SIMILAR PATTERNS OF AMINO ACIDS FOR 5NWU_A_ACAA18_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		3 LEU A 191
LEU A 195
TRP A 230
 None
 0.94A 5nwuA-1ehkA:
0.0		 5nwuA-1ehkA:
5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		3 LEU A 274
LEU A 258
TRP A 270
 None
 0.86A 5nwuA-1gcyA:
undetectable		 5nwuA-1gcyA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		3 LEU B 321
LEU B 323
TRP B 325
 None
 0.87A 5nwuA-1gydB:
0.0		 5nwuA-1gydB:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		3 LEU A 222
LEU A 223
TRP A 234
 None
 0.81A 5nwuA-1l5aA:
0.0		 5nwuA-1l5aA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		3 LEU E 951
LEU E1001
TRP E 908
 None
 0.80A 5nwuA-1o7dE:
undetectable		 5nwuA-1o7dE:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE

(Saccharomyces
cerevisiae) 		PF01259
(SAICAR_synt) 		3 LEU A  56
LEU A  60
TRP A  64
 None
 0.90A 5nwuA-1obgA:
0.0		 5nwuA-1obgA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9u PUTATIVE COMPONENT
OF ANAEROBIC
DEHYDROGENASES

(Salmonella
enterica) 		PF02613
(Nitrate_red_del) 		3 LEU A 131
LEU A 134
TRP A 137
 None
PEG  A 305 (-4.6A)
None
 0.88A 5nwuA-1s9uA:
0.0		 5nwuA-1s9uA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		3 LEU A 379
LEU A 375
TRP A 371
 None
 0.85A 5nwuA-1t6pA:
0.0		 5nwuA-1t6pA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tve HOMOSERINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		3 LEU A  37
LEU A  38
TRP A  59
 None
 0.75A 5nwuA-1tveA:
0.0		 5nwuA-1tveA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpk DNA POLYMERASE III,
BETA SUBUNIT

(Thermotoga
maritima) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 LEU A 178
LEU A 168
TRP A 159
 None
 0.94A 5nwuA-1vpkA:
undetectable		 5nwuA-1vpkA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		3 LEU A 243
LEU A 242
TRP A 274
 None
 0.85A 5nwuA-1wkrA:
undetectable		 5nwuA-1wkrA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		3 LEU A 274
LEU A 258
TRP A 270
 None
 0.90A 5nwuA-2amgA:
undetectable		 5nwuA-2amgA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bh1 GENERAL SECRETION
PATHWAY PROTEIN E,

(Vibrio cholerae) 		no annotation 3 LEU X  27
LEU X  29
TRP X  31
 None
 0.91A 5nwuA-2bh1X:
undetectable		 5nwuA-2bh1X:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhr FTSH

(Thermus
thermophilus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		3 LEU A 466
LEU A 465
TRP A 460
 None
 0.94A 5nwuA-2dhrA:
undetectable		 5nwuA-2dhrA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 LEU A   3
LEU A   4
TRP A 238
 None
 0.90A 5nwuA-2dy3A:
undetectable		 5nwuA-2dy3A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		3 LEU A 262
LEU A 261
TRP A 328
 None
 0.79A 5nwuA-2gqfA:
undetectable		 5nwuA-2gqfA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		3 LEU A 145
LEU A 144
TRP A 196
 None
 0.80A 5nwuA-2jh3A:
undetectable		 5nwuA-2jh3A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwt PROTEASE NS2-3

(Hepacivirus C) 		PF01538
(HCV_NS2) 		3 LEU A   4
LEU A   7
TRP A  10
 None
 0.92A 5nwuA-2kwtA:
undetectable		 5nwuA-2kwtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7h HYPOTHETICAL PROTEIN

(Pectobacterium
atrosepticum) 		PF13489
(Methyltransf_23) 		3 LEU A  45
LEU A  46
TRP A 129
 None
 0.72A 5nwuA-2p7hA:
undetectable		 5nwuA-2p7hA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		3 LEU C 242
LEU C 143
TRP C 248
 None
 0.92A 5nwuA-2vpwC:
undetectable		 5nwuA-2vpwC:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides) 		PF09140
(MipZ) 		3 LEU A 158
LEU A 161
TRP A 164
 None
 0.85A 5nwuA-2xj9A:
undetectable		 5nwuA-2xj9A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk3 CYTOCHROME C

