SIMILAR PATTERNS OF AMINO ACIDS FOR 5NUK_A_Z80A201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 ALA A 283
VAL A 286
ILE A 242
VAL A 231
ALA A 271
 None
None
None
None
AMP  A1100 (-3.6A)
 1.09A 5nukA-1ct9A:
0.0		 5nukA-1ct9A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		5 ALA A 236
VAL A 235
LYS A 190
ILE A 187
ILE A 224
 None
 1.19A 5nukA-1dk5A:
undetectable		 5nukA-1dk5A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io1 PHASE 1 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		5 ILE A  73
ILE A 157
VAL A 428
PHE A 432
ALA A 435
 None
 1.16A 5nukA-1io1A:
0.0		 5nukA-1io1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN

(Escherichia
coli) 		PF00899
(ThiF) 		5 ALA B  46
ILE B 103
ILE B 101
VAL B  55
ALA B 205
 None
 1.22A 5nukA-1jwaB:
undetectable		 5nukA-1jwaB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nig HYPOTHETICAL PROTEIN
TA1238

(Thermoplasma
acidophilum) 		PF09155
(DUF1940) 		5 ALA A  32
ILE A  50
ILE A 142
VAL A 107
ALA A  29
 None
 1.07A 5nukA-1nigA:
undetectable		 5nukA-1nigA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 ALA A 464
VAL A 472
ILE A 516
VAL A 542
ALA A 455
 None
 1.19A 5nukA-1nr0A:
0.0		 5nukA-1nr0A:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvt SHIKIMATE
5'-DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ALA A 144
VAL A 143
ILE A 196
VAL A 126
ALA A 148
 None
 1.15A 5nukA-1nvtA:
0.0		 5nukA-1nvtA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		5 ALA A 351
VAL A 360
ILE A 449
ILE A 547
VAL A 325
 None
 1.13A 5nukA-1pixA:
1.7		 5nukA-1pixA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 184
ILE A  18
ILE A  51
VAL A  26
ALA A 186
 None
 1.22A 5nukA-1poxA:
0.0		 5nukA-1poxA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tev UMP-CMP KINASE

(Homo sapiens) 		PF00406
(ADK) 		5 ALA A 177
VAL A 184
ILE A 191
VAL A   8
ALA A  14
 None
None
None
None
SO4  A 500 (-3.9A)
 1.18A 5nukA-1tevA:
undetectable		 5nukA-1tevA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Enterococcus
faecalis) 		PF02504
(FA_synthesis) 		5 ALA A  83
VAL A  86
ILE A 312
ILE A 294
ALA A 106
 None
 1.07A 5nukA-1u7nA:
undetectable		 5nukA-1u7nA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ALA A 257
VAL A 254
ILE A 241
VAL A 167
ALA A 164
 None
 1.18A 5nukA-1vc2A:
undetectable		 5nukA-1vc2A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		5 ALA A  66
VAL A  52
ILE A  80
ILE A  77
ALA A  47
 None
 1.20A 5nukA-1vzhA:
undetectable		 5nukA-1vzhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 431
VAL A 434
PHE A 405
ILE A 404
ALA A 353
 None
 1.08A 5nukA-1xdiA:
undetectable		 5nukA-1xdiA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		5 ALA A 461
ILE A 497
ILE A 530
VAL A 403
PHE A 371
 None
 1.21A 5nukA-1yvpA:
undetectable		 5nukA-1yvpA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z4h TOR INHIBITION
PROTEIN

(Escherichia
coli) 		no annotation 5 LYS A  32
ILE A  31
ILE A  16
VAL A  11
ALA A  46
 None
 1.01A 5nukA-1z4hA:
undetectable		 5nukA-1z4hA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		5 ALA A 331
ILE A 326
ILE A 355
PHE A 261
ALA A 297
 None
 1.21A 5nukA-1zy9A:
undetectable		 5nukA-1zy9A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 PHE A 574
ILE A  79
ILE A   4
PHE A 610
ALA A 626
 None
 1.21A 5nukA-2b0tA:
undetectable		 5nukA-2b0tA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2i AMMONIUM TRANSPORTER

