBDIN

(Drimia maritima) 		PF00161
(RIP) 		5 GLY A 107
GLU A  95
LEU A 111
GLU A 109
LEU A  92
 None
 1.30A 5nwvA-2b7uA:
undetectable		 5nwvA-2b7uA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		no annotation 5 GLY A 177
SER A 194
GLU A 286
LEU A 287
LEU A 198
 None
 1.19A 5nwvA-2be1A:
undetectable		 5nwvA-2be1A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d81 PHB DEPOLYMERASE

(Talaromyces
funiculosus) 		PF10503
(Esterase_phd) 		5 LEU A 204
GLY A 206
SER A 207
LEU A 228
LEU A 209
 None
 1.28A 5nwvA-2d81A:
undetectable		 5nwvA-2d81A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk5 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE

(Homo sapiens) 		PF05158
(RNA_pol_Rpc34) 		5 LYS A  55
ASN A  59
GLU A  61
GLU A  22
LEU A  57
 None
 1.26A 5nwvA-2dk5A:
undetectable		 5nwvA-2dk5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LYS A 265
GLU A 267
GLU A 269
LEU A 270
LEU A 273
 None
 1.15A 5nwvA-2eklA:
undetectable		 5nwvA-2eklA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fep CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF13377
(Peripla_BP_3) 		5 GLY A 125
GLU A 104
GLU A 106
LEU A 107
LEU A 110
 None
 0.96A 5nwvA-2fepA:
undetectable		 5nwvA-2fepA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi0 CONSERVED DOMAIN
PROTEIN

(Streptococcus
pneumoniae) 		PF08984
(DUF1858) 		5 LEU A  52
GLY A  55
SER A  56
LYS A  57
GLU A  31
 None
 1.15A 5nwvA-2fi0A:
undetectable		 5nwvA-2fi0A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K

(Homo sapiens) 		PF00481
(PP2C) 		5 LEU A 285
GLY A 198
LEU A 194
GLU A 200
LEU A 156
 None
 1.21A 5nwvA-2iq1A:
undetectable		 5nwvA-2iq1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		5 GLY A  64
ASN A  41
GLU A  40
LEU A  37
LEU A  34
 None
 1.30A 5nwvA-2jh9A:
undetectable		 5nwvA-2jh9A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgl MESODERM DEVELOPMENT
CANDIDATE 2

(Mus musculus) 		PF10185
(Mesd) 		5 LEU A 102
GLY A 100
LYS A  72
GLU A  64
LEU A  67
 None
 1.31A 5nwvA-2kglA:
undetectable		 5nwvA-2kglA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mdr DOUBLE-STRANDED
RNA-SPECIFIC
ADENOSINE DEAMINASE

(Homo sapiens) 		PF00035
(dsrm) 		5 GLY A 717
ASN A 796
GLU A 795
LEU A 792
LEU A 789
 None
 0.75A 5nwvA-2mdrA:
undetectable		 5nwvA-2mdrA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Pseudomonas
aeruginosa) 		PF01242
(PTPS) 		5 LEU A  93
LYS A   5
GLU A   2
LEU A   3
GLU A  99
 None
 1.30A 5nwvA-2obaA:
undetectable		 5nwvA-2obaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLY A 337
GLU A 156
LEU A 123
GLU A 125
LEU A 126
 None
 1.31A 5nwvA-2pajA:
undetectable		 5nwvA-2pajA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD

(Aquifex
aeolicus) 		PF00005
(ABC_tran) 		5 ASN A  72
GLU A  73
GLU A  75
LEU A  76
LEU A  79
 None
EDO  A 232 ( 4.5A)
None
EDO  A 233 ( 4.9A)
EDO  A 233 ( 4.1A)
 1.32A 5nwvA-2pclA:
undetectable		 5nwvA-2pclA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pql D7R4 PROTEIN

(Anopheles
gambiae) 		PF01395
(PBP_GOBP) 		5 GLY A 103
ASN A  73
GLU A  75
LEU A  74
LEU A  57
 None
 1.32A 5nwvA-2pqlA:
undetectable		 5nwvA-2pqlA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		5 LEU A 244
GLY A 241
SER A 240
ASN A 308
LEU A 187
 None
ADP  A2001 (-3.2A)
None
ADP  A2001 (-3.3A)
None
 1.27A 5nwvA-2q2rA:
undetectable		 5nwvA-2q2rA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 251
GLY A 247
GLU A 275
LEU A 270
LEU A 368
 None
None
None
None
IBP  A1570 ( 4.4A)
 1.17A 5nwvA-2wd9A:
undetectable		 5nwvA-2wd9A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we3 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Human
gammaherpesvirus
4) 		PF00692
(dUTPase) 		5 LEU A 102
GLY A  62
GLU A  82
LEU A  83
LEU A 106
 None
None
None
DUT  A1257 ( 4.4A)
None
 1.23A 5nwvA-2we3A:
undetectable		 5nwvA-2we3A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Thermus
thermophilus) 		PF09488
(Osmo_MPGsynth) 		5 GLY A  75
SER A  74
GLU A  64
LEU A  69
GLU A  70
 None
None
GDD  A 400 (-3.7A)
None
None
 1.21A 5nwvA-2wvlA:
undetectable		 5nwvA-2wvlA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00535
(Glycos_transf_2) 		5 GLY A  47
GLU A  40
LEU A  41
GLU A  42
LEU A  77
 None
 1.30A 5nwvA-3cknA:
undetectable		 5nwvA-3cknA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e61 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR OF RIBOSE
OPERON

