SIMILAR PATTERNS OF AMINO ACIDS FOR 5NU7_A_RTLA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 LEU A 609
ALA A 625
VAL A 605
TYR A 672
 None
 0.93A 5nu7A-1amoA:
0.0		 5nu7A-1amoA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhe POLYGALACTURONASE

(Pectobacterium
carotovorum) 		PF00295
(Glyco_hydro_28) 		4 LEU A  65
ALA A  75
VAL A  42
GLN A  30
 None
 0.98A 5nu7A-1bheA:
undetectable		 5nu7A-1bheA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		4 LEU A  34
ALA A  30
VAL A 115
GLN A  91
 None
 0.81A 5nu7A-1c4xA:
undetectable		 5nu7A-1c4xA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		4 LEU L 231
TYR L 118
GLN L 164
HIS L 116
 None
 0.88A 5nu7A-1cc1L:
0.0		 5nu7A-1cc1L:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 LEU A 532
ALA A 547
VAL A 528
TYR A 594
 None
 1.00A 5nu7A-1ddgA:
0.0		 5nu7A-1ddgA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		4 LEU B 268
VAL B 400
TYR B 263
HIS B 201
 None
 0.91A 5nu7A-1e3dB:
0.0		 5nu7A-1e3dB:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ALA A1394
MET A1451
TYR A1448
GLN A1469
 None
 0.97A 5nu7A-1e6yA:
0.0		 5nu7A-1e6yA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ieh BRUC.D4.4

(Lama glama) 		PF07686
(V-set) 		4 LEU A  18
ALA A   6
VAL A  12
TYR A  94
 None
 1.03A 5nu7A-1iehA:
undetectable		 5nu7A-1iehA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		4 LEU A 472
ALA A 426
VAL A 468
MET A 429
 None
 0.89A 5nu7A-1ii2A:
0.0		 5nu7A-1ii2A:
16.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		8 LEU A  37
ALA A  55
VAL A  61
MET A  73
MET A  88
TYR A  90
GLN A  98
HIS A 104
 RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.7A)
 0.36A 5nu7A-1iiuA:
31.7		 5nu7A-1iiuA:
84.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		5 LEU A  37
VAL A  61
MET A  73
GLN A  98
HIS A 117
 RTL  A 176 ( 4.5A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.6A)
 1.31A 5nu7A-1iiuA:
31.7		 5nu7A-1iiuA:
84.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		4 LEU A 831
ALA A 793
VAL A 866
MET A 821
 B12  A1248 (-4.3A)
None
None
None
 1.02A 5nu7A-1k7yA:
undetectable		 5nu7A-1k7yA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ALA A1671
VAL A1663
GLN A1736
HIS A1704
 None
 0.90A 5nu7A-1larA:
undetectable		 5nu7A-1larA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp9 TATA-BINDING PROTEIN

(Sulfolobus
acidocaldarius) 		PF00352
(TBP) 		4 LEU A 115
ALA A 111
VAL A 119
HIS A 172
 None
 0.92A 5nu7A-1mp9A:
undetectable		 5nu7A-1mp9A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ALA A 374
MET A 431
TYR A 428
GLN A 449
 None
 0.98A 5nu7A-1mroA:
undetectable		 5nu7A-1mroA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni5 PUTATIVE CELL CYCLE
PROTEIN MESJ

(Escherichia
coli) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		4 LEU A 262
ALA A 283
MET A 246
GLN A 235
 None
 0.96A 5nu7A-1ni5A:
undetectable		 5nu7A-1ni5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pui PROBABLE GTP-BINDING
PROTEIN ENGB

(Escherichia
coli) 		PF01926
(MMR_HSR1) 		4 LEU A 112
ALA A  98
VAL A 140
TYR A  82
 None
 1.03A 5nu7A-1puiA:
undetectable		 5nu7A-1puiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1e KV CHANNEL
INTERACTING PROTEIN
1

(Homo sapiens) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 LEU A 127
VAL A 123
MET A 206
MET A 182
GLN A 200
 None
 1.15A 5nu7A-1s1eA:
undetectable		 5nu7A-1s1eA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		4 LEU A 114
ALA A 135
VAL A  91
HIS A 141
 None
 1.03A 5nu7A-1vpeA:
undetectable		 5nu7A-1vpeA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa4 PCZA361.16