(Archaeoglobus
fulgidus) 		PF00909
(Ammonium_transp) 		5 ALA A 279
VAL A 282
ILE A 318
VAL A 314
ALA A 259
 None
 1.01A 5nukA-2b2iA:
undetectable		 5nukA-2b2iA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctm VIGILIN

(Homo sapiens) 		PF00013
(KH_1) 		5 ALA A  29
LYS A  41
ILE A  42
ILE A  79
VAL A  63
 None
 1.21A 5nukA-2ctmA:
undetectable		 5nukA-2ctmA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 ALA A 542
PHE A 536
ILE A 706
VAL A 509
ALA A 474
 None
 1.09A 5nukA-2cvtA:
undetectable		 5nukA-2cvtA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 ALA A 317
VAL A 316
ILE A 260
VAL A 272
ALA A 320
 None
 1.12A 5nukA-2e4uA:
undetectable		 5nukA-2e4uA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i8l HYDROGENASE 3
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		5 ALA A  63
PHE A 148
ILE A  75
VAL A 135
ALA A  18
 None
 1.22A 5nukA-2i8lA:
undetectable		 5nukA-2i8lA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE

(Chlamydia
trachomatis) 		PF00132
(Hexapep)
PF04613
(LpxD) 		5 ALA A 288
VAL A 291
ILE A 275
ILE A 263
VAL A 251
 None
 1.21A 5nukA-2iu8A:
undetectable		 5nukA-2iu8A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jau 5'(3')-DEOXYRIBONUCL
EOTIDASE

(Homo sapiens) 		PF06941
(NT5C) 		5 ALA A 119
VAL A 126
VAL A 147
PHE A 151
GLN A 158
 None
 0.92A 5nukA-2jauA:
undetectable		 5nukA-2jauA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jys PROTEASE/REVERSE
TRANSCRIPTASE

(Macaque simian
foamy virus) 		PF03539
(Spuma_A9PTase) 		5 ALA A  21
VAL A  71
PHE A  64
ALA A  12
GLN A  67
 None
 1.09A 5nukA-2jysA:
undetectable		 5nukA-2jysA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzx POLY(RC)-BINDING
PROTEIN 2

(Homo sapiens) 		PF00013
(KH_1) 		5 ALA A 149
PHE A  72
ILE A  76
ILE A 156
VAL A 159
 None
 1.18A 5nukA-2jzxA:
undetectable		 5nukA-2jzxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lcw RNA-BINDING PROTEIN
FUS

(Homo sapiens) 		PF00076
(RRM_1) 		5 PHE A 305
ILE A 311
ILE A 322
VAL A 289
ALA A 369
 None
 1.08A 5nukA-2lcwA:
undetectable		 5nukA-2lcwA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		5 ALA A  56
VAL A  58
ILE A 165
VAL A 142
PHE A 118
 None
 1.21A 5nukA-2o2gA:
undetectable		 5nukA-2o2gA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ALA A 436
PHE A 499
ILE A 296
ILE A 299
ALA A 439
 None
 1.22A 5nukA-2oipA:
undetectable		 5nukA-2oipA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		5 ALA A 143
PHE A  61
ILE A  67
VAL A  36
ALA A  33
 None
 1.20A 5nukA-2q6kA:
undetectable		 5nukA-2q6kA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg8 ACYL CARRIER PROTEIN
SYNTHASE PY06285

(Plasmodium
yoelii) 		PF01648
(ACPS) 		5 LYS A  39
ILE A  40
VAL A  51
PHE A  88
ALA A  89
 None
 1.11A 5nukA-2qg8A:
undetectable		 5nukA-2qg8A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA X 213
PHE X 157
ILE X 173
VAL X   4
ALA X 217
 None
 1.00A 5nukA-2qvxX:
undetectable		 5nukA-2qvxX:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C