(Crithidia
fasciculata) 		PF00034
(Cytochrom_C) 		3 LEU A 112
LEU A  46
TRP A  70
 None
HEM  A 200 (-4.3A)
HEM  A 200 (-4.0A)
 0.94A 5nwuA-2yk3A:
undetectable		 5nwuA-2yk3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqk POLY(A) POLYMERASE

(Escherichia
coli) 		PF01743
(PolyA_pol)
PF12626
(PolyA_pol_arg_C)
PF12627
(PolyA_pol_RNAbd) 		3 LEU A 405
LEU A 408
TRP A 411
 None
 0.74A 5nwuA-3aqkA:
undetectable		 5nwuA-3aqkA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqk POLY(A) POLYMERASE

(Escherichia
coli) 		PF01743
(PolyA_pol)
PF12626
(PolyA_pol_arg_C)
PF12627
(PolyA_pol_RNAbd) 		3 LEU A 430
LEU A 427
TRP A 378
 None
 0.94A 5nwuA-3aqkA:
undetectable		 5nwuA-3aqkA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		3 LEU A 338
LEU A 342
TRP A 346
 None
 0.94A 5nwuA-3d3lA:
undetectable		 5nwuA-3d3lA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 LEU A 276
LEU A 279
TRP A 282
 None
 0.83A 5nwuA-3dzuA:
undetectable		 5nwuA-3dzuA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efe THIJ/PFPI FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01965
(DJ-1_PfpI) 		3 LEU A 183
LEU A 186
TRP A 189
 None
 0.93A 5nwuA-3efeA:
undetectable		 5nwuA-3efeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		3 LEU A 222
LEU A 225
TRP A 234
 None
 0.93A 5nwuA-3egeA:
undetectable		 5nwuA-3egeA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU A 186
LEU A 189
TRP A 192
 None
 0.80A 5nwuA-3fs1A:
undetectable		 5nwuA-3fs1A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g64 PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
coelicolor) 		PF00378
(ECH_1) 		3 LEU A  30
LEU A  17
TRP A  14
 None
 0.81A 5nwuA-3g64A:
undetectable		 5nwuA-3g64A:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N) 		3 LEU A  24
LEU A  26
TRP A  12
 None
 0.81A 5nwuA-3gonA:
undetectable		 5nwuA-3gonA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		3 LEU A 211
LEU A 319
TRP A 322
 None
 0.93A 5nwuA-3h2iA:
undetectable		 5nwuA-3h2iA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		3 LEU A  23
LEU A  26
TRP A  29
 None
 0.88A 5nwuA-3hoaA:
undetectable		 5nwuA-3hoaA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		3 LEU T  62
LEU T  65
TRP T  40
 None
 0.88A 5nwuA-3icqT:
undetectable		 5nwuA-3icqT:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1w UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF03372
(Exo_endo_phos) 		3 LEU A 149
LEU A 152
TRP A 114
 None
None
EDO  A 262 (-4.1A)
 0.91A 5nwuA-3l1wA:
undetectable		 5nwuA-3l1wA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE

(Ehrlichia
chaffeensis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 LEU A 404
LEU A 405
TRP A 407
 None
 0.86A 5nwuA-3lp8A:
undetectable		 5nwuA-3lp8A:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Streptococcus
suis) 		PF01297
(ZnuA) 		3 LEU A 172
LEU A 175
TRP A 178
 None
 0.83A 5nwuA-3mfqA:
undetectable		 5nwuA-3mfqA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfx SENSORY BOX/GGDEF
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF00989
(PAS) 		3 LEU A  84
LEU A  83
TRP A  68
 None
 0.76A 5nwuA-3mfxA:
undetectable		 5nwuA-3mfxA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN

(Escherichia
virus Qbeta) 		no annotation 3 LEU G 426
LEU G 429
TRP G 432
 None
 0.86A 5nwuA-3mmpG:
undetectable		 5nwuA-3mmpG:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		3 LEU X 271
LEU X 270
TRP X 350
 None
1BN  X 390 ( 4.7A)
1BN  X 390 (-4.8A)
 0.94A 5nwuA-3pb9X:
undetectable		 5nwuA-3pb9X:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		3 LEU A 125
LEU A 124
TRP A 175
 None
 0.74A 5nwuA-3r7wA:
undetectable		 5nwuA-3r7wA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sob LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 LEU B 187
LEU B 230
TRP B 239
 None
 0.75A 5nwuA-3sobB:
undetectable		 5nwuA-3sobB:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		3 LEU A 297
LEU A 296
TRP A 288
 None
 0.85A 5nwuA-3up4A:
undetectable		 5nwuA-3up4A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux4 ACID-ACTIVATED UREA
CHANNEL

(Helicobacter
pylori) 		PF02293
(AmiS_UreI) 		3 LEU A   4
LEU A   7
TRP A 183
 None
 0.72A 5nwuA-3ux4A:
undetectable		 5nwuA-3ux4A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 LEU A 712
LEU A 711
TRP A 706
 None
 0.61A 5nwuA-3viuA:
undetectable		 5nwuA-3viuA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		3 LEU A 325
LEU A 326
TRP A 331
 None
 0.91A 5nwuA-3vohA:
undetectable		 5nwuA-3vohA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zd0 P7 PROTEIN

(Hepacivirus C) 		no annotation 3 LEU A  27
LEU A  71
TRP A  67
 None
 0.72A 5nwuA-3zd0A:
undetectable		 5nwuA-3zd0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		3 LEU A 117
LEU A 120
TRP A  75
 None
 0.90A 5nwuA-4ac0A:
undetectable		 5nwuA-4ac0A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx8 KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens) 		PF16705
(NUDIX_5) 		3 LEU H 157
LEU H 160
TRP H 163
 None
 0.85A 5nwuA-4dx8H:
undetectable		 5nwuA-4dx8H:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fah GENTISATE
1,2-DIOXYGENASE

(Pseudaminobacter
salicylatoxidans) 		PF07883
(Cupin_2) 		3 LEU A  65
LEU A  64
TRP A  59
 None
 0.93A 5nwuA-4fahA:
undetectable		 5nwuA-4fahA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		3 LEU A 230
LEU A 229
TRP A 317
 None
PBD  A 402 (-4.8A)
PBD  A 402 (-4.7A)
 0.93A 5nwuA-4faiA:
undetectable		 5nwuA-4faiA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 LEU B 722
LEU B 725
TRP B 728
 None
 0.75A 5nwuA-4fhnB:
undetectable		 5nwuA-4fhnB:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		3 LEU A1120
LEU A1123
TRP A1126
 None
 0.82A 5nwuA-4fwtA:
undetectable		 5nwuA-4fwtA:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbx BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		3 LEU A  66
LEU A  71
TRP A  75
 None
 0.89A 5nwuA-4hbxA:
undetectable		 5nwuA-4hbxA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi2 ACYLPHOSPHATASE

(Vibrio cholerae) 		PF00708
(Acylphosphatase) 		3 LEU A  55
LEU A  58
TRP A  61
 None
 0.90A 5nwuA-4hi2A:
undetectable		 5nwuA-4hi2A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqe TRANSCRIPTIONAL
REGULATOR QSRR

(Staphylococcus
aureus) 		PF01638
(HxlR) 		3 LEU A  81
LEU A  64
TRP A  62
 None
 0.71A 5nwuA-4hqeA:
undetectable		 5nwuA-4hqeA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans) 		PF00303
(Thymidylat_synt) 		3 LEU A  76
LEU A  75
TRP A  83
 None
 0.83A 5nwuA-4iqqA:
undetectable		 5nwuA-4iqqA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 LEU A 186
LEU A 189
TRP A 192
 None
 0.80A 5nwuA-4iqrA:
undetectable		 5nwuA-4iqrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I