(Amycolatopsis
orientalis) 		PF00908
(dTDP_sugar_isom) 		4 ALA A  72
VAL A 102
TYR A  74
HIS A  39
 None
 0.98A 5nu7A-1wa4A:
undetectable		 5nu7A-1wa4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 LEU A 624
ALA A 639
VAL A 620
TYR A 686
 None
None
NAP  A 753 ( 4.8A)
None
 0.91A 5nu7A-2bf4A:
undetectable		 5nu7A-2bf4A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl5 MGC83862 PROTEIN

(Xenopus laevis) 		PF00013
(KH_1) 		4 LEU A  99
ALA A 133
VAL A  73
MET A 112
 None
 1.00A 5nu7A-2bl5A:
undetectable		 5nu7A-2bl5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 LEU A 147
ALA A 255
VAL A 145
GLN A 309
 None
 0.91A 5nu7A-2dsjA:
undetectable		 5nu7A-2dsjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2e PA1607

(Pseudomonas
aeruginosa) 		PF01638
(HxlR) 		4 LEU A  54
ALA A  33
MET A  67
TYR A  80
 None
 0.84A 5nu7A-2f2eA:
undetectable		 5nu7A-2f2eA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		4 ALA A 289
VAL A  36
TYR A 108
GLN A  15
 None
None
None
MLR  A2913 ( 3.9A)
 0.83A 5nu7A-2fncA:
undetectable		 5nu7A-2fncA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima) 		PF00579
(tRNA-synt_1b) 		4 LEU A 103
ALA A 135
VAL A 100
HIS A  43
 None
None
None
TRP  A 401 (-3.9A)
 0.98A 5nu7A-2g36A:
undetectable		 5nu7A-2g36A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B) 		4 LEU A 107
VAL A 122
MET A  69
TYR A  67
 None
 1.03A 5nu7A-2gcuA:
undetectable		 5nu7A-2gcuA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfp MULTIDRUG RESISTANCE
PROTEIN D

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ALA A  35
VAL A 245
TYR A  27
GLN A  24
 None
 0.95A 5nu7A-2gfpA:
undetectable		 5nu7A-2gfpA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzm GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		4 ALA A   6
VAL A  96
TYR A  34
HIS A 235
 None
 0.93A 5nu7A-2gzmA:
undetectable		 5nu7A-2gzmA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN

(Clytia gregaria) 		PF01353
(GFP) 		4 ALA A 180
VAL A 124
GLN A  95
HIS A 149
 None
None
GYS  A  68 ( 3.5A)
GYS  A  68 ( 3.8A)
 0.97A 5nu7A-2hpwA:
undetectable		 5nu7A-2hpwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j87 THYMIDINE KINASE

(Vaccinia virus) 		PF00265
(TK) 		4 LEU A  66
ALA A 108
VAL A  69
TYR A  40
 None
 0.95A 5nu7A-2j87A:
undetectable		 5nu7A-2j87A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA

(Pseudomonas
aeruginosa) 		PF13420
(Acetyltransf_4) 		4 LEU A 158
VAL A 148
GLN A 144
HIS A 134
 None
 0.98A 5nu7A-2j8mA:
undetectable		 5nu7A-2j8mA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2orv THYMIDINE KINASE

(Homo sapiens) 		PF00265
(TK) 		4 LEU A  81
ALA A 123
VAL A  84
TYR A  55
 None
 0.91A 5nu7A-2orvA:
undetectable		 5nu7A-2orvA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pau 5'-DEOXYNUCLEOTIDASE
YFBR

(Escherichia
coli) 		PF13023
(HD_3) 		4 LEU A  13
ALA A  38
VAL A  73
TYR A  67
 None
 0.96A 5nu7A-2pauA:
undetectable		 5nu7A-2pauA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		4 ALA A   6
VAL A  96
TYR A  34
HIS A 236
 None
 0.96A 5nu7A-2vvtA:
undetectable		 5nu7A-2vvtA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 LEU A  37
ALA A  55
VAL A  61
MET A  73
MET A  88
TYR A  90
GLN A  98
HIS A 104
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
OLA  A1179 (-4.5A)
 0.68A 5nu7A-2wq9A:
33.1		 5nu7A-2wq9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wul GLUTAREDOXIN RELATED
PROTEIN 5

