SIMILAR PATTERNS OF AMINO ACIDS FOR 5NVP_A_ACAA18

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nln ADENAIN

(Human
mastadenovirus
C) 		PF00770
(Peptidase_C5) 		5 SER A   4
LYS A   2
LYS A   9
GLU A   7
LEU A 124
 None
 1.20A 5nvpA-1nlnA:
0.0		 5nvpA-1nlnA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu9 STAPHYLOCOAGULASE

(Staphylococcus
aureus) 		PF08764
(Coagulase) 		5 LYS C  53
GLU C 140
GLN C 142
GLU C  54
LEU C 146
 None
 1.49A 5nvpA-1nu9C:
0.0		 5nvpA-1nu9C:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 ALPHA-SOLUBLE NSF
ATTACHMENT PROTEIN

(Rattus
norvegicus) 		no annotation 5 SER H 238
LYS H 242
LYS H 203
GLU H 229
GLU H 230
 None
 1.45A 5nvpA-3j97H:
0.0		 5nvpA-3j97H:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r64 NAD DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00171
(Aldedh) 		5 SER A 327
ASN A  34
GLU A  99
GLU A  94
LEU A  96
 SER  A 327 ( 0.0A)
ASN  A  34 ( 0.6A)
GLU  A  99 ( 0.6A)
GLU  A  94 ( 0.6A)
LEU  A  96 ( 0.6A)
 1.11A 5nvpA-3r64A:
0.0		 5nvpA-3r64A:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 SER A 519
ASN A 487
LEU A 484
GLU A 569
LEU A 490
 None
 1.48A 5nvpA-3s1sA:
0.0		 5nvpA-3s1sA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 SER A 194
ASN A 214
GLN A 212
LEU A 201
LEU A 191
 None
 1.38A 5nvpA-3w15A:
0.0		 5nvpA-3w15A:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus) 		PF01979
(Amidohydro_1) 		5 SER A 279
LYS A 284
GLU A 282
LEU A 261
GLU A 258
 None
 1.36A 5nvpA-4f0lA:
0.0		 5nvpA-4f0lA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE

(Enterococcus
faecalis) 		PF02557
(VanY) 		5 LYS A  22
ASN A  23
GLU A 187
LEU A  19
LEU A 186
 None
EDO  A 309 ( 4.2A)
None
None
None
 1.42A 5nvpA-4f78A:
0.0		 5nvpA-4f78A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Yersinia pestis) 		PF00005
(ABC_tran) 		5 SER C  15
ASN C  74
LEU C  70
GLU C  13
LEU C  12
 None
 1.41A 5nvpA-4g1uC:
undetectable		 5nvpA-4g1uC:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po4 LAMPETRA PLANERI
VLRC

(Lampetra
planeri) 		PF13855
(LRR_8) 		5 ASN A  48
GLN A  46
LEU A  69
GLU A  92
LEU A  93
 None
 1.44A 5nvpA-4po4A:
undetectable		 5nvpA-4po4A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 SER A  33
ASN A 468
LEU A 479
GLU A 521
LEU A 522
 None
 0.96A 5nvpA-4rvwA:
undetectable		 5nvpA-4rvwA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 SER A  33
LYS A 476
LEU A 479
GLU A 521
LEU A 522
 None
 1.26A 5nvpA-4rvwA:
undetectable		 5nvpA-4rvwA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 ASN B 266
GLN B 265
LEU B 288
GLU B 311
LEU B 312
 None
 1.33A 5nvpA-5hz1B:
undetectable		 5nvpA-5hz1B:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im4 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Candida
albicans) 		PF00885
(DMRL_synthase) 		5 LYS A  69
GLU A  56
GLN A  75
GLU A  73
LEU A  70
 None
 1.32A 5nvpA-5im4A:
undetectable		 5nvpA-5im4A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 LYS A1088
GLU A1085
LEU A1121
GLU A1122
LEU A1126
 None
 1.42A 5nvpA-5m59A:
undetectable		 5nvpA-5m59A:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9c SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 LEU A 449
LYS A 200
LEU A 202
TRP A 204
 None
None
SO4  A7503 (-3.8A)
SO4  A7503 (-4.5A)
 1.40A 5nvpA-2a9cA:
0.0		 5nvpA-2a9cA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE

(Coffea
canephora) 		PF02458
(Transferase) 		4 LEU A 426
LYS A 268
LEU A 315
TRP A 263
 None
 1.42A 5nvpA-4g0bA:
0.0		 5nvpA-4g0bA:
5.73