(Escherichia
coli) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		3 LEU A 450
LEU A 447
TRP A 468
 None
 0.93A 5nwuA-4js5A:
undetectable		 5nwuA-4js5A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 3 LEU A 265
LEU A 263
TRP A 285
 None
 0.87A 5nwuA-4ofzA:
undetectable		 5nwuA-4ofzA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo3 HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF01408
(GFO_IDH_MocA)
PF16490
(Oxidoreduct_C) 		3 LEU A 247
LEU A 250
TRP A 253
 None
 0.85A 5nwuA-4oo3A:
undetectable		 5nwuA-4oo3A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt RETINOID X RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		3 LEU U 209
LEU U 212
TRP U 215
 None
 0.94A 5nwuA-4oztU:
undetectable		 5nwuA-4oztU:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0s CROSSOVER JUNCTION
ENDONUCLEASE MUS81

(Homo sapiens) 		PF02732
(ERCC4) 		3 LEU A 453
LEU A 454
TRP A 433
 None
 0.68A 5nwuA-4p0sA:
undetectable		 5nwuA-4p0sA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p79 CLAUDIN-15

(Mus musculus) 		PF00822
(PMP22_Claudin) 		3 LEU A  20
LEU A  24
TRP A  49
 None
OLC  A 201 (-4.0A)
OLC  A 201 (-4.2A)
 0.88A 5nwuA-4p79A:
undetectable		 5nwuA-4p79A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 LEU A 607
LEU A 618
TRP A 435
 None
 0.93A 5nwuA-4pd3A:
undetectable		 5nwuA-4pd3A:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phq HEMOLYSIN E,
CHROMOSOMAL

(Escherichia
coli) 		PF06109
(HlyE) 		3 LEU A  26
LEU A  31
TRP A  37
 None
 0.71A 5nwuA-4phqA:
undetectable		 5nwuA-4phqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		3 LEU A 168
LEU A 172
TRP A 176
 None
 0.92A 5nwuA-4uxvA:
undetectable		 5nwuA-4uxvA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 LEU A 563
LEU A 564
TRP A 584
 None
 0.92A 5nwuA-4wjlA:
undetectable		 5nwuA-4wjlA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3k SEPIAPTERIN
REDUCTASE

(Homo sapiens) 		PF00106
(adh_short) 		3 LEU A 129
LEU A 125
TRP A 121
 None
 0.89A 5nwuA-4z3kA:
undetectable		 5nwuA-4z3kA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn6 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Acinetobacter
baumannii) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 LEU A 131
LEU A 156
TRP A 294
 EDO  A 503 (-4.4A)
None
None
 0.87A 5nwuA-4zn6A:
undetectable		 5nwuA-4zn6A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		3 LEU A1694
LEU A1695
TRP A1730
 None
 0.93A 5nwuA-5a22A:
undetectable		 5nwuA-5a22A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9o CH235.9 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LEU H 107
LEU H 106
TRP H  50
 None
 0.89A 5nwuA-5f9oH:
undetectable		 5nwuA-5f9oH:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LEU B 100
LEU B 100
TRP B  50
 None
 0.76A 5nwuA-5f9wB:
undetectable		 5nwuA-5f9wB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 LEU A 168
LEU A 211
TRP A 220
 None
 0.90A 5nwuA-5gjeA:
undetectable		 5nwuA-5gjeA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 LEU B 753
LEU B 796
TRP B 807
 None
 0.84A 5nwuA-5gjeB:
undetectable		 5nwuA-5gjeB:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 3 LEU A 448
LEU A 451
TRP A 455
 None
 0.84A 5nwuA-5h7jA:
undetectable		 5nwuA-5h7jA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr6 RLMN METHYLASE

(Escherichia
coli) 		PF04055
(Radical_SAM) 		3 LEU A  23
LEU A  21
TRP A 153
 None
 0.92A 5nwuA-5hr6A:
undetectable		 5nwuA-5hr6A:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		3 LEU A 186
LEU A 185
TRP A 136
 None
 0.90A 5nwuA-5htpA:
undetectable		 5nwuA-5htpA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kq1 MRNA DECAPPING
COMPLEX SUBUNIT 2

(Schizosaccharomyces
pombe) 		PF00293
(NUDIX)
PF05026
(DCP2) 		3 LEU B 226
LEU B 229
TRP B 232
 None
 0.90A 5nwuA-5kq1B:
undetectable		 5nwuA-5kq1B:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 LEU A 242
LEU A 246
TRP A 250
 None
 0.92A 5nwuA-5mkkA:
undetectable		 5nwuA-5mkkA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr8 E3 UBIQUITIN-PROTEIN
LIGASE TRIM33