(Homo sapiens) 		PF00462
(Glutaredoxin) 		4 LEU A  96
ALA A  47
VAL A  90
GLN A 111
 None
 1.02A 5nu7A-2wulA:
undetectable		 5nu7A-2wulA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		4 LEU A 297
ALA A 168
VAL A 455
MET A 182
 None
 0.93A 5nu7A-2ww9A:
undetectable		 5nu7A-2ww9A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 LEU A  83
VAL A  79
MET A 106
TYR A 175
 None
 0.92A 5nu7A-2zb9A:
undetectable		 5nu7A-2zb9A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		4 VAL A 492
TYR A 392
GLN A  45
HIS A  36
 None
 0.95A 5nu7A-3c9fA:
undetectable		 5nu7A-3c9fA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8x THIOREDOXIN
REDUCTASE 1

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 ALA A 247
VAL A 149
GLN A 136
HIS A 250
 None
None
FAD  A1001 ( 4.6A)
None
 0.97A 5nu7A-3d8xA:
undetectable		 5nu7A-3d8xA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 241
ALA A 290
VAL A 239
HIS A 149
 None
 0.89A 5nu7A-3eoqA:
undetectable		 5nu7A-3eoqA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 LEU A 589
ALA A 604
VAL A 585
TYR A 651
 None
 0.97A 5nu7A-3fjoA:
undetectable		 5nu7A-3fjoA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 305
ALA A 201
VAL A 263
TYR A 204
 None
 1.03A 5nu7A-3fk5A:
undetectable		 5nu7A-3fk5A:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ALA A  55
MET A  88
TYR A  90
GLN A  98
HIS A 104
 2T1  A 184 ( 4.3A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.0A)
2T1  A 184 (-3.7A)
 0.71A 5nu7A-3fmzA:
30.8		 5nu7A-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  37
ALA A  55
VAL A  61
MET A  73
 2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
None
2T1  A 184 (-3.6A)
 0.99A 5nu7A-3fmzA:
30.8		 5nu7A-3fmzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  37
ALA A  55
VAL A  61
MET A  88
TYR A  90
HIS A 104
 2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.7A)
 0.65A 5nu7A-3fmzA:
30.8		 5nu7A-3fmzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		4 LEU A  20
ALA A 132
VAL A  25
TYR A 332
 None
 0.89A 5nu7A-3g5sA:
undetectable		 5nu7A-3g5sA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN

(Methanopyrus
kandleri) 		PF00383
(dCMP_cyt_deam_1)
PF02926
(THUMP) 		4 LEU A  28
ALA A  77
VAL A  35
GLN A   8
 None
 1.00A 5nu7A-3g8qA:
undetectable		 5nu7A-3g8qA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 LEU A 117
ALA A 105
VAL A 216
MET A 207
 None
 0.97A 5nu7A-3heaA:
undetectable		 5nu7A-3heaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 LEU A  27
ALA A   8
VAL A  52
HIS A  64
 None
None
None
ZN  A 452 (-3.5A)
 0.98A 5nu7A-3ie1A:
undetectable		 5nu7A-3ie1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 308
VAL A 102
MET A 300
HIS A 146
 None
 1.00A 5nu7A-3ijlA:
undetectable		 5nu7A-3ijlA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ist GLUTAMATE RACEMASE

(Listeria
monocytogenes) 		PF01177
(Asp_Glu_race) 		4 ALA A   4
VAL A  94
TYR A  32
HIS A 233
 None
 0.96A 5nu7A-3istA:
undetectable		 5nu7A-3istA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 LEU A  97
ALA A 197
GLN A 118
HIS A 133
 None
 0.90A 5nu7A-3kl8A:
undetectable		 5nu7A-3kl8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Bacillus
anthracis) 		PF01470
(Peptidase_C15) 		5 LEU A  53
ALA A  61
VAL A  42
MET A 161
HIS A 157
 None
 1.30A 5nu7A-3lacA:
undetectable		 5nu7A-3lacA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 LEU A 408
MET A 250
TYR A 464
GLN A 422
 None
 1.02A 5nu7A-3mzbA:
undetectable		 5nu7A-3mzbA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		4 LEU A 476
ALA A  41
VAL A 387
MET A 244
 None
 0.96A 5nu7A-3nz4A:
undetectable		 5nu7A-3nz4A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 105
VAL A 272
MET A  82
TYR A 246
 None
None
None
FAD  A 500 (-4.5A)
 1.01A 5nu7A-3oc4A:
undetectable		 5nu7A-3oc4A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4l NEOGENIN

