SIMILAR PATTERNS OF AMINO ACIDS FOR 5NUN_A_Z80A201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byr PROTEIN
(ENDONUCLEASE)

(Salmonella
enterica) 		PF13091
(PLDc_2) 		6 ALA A  39
ILE A  77
LEU A  46
ILE A  58
ILE A  60
ASN A  65
 None
 1.37A 5nunA-1byrA:
0.0		 5nunA-1byrA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		5 ALA A  54
VAL A  56
LEU A  28
ILE A 390
ILE A 336
 None
 1.00A 5nunA-1d9zA:
0.0		 5nunA-1d9zA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gaj HIGH-AFFINITY
BRANCHED CHAIN AMINO
ACID TRANSPORT
ATP-BINDING PROTEIN

(Methanocaldococcus
jannaschii) 		PF00005
(ABC_tran) 		5 ILE A  38
ILE A 209
ILE A  50
ASN A  51
ALA A  22
 None
None
None
PEG  A 600 (-3.7A)
None
 0.93A 5nunA-1gajA:
undetectable		 5nunA-1gajA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2z ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Helicobacter
pylori) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ALA A 154
VAL A 135
LEU A 131
ILE A 143
ILE A 161
 None
 1.00A 5nunA-1j2zA:
0.0		 5nunA-1j2zA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqv CYTOCHROME C'

(Rhodopseudomonas
palustris) 		PF01322
(Cytochrom_C_2) 		5 ALA A  18
LEU A 110
ILE A 106
ILE A  96
ALA A  43
 None
 0.67A 5nunA-1mqvA:
undetectable		 5nunA-1mqvA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0v TRNA-INTRON
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		5 ALA A 120
VAL A 121
LEU A 272
ILE A 102
ILE A 107
 None
 1.00A 5nunA-1r0vA:
undetectable		 5nunA-1r0vA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 ALA A  97
ILE A  91
ILE A 133
ILE A 117
PHE A 113
 None
 0.97A 5nunA-1r47A:
0.0		 5nunA-1r47A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Mytilus edulis) 		PF13714
(PEP_mutase) 		5 ALA A 111
VAL A 157
ILE A 236
ILE A  23
ALA A  86
 None
 0.92A 5nunA-1s2tA:
0.0		 5nunA-1s2tA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		5 ALA A 150
ILE A  42
LEU A  40
ILE A  84
ILE A 112
 None
 0.96A 5nunA-1tzbA:
0.0		 5nunA-1tzbA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u37 AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING,
FAMILY A, MEMBER 1

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A  99
ILE A  89
LEU A  93
ILE A  90
ILE A  35
 None
 1.00A 5nunA-1u37A:
0.0		 5nunA-1u37A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9c CRM1 PROTEIN

(Homo sapiens) 		PF08767
(CRM1_C) 		5 ALA A 773
VAL A 777
LEU A 781
ILE A 822
ILE A 819
 None
 0.91A 5nunA-1w9cA:
undetectable		 5nunA-1w9cA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5i NEOGENIN

(Homo sapiens) 		PF00041
(fn3) 		5 ILE A  85
LEU A  88
ILE A  43
ILE A  96
ALA A  71
 None
 0.97A 5nunA-1x5iA:
undetectable		 5nunA-1x5iA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x94 PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Vibrio cholerae) 		PF13580
(SIS_2) 		5 ALA A  59
ILE A 183
ILE A 182
ILE A  37
ALA A  81
 None
 0.96A 5nunA-1x94A:
undetectable		 5nunA-1x94A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		6 VAL A 353
ILE A 382
LEU A 357
ILE A 371
ILE A 373
ALA A 465
 None
 1.42A 5nunA-1xdpA:
undetectable		 5nunA-1xdpA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpn HYPOTHETICAL PROTEIN
PA1324

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A  72
ILE A  46
LEU A  69
ILE A 124
ASN A 126
 None
 0.98A 5nunA-1xpnA:
undetectable		 5nunA-1xpnA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		5 VAL A 325
ILE A 304
LEU A 298
ASN A 307
ALA A 346
 None
 0.98A 5nunA-1zmrA:
undetectable		 5nunA-1zmrA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a18 CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK HOMOLOG 4