(Staphylococcus
saprophyticus) 		PF13377
(Peripla_BP_3) 		5 LEU A  61
GLY A 118
LYS A 138
LEU A  65
LEU A 108
 None
 1.23A 5nwvA-3e61A:
undetectable		 5nwvA-3e61A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		5 LEU A 107
GLY A 157
GLU A 398
LEU A 399
LEU A 163
 None
 1.05A 5nwvA-3e73A:
undetectable		 5nwvA-3e73A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME

(Klebsiella
pneumoniae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 279
SER A 107
LYS A 106
ASN A 282
GLU A 110
 None
 1.30A 5nwvA-3fcpA:
undetectable		 5nwvA-3fcpA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 SER A 445
GLU A 425
LEU A 424
GLU A 422
LEU A 421
 None
 0.95A 5nwvA-3fxiA:
undetectable		 5nwvA-3fxiA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		5 LEU A4254
GLY A4253
SER A4252
LEU A4247
GLU A4248
 None
 1.21A 5nwvA-3g1nA:
undetectable		 5nwvA-3g1nA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)

(Homo sapiens) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		5 GLY B 115
SER B 113
LYS B  62
GLU B 120
LEU B 111
 None
 1.32A 5nwvA-3hhrB:
undetectable		 5nwvA-3hhrB:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 15

(Thermus
thermophilus) 		PF11497
(NADH_Oxid_Nqo15) 		5 GLY 7 100
LYS 7 101
GLU 7   6
LEU 7   9
GLU 7   8
 None
 1.27A 5nwvA-3i9v7:
undetectable		 5nwvA-3i9v7:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Helicobacter
pylori;
Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA)
PF03507
(CagA) 		5 LEU A 220
GLY A 211
LYS E 955
LEU A 258
LEU A 255
 None
 1.34A 5nwvA-3iecA:
undetectable		 5nwvA-3iecA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0o RIBOSOMAL PROTEIN
S15

(Oryctolagus
cuniculus) 		PF00203
(Ribosomal_S19) 		5 LEU S  24
GLY S  27
SER S  26
LEU S  33
GLU S  93
 None
 1.32A 5nwvA-3j0oS:
undetectable		 5nwvA-3j0oS:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		5 GLY A 417
GLU A 452
GLU A 422
LEU A 451
LEU A 425
 None
 1.26A 5nwvA-3j1cA:
undetectable		 5nwvA-3j1cA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 SER A1113
LYS A1111
GLU A1296
LEU A1295
GLU A1114
 None
 1.33A 5nwvA-3k9bA:
undetectable		 5nwvA-3k9bA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwl UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 5 LEU A 139
GLY A 140
ASN A 102
GLU A 104
LEU A 100
 None
 1.24A 5nwvA-3kwlA:
undetectable		 5nwvA-3kwlA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhn LIPOPROTEIN

(Shewanella
oneidensis) 		PF04170
(NlpE) 		5 GLY A 107
SER A 108
LYS A 109
ASN A  49
LEU A  51
 None
None
SO4  A   1 ( 4.8A)
None
None
 1.21A 5nwvA-3lhnA:
undetectable		 5nwvA-3lhnA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyk STRINGENT STARVATION
PROTEIN A HOMOLOG

(Haemophilus
influenzae) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 GLY A 179
SER A 180
LYS A 181
GLU A 135
LEU A 136
 None
 1.25A 5nwvA-3lykA:
undetectable		 5nwvA-3lykA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		5 GLY A 315
SER A 316
LYS A 317
GLU A 115
GLU A  58
 None
 1.19A 5nwvA-3nixA:
undetectable		 5nwvA-3nixA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		5 LEU A 395
GLY A 398
LYS A 400
GLU A 379
LEU A 378
 None
None
None
EDO  A   7 (-3.8A)
None
 1.18A 5nwvA-3puaA:
undetectable		 5nwvA-3puaA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ren GLYCOSYL HYDROLASE,
FAMILY 8

(Clostridium
perfringens) 		PF01270
(Glyco_hydro_8) 		5 GLY A 185
LYS A 186
ASN A 183
LEU A 114
LEU A 118
 None
 1.23A 5nwvA-3renA:
undetectable		 5nwvA-3renA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		5 SER A  90
LYS A  89
GLU A 318
GLU A 313
LEU A 308
 None
 1.15A 5nwvA-3sgzA:
undetectable		 5nwvA-3sgzA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Campylobacter
jejuni) 		PF00290
(Trp_syntA) 		5 GLY A 172
SER A 170
LYS A 177
GLU A 180
LEU A 184
 None
 1.15A 5nwvA-3thaA:
undetectable		 5nwvA-3thaA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A 147
GLY A  99
SER A  98
LEU A  37
LEU A  46
 None
 1.08A 5nwvA-3ujgA:
undetectable		 5nwvA-3ujgA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2i PEPTIDYL-TRNA
HYDROLASE

(Burkholderia
thailandensis) 		PF01195
(Pept_tRNA_hydro) 		5 GLY A 107
LYS A 105
ASN A  86
GLU A  87
LEU A  89
 None
 1.14A 5nwvA-3v2iA:
undetectable		 5nwvA-3v2iA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 GLY A 180
LYS A 253
GLU A 280
LEU A 255
GLU A 247
 None
 1.13A 5nwvA-3v8uA:
undetectable		 5nwvA-3v8uA:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7