(Francisella
tularensis) 		PF11550
(IglC) 		5 ALA A 115
ILE A 120
ILE A 180
PHE A 156
ALA A 153
 None
 1.15A 5nukA-2qwuA:
undetectable		 5nukA-2qwuA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjn RESPONSE REGULATOR
RECEIVER:METAL-DEPEN
DENT
PHOSPHOHYDROLASE, HD
SUBDOMAIN

(Neptuniibacter
caesariensis) 		PF00072
(Response_reg) 		5 VAL A  52
ILE A  56
VAL A 120
ALA A 127
GLN A  53
 None
 1.19A 5nukA-2rjnA:
undetectable		 5nukA-2rjnA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Geobacillus
stearothermophilus) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 ILE A 397
ILE A 331
PHE A 371
ALA A 369
GLN A 370
 None
 1.12A 5nukA-2w8zA:
undetectable		 5nukA-2w8zA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whk MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus
subtilis) 		PF02156
(Glyco_hydro_26) 		5 ALA A 297
VAL A 267
ILE A 285
ILE A 282
ALA A 304
 None
 1.18A 5nukA-2whkA:
undetectable		 5nukA-2whkA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B) 		5 ALA A  26
VAL A 119
PHE A 139
ILE A 148
GLN A  51
 None
 1.19A 5nukA-2xf4A:
undetectable		 5nukA-2xf4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		5 ALA A 229
LYS A 166
ILE A 164
ILE A 180
GLN A 202
 None
 1.11A 5nukA-3akfA:
undetectable		 5nukA-3akfA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		5 ALA A 229
VAL A 141
LYS A 166
ILE A 164
ILE A 180
 None
 1.08A 5nukA-3akfA:
undetectable		 5nukA-3akfA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aux DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Methanocaldococcus
jannaschii) 		PF13476
(AAA_23) 		5 ALA A  29
ILE A 943
ILE A 970
VAL A 967
ALA A 986
 None
 1.06A 5nukA-3auxA:
undetectable		 5nukA-3auxA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlo UNIVERSAL STRESS
PROTEIN

(Archaeoglobus
fulgidus) 		PF00582
(Usp) 		5 ALA A  17
VAL A  20
ILE A 100
ILE A  88
VAL A  38
 None
 1.09A 5nukA-3dloA:
undetectable		 5nukA-3dloA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF01266
(DAO) 		5 ALA A  94
VAL A 250
ILE A  55
ALA A 100
GLN A 102
 None
 1.20A 5nukA-3dmeA:
undetectable		 5nukA-3dmeA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		5 ALA A  12
VAL A  13
PHE A  70
ILE A  74
ILE A  82
 None
 0.91A 5nukA-3e49A:
undetectable		 5nukA-3e49A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 ALA A  21
VAL A  17
ILE A   6
ILE A  73
GLN A  30
 None
 0.98A 5nukA-3fahA:
undetectable		 5nukA-3fahA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 178
VAL A 180
ILE A 148
ILE A 228
ALA A 211
 None
 1.10A 5nukA-3gd5A:
undetectable		 5nukA-3gd5A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Burkholderia
pseudomallei) 		PF03740
(PdxJ) 		5 LYS A 195
ILE A 159
ILE A 141
VAL A 116
ALA A 126
 None
 1.20A 5nukA-3gk0A:
undetectable		 5nukA-3gk0A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmt ADENYLATE KINASE

(Burkholderia
pseudomallei) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 PHE A  83
ILE A   4
ILE A 103
VAL A 101
ALA A  95
 None
 1.15A 5nukA-3gmtA:
undetectable		 5nukA-3gmtA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr3 NITROREDUCTASE

(Bartonella
henselae) 		PF00881
(Nitroreductase) 		5 ALA A 198
ILE A  34
ILE A  31
VAL A  26
ALA A 130
 None
 1.23A 5nukA-3gr3A:
undetectable		 5nukA-3gr3A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv9 PROTEIN FIMX