(Homo sapiens) 		PF00041
(fn3) 		4 ALA A1000
TYR A 993
GLN A1033
HIS A1003
 None
 1.02A 5nu7A-3p4lA:
undetectable		 5nu7A-3p4lA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pi7 NADH OXIDOREDUCTASE

(Mesorhizobium
loti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 133
ALA A 110
VAL A 137
MET A 145
 None
 0.83A 5nu7A-3pi7A:
undetectable		 5nu7A-3pi7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pry HEAT SHOCK PROTEIN
HSP 90-BETA

(Homo sapiens) 		PF00183
(HSP90) 		4 LEU A 533
VAL A 522
MET A 476
TYR A 472
 None
 0.98A 5nu7A-3pryA:
undetectable		 5nu7A-3pryA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 LEU A 612
ALA A 627
VAL A 608
TYR A 674
 None
 0.97A 5nu7A-3qfsA:
undetectable		 5nu7A-3qfsA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE

(Paraburkholderia
xenovorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 216
ALA A 203
VAL A 242
HIS A 167
 None
 0.97A 5nu7A-3sn0A:
undetectable		 5nu7A-3sn0A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss6 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 257
ALA A 374
VAL A 110
TYR A 277
 None
 1.02A 5nu7A-3ss6A:
undetectable		 5nu7A-3ss6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w79 FMN-DEPENDENT
NADH-AZOREDUCTASE

(Bacillus sp.
B29) 		PF02525
(Flavodoxin_2) 		4 LEU A 166
VAL A 111
TYR A 180
GLN A 145
 None
 0.99A 5nu7A-3w79A:
undetectable		 5nu7A-3w79A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A 533
ALA A 598
VAL A 578
TYR A 544
 None
 0.94A 5nu7A-3wmeA:
undetectable		 5nu7A-3wmeA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg8 PENICILLIN-BINDING
PROTEIN 4

(Listeria
monocytogenes) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 LEU B 359
ALA B 565
MET B 572
GLN B 641
 None
 0.96A 5nu7A-3zg8B:
undetectable		 5nu7A-3zg8B:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		4 ALA A  57
VAL A  40
GLN A 520
HIS A  25
 None
 0.83A 5nu7A-4aahA:
undetectable		 5nu7A-4aahA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ann ESSB

(Staphylococcus
aureus) 		PF10140
(YukC) 		4 LEU A 136
ALA A  61
VAL A 139
TYR A  49
 None
 1.01A 5nu7A-4annA:
undetectable		 5nu7A-4annA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqq L2 PROTEIN III
(PENTON BASE)

(Human
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		4 LEU A  71
VAL A  95
MET A 417
HIS A 499
 None
 0.93A 5nu7A-4aqqA:
undetectable		 5nu7A-4aqqA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		4 LEU A 111
ALA A  51
VAL A 107
HIS A 353
 None
 0.86A 5nu7A-4au2A:
undetectable		 5nu7A-4au2A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU C 300
ALA C 229
VAL C 333
MET C 127
 None
 0.98A 5nu7A-4b3iC:
undetectable		 5nu7A-4b3iC:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		4 LEU A 269
VAL A 274
TYR A 322
HIS A 242
 None
 1.01A 5nu7A-4b3kA:
undetectable		 5nu7A-4b3kA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Pyrobaculum
neutrophilum) 		PF00215
(OMPdecase) 		4 LEU A  11
ALA A  28
VAL A  34
TYR A  53
 None
 0.96A 5nu7A-4df1A:
undetectable		 5nu7A-4df1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 259
ALA A 376
VAL A 110
TYR A 279
 None
None
None
IOD  A 413 ( 4.1A)
 0.91A 5nu7A-4e1lA:
undetectable		 5nu7A-4e1lA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecj GLUTATHIONE
S-TRANSFERASE

(Pseudomonas
aeruginosa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 181
ALA A 157
VAL A 175
TYR A 162
 None
 0.98A 5nu7A-4ecjA:
undetectable		 5nu7A-4ecjA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he4 YELLOW FLUORESCENT
PROTEIN