(Synechocystis
sp. PCC 6803) 		PF00936
(BMC) 		5 ALA A  20
ILE A  48
LEU A  46
ILE A  33
ALA A  65
 None
 0.86A 5nunA-2a18A:
undetectable		 5nunA-2a18A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bqp PROTEIN (PEA LECTIN)

(Pisum sativum) 		PF00139
(Lectin_legB) 		5 ALA A 165
ILE A  52
LEU A 199
ILE A  87
ILE A 209
 None
 0.87A 5nunA-2bqpA:
undetectable		 5nunA-2bqpA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ALA A 331
ILE A 351
LEU A 349
ILE A 319
ALA A 224
 None
 1.01A 5nunA-2bvgA:
1.3		 5nunA-2bvgA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		5 ALA A 193
LEU A 199
ILE A 153
ILE A 155
ASN A 221
 None
 1.00A 5nunA-2cxnA:
undetectable		 5nunA-2cxnA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF01063
(Aminotran_4) 		5 ALA A 240
VAL A 191
LEU A 183
ILE A 266
ILE A 271
 None
 0.94A 5nunA-2ej0A:
undetectable		 5nunA-2ej0A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1r MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
B (MOBB)

(Archaeoglobus
fulgidus) 		PF03205
(MobB) 		5 ALA A  34
VAL A  33
ILE A 156
LEU A  26
ILE A   7
 None
 0.99A 5nunA-2f1rA:
undetectable		 5nunA-2f1rA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ALA A 600
ILE A 528
ILE A 523
ILE A 613
ALA A 809
 None
 1.00A 5nunA-2gv9A:
undetectable		 5nunA-2gv9A:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		5 VAL A 181
ILE A   5
LEU A 131
ILE A  16
ILE A  20
 None
 0.98A 5nunA-2jaqA:
undetectable		 5nunA-2jaqA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 VAL A   6
LEU A 137
ILE A 164
ILE A 166
ALA A  58
 None
None
None
CL  A 403 ( 4.3A)
None
 0.95A 5nunA-2nwhA:
undetectable		 5nunA-2nwhA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		5 ALA A 149
ILE A 119
LEU A  69
ILE A 109
ASN A 104
 None
 0.94A 5nunA-2ozeA:
undetectable		 5nunA-2ozeA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p26 INTEGRIN BETA-2

(Homo sapiens) 		PF17205
(PSI_integrin) 		6 ALA A  91
VAL A 393
ILE A 406
ASN A  94
PHE A  93
ALA A  63
 None
None
None
NAG  A 301 (-1.7A)
None
None
 1.24A 5nunA-2p26A:
undetectable		 5nunA-2p26A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p28 INTEGRIN BETA-2

(Homo sapiens) 		PF17205
(PSI_integrin)
no annotation 		6 ALA A  91
VAL B 393
ILE B 406
ASN A  94
PHE A  93
ALA A  63
 None
None
None
NAG  A 401 (-2.7A)
None
None
 1.24A 5nunA-2p28A:
undetectable		 5nunA-2p28A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjq UNCHARACTERIZED
PROTEIN LP_2664

(Lactobacillus
plantarum) 		PF01966
(HD) 		5 ILE A  93
LEU A  57
ILE A   2
ASN A  49
ALA A  37
 None
 0.92A 5nunA-2pjqA:
undetectable		 5nunA-2pjqA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqu POLY(RC)-BINDING
PROTEIN 2

(Homo sapiens) 		PF00013
(KH_1) 		5 ALA A  73
ILE A  47
LEU A  61
ILE A  59
ILE A  28
 None
 0.96A 5nunA-2pquA:
undetectable		 5nunA-2pquA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 192
ILE A 275
ILE A 279
ASN A 295
PHE A 296
 None
 0.99A 5nunA-2q9gA:
undetectable		 5nunA-2q9gA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		5 ALA A 400
ILE A  27
LEU A  31
ILE A 335
ASN A 330
 None
 1.01A 5nunA-2qfvA:
undetectable		 5nunA-2qfvA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE

(Acetobacter
pasteurianus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A  69
ILE A  16
LEU A  13
ILE A 152
ALA A  57
 None
 0.88A 5nunA-2vbiA:
undetectable		 5nunA-2vbiA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd3 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Methanothermobacter
thermautotrophicus) 		PF01634
(HisG)
PF08029
(HisG_C) 		5 ALA A 153
ILE A 174
ILE A 104
ILE A 110
ALA A 117
 None
 1.01A 5nunA-2vd3A:
undetectable		 5nunA-2vd3A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1)
PF10150
(RNase_E_G) 		5 ILE A 291
LEU A 285
ILE A 304
ILE A 345
ALA A 366
 None
 1.01A 5nunA-2vrtA:
undetectable		 5nunA-2vrtA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqq ALPHA-2,3-/2,8-SIALY
LTRANSFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		5 ALA A 196
ILE A 148
LEU A 208
ILE A 206
ILE A 141
 None
 0.94A 5nunA-2wqqA:
undetectable		 5nunA-2wqqA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A  69
ILE A  16
LEU A  13
ILE A 152
ALA A  57
 None
 0.94A 5nunA-2wvgA:
undetectable		 5nunA-2wvgA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		5 ALA A 196
ILE A 148
LEU A 208
ILE A 206
ILE A 141
 None
 0.96A 5nunA-2x63A:
undetectable		 5nunA-2x63A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		5 ALA A 476
ILE A 462
LEU A 496
ILE A 441
ALA A 466
 None
 0.93A 5nunA-2xkkA:
undetectable		 5nunA-2xkkA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yug PROTEIN FRG1

(Mus musculus) 		PF06229
(FRG1) 		5 ALA A 118
ILE A  37
ILE A  29
ILE A 145
ALA A 134
 None
 0.91A 5nunA-2yugA:
undetectable		 5nunA-2yugA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2x TK-SUBTILISIN

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		5 ILE A 248
LEU A 244
ILE A 200
ILE A 231
ALA A 261
 None
None
None
None
MIS  A 324 ( 3.7A)
 0.95A 5nunA-2z2xA:
undetectable		 5nunA-2z2xA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Methanococcus
maripaludis) 		PF05889
(SepSecS) 		5 ALA A 271
VAL A 269
ILE A 233
ILE A 230
ASN A 247
 None
None
None
None
PLP  A1001 (-3.3A)
 0.96A 5nunA-2z67A:
undetectable		 5nunA-2z67A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF13561
(adh_short_C2) 		5 ALA A  62
ILE A  35
LEU A  37
ILE A  11
ILE A  74
 None
 0.99A 5nunA-2zk7A:
undetectable		 5nunA-2zk7A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		5 ALA A 395
ILE A 364
LEU A 366
ILE A 372
ALA A 449
 None
 1.00A 5nunA-3bh1A:
undetectable		 5nunA-3bh1A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn6 LACTADHERIN

(Bos taurus) 		PF00754
(F5_F8_type_C) 		6 ALA A  88
VAL A  87
ILE A 140
LEU A 151
ILE A  73
ASN A 127
 None
 1.38A 5nunA-3bn6A:
undetectable		 5nunA-3bn6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ALA A1137
ILE A2017
LEU A1132
ILE A2026
ALA A2009
 None
 1.01A 5nunA-3cmvA:
undetectable		 5nunA-3cmvA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ALA A2137
ILE A3017
LEU A2132
ILE A3026
ALA A3009
 None
 1.01A 5nunA-3cmvA:
undetectable		 5nunA-3cmvA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 178
VAL A 180
ILE A 148
ILE A 228
ALA A 211
 None
 1.00A 5nunA-3gd5A:
undetectable		 5nunA-3gd5A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 178
VAL A 180
LEU A 155
ILE A 148
ILE A 228
 None
 0.99A 5nunA-3gd5A:
undetectable		 5nunA-3gd5A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A 797
VAL A 798
ILE A 590
LEU A 834
ALA A 573
 None
 1.00A 5nunA-3ho8A:
undetectable		 5nunA-3ho8A:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jte RESPONSE REGULATOR
RECEIVER PROTEIN