(Mus musculus) 		PF00957
(Synaptobrevin)
PF13774
(Longin) 		5 GLY A  48
GLU A 152
GLU A 155
LEU A 154
LEU A 146
 None
 1.34A 5nwvA-4b93A:
undetectable		 5nwvA-4b93A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ASN A 253
GLU A 250
LEU A 251
GLU A 248
LEU A 355
 None
 0.89A 5nwvA-4c02A:
undetectable		 5nwvA-4c02A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 GLY B 468
ASN B 449
GLU B 356
LEU B 357
GLU B 358
 None
NAG  B3452 (-3.1A)
None
None
None
 1.30A 5nwvA-4cakB:
undetectable		 5nwvA-4cakB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL

(Homo sapiens) 		PF00481
(PP2C) 		5 LEU A 285
GLY A 198
LEU A 194
GLU A 200
LEU A 156
 None
 1.19A 5nwvA-4da1A:
undetectable		 5nwvA-4da1A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 5 GLY A 342
SER A 355
GLU A 376
LEU A 375
LEU A 378
 None
 1.34A 5nwvA-4ecoA:
undetectable		 5nwvA-4ecoA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 LEU A 335
GLU A 510
GLU A 370
LEU A 369
LEU A 460
 None
 1.22A 5nwvA-4eqvA:
undetectable		 5nwvA-4eqvA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eto PROTEIN S100-A4

(Homo sapiens) 		PF01023
(S_100) 		5 GLY A  21
SER A  20
LYS A  26
ASN A  30
GLU A  33
 CA  A 101 ( 4.9A)
None
None
None
CA  A 101 (-2.2A)
 1.24A 5nwvA-4etoA:
undetectable		 5nwvA-4etoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3l BMAL1B

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		5 LEU B 125
GLY B 127
LEU B 147
GLU B 146
LEU B 142
 None
 1.10A 5nwvA-4f3lB:
undetectable		 5nwvA-4f3lB:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fib UNCHARACTERIZED
PROTEIN YDHK

(Bacillus
subtilis) 		PF07563
(DUF1541) 		5 GLY A  85
SER A  86
LYS A  83
LEU A 202
GLU A 204
 None
 1.29A 5nwvA-4fibA:
undetectable		 5nwvA-4fibA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4got METHIONINE-BINDING
LIPOPROTEIN METQ

(Bacillus
subtilis) 		PF03180
(Lipoprotein_9) 		5 LYS A  73
GLU A  92
GLU A  94
LEU A  91
LEU A 103
 None
 1.14A 5nwvA-4gotA:
undetectable		 5nwvA-4gotA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvo LMO2349 PROTEIN

(Listeria
monocytogenes) 		PF00497
(SBP_bac_3) 		5 GLY A  92
LYS A 112
LEU A 114
GLU A 232
LEU A 228
 None
 1.33A 5nwvA-4gvoA:
undetectable		 5nwvA-4gvoA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 422
LYS A 421
GLU A 411
LEU A 355
LEU A 410
 None
 1.16A 5nwvA-4isbA:
undetectable		 5nwvA-4isbA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhj MIF4G
DOMAIN-CONTAINING
PROTEIN B

(Danio rerio) 		PF02854
(MIF4G) 		5 LYS A 143
ASN A 144
GLU A 145
GLU A 147
LEU A 151
 None
 1.19A 5nwvA-4jhjA:
undetectable		 5nwvA-4jhjA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq8 SCA-FAMILY PROTEIN

(Rickettsia
rickettsii) 		PF12574
(120_Rick_ant) 		5 GLY A 255
SER A 256
GLU A 337
LEU A 293
GLU A 284
 None
 1.11A 5nwvA-4lq8A:
undetectable		 5nwvA-4lq8A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg4 PHOSPHONOMUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		5 GLY A  45
SER A  46
ASN A 112
LEU A  85
GLU A  86
 CL  A 301 (-3.4A)
None
None
None
None
 1.28A 5nwvA-4mg4A:
undetectable		 5nwvA-4mg4A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p94 CONSERVED FLAGELLAR
PROTEIN F

(Sulfolobus
acidocaldarius) 		no annotation 5 LEU A 123
ASN A  71
GLU A  70
LEU A  69
LEU A 132
 None
 1.24A 5nwvA-4p94A:
undetectable		 5nwvA-4p94A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 LEU A 111
GLY A 107
LYS A 136
GLU A 110
LEU A 145
 None
 1.34A 5nwvA-4qfeA:
undetectable		 5nwvA-4qfeA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		5 LEU A 304
GLY A 307
SER A 452
LEU A 408
LEU A 406
 None
 1.08A 5nwvA-4yj1A:
undetectable		 5nwvA-4yj1A:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 LEU A 120
GLY A 197
SER A 117
LYS A 116
LEU A 123
 None
 1.34A 5nwvA-4z3yA:
undetectable		 5nwvA-4z3yA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrm UDP-GLUCOSE
4-EPIMERASE

(Thermotoga
maritima) 		PF01370
(Epimerase) 		5 GLY A 162
LYS A 164
GLU A 102
LEU A 101
LEU A 154
 None
 1.24A 5nwvA-4zrmA:
undetectable		 5nwvA-4zrmA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 370
GLY A 366
GLU A 387
LEU A 386
GLU A 323
 None
 1.29A 5nwvA-5bz4A:
undetectable		 5nwvA-5bz4A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2j 4-OXALOCROTONATE
DECARBOXYLASE NAHK