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 ILE A 515
ILE A 511
VAL A 532
PHE A 564
ALA A 592
 None
 1.10A 5nukA-3hv9A:
undetectable		 5nukA-3hv9A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		5 ALA E 305
ILE E 301
ILE E 256
VAL E 214
ALA E 207
 None
 1.19A 5nukA-3kdsE:
undetectable		 5nukA-3kdsE:
10.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		5 VAL A  41
ILE A  84
VAL A  92
ALA A 118
GLN A 120
 None
 0.70A 5nukA-3kzaA:
25.3		 5nukA-3kzaA:
75.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472

(Streptococcus
mutans) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 ALA A 213
ILE A 186
ILE A 305
VAL A 303
PHE A 198
 None
 1.14A 5nukA-3ldgA:
undetectable		 5nukA-3ldgA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtj HOMOSERINE
DEHYDROGENASE

(Thiobacillus
denitrificans) 		PF00742
(Homoserine_dh)
PF01842
(ACT)
PF03447
(NAD_binding_3) 		5 ALA A 308
ILE A  37
ILE A  74
VAL A  76
ALA A 129
 None
 1.13A 5nukA-3mtjA:
undetectable		 5nukA-3mtjA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7t MACROPHAGE BINDING
PROTEIN

(Coccidioides
immitis) 		PF01965
(DJ-1_PfpI) 		5 ALA A  94
ILE A 150
ILE A 137
VAL A 107
ALA A  50
 None
 1.04A 5nukA-3n7tA:
undetectable		 5nukA-3n7tA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfk TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A 601
ILE A 569
ILE A 586
VAL A 532
PHE A 530
 None
 1.20A 5nukA-3nfkA:
undetectable		 5nukA-3nfkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooo PROLINE DIPEPTIDASE

(Streptococcus
agalactiae) 		PF01321
(Creatinase_N) 		5 ALA A  19
VAL A  97
PHE A  92
ILE A  85
PHE A  45
 None
 1.17A 5nukA-3oooA:
undetectable		 5nukA-3oooA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		6 VAL A  57
LYS A  85
ILE A 100
VAL A 108
ALA A 134
GLN A 136
 None
 0.66A 5nukA-3ph5A:
29.1		 5nukA-3ph5A:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426

(Clostridium
perfringens) 		PF06824
(Glyco_hydro_125) 		5 ALA A 235
VAL A 237
LYS A 315
ILE A 309
VAL A 303
 None
 1.11A 5nukA-3qt3A:
undetectable		 5nukA-3qt3A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3two MANNITOL
DEHYDROGENASE

(Helicobacter
pylori) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A  77
LYS A  81
ILE A  70
ILE A  34
VAL A 137
 None
 1.16A 5nukA-3twoA:
undetectable		 5nukA-3twoA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ILE A 134
ILE A 170
VAL A 217
ALA A 559
GLN A 558
 None
None
None
None
CIT  A 670 ( 4.9A)
 1.20A 5nukA-3u1kA:
undetectable		 5nukA-3u1kA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wva UPF0254 PROTEIN
MJ1251

(Methanocaldococcus
jannaschii) 		PF06787
(UPF0254) 		5 ALA A  13
PHE A 158
ILE A 120
VAL A   4
ALA A  51
 None
 1.16A 5nukA-3wvaA:
undetectable		 5nukA-3wvaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A  70
VAL A  73
ILE A 261
VAL A  51
ALA A  85
 None
 0.98A 5nukA-4c2kA:
undetectable		 5nukA-4c2kA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A  36
VAL A  33
ILE A 100
ILE A 143
VAL A 139
 None
 1.19A 5nukA-4d5gA:
undetectable		 5nukA-4d5gA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis) 		PF11468
(PTase_Orf2) 		5 PHE A 150
ILE A 155
ILE A 219
VAL A 221
PHE A 233
 None
 1.08A 5nukA-4ee8A:
undetectable		 5nukA-4ee8A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 LYS A 242
ILE A 245
ILE A 163
VAL A 161
ALA A  31
 None
None
NAP  A 401 (-4.6A)
None
None
 1.18A 5nukA-4fc7A:
undetectable		 5nukA-4fc7A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 ALA A 578
VAL A 527
ILE A 566
ILE A 571
VAL A 512
 None
 1.22A 5nukA-4fwtA:
undetectable		 5nukA-4fwtA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hht RIBONUCLEASE HII

