SIMILAR PATTERNS OF AMINO ACIDS FOR 5NWU_A_ACAA18_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a87 COLICIN N

(Escherichia
coli) 		PF01024
(Colicin) 		5 LYS A 190
ASN A 191
GLU A 192
GLU A 194
LEU A 196
 None
 1.27A 5nwuA-1a87A:
0.0		 5nwuA-1a87A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak0 P1 NUCLEASE

(Penicillium
citrinum) 		PF02265
(S1-P1_nuclease) 		5 GLY A  30
SER A  31
ASN A 106
GLU A 109
LEU A 111
 None
None
None
NAG  A 281 (-3.2A)
None
 1.22A 5nwuA-1ak0A:
0.0		 5nwuA-1ak0A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8u PROTEIN (MALATE
DEHYDROGENASE)

(Aquaspirillum
arcticum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 276
ASN A 189
GLU A 316
LEU A 318
GLU A 319
 None
 0.95A 5nwuA-1b8uA:
0.0		 5nwuA-1b8uA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR

(Bos taurus) 		PF00996
(GDI) 		5 ALA A 243
GLY A 247
LYS A  -2
GLU A 273
GLU A   3
 None
 1.23A 5nwuA-1d5tA:
undetectable		 5nwuA-1d5tA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 257
GLY A 256
ASN A 280
GLU A 279
LEU A 237
 None
 1.09A 5nwuA-1gzkA:
0.0		 5nwuA-1gzkA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mus musculus) 		PF00268
(Ribonuc_red_sm) 		5 ALA A 274
GLU A 153
GLN A 155
LEU A  74
GLU A  76
 None
 1.26A 5nwuA-1h0nA:
0.0		 5nwuA-1h0nA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hux ACTIVATOR OF
(R)-2-HYDROXYGLUTARY
L-COA DEHYDRATASE

(Acidaminococcus
fermentans) 		PF01869
(BcrAD_BadFG) 		5 ALA A 129
GLY A 130
GLU A 230
LEU A 228
GLU A 229
 SF4  A 290 ( 4.5A)
None
None
None
None
 1.06A 5nwuA-1huxA:
0.0		 5nwuA-1huxA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		5 GLY A 172
ASN A 206
GLU A 207
GLU A 243
LEU A 202
 None
 0.96A 5nwuA-1j0aA:
0.0		 5nwuA-1j0aA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jj7 PEPTIDE TRANSPORTER
TAP1

(Homo sapiens) 		PF00005
(ABC_tran) 		5 ALA A 621
GLY A 620
SER A 677
GLN A 683
GLU A 687
 None
 1.21A 5nwuA-1jj7A:
0.0		 5nwuA-1jj7A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl7 MONOMER HEMOGLOBIN
COMPONENT III

(Glycera
dibranchiata) 		PF00042
(Globin) 		5 ALA A  60
GLY A  59
LYS A  28
LYS A  33
LEU A 106
 None
None
None
None
HEM  A 148 ( 4.2A)
 1.07A 5nwuA-1jl7A:
undetectable		 5nwuA-1jl7A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 ALA A  21
GLY A  22
ASN A 484
LEU A 479
GLU A  73
 None
FAD  A 600 (-3.3A)
None
None
None
 1.19A 5nwuA-1sezA:
undetectable		 5nwuA-1sezA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  69
GLY A 101
GLN A   9
GLU A  11
LEU A  63
 None
 1.20A 5nwuA-1tt7A:
undetectable		 5nwuA-1tt7A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE

(Aeropyrum
pernix) 		PF00793
(DAHP_synth_1) 		5 ALA A 236
ASN A 156
GLU A 160
LEU A 162
GLU A 159
 None
 1.25A 5nwuA-1vs1A:
undetectable		 5nwuA-1vs1A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ALA A 310
SER A 312
ASN A 191
LEU A 196
GLU A 197
 None
 1.27A 5nwuA-1yfmA:
undetectable		 5nwuA-1yfmA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Chromobacterium
violaceum) 		PF04952
(AstE_AspA) 		5 ALA A  11
GLY A  35
GLU A 127
GLU A 129
LEU A 131
 None
 1.27A 5nwuA-1yw4A:
undetectable		 5nwuA-1yw4A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6o FERRITIN LIGHT CHAIN

(Trichoplusia ni) 		PF00210
(Ferritin) 		5 ALA A  70
GLY A  71
ASN A 120
GLU A 124
LEU A 126
 None
 1.18A 5nwuA-1z6oA:
undetectable		 5nwuA-1z6oA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ako GLUTAMATE 5-KINASE