(Pseudomonas
putida) 		no annotation 5 GLY A 124
GLU A 224
LEU A 219
GLU A 221
LEU A 218
 None
None
None
EDO  A 304 (-3.3A)
EDO  A 304 (-4.8A)
 1.14A 5nwvA-5d2jA:
undetectable		 5nwvA-5d2jA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		5 LEU A 301
GLY A 281
GLU A 290
LEU A 289
GLU A 288
 None
 1.27A 5nwvA-5ddbA:
undetectable		 5nwvA-5ddbA:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df6 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2) 		5 GLY A 133
SER A 134
LYS A 131
LEU A 136
LEU A 216
 None
None
UNX  A 305 ( 4.3A)
None
None
 1.12A 5nwvA-5df6A:
undetectable		 5nwvA-5df6A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7s LON PROTEASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C) 		5 GLY A 717
ASN A 739
GLU A 740
LEU A 743
LEU A 746
 None
 1.22A 5nwvA-5e7sA:
undetectable		 5nwvA-5e7sA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 LEU A 517
GLY A 492
GLU A 256
LEU A 259
LEU A 262
 None
 1.24A 5nwvA-5ficA:
undetectable		 5nwvA-5ficA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin)
PF06105
(Aph-1) 		5 GLY C   2
GLU A 667
GLU A 669
LEU A 670
LEU A 673
 None
 0.89A 5nwvA-5fn4C:
undetectable		 5nwvA-5fn4C:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 LEU A 517
GLY A 492
GLU A 256
LEU A 259
LEU A 262
 None
 1.21A 5nwvA-5hqnA:
undetectable		 5nwvA-5hqnA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		5 LEU A 519
GLY A 494
GLU A 258
LEU A 261
LEU A 264
 None
 1.21A 5nwvA-5i85A:
undetectable		 5nwvA-5i85A:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 GLY A 885
SER A 913
GLU A 938
LEU A 937
LEU A 940
 None
 1.22A 5nwvA-5irmA:
undetectable		 5nwvA-5irmA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA

(Bacillus
subtilis) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLY A 138
LYS A 140
GLU A 129
LEU A 132
GLU A 136
 None
 1.33A 5nwvA-5iufA:
undetectable		 5nwvA-5iufA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE

(Schistosoma
mansoni) 		PF00334
(NDK) 		5 LEU A 136
SER A 132
ASN A 128
GLU A 126
LEU A 129
 None
 1.18A 5nwvA-5kk8A:
undetectable		 5nwvA-5kk8A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU B 560
GLU B 575
LEU B 572
GLU B 568
LEU A 595
 None
 1.19A 5nwvA-5mkkB:
undetectable		 5nwvA-5mkkB:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 5 LEU A 410
GLY A 409
ASN A 380
GLU A 381
LEU A 379
 None
 1.31A 5nwvA-5mpmA:
undetectable		 5nwvA-5mpmA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 LEU A 673
LYS A 718
LYS A 681
GLU A 686
LEU A 685
 None
 1.13A 5nwvA-5ve8A:
undetectable		 5nwvA-5ve8A:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wml -

(-) 		no annotation 5 LEU A 315
GLY A 167
LYS A 169
LEU A 163
LEU A 318
 None
PMP  A 501 (-3.4A)
GLU  A 502 ( 2.3A)
None
None
 1.26A 5nwvA-5wmlA:
undetectable		 5nwvA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 5 LEU A 521
GLY A 524
LYS A 527
LEU A 401
LEU A 361
 None
 1.24A 5nwvA-5x9wA:
undetectable		 5nwvA-5x9wA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyk PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		no annotation 5 LEU E 170
GLY E 173
LYS E 176
GLU E 153
LEU E 152
 None
 1.19A 5nwvA-5xykE:
undetectable		 5nwvA-5xykE:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 5 GLY A 815
LYS A 814
ASN A 819
GLU A 670
LEU A 673
 None
 1.25A 5nwvA-6bhuA:
undetectable		 5nwvA-6bhuA:
1.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 5 LEU A 392
GLY A 394
LYS A 395
LYS A 396
LEU A 402
 None
 1.34A 5nwvA-6d6vA:
undetectable		 5nwvA-6d6vA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 LEU A  58
ALA A  61
LEU A  52
TRP A  62
 None
 1.08A 5nwvA-1e6zA:
0.0		 5nwvA-1e6zA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLN A 404
ASP A 399
ALA A 395
LEU A 203
 None
 1.09A 5nwvA-1hrdA:
0.0		 5nwvA-1hrdA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		4 LEU A 251
TRP A 287
ALA A 284
LEU A 288
 None
 1.11A 5nwvA-1js4A:
0.0		 5nwvA-1js4A:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU A 590
ALA A 552
LEU A 551
TRP A 563
 None
 0.88A 5nwvA-1nr0A:
0.0		 5nwvA-1nr0A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7n GAG POLYPROTEIN
CAPSID PROTEIN P27

(Rous sarcoma
virus) 		no annotation 4 LEU A  68
ASP A  71
TRP A  73
LEU A  77
 None
 1.03A 5nwvA-1p7nA:
0.0		 5nwvA-1p7nA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttx ONCOMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 LEU A   7
ASP A  10
ALA A  13
LEU A  16
 None
 1.10A 5nwvA-1ttxA:
0.0		 5nwvA-1ttxA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 ASP A 268
ALA A 271
LEU A 324
TRP A 234
 None
 1.04A 5nwvA-1wvgA:
0.0		 5nwvA-1wvgA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		4 GLN A 402
ASP A 486
ALA A 490
LEU A 438
 None
 1.04A 5nwvA-1x9dA:
0.0		 5nwvA-1x9dA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLN A 457
LEU A 460
ALA A 466
LEU A 469
 None
 1.09A 5nwvA-1x9nA:
0.0		 5nwvA-1x9nA:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3