(Homo sapiens) 		no annotation 3 LEU A 919
LEU A 918
TRP A 926
 None
 0.80A 5nwuA-5mr8A:
undetectable		 5nwuA-5mr8A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae) 		no annotation 3 LEU B 516
LEU B 189
TRP B 218
 None
 0.76A 5nwuA-5oarB:
undetectable		 5nwuA-5oarB:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION

(Mus musculus) 		no annotation 3 LEU B 231
LEU B 234
TRP B 237
 None
 0.80A 5nwuA-5oenB:
undetectable		 5nwuA-5oenB:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 LEU T1989
LEU T1931
TRP T1969
 None
 0.91A 5nwuA-5ojsT:
undetectable		 5nwuA-5ojsT:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 LEU A 528
LEU A 527
TRP A 375
 None
 0.62A 5nwuA-5t0lA:
undetectable		 5nwuA-5t0lA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 LEU B 554
LEU B 553
TRP B 597
 None
 0.61A 5nwuA-5up2B:
undetectable		 5nwuA-5up2B:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve6 TYROSINE-PROTEIN
KINASE SGK223

(Homo sapiens) 		no annotation 3 LEU A1329
LEU A1383
TRP A1382
 None
 0.82A 5nwuA-5ve6A:
undetectable		 5nwuA-5ve6A:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi4 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN

(Mus musculus) 		PF13895
(Ig_2)
PF13927
(Ig_3) 		3 LEU C  66
LEU C  68
TRP C  70
 None
 0.71A 5nwuA-5vi4C:
undetectable		 5nwuA-5vi4C:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vp3 MNEMIOPSIN 1

(Mnemiopsis
leidyi) 		no annotation 3 LEU A 126
LEU A 127
TRP A 190
 None
 0.90A 5nwuA-5vp3A:
undetectable		 5nwuA-5vp3A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 3 LEU A 427
LEU A 423
TRP A 461
 None
 0.80A 5nwuA-5w7dA:
undetectable		 5nwuA-5w7dA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3h URACIL-DNA
GLYCOSYLASE

(Nitratifractor
salsuginis) 		no annotation 3 LEU A  14
LEU A  31
TRP A  27
 None
 0.91A 5nwuA-5x3hA:
undetectable		 5nwuA-5x3hA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 3 LEU A1907
LEU A1910
TRP A1779
 None
 0.86A 5nwuA-5yz0A:
undetectable		 5nwuA-5yz0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhc PSEUDOPODIUM-ENRICHE
D ATYPICAL KINASE 1

(Homo sapiens) 		no annotation 3 LEU A1667
LEU A1723
TRP A1722
 None
 0.74A 5nwuA-6bhcA:
undetectable		 5nwuA-6bhcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN DEPDC5

(Homo sapiens) 		no annotation 3 LEU D1415
LEU D1416
TRP D1405
 None
 0.91A 5nwuA-6cetD:
undetectable		 5nwuA-6cetD:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		no annotation 3 LEU A  66
LEU A  71
TRP A  75
 None
 0.94A 5nwuA-6dneA:
undetectable		 5nwuA-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewx PEAK1-RELATED
KINASE-ACTIVATING
PSEUDOKINASE 1

(Rattus
norvegicus) 		no annotation 3 LEU A1291
LEU A1345
TRP A1344
 None
 0.87A 5nwuA-6ewxA:
undetectable		 5nwuA-6ewxA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL

(Mus musculus) 		no annotation 3 LEU B  43
LEU B  46
TRP B  49
 None
 0.76A 5nwuA-6g72B:
undetectable		 5nwuA-6g72B:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 3 LEU A 315
LEU A 316
TRP A 113
 None
 0.91A 5nwuA-6gh2A:
undetectable		 5nwuA-6gh2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gii CYTOCHROME P450

(Tepidiphilus
thermophilus) 		no annotation 3 LEU A 215
LEU A 218
TRP A 278
 None
 0.81A 5nwuA-6giiA:
undetectable		 5nwuA-6giiA:
15.85