(Campylobacter
jejuni) 		PF00696
(AA_kinase) 		5 GLY A   9
SER A  10
ASN A  26
GLU A  22
LEU A  24
 None
 1.26A 5nwuA-2akoA:
undetectable		 5nwuA-2akoA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		5 ALA A  59
GLY A  60
GLN A 254
GLU A 257
GLU A 256
 ALA  A  59 ( 0.0A)
GLY  A  60 ( 0.0A)
GLN  A 254 ( 0.6A)
GLU  A 257 ( 0.6A)
GLU  A 256 ( 0.6A)
 1.13A 5nwuA-2b92A:
undetectable		 5nwuA-2b92A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		5 ALA A 251
GLY A 252
LYS A 292
GLU A 295
LEU A 297
 None
 0.90A 5nwuA-2c49A:
undetectable		 5nwuA-2c49A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d93 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6

(Homo sapiens) 		PF00027
(cNMP_binding) 		5 ALA A  47
GLY A  48
ASN A  80
GLU A  70
GLU A  79
 None
 0.96A 5nwuA-2d93A:
undetectable		 5nwuA-2d93A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkw HYPOTHETICAL PROTEIN
KIAA1240

(Homo sapiens) 		PF00439
(Bromodomain) 		5 GLY A   4
SER A   3
LYS A   1
LEU A 119
GLU A 121
 None
 1.16A 5nwuA-2dkwA:
undetectable		 5nwuA-2dkwA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		5 GLY A 333
SER A 334
LYS A 139
ASN A 180
LEU A 177
 None
 1.10A 5nwuA-2dv6A:
undetectable		 5nwuA-2dv6A:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		5 ALA A 766
GLY A 767
ASN A 750
LEU A 748
GLU A 745
 None
 1.24A 5nwuA-2eaeA:
undetectable		 5nwuA-2eaeA:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gie TYPE II RESTRICTION
ENZYME HINCII

(Haemophilus
influenzae) 		PF09226
(Endonuc-HincII) 		5 ALA A  33
GLY A  34
LYS A  19
GLN A  18
LEU A  15
 None
 0.89A 5nwuA-2gieA:
undetectable		 5nwuA-2gieA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kr7 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Helicobacter
pylori) 		PF00254
(FKBP_C) 		5 ALA A 131
GLY A 132
GLU A  21
GLN A  22
GLU A  64
 None
 1.26A 5nwuA-2kr7A:
undetectable		 5nwuA-2kr7A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l2g IGF2R DOMAIN 11

(Monodelphis
domestica) 		PF00878
(CIMR) 		5 ALA A1590
GLY A1591
SER A1592
LYS A1623
GLN A1596
 None
 1.02A 5nwuA-2l2gA:
undetectable		 5nwuA-2l2gA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfw NEPR ANTI SIGMA
FACTOR
PHYR SIGMA-LIKE
DOMAIN

(Sphingomonas
sp. Fr1) 		no annotation 5 ALA B  30
GLY B  29
GLU A 136
LEU A 134
GLU A 132
 None
 1.12A 5nwuA-2lfwB:
undetectable		 5nwuA-2lfwB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrv UNCHARACTERIZED
PROTEIN YMGD

(Escherichia
coli) 		PF16456
(YmgD) 		5 ALA A  41
GLY A  39
LYS A  59
GLU A  62
LEU A  64
 None
 1.17A 5nwuA-2lrvA:
undetectable		 5nwuA-2lrvA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ALA A  59
GLY A  50
LYS A  62
GLU A  48
GLU A 241
 UNX  A   4 (-3.3A)
UNX  A   4 ( 4.6A)
None
None
None
 1.20A 5nwuA-2nztA:
undetectable		 5nwuA-2nztA:
3.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Shigella
flexneri) 		PF03009
(GDPD) 		5 GLY A  48
SER A  45
LYS A  46
GLU A 149
GLU A 114
 None
None
None
None
PO4  A 301 (-3.4A)
 1.22A 5nwuA-2otdA:
undetectable		 5nwuA-2otdA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 ALA A 128
GLY A 129
LYS A 127
GLN A 314
GLU A 312
 None
None
COA  A 500 (-3.2A)
None
None
 1.25A 5nwuA-2ozgA:
undetectable		 5nwuA-2ozgA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ALA B 164
GLY B  48
SER B  49
ASN B  83
GLU B  85
 None
 1.17A 5nwuA-2po2B:
undetectable		 5nwuA-2po2B:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		5 ALA A 232
GLY A 236
GLU A 250
LEU A 204
GLU A  30
 None
 1.02A 5nwuA-2qneA:
undetectable		 5nwuA-2qneA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE

(Dictyostelium
discoideum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 GLU A 358
GLN A 360
GLU A 357
LEU A 361
GLU A  62
 None
None
None
PL3  A1588 ( 4.6A)
None
 1.16A 5nwuA-2uuuA:
undetectable		 5nwuA-2uuuA:
5.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x7r TRANSMEMBRANE
PROTEIN GP41

(Human
immunodeficiency
virus 1) 		PF00517
(GP41) 		5 ASN B 656
GLN B 658
GLU B 659
LEU B 661
GLU B 662
 None
 0.95A 5nwuA-2x7rB:
undetectable		 5nwuA-2x7rB:
41.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x7r TRANSMEMBRANE
PROTEIN GP41

(Human
immunodeficiency
virus 1) 		PF00517
(GP41) 		5 ASN B 656
GLU B 657
GLN B 658
GLU B 659
GLU B 662
 None
 1.15A 5nwuA-2x7rB:
undetectable		 5nwuA-2x7rB:
41.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xcm CYTOSOLIC HEAT SHOCK
PROTEIN 90

(Hordeum vulgare) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 GLY A 102
SER A 101
LYS A 104
ASN A  15
GLN A  11
 None
 0.93A 5nwuA-2xcmA:
undetectable		 5nwuA-2xcmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		5 GLY A 282
SER A 283
LYS A 281
GLU A  27
GLU A 317
 None
 1.23A 5nwuA-2xu0A:
undetectable		 5nwuA-2xu0A:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ym9 CELL INVASION
PROTEIN SIPD

(Salmonella
enterica) 		PF06511
(IpaD) 		5 ALA A 296
GLY A 293
SER A 292
LYS A 295
LEU A 271
 None
 1.17A 5nwuA-2ym9A:
undetectable		 5nwuA-2ym9A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		5 GLY A  82
SER A  81
GLU A  43
LEU A  41
GLU A  42
 SAH  A 301 (-4.8A)
None
None
None
None
 1.22A 5nwuA-2zvbA:
undetectable		 5nwuA-2zvbA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 BETA-GLOBIN

(Podocnemis
unifilis) 		PF00042
(Globin) 		5 ALA B  62
GLY B  64
LYS B  65
LYS B  66
LEU B 106
 None
None
None
None
HEM  B 147 ( 4.8A)
 1.20A 5nwuA-3at6B:
undetectable		 5nwuA-3at6B:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE

(Plectranthus
scutellarioides) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A  55
GLY A  56
LYS A  80
GLU A  88
GLU A  87
 None
 1.16A 5nwuA-3bazA:
undetectable		 5nwuA-3bazA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2q UNCHARACTERIZED
CONSERVED PROTEIN

(Methanococcus
maripaludis) 		no annotation 5 ALA A 184
LYS A 406
GLU A 409
LEU A 411
GLU A 412
 None
 1.23A 5nwuA-3c2qA:
undetectable		 5nwuA-3c2qA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 ALA A  99
GLY A 100
GLN A 131
LEU A 103
GLU A 116
 None
 1.06A 5nwuA-3ct4A:
undetectable		 5nwuA-3ct4A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7l LIN1944 PROTEIN

(Listeria
innocua) 		PF13561
(adh_short_C2) 		5 ALA A   8
GLY A  13
LYS A  17
LEU A 157
GLU A 158
 None
 1.18A 5nwuA-3d7lA:
undetectable		 5nwuA-3d7lA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkt MARITIMACIN

(Thermotoga
maritima) 		PF04454
(Linocin_M18) 		5 GLY A 133
SER A 136
ASN A 259
GLU A 261
LEU A 263
 None
 1.21A 5nwuA-3dktA:
undetectable		 5nwuA-3dktA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR

(Bordetella
pertussis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 537
GLY A 536
SER A 526
GLN A  60
GLU A  63
 None
 1.21A 5nwuA-3efmA:
undetectable		 5nwuA-3efmA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Glutamicibacter
protophormiae) 		PF03644
(Glyco_hydro_85) 		5 ALA A  94
GLY A  95
SER A  96
GLU A  14
GLU A 136
 None
 1.21A 5nwuA-3fhaA:
undetectable		 5nwuA-3fhaA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv5 DNA POLYMERASE IOTA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 GLY B 195
LYS B 108
GLU B 111
LEU B 113
GLU B 114
 None
 1.22A 5nwuA-3gv5B:
undetectable		 5nwuA-3gv5B:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h04 UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		5 ALA A 107
GLY A 106
LYS A  44
ASN A  46
LEU A  65
 None
 1.26A 5nwuA-3h04A:
undetectable		 5nwuA-3h04A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 ALA A 407
GLY A 408
SER A 388
LYS A 387
ASN A 402
 None
 1.22A 5nwuA-3h09A:
undetectable		 5nwuA-3h09A:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE

(Clostridium
acetobutylicum) 		PF00730
(HhH-GPD)
PF07934
(OGG_N) 		6 ALA A 144
GLY A 145
SER A 141
LYS A 143
GLU A 149
LEU A 148
 None
None
None
None
None
EDO  A 291 (-3.6A)
 1.31A 5nwuA-3i0wA:
undetectable		 5nwuA-3i0wA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jte RESPONSE REGULATOR
RECEIVER PROTEIN

(Ruminiclostridium
thermocellum) 		PF00072
(Response_reg) 		5 GLY A  64
SER A  63
LYS A  58
GLU A  38
LEU A  40
 None
 0.86A 5nwuA-3jteA:
undetectable		 5nwuA-3jteA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3p IPAH9.8

(Shigella
flexneri) 		PF14496
(NEL) 		5 ALA A 510
GLY A 511
ASN A 485
GLU A 481
LEU A 483
 None
 1.03A 5nwuA-3l3pA:
undetectable		 5nwuA-3l3pA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4x REVERSE GYRASE
HELICASE-LIKE DOMAIN

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ALA A 316
LYS A 300
GLU A 303
LEU A 305
GLU A 306
 None
 1.19A 5nwuA-3p4xA:
undetectable		 5nwuA-3p4xA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		5 ALA A 244
ASN A 331
GLU A 365
LEU A 364
GLU A 373
 None
None
None
HEC  A1007 (-4.1A)
None
 0.97A 5nwuA-3ttbA:
undetectable		 5nwuA-3ttbA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 ALA A 231
GLY A 232
SER A 233
GLU A 243
LEU A 444
 ALA  A 231 ( 0.0A)
GLY  A 232 ( 0.0A)
SER  A 233 ( 0.0A)
GLU  A 243 ( 0.6A)
LEU  A 444 ( 0.6A)
 0.94A 5nwuA-3ulkA:
undetectable		 5nwuA-3ulkA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		5 ALA A 288
GLY A 289
ASN A 707
LEU A 259
GLU A 258
 None
 1.25A 5nwuA-4aioA:
undetectable		 5nwuA-4aioA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmv SHORT-CHAIN
DEHYDROGENASE

(Sphingobium
yanoikuyae) 		PF00106
(adh_short) 		5 ALA A  12
GLY A  17
GLU A 206
LEU A 210
GLU A 209
 None
 1.27A 5nwuA-4bmvA:
undetectable		 5nwuA-4bmvA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 ALA A 429
GLY A 426
GLN A 398
LEU A 397
GLU A 369
 None
 1.16A 5nwuA-4cjaA:
undetectable		 5nwuA-4cjaA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc5 TRANSMEMBRANE
PROTEIN 173

(Mus musculus) 		PF15009
(TMEM173) 		5 ALA A 192
GLY A 193
SER A 194
GLU A 327
LEU A 329
 None
 1.04A 5nwuA-4jc5A:
undetectable		 5nwuA-4jc5A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1

(Homo sapiens) 		PF16363
(GDP_Man_Dehyd) 		5 ALA A  97
GLY A  96
ASN A 137
GLU A 114
LEU A 108
 NAD  A 501 (-4.7A)
None
None
None
None
 1.24A 5nwuA-4lk3A:
undetectable		 5nwuA-4lk3A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu1 MAF-LIKE PROTEIN
YCEF

(Escherichia
coli) 		PF02545
(Maf) 		5 ALA A  49
GLY A  67
ASN A 170
LEU A  17
GLU A  18
 None
 1.27A 5nwuA-4lu1A:
undetectable		 5nwuA-4lu1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjk CRISPR PROTEIN