(Mus musculus) 		PF00104
(Hormone_recep) 		4 GLN E 144
ASP E 173
ALA E 172
LEU E 353
 None
None
TCD  E 805 ( 4.3A)
TCD  E 805 (-4.2A)
 1.05A 5nwvA-1xlsE:
undetectable		 5nwvA-1xlsE:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqq XANTHOSINE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		4 GLN A  42
LEU A  39
ALA A 258
LEU A 260
 None
 1.03A 5nwvA-1yqqA:
undetectable		 5nwvA-1yqqA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 511
ASP A 514
ALA A 517
LEU A 520
 None
 1.10A 5nwvA-1z1wA:
undetectable		 5nwvA-1z1wA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aie PEPTIDE DEFORMYLASE

(Streptococcus
pneumoniae) 		PF01327
(Pep_deformylase) 		4 GLN P  76
LEU P  72
ALA P 106
LEU P 104
 SB9  P 501 ( 2.7A)
None
None
None
 1.05A 5nwvA-2aieP:
undetectable		 5nwvA-2aieP:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ev2 HYPOTHETICAL PROTEIN
RV1264/MT1302

(Mycobacterium
tuberculosis) 		PF16701
(Ad_Cy_reg) 		4 GLN A 173
LEU A 170
ALA A 164
LEU A 161
 None
 1.08A 5nwvA-2ev2A:
undetectable		 5nwvA-2ev2A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 GLN A 140
LEU A 104
ASP A  83
LEU A  80
 None
 0.86A 5nwvA-2fmtA:
undetectable		 5nwvA-2fmtA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0b FEEM

(uncultured
bacterium) 		no annotation 4 GLN A 183
LEU A 175
ALA A  93
LEU A  72
 None
 1.11A 5nwvA-2g0bA:
undetectable		 5nwvA-2g0bA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2juh TELOMERE BINDING
PROTEIN TBP1

(Nicotiana
glutinosa) 		PF00249
(Myb_DNA-binding) 		4 GLN A 644
LEU A 647
ALA A 653
TRP A 657
 None
 1.05A 5nwvA-2juhA:
undetectable		 5nwvA-2juhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kc7 BFR218_PROTEIN

(Bacteroides
fragilis) 		PF00515
(TPR_1) 		4 GLN A  52
LEU A  55
ALA A  61
LEU A  64
 None
 1.08A 5nwvA-2kc7A:
undetectable		 5nwvA-2kc7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kr0 PROTEASOMAL
UBIQUITIN RECEPTOR
ADRM1

(Homo sapiens) 		PF04683
(Proteasom_Rpn13)
PF16550
(RPN13_C) 		4 GLN A 157
LEU A 156
ALA A 149
LEU A 150
 None
 1.11A 5nwvA-2kr0A:
undetectable		 5nwvA-2kr0A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqd UNCHARACTERIZED
PROTEIN

(Lactobacillus
reuteri) 		no annotation 4 GLN A 123
ASP A 129
ALA A 132
LEU A 134
 None
 0.90A 5nwvA-2mqdA:
undetectable		 5nwvA-2mqdA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		4 LEU A 295
ASP A 298
ALA A 301
LEU A 304
 None
 1.06A 5nwvA-2nq2A:
undetectable		 5nwvA-2nq2A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6i UNCHARACTERIZED
PROTEIN ATU1473

(Agrobacterium
fabrum) 		PF07542
(ATP12) 		4 GLN A 232
ASP A 227
ALA A 220
LEU A 221
 None
 1.07A 5nwvA-2r6iA:
undetectable		 5nwvA-2r6iA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		4 GLN A  52
LEU A  49
ASP A  46
LEU A  40
 None
 1.09A 5nwvA-2r98A:
undetectable		 5nwvA-2r98A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd3 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Methanothermobacter
thermautotrophicus) 		PF01634
(HisG)
PF08029
(HisG_C) 		4 LEU A 159
ASP A 158
ALA A  97
LEU A 155
 None
MG  A1294 (-2.9A)
None
None
 1.05A 5nwvA-2vd3A:
undetectable		 5nwvA-2vd3A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 GLN A 388
LEU A 391
ALA A 397
LEU A 400
 None
 1.10A 5nwvA-2w1zA:
undetectable		 5nwvA-2w1zA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whn PILUS ASSEMBLY
PROTEIN PILC

(Thermus
thermophilus) 		PF00482
(T2SSF) 		4 LEU A 146
ASP A 149
ALA A 152
LEU A 155
 None
 0.90A 5nwvA-2whnA:
undetectable		 5nwvA-2whnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhs NUCLEAR HORMONE
RECEPTOR FTZ-F1

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 GLN A 844
LEU A 841
ASP A 838
LEU A 832
 None
 1.09A 5nwvA-2xhsA:
undetectable		 5nwvA-2xhsA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqy HYPOTHETICAL PROTEIN
TTHA0303