(Thermotoga
maritima) 		PF01351
(RNase_HII) 		5 ALA A  33
VAL A  67
ILE A  61
ILE A  43
ALA A  15
 None
 1.17A 5nukA-4hhtA:
undetectable		 5nukA-4hhtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ALA A 437
LYS A 419
ILE A 421
VAL A 310
ALA A 396
 None
 1.21A 5nukA-4ksiA:
1.0		 5nukA-4ksiA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw5 OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 ALA A  43
VAL A  42
ILE A  72
ILE A 183
PHE A 450
 None
None
None
FAD  A 501 ( 4.7A)
None
 1.19A 5nukA-4kw5A:
undetectable		 5nukA-4kw5A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4i RYANODINE RECEPTOR 2

(Mus musculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 ALA A 215
VAL A  20
ILE A 119
ILE A 162
VAL A 175
 None
 1.22A 5nukA-4l4iA:
undetectable		 5nukA-4l4iA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		5 ALA A   4
VAL A   6
PHE A  38
ILE A  37
VAL A 237
 None
 1.13A 5nukA-4nq3A:
undetectable		 5nukA-4nq3A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omu SHIKIMATE
DEHYDROGENASE

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ALA A 127
VAL A 131
ILE A 138
VAL A 169
ALA A 156
 None
 1.20A 5nukA-4omuA:
undetectable		 5nukA-4omuA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Sulfurospirillum
deleyianum) 		PF03480
(DctP) 		5 VAL A 236
ILE A  26
VAL A 254
PHE A  45
ALA A 261
 None
 1.19A 5nukA-4ovsA:
undetectable		 5nukA-4ovsA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP1
COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C) 		PF00073
(Rhv) 		5 ALA 1 298
VAL 1 299
ILE 3  84
ILE 3  53
ALA 3  62
 CL  3 602 ( 4.1A)
CL  15009 (-3.9A)
None
None
CL  3 602 ( 4.1A)
 1.15A 5nukA-4q4y1:
undetectable		 5nukA-4q4y1:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 ALA A 108
ILE A  91
ILE A  42
VAL A  56
ALA A  53
 SAH  A 301 ( 4.9A)
None
None
SAH  A 301 ( 4.2A)
SAH  A 301 (-3.2A)
 1.05A 5nukA-4qpnA:
undetectable		 5nukA-4qpnA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 ALA A 359
VAL A 373
ILE A 433
VAL A  23
ALA A 345
 None
 1.00A 5nukA-4um8A:
undetectable		 5nukA-4um8A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2p KETOSYNTHASE

(Myxococcus
fulvus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A  66
ILE A  84
ILE A 143
VAL A 175
ALA A  69
 None
 1.21A 5nukA-4v2pA:
undetectable		 5nukA-4v2pA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Pseudomonas
aeruginosa) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 ILE B  11
ILE B 173
VAL B 177
PHE B  62
ALA B  59
 None
 1.15A 5nukA-4wj3B:
undetectable		 5nukA-4wj3B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		5 VAL A 174
ILE A 127
VAL A 138
PHE A 141
ALA A 144
 None
 1.09A 5nukA-4x9tA:
undetectable		 5nukA-4x9tA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8s RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00161
(RIP) 		5 ALA A  75
ILE A  91
ILE A  45
PHE A  49
ALA A  65
 None
 1.21A 5nukA-4z8sA:
undetectable		 5nukA-4z8sA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 ILE A 480
ILE A 572
VAL A 570
PHE A 567
GLN A 488
 None
 1.17A 5nukA-4zhjA:
undetectable		 5nukA-4zhjA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 ILE A 252
ILE A 139
VAL A 127
PHE A 124
ALA A 120
 None
 0.97A 5nukA-5a22A:
1.7		 5nukA-5a22A:
3.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		5 ALA A 469
LYS A 451
ILE A 453
VAL A 344
ALA A 428
 None
 1.07A 5nukA-5cbmA:
1.0		 5nukA-5cbmA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbn ACETATE
COA-TRANSFERASE
SUBUNIT BETA