(Archaeoglobus
fulgidus) 		PF09704
(Cas_Cas5d) 		5 ALA A 252
LYS A 135
ASN A  65
GLU A 136
GLU A 137
 None
 1.27A 5nwuA-4mjkA:
undetectable		 5nwuA-4mjkA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Toxoplasma
gondii) 		PF00215
(OMPdecase) 		5 GLY A  43
SER A 286
ASN A 300
GLN A 298
LEU A 295
 None
 1.26A 5nwuA-4mjzA:
undetectable		 5nwuA-4mjzA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlk CT584 PROTEIN

(Chlamydia
trachomatis) 		PF17435
(DUF5414) 		5 SER A  79
LYS A  64
ASN A  62
GLU A  58
LEU A  60
 None
 1.13A 5nwuA-4mlkA:
undetectable		 5nwuA-4mlkA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1l TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		5 ALA A 155
GLY A 154
SER A 153
GLU A 280
GLU A 274
 None
None
BDP  A 401 ( 4.9A)
None
None
 0.86A 5nwuA-4p1lA:
undetectable		 5nwuA-4p1lA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		5 ALA B 180
GLY B 181
ASN B 174
GLU B 145
LEU B 201
 None
 1.22A 5nwuA-4peqB:
undetectable		 5nwuA-4peqB:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmz EIF5B

(Chaetomium
thermophilum) 		no annotation 5 ALA B 562
GLY B 561
ASN B 547
GLN B 549
GLU B 550
 None
None
None
GSP  B 901 (-3.9A)
None
 1.20A 5nwuA-4tmzB:
undetectable		 5nwuA-4tmzB:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR

(Trypanosoma
brucei) 		no annotation 5 ALA E 169
GLY E 167
GLN E  54
LEU E 210
GLU E 209
 None
 1.15A 5nwuA-4wjgE:
undetectable		 5nwuA-4wjgE:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 849
GLY A 818
SER A 819
GLU A 860
LEU A 912
 None
 1.21A 5nwuA-4zdnA:
undetectable		 5nwuA-4zdnA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv1 ANCQR

(synthetic
construct) 		PF00497
(SBP_bac_3) 		5 LYS A  45
LYS A  46
GLU A 208
LEU A 206
GLU A 205
 None
 1.22A 5nwuA-4zv1A:
undetectable		 5nwuA-4zv1A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cml OSMC FAMILY PROTEIN

(Rhodothermus
marinus) 		PF12146
(Hydrolase_4) 		5 ALA A  35
GLY A 111
GLU A 174
LEU A 176
GLU A 177
 None
 1.25A 5nwuA-5cmlA:
undetectable		 5nwuA-5cmlA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		5 ALA A 295
GLY A 292
GLN A 286
GLU A 283
LEU A 281
 None
 1.26A 5nwuA-5dxiA:
undetectable		 5nwuA-5dxiA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 ALA A 145
LYS A 144
GLN A 103
LEU A 102
GLU A 101
 None
 1.09A 5nwuA-5e5uA:
undetectable		 5nwuA-5e5uA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyg CYTOCHROME P450

(Marinobacter
hydrocarbonoclasticus) 		PF00067
(p450) 		5 ALA A 326
GLY A 323
GLU A 437
LEU A 435
GLU A 438
 None
 1.17A 5nwuA-5fygA:
undetectable		 5nwuA-5fygA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR

(Trypanosoma
brucei) 		no annotation 5 ALA D 169
GLY D 167
GLN D  54
LEU D 210
GLU D 209
 None
 1.14A 5nwuA-5hu6D:
undetectable		 5nwuA-5hu6D:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iig VACUOLAR TRANSPORTER
CHAPERONE 4

(Saccharomyces
cerevisiae) 		PF03105
(SPX)
PF09359
(VTC) 		5 ASN A 330
GLU A 331
GLU A 333
LEU A 335
GLU A 336
 None
 1.24A 5nwuA-5iigA:
undetectable		 5nwuA-5iigA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 ALA A 950
GLY A 951
ASN A 972
GLU A 944
LEU A 942
 None
 1.23A 5nwuA-5irmA:
undetectable		 5nwuA-5irmA:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		5 ALA A  26
GLY A  25
GLN A  22
LEU A 440
GLU A 441
 None
 1.24A 5nwuA-5jboA:
undetectable		 5nwuA-5jboA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Aspergillus
fumigatus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ALA A 347
GLY A 348
SER A 349
GLU A 355
GLU A 280
 None
 1.21A 5nwuA-5jw6A:
undetectable		 5nwuA-5jw6A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		5 ALA A 175
GLY A 227
GLN A 207
GLU A 208
LEU A 210
 None
 1.25A 5nwuA-5k52A:
undetectable		 5nwuA-5k52A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ALA A 170
GLY A 169
SER A 168
LYS A  40
LEU A  23
 None
 1.18A 5nwuA-5kp7A:
undetectable		 5nwuA-5kp7A:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		5 ALA A 324
GLY A 325
LYS A 322
GLU A 297
LEU A 299
 None
 1.16A 5nwuA-5lmcA:
undetectable		 5nwuA-5lmcA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpl HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1