(Ruminiclostridium
thermocellum) 		PF00072
(Response_reg) 		6 ALA A 110
ILE A  81
LEU A  83
ILE A  54
ILE A   6
ASN A  28
 None
 1.34A 5nunA-3jteA:
undetectable		 5nunA-3jteA:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		6 VAL A  41
ILE A  56
LEU A  58
ILE A  71
ILE A  84
ALA A 118
 None
 0.80A 5nunA-3kzaA:
25.5		 5nunA-3kzaA:
76.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 VAL A 109
ILE A 186
LEU A 190
ILE A  82
ASN A 158
 None
 0.98A 5nunA-3l2zA:
undetectable		 5nunA-3l2zA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Staphylococcus
aureus) 		PF00724
(Oxidored_FMN) 		5 ALA A 172
ILE A 250
LEU A 249
ILE A 259
ALA A 265
 None
 1.00A 5nunA-3l5aA:
undetectable		 5nunA-3l5aA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5w TRYPTOPHANYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00579
(tRNA-synt_1b) 		5 ALA A 272
ILE A 211
LEU A 207
ILE A 198
ILE A 235
 None
 0.93A 5nunA-3m5wA:
undetectable		 5nunA-3m5wA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 254
ILE A 309
LEU A 271
ILE A 275
ALA A 163
 None
 0.91A 5nunA-3ov3A:
undetectable		 5nunA-3ov3A:
11.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		6 VAL A  57
ILE A  72
LEU A  74
ILE A  87
ILE A 100
ALA A 134
 None
 0.59A 5nunA-3ph5A:
29.1		 5nunA-3ph5A:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 VAL A  57
ILE A  87
LEU A  74
ASN A 104
ALA A 134
 None
 1.01A 5nunA-3ph5A:
29.1		 5nunA-3ph5A:
96.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxi NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 VAL A 660
ILE A 542
LEU A 544
ILE A 708
PHE A 697
 None
 1.01A 5nunA-3pxiA:
undetectable		 5nunA-3pxiA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		6 ALA A 289
VAL A 292
LEU A 296
ILE A  26
ASN A  61
ALA A  49
 None
None
None
NAG  A 405 ( 4.1A)
NAG  A 405 (-1.8A)
None
 1.31A 5nunA-3q41A:
undetectable		 5nunA-3q41A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 ILE A 274
LEU A 270
ILE A 230
ILE A 241
ALA A 287
 None
 0.90A 5nunA-3qfhA:
undetectable		 5nunA-3qfhA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ALA A 343
ILE A   5
LEU A   3
ILE A  67
ILE A  92
 None
 0.97A 5nunA-3tz6A:
undetectable		 5nunA-3tz6A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10672
(Methyltrans_SAM) 		5 ALA A 137
ILE A 115
LEU A 113
ILE A 124
ILE A 151
 None
 1.00A 5nunA-3vseA:
undetectable		 5nunA-3vseA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ALA A 113
VAL A  19
ILE A  41
ILE A  93
ALA A  82
 None
 1.01A 5nunA-3wgkA:
undetectable		 5nunA-3wgkA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		5 ALA A 405
ILE A 190
ILE A 188
PHE A 335
ALA A 338
 None
 0.96A 5nunA-4binA:
undetectable		 5nunA-4binA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A  69
ILE A  16
LEU A  13
ILE A 152
ALA A  57
 None
 0.95A 5nunA-4cokA:
undetectable		 5nunA-4cokA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 ALA A  36
VAL A  33
ILE A 162
LEU A 102
ILE A 100
ILE A 143
 None
 1.07A 5nunA-4d5gA:
undetectable		 5nunA-4d5gA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6u ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ILE A 158
ILE A 164
ILE A 146
ASN A 132
ALA A 135
 None
None
None
None
EDO  A 309 ( 4.0A)
 0.98A 5nunA-4e6uA:
undetectable		 5nunA-4e6uA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN

(Enterococcus
faecalis) 		PF00497
(SBP_bac_3) 		5 ALA A 134
VAL A 133
ILE A 122
LEU A 128
ALA A 168
 None
 0.94A 5nunA-4g4pA:
undetectable		 5nunA-4g4pA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4w PEPTIDOGLYCAN-ASSOCI
ATED LIPOPROTEIN

(Acinetobacter
baumannii) 		PF00691
(OmpA) 		5 ALA A 136
VAL A 139
LEU A  98
ASN A 182
ALA A 155
 None
 0.73A 5nunA-4g4wA:
undetectable		 5nunA-4g4wA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 ALA A 390
ILE A 341
LEU A 361
ASN A 373
ALA A 366
 None
 1.00A 5nunA-4gqbA:
undetectable		 5nunA-4gqbA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Drosophila
melanogaster) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ALA A  26
ILE A  15
LEU A  16
ILE A  35
ALA A  39
 None
 1.01A 5nunA-4hk1A:
undetectable		 5nunA-4hk1A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		5 ALA A 126
ILE A  29
ILE A  42
ILE A  52
ALA A 244
 None
 0.88A 5nunA-4n2xA:
undetectable		 5nunA-4n2xA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 VAL A 817
ILE A 825
LEU A 796
ILE A 793
ILE A 780
 None
 0.99A 5nunA-4n3nA:
undetectable		 5nunA-4n3nA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 VAL A 699
ILE A 707
LEU A 678
ILE A 675
ILE A 662
 None
 0.99A 5nunA-4n3sA:
undetectable		 5nunA-4n3sA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF17205
(PSI_integrin) 		6 ALA B  91
VAL B 393
ILE B 406
ASN B  94
PHE B  93
ALA B  63
 None
None
None
NAG  B 701 (-1.8A)
None
None
 1.19A 5nunA-4nenB:
undetectable		 5nunA-4nenB:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01148
(CTP_transf_1) 		5 ALA A  35
VAL A  38
LEU A  51
ILE A  55
ILE A 268
 None
 1.01A 5nunA-4q2eA:
undetectable		 5nunA-4q2eA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qa8 PUTATIVE LIPOPROTEIN
LPRF

(Mycobacterium
bovis) 		PF07161
(LppX_LprAFG) 		5 VAL A  75
ILE A 245
LEU A 247
ILE A 200
ALA A 106
 None
PJZ  A 301 ( 4.2A)
None
None
PJZ  A 301 (-3.3A)
 1.00A 5nunA-4qa8A:
undetectable		 5nunA-4qa8A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 VAL A 594
ILE A 642
LEU A 627
ILE A 640
ALA A 502
 None
 0.99A 5nunA-4rt6A:
undetectable		 5nunA-4rt6A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtt PUTATIVE POTASSIUM
TRANSPORT PROTEIN

(Staphylococcus
aureus) 		PF02080
(TrkA_C) 		5 ALA A 135
ILE A 149
LEU A 141
ILE A 204
ILE A 177
 None
 0.88A 5nunA-4xttA:
undetectable		 5nunA-4xttA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 ALA A 236
ILE A 202
LEU A 226
ILE A 198
ILE A 173
 None
 0.97A 5nunA-4z61A:
undetectable		 5nunA-4z61A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpq MCG133388, ISOFORM
CRA_F

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 ALA A 237
ILE A 307
LEU A 218
ILE A 273
ALA A 293
 None
 1.00A 5nunA-4zpqA:
undetectable		 5nunA-4zpqA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zve DIGUANYLATE CYCLASE
DOSC

(Escherichia
coli) 		PF00990
(GGDEF) 		5 VAL A 401
ILE A 420
LEU A 418
ILE A 332
ILE A 380
 None
 0.86A 5nunA-4zveA:
undetectable		 5nunA-4zveA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ALA A 436
ILE A 261
LEU A 443
ILE A 262
ASN A 387
 None
 0.98A 5nunA-5chcA:
undetectable		 5nunA-5chcA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 VAL A 645
ILE A 741
ILE A 737
ILE A 750
ALA A 330
 None
 1.00A 5nunA-5dotA:
undetectable		 5nunA-5dotA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		6 ALA B  91
VAL B 393
ILE B 406
ASN B  94
PHE B  93
ALA B  63
 None
None
None
NAG  B3094 (-1.9A)
None
None
 1.21A 5nunA-5e6sB:
undetectable		 5nunA-5e6sB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6v INTEGRIN BETA-2