(Thermus
thermophilus) 		PF12867
(DinB_2) 		4 LEU A  56
ASP A  59
ALA A  62
LEU A  65
 None
 0.94A 5nwvA-2yqyA:
undetectable		 5nwvA-2yqyA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Methanocaldococcus
jannaschii) 		PF01680
(SOR_SNZ)
PF05690
(ThiG) 		4 GLN A 262
LEU A 259
ASP A 256
LEU A 307
 None
 0.95A 5nwvA-2yzrA:
undetectable		 5nwvA-2yzrA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A  74
TRP A  79
ALA A  80
LEU A  83
 None
 1.01A 5nwvA-2z0fA:
undetectable		 5nwvA-2z0fA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 109
TRP A 111
ALA A 112
LEU A 115
 None
 1.06A 5nwvA-2zc8A:
undetectable		 5nwvA-2zc8A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvf ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF02272
(DHHA1) 		4 ASP A 792
TRP A 794
ALA A 791
LEU A 825
 None
 0.99A 5nwvA-2zvfA:
undetectable		 5nwvA-2zvfA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		4 LEU A 312
ASP A 330
ALA A 328
LEU A 327
 None
 1.11A 5nwvA-3ay0A:
undetectable		 5nwvA-3ay0A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		4 LEU A 237
ASP A 241
ALA A 244
LEU A 247
 MLI  A 500 ( 4.5A)
None
None
None
 1.07A 5nwvA-3bdzA:
undetectable		 5nwvA-3bdzA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 LEU A 571
ASP A 568
TRP A 592
ALA A 565
 None
 1.12A 5nwvA-3dlaA:
undetectable		 5nwvA-3dlaA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01715
(IPPT) 		4 ASP A 316
TRP A 323
ALA A 317
LEU A 320
 None
MG  A   5 ( 4.2A)
None
None
 1.05A 5nwvA-3epjA:
undetectable		 5nwvA-3epjA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1w SUGAR ABC
TRANSPORTER

(Bacillus
halodurans) 		PF13407
(Peripla_BP_4) 		4 GLN A 180
LEU A 177
ALA A 107
LEU A 113
 None
 1.06A 5nwvA-3g1wA:
undetectable		 5nwvA-3g1wA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 184
TRP A 189
ALA A 214
LEU A  59
 None
 0.72A 5nwvA-3g5wA:
undetectable		 5nwvA-3g5wA:
7.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h00 ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00517
(GP41) 		4 GLN A  23
LEU A  26
ASP A  29
ALA A  32
 None
 0.91A 5nwvA-3h00A:
undetectable		 5nwvA-3h00A:
54.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icv LIPASE B

(Moesziomyces
antarcticus) 		no annotation 4 GLN A 191
LEU A 143
ALA A 164
LEU A 136
 None
 0.99A 5nwvA-3icvA:
undetectable		 5nwvA-3icvA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9a HIV GLYCOPROTEIN
GP41

(Human
immunodeficiency
virus 1) 		PF00517
(GP41) 		4 LEU A  80
ASP A  83
TRP A  85
ALA A  86
 None
 0.42A 5nwvA-3k9aA:
undetectable		 5nwvA-3k9aA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 GLN A 503
ASP A 463
ALA A 424
LEU A 425
 None
 1.01A 5nwvA-3khkA:
undetectable		 5nwvA-3khkA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2p DNA LIGASE 3

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLN A 197
ASP A 344
ALA A 350
LEU A 384
 None
 0.82A 5nwvA-3l2pA:
undetectable		 5nwvA-3l2pA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 GLN A1167
LEU A1170
ASP A1173
ALA A1176
 None
 0.84A 5nwvA-3l4kA:
undetectable		 5nwvA-3l4kA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 LEU A 114
ASP A 188
ALA A 190
LEU A 193
 None
 0.89A 5nwvA-3lfuA:
undetectable		 5nwvA-3lfuA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llc PUTATIVE HYDROLASE

(Agrobacterium
vitis) 		PF12697
(Abhydrolase_6) 		4 LEU A  55
ASP A  58
ALA A  61
LEU A  64
 EDO  A 275 ( 4.2A)
None
None
None
 0.93A 5nwvA-3llcA:
undetectable		 5nwvA-3llcA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		4 GLN A  73
LEU A  76
ALA A  82
LEU A  85
 None
 1.06A 5nwvA-3lomA:
undetectable		 5nwvA-3lomA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 GLN A 955
ASP A1080
ALA A 774
LEU A 794
 None
 1.09A 5nwvA-3poyA:
undetectable		 5nwvA-3poyA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 333
ASP A 336
TRP A 338
ALA A 339
 None
 0.88A 5nwvA-3rimA:
undetectable		 5nwvA-3rimA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkg MAGNESIUM
TRANSPORTER MRS2,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 4 GLN A 228
LEU A 225
ASP A 222
LEU A 216
 None
 1.03A 5nwvA-3rkgA:
undetectable		 5nwvA-3rkgA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2

(Mus musculus) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		4 LEU A  68
ASP A  70
ALA A  72
LEU A  75
 None
 0.93A 5nwvA-3ro2A:
undetectable		 5nwvA-3ro2A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
fragilis) 		PF10282
(Lactonase) 		4 GLN A 175
LEU A 197
ALA A 194
LEU A 193
 None
 0.94A 5nwvA-3scyA:
undetectable		 5nwvA-3scyA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tul CELL INVASION
PROTEIN SIPB

(Salmonella
enterica) 		PF16535
(T3SSipB) 		4 GLN A 130
LEU A 133
ALA A 139
LEU A 142
 None
 1.07A 5nwvA-3tulA:
undetectable		 5nwvA-3tulA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u80 3-DEHYDROQUINATE
DEHYDRATASE, TYPE II