(Homo sapiens) 		PF00076
(RRM_1) 		5 GLY A 111
LYS A 113
GLU A 117
LEU A 121
GLU A 118
 C  B   2 ( 2.7A)
None
None
None
None
 1.22A 5nwuA-5mplA:
undetectable		 5nwuA-5mplA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpt CITRININ POLYKETIDE
SYNTHASE

(Monascus
purpureus) 		PF08242
(Methyltransf_12) 		5 GLY A1924
SER A1925
GLU A1905
LEU A1903
GLU A1904
 None
 1.17A 5nwuA-5mptA:
undetectable		 5nwuA-5mptA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n56 SUPEROXIDE DISMUTASE
[MN/FE] 1

(Staphylococcus
aureus) 		no annotation 5 ALA A 181
LYS A 114
GLU A 110
GLU A 111
LEU A 109
 None
 1.26A 5nwuA-5n56A:
undetectable		 5nwuA-5n56A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe) 		PF10156
(Med17) 		5 GLY W 242
LYS W 300
GLN W 302
GLU W 303
LEU W 305
 None
 1.21A 5nwuA-5n9jW:
undetectable		 5nwuA-5n9jW:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S4
30S RIBOSOMAL
PROTEIN S5

(Mycolicibacterium
smegmatis) 		PF00163
(Ribosomal_S4)
PF00333
(Ribosomal_S5)
PF01479
(S4)
PF03719
(Ribosomal_S5_C) 		5 ALA E 138
GLU D 197
GLN D 193
LEU D 194
GLU D 192
 None
 1.25A 5nwuA-5o5jE:
undetectable		 5nwuA-5o5jE:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5orm CPPR-TELO1

(synthetic
construct) 		no annotation 5 GLY A 294
SER A 293
GLU A 303
LEU A 307
GLU A 309
 None
 1.26A 5nwuA-5ormA:
undetectable		 5nwuA-5ormA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t09 TYPE III SECRETION
SYSTEM EFFECTOR
HOPBA1

(Pseudomonas
syringae) 		no annotation 5 ALA A 191
GLY A  53
LYS A  63
GLU A  67
LEU A  40
 None
 1.17A 5nwuA-5t09A:
undetectable		 5nwuA-5t09A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		5 ALA A  53
GLY A  54
ASN A  26
LEU A 113
GLU A 117
 None
 1.18A 5nwuA-5thwA:
undetectable		 5nwuA-5thwA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		5 ALA A 527
GLY A 529
ASN A 498
LEU A 503
GLU A 504
 None
 0.95A 5nwuA-5txeA:
undetectable		 5nwuA-5txeA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txv ATP-DEPENDENT
PROTEASE ATPASE
SUBUNIT HSLU

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 ALA A 422
GLY A 372
GLU A 341
GLU A 346
LEU A 344
 None
 1.21A 5nwuA-5txvA:
undetectable		 5nwuA-5txvA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v07 EXONUCLEASE 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 ALA Z 115
GLY Z 103
ASN Z 124
GLN Z  97
GLU Z  94
 None
 1.25A 5nwuA-5v07Z:
undetectable		 5nwuA-5v07Z:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 5 ALA A 371
SER A 373
ASN A 401
GLU A 398
LEU A 396
 None
 1.26A 5nwuA-5wi9A:
undetectable		 5nwuA-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE

(Sphingobium sp.
SYK-6) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 ALA A 287
GLY A 286
SER A 285
GLU A   8
LEU A 277
 None
EDO  A 504 (-3.2A)
None
None
None
 1.24A 5nwuA-5x1nA:
undetectable		 5nwuA-5x1nA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE

(Chromobacterium
sp. USM2) 		PF07167
(PhaC_N) 		5 ALA A 549
GLY A 551
ASN A 192
GLU A 193
GLU A 255
 None
 1.20A 5nwuA-5xavA:
undetectable		 5nwuA-5xavA:
6.58