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 ALA B 163
VAL B 135
ILE B  93
ILE B  88
ALA B 160
 None
 1.22A 5nukA-5dbnB:
undetectable		 5nukA-5dbnB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		5 ALA A   8
VAL A  11
ILE A 101
VAL A  23
ALA A  37
 None
 1.20A 5nukA-5esoA:
undetectable		 5nukA-5esoA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyb DNA-BINDING PROTEIN
REB1

(Schizosaccharomyces
pombe) 		PF00249
(Myb_DNA-binding) 		5 PHE A 283
ILE A 280
ILE A 271
VAL A 303
ALA A 296
 None
 1.19A 5nukA-5eybA:
undetectable		 5nukA-5eybA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fda DIHYDROFOLATE
REDUCTASE

(Yersinia pestis) 		PF00186
(DHFR_1) 		5 VAL A  92
ILE A  61
VAL A 100
PHE A 104
ALA A 108
 None
 1.16A 5nukA-5fdaA:
undetectable		 5nukA-5fdaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		5 ALA A 123
ILE A 216
ILE A 218
VAL A 248
ALA A 144
 None
 1.19A 5nukA-5ijlA:
undetectable		 5nukA-5ijlA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2

(Homo sapiens) 		PF05609
(LAP1C) 		5 ALA B 393
PHE B 378
ILE B 450
VAL B 364
ALA B 361
 None
 1.10A 5nukA-5j1sB:
undetectable		 5nukA-5j1sB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		5 ALA A  27
ILE A  11
ILE A  92
PHE A  24
ALA A 148
 None
 1.22A 5nukA-5kh0A:
undetectable		 5nukA-5kh0A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 ALA 1 233
ILE 1 184
VAL 1 211
ALA 1 236
GLN 1 235
 None
 1.19A 5nukA-5kz51:
undetectable		 5nukA-5kz51:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Psychrobacter
arcticus) 		PF01634
(HisG) 		5 ALA E  27
VAL E  69
ILE E 219
PHE E  88
ALA E  86
 None
 1.13A 5nukA-5m8hE:
undetectable		 5nukA-5m8hE:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ALA B 324
ILE B 208
ILE B 316
VAL C  73
ALA B 322
 None
 1.16A 5nukA-5n28B:
undetectable		 5nukA-5n28B:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 PHE A 460
ILE A 486
ILE A 498
PHE A 475
GLN A 471
 None
 1.21A 5nukA-5n94A:
undetectable		 5nukA-5n94A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		5 ALA A 303
PHE A 328
VAL A 298
PHE A 299
ALA A 281
 None
 1.10A 5nukA-5uaoA:
4.0		 5nukA-5uaoA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 5 VAL A 500
PHE A 498
ILE A 364
VAL A 553
GLN A 549
 None
 1.16A 5nukA-5w7dA:
undetectable		 5nukA-5w7dA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 5 ALA A 580
VAL A 581
ILE A 589
ILE A 567
VAL A 465
 ATP  A1501 ( 4.8A)
None
None
None
None
 1.21A 5nukA-5yudA:
undetectable		 5nukA-5yudA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 379
ILE A 419
PHE A 366
ALA A 367
GLN A 368
 None
 1.16A 5nukA-6az0A:
undetectable		 5nukA-6az0A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dcl HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1

(Homo sapiens) 		no annotation 5 PHE A 125
LYS A 130
ILE A 131
ILE A 134
ALA A 180
 None
None
None
None
A  D   9 ( 3.9A)
 1.07A 5nukA-6dclA:
undetectable		 5nukA-6dclA:
17.86