(Homo sapiens) 		PF17205
(PSI_integrin) 		6 ALA A  91
VAL A 393
ILE A 406
ASN A  94
PHE A  93
ALA A  63
 None
None
None
NAG  A 502 (-1.8A)
None
None
 1.20A 5nunA-5e6vA:
undetectable		 5nunA-5e6vA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6w INTEGRIN BETA-2

(Homo sapiens) 		PF17205
(PSI_integrin) 		6 ALA A  91
VAL A 393
ILE A 406
ASN A  94
PHE A  93
ALA A  63
 None
None
None
NAG  A 901 (-1.8A)
None
None
 1.24A 5nunA-5e6wA:
undetectable		 5nunA-5e6wA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		5 ALA A 180
ILE A 134
ILE A 132
ILE A  86
ALA A 145
 None
 0.94A 5nunA-5g5nA:
undetectable		 5nunA-5g5nA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 ALA A 573
ILE A 338
LEU A 576
ILE A 605
ALA A 570
 None
 0.94A 5nunA-5h3kA:
1.8		 5nunA-5h3kA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5t FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Salmonella
enterica) 		PF07195
(FliD_C)
PF07196
(Flagellin_IN) 		5 ALA A 208
ILE A 167
LEU A 183
ILE A 160
ILE A 144
 None
 0.84A 5nunA-5h5tA:
undetectable		 5nunA-5h5tA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED

(Oryza sativa) 		PF03514
(GRAS) 		5 ALA A 303
ILE A 316
LEU A 330
ILE A 314
ALA A 576
 None
 0.97A 5nunA-5hyzA:
undetectable		 5nunA-5hyzA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 ALA A  67
ILE A 365
LEU A  64
ILE A  74
ALA A 133
 FAD  A 401 (-3.3A)
None
None
None
FAD  A 401 (-3.2A)
 0.96A 5nunA-5jzxA:
undetectable		 5nunA-5jzxA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis) 		PF00290
(Trp_syntA) 		5 VAL A 124
ILE A  53
LEU A 100
ILE A  26
PHE A  83
 None
 0.98A 5nunA-5kzmA:
undetectable		 5nunA-5kzmA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		5 ALA A  88
ILE A 198
ASN A  84
PHE A  83
ALA A  79
 None
 0.89A 5nunA-5vc2A:
undetectable		 5nunA-5vc2A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wez TIR CHAPERONE

(Escherichia
coli) 		no annotation 5 ILE A  51
LEU A  41
ILE A 113
ASN A 111
ALA A 104
 None
 0.89A 5nunA-5wezA:
undetectable		 5nunA-5wezA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6all FE(3+)-CITRATE-BINDI
NG PROTEIN YFMC

(Bacillus
anthracis) 		PF01497
(Peripla_BP_2) 		5 ALA A 313
LEU A 296
ILE A 262
ILE A 199
ALA A 185
 None
 1.00A 5nunA-6allA:
undetectable		 5nunA-6allA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs NPL4

(Chaetomium
thermophilum) 		no annotation 5 ALA A 263
VAL A 304
ILE A 345
LEU A 286
ILE A 416
 None
 0.93A 5nunA-6chsA:
undetectable		 5nunA-6chsA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3u ULVAN LYASE

(Nonlabens
ulvanivorans) 		no annotation 5 ALA A 252
ILE A 200
ILE A 256
ILE A 232
ALA A 161
 None
 0.95A 5nunA-6d3uA:
undetectable		 5nunA-6d3uA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 ALA A 559
VAL A 577
ILE A 384
LEU A 625
ILE A 642
 None
 1.00A 5nunA-6fikA:
undetectable		 5nunA-6fikA:
20.48