(Bifidobacterium
longum) 		PF01220
(DHquinase_II) 		4 LEU A 137
ASP A 140
ALA A 143
LEU A 146
 None
 1.05A 5nwvA-3u80A:
undetectable		 5nwvA-3u80A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		4 LEU A 235
ASP A 237
ALA A  36
LEU A  40
 None
 1.01A 5nwvA-3vi1A:
undetectable		 5nwvA-3vi1A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 GLN A 155
LEU A 152
ASP A 149
ALA A 146
 None
 1.05A 5nwvA-4awnA:
undetectable		 5nwvA-4awnA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czd PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY

(Desulfovibrio
desulfuricans) 		PF13404
(HTH_AsnC-type)
no annotation 		4 GLN A  97
ASP A 122
TRP A 126
LEU B 144
 None
 1.11A 5nwvA-4czdA:
undetectable		 5nwvA-4czdA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2o PER-2 BETA-LACTAMASE

(Citrobacter
freundii) 		PF13354
(Beta-lactamase2) 		4 LEU A  60
TRP A  49
ALA A 187
LEU A 260
 None
 1.05A 5nwvA-4d2oA:
undetectable		 5nwvA-4d2oA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewf BETA-LACTAMASE

(Sphaerobacter
thermophilus) 		PF13354
(Beta-lactamase2) 		4 GLN A 169
LEU A 166
ASP A 163
ALA A 159
 None
 1.08A 5nwvA-4ewfA:
undetectable		 5nwvA-4ewfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 GLN A1167
LEU A1170
ASP A1173
ALA A1176
 None
 0.88A 5nwvA-4gfhA:
undetectable		 5nwvA-4gfhA:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		4 GLN L 582
LEU L 592
ALA L 597
LEU L 600
 None
 1.12A 5nwvA-4heaL:
undetectable		 5nwvA-4heaL:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		4 GLN A  32
LEU A  35
ALA A 332
LEU A 335
 UBD  A 401 (-3.0A)
None
None
None
 0.97A 5nwvA-4j7mA:
undetectable		 5nwvA-4j7mA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgh CULLIN-5

(Homo sapiens) 		PF00888
(Cullin) 		4 LEU D  43
ASP D  46
ALA D  49
TRP D  53
 None
 1.04A 5nwvA-4jghD:
undetectable		 5nwvA-4jghD:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 4 GLN A 373
LEU A 376
ASP A 379
ALA A 382
 None
 1.02A 5nwvA-4jw1A:
undetectable		 5nwvA-4jw1A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf9 HEMIN DEGRADING
FACTOR

(Pseudomonas
aeruginosa) 		PF05171
(HemS) 		4 ASP A  32
TRP A  18
ALA A  30
LEU A  44
 None
 1.05A 5nwvA-4mf9A:
undetectable		 5nwvA-4mf9A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9f CULLIN-5

(Homo sapiens) 		no annotation 4 LEU U  43
ALA U  49
LEU U  52
TRP U  53
 None
 0.98A 5nwvA-4n9fU:
undetectable		 5nwvA-4n9fU:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9f CULLIN-5

(Homo sapiens) 		no annotation 4 LEU U  43
ASP U  46
ALA U  49
TRP U  53
 None
 1.02A 5nwvA-4n9fU:
undetectable		 5nwvA-4n9fU:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrt STFQ
AROMATASE/CYCLASE

(Streptomyces
steffisburgensis) 		PF03364
(Polyketide_cyc) 		4 LEU A  21
ASP A  24
ALA A  27
LEU A  29
 None
 1.04A 5nwvA-4xrtA:
undetectable		 5nwvA-4xrtA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxn ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPB

(Mycobacterium
tuberculosis) 		no annotation 4 GLN A  48
LEU A  51
ASP A  54
LEU A  60
 None
 1.11A 5nwvA-4xxnA:
undetectable		 5nwvA-4xxnA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyi KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
japonicus) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 LEU A 247
ALA A 196
LEU A 195
TRP A 207
 None
 1.11A 5nwvA-4xyiA:
undetectable		 5nwvA-4xyiA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN

(Homo sapiens) 		PF13176
(TPR_7)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 LEU A  68
ASP A  70
ALA A  72
LEU A  75
 None
 0.91A 5nwvA-5a6cA:
undetectable		 5nwvA-5a6cA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		4 GLN A 148
LEU A 151
ALA A 157
LEU A 160
 None
 1.12A 5nwvA-5eo6A:
undetectable		 5nwvA-5eo6A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		4 ASP A 128
TRP A 182
ALA A 129
LEU A 131
 None
 1.09A 5nwvA-5ikpA:
undetectable		 5nwvA-5ikpA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j32 3-ISOPROPYLMALATE
DEHYDROGENASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00180
(Iso_dh) 		4 GLN A 134
LEU A  95
TRP A 119
ALA A  86
 None
 0.90A 5nwvA-5j32A:
undetectable		 5nwvA-5j32A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		4 GLN A 662
LEU A 576
ALA A 566
LEU A 569
 None
 1.03A 5nwvA-5jjhA:
undetectable		 5nwvA-5jjhA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3

(Arabidopsis
thaliana) 		PF01680
(SOR_SNZ) 		4 GLN A 242
LEU A 239
ASP A 236
LEU A 287
 None
 0.96A 5nwvA-5k2zA:
undetectable		 5nwvA-5k2zA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		4 GLN A 402
ASP A 486
ALA A 490
LEU A 438
 None
 1.05A 5nwvA-5kijA:
undetectable		 5nwvA-5kijA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Vibrio
vulnificus) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 383
ASP A 386
ALA A 389
LEU A 392
 None
 1.02A 5nwvA-5ks1A:
undetectable		 5nwvA-5ks1A:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l94 CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		4 GLN A 375
ASP A 371
ALA A 367
LEU A 275
 None
 1.02A 5nwvA-5l94A:
undetectable		 5nwvA-5l94A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnt PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.1

(Arabidopsis
thaliana) 		PF01680
(SOR_SNZ) 		4 GLN A 243
LEU A 240
ASP A 237
LEU A 288
 None
 0.92A 5nwvA-5lntA:
undetectable		 5nwvA-5lntA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m42 PROLINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		4 GLN A  77
LEU A  80
TRP A  85
ALA A  86
 None
 0.83A 5nwvA-5m42A:
undetectable		 5nwvA-5m42A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN

(Homo sapiens) 		PF00023
(Ank)
PF00225
(Kinesin)
PF12796
(Ank_2) 		5 GLN C 387
LEU C 383
ASP C 380
ALA C 330
LEU C 332
 None
 1.38A 5nwvA-5mioC:
undetectable		 5nwvA-5mioC:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mua RICIN B-RELATED
LECTIN

(Polyporus
squamosus) 		PF14200
(RicinB_lectin_2) 		4 GLN A 186
TRP A  49
ALA A  22
LEU A  21
 None
 1.06A 5nwvA-5muaA:
undetectable		 5nwvA-5muaA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muw PACKAGING ENZYME P4

(Pseudomonas
virus phi6) 		PF11602
(NTPase_P4) 		4 LEU A 158
ASP A 159
ALA A  60
LEU A  59
 None
 1.12A 5nwvA-5muwA:
undetectable		 5nwvA-5muwA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 LEU A 166
TRP A 199
ALA A 120
LEU A 119
 None
 1.04A 5nwvA-5nj6A:
undetectable		 5nwvA-5nj6A:
5.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nwu WTFP-TAG,GP41

(Human
immunodeficiency
virus 1;
unidentified) 		no annotation 4 GLN A  22
LEU A  25
ASP A  28
ALA A  31
 ACA  A  18 ( 4.1A)
None
None
None
 1.02A 5nwvA-5nwuA:
undetectable		 5nwvA-5nwuA:
88.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1

(Homo sapiens) 		no annotation 4 LEU A 166
TRP A 161
ALA A 122
LEU A 126
 None
 1.05A 5nwvA-5o9hA:
undetectable		 5nwvA-5o9hA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7w APYRASE

(Trifolium
repens) 		PF01150
(GDA1_CD39) 		4 GLN A 377
TRP A 136
ALA A 169
LEU A 201
 None
 1.03A 5nwvA-5u7wA:
undetectable		 5nwvA-5u7wA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		4 GLN F 374
TRP F 136
ALA F 169
LEU F 201
 None
 0.95A 5nwvA-5u7xF:
undetectable		 5nwvA-5u7xF:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 GLN B 153
LEU B 196
ALA B 135
LEU B 139
 BEN  B 312 (-4.3A)
None
None
None
 1.11A 5nwvA-5uniB:
undetectable		 5nwvA-5uniB:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vey E3 UBIQUITIN-PROTEIN
LIGASE RNF169

(Homo sapiens) 		no annotation 4 GLN C 675
LEU C 672
ASP C 669
LEU C 663
 None
 1.03A 5nwvA-5veyC:
undetectable		 5nwvA-5veyC:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x87 BESTROPHIN

(Klebsiella
pneumoniae) 		no annotation 4 LEU A 250
ASP A 253
ALA A 256
LEU A 259
 None
 1.05A 5nwvA-5x87A:
undetectable		 5nwvA-5x87A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbb -

(-) 		no annotation 4 GLN A 307
ALA A 139
LEU A 164
TRP A 168
 None
None
None
IOD  A 601 (-4.6A)
 1.08A 5nwvA-5zbbA:
undetectable		 5nwvA-5zbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b85 TMHC4_R

(synthetic
construct) 		no annotation 4 ASP J 181
ALA J 174
LEU J 177
TRP J 151
 None
 1.07A 5nwvA-6b85J:
undetectable		 5nwvA-6b85J:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek7 YAXA

(Yersinia
enterocolitica) 		no annotation 4 GLN A 112
LEU A 115
ASP A 118
ALA A 121
 None
 0.91A 5nwvA-6ek7A:
undetectable		 5nwvA-6ek7A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6el1 YAXB

(Yersinia
enterocolitica) 		no annotation 4 GLN O 160
LEU O 163
ASP O 166
LEU O 172
 None
 0.86A 5nwvA-6el1O:
undetectable		 5nwvA-6el1O:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et8 -

(-) 		no annotation 4 GLN A  25
LEU A  28
ALA A  34
LEU A  37
 None
 1.04A 5nwvA-6et8A:
undetectable		 5nwvA-6et8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 4 GLN F  61
LEU F 367
TRP F 361
TRP F 304
 None
 1.10A 5nwvA-6f0kF:
undetectable		 5nwvA-6f0kF:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 GLN B  60
LEU B 514
ALA B 685
LEU B 687
 None
 1.06A 5nwvA-6f42B:
undetectable		 5nwvA-6f42B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 4 GLN L 321
LEU L 394
ASP L 393
ALA L 490
 None
 1.03A 5nwvA-6g2jL:
undetectable		 5nwvA-6g2jL:
17.95