(Phialidium sp.
SL-2003) 		PF01353
(GFP) 		4 ALA A 179
VAL A 121
GLN A  92
HIS A 146
 None
None
CRO  A  65 ( 3.7A)
CRO  A  65 ( 3.8A)
 1.03A 5nu7A-4he4A:
undetectable		 5nu7A-4he4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea) 		PF00230
(MIP) 		4 LEU A 197
ALA A 111
VAL A  89
HIS A 260
 None
 0.87A 5nu7A-4ia4A:
undetectable		 5nu7A-4ia4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN

(Streptococcus
gordonii) 		no annotation 4 LEU D 115
ALA D 197
VAL D  61
GLN D  72
 None
 0.96A 5nu7A-4igbD:
undetectable		 5nu7A-4igbD:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A  38
ALA A  69
VAL A  43
MET A  53
 None
 1.02A 5nu7A-4o99A:
undetectable		 5nu7A-4o99A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Bacillus
anthracis) 		PF13407
(Peripla_BP_4) 		4 ALA A 323
VAL A 330
TYR A 319
GLN A 317
 None
EDO  A 407 ( 4.8A)
None
None
 1.00A 5nu7A-4pz0A:
undetectable		 5nu7A-4pz0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		4 LEU A 171
ALA A 199
VAL A 172
TYR A 208
 None
 1.00A 5nu7A-4rnzA:
undetectable		 5nu7A-4rnzA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Beutenbergia
cavernae) 		PF03372
(Exo_endo_phos) 		4 LEU A  91
ALA A  79
VAL A 147
GLN A 107
 None
 0.98A 5nu7A-4ruwA:
undetectable		 5nu7A-4ruwA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 LEU L 278
VAL L 409
TYR L 273
HIS L 211
 None
 0.99A 5nu7A-4u9iL:
undetectable		 5nu7A-4u9iL:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		4 LEU Q 271
VAL Q 407
TYR Q 266
HIS Q 204
 None
 0.88A 5nu7A-4upeQ:
undetectable		 5nu7A-4upeQ:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 427
VAL A 442
MET A 414
TYR A 417
 None
 1.02A 5nu7A-4zlgA:
undetectable		 5nu7A-4zlgA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		4 LEU E  90
ALA E 102
VAL E  43
TYR E 108
 None
 0.99A 5nu7A-5b04E:
undetectable		 5nu7A-5b04E:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czr CADHERIN-RELATED
FAMILY MEMBER 2

(Homo sapiens) 		PF00028
(Cadherin) 		4 LEU A  65
ALA A  51
VAL A  94
TYR A  48
 None
 0.94A 5nu7A-5czrA:
undetectable		 5nu7A-5czrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		4 LEU A 104
ALA A  47
TYR A  54
GLN A  53
 None
 1.01A 5nu7A-5d8wA:
undetectable		 5nu7A-5d8wA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA
CRISPR SYSTEM
CASCADE SUBUNIT CASD

(Escherichia
coli;
Escherichia
coli) 		PF09481
(CRISPR_Cse1)
PF09704
(Cas_Cas5d) 		4 LEU A 118
ALA A  46
GLN J 207
HIS A 362
 None
 1.01A 5nu7A-5h9fA:
undetectable		 5nu7A-5h9fA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 LEU A  98
ALA A 199
GLN A 119
HIS A 134
 None
 0.93A 5nu7A-5hu3A:
undetectable		 5nu7A-5hu3A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 107
ALA A 122
VAL A 110
GLN A 214
 None
 0.98A 5nu7A-5jjqA:
undetectable		 5nu7A-5jjqA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 545
TYR A 139
GLN A 128
HIS A  95
 None
 0.89A 5nu7A-5lm8A:
undetectable		 5nu7A-5lm8A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16)
PF00583
(Acetyltransf_1) 		4 LEU B 106
ALA A 246
VAL B 109
GLN B 167
 None
 1.00A 5nu7A-5nnpB:
undetectable		 5nu7A-5nnpB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN

(Yersinia pestis) 		PF01042
(Ribonuc_L-PSP) 		4 LEU A 118
ALA A  34
VAL A  84
GLN A  54
 None
GOL  A 206 ( 4.8A)
None
None
 0.97A 5nu7A-5v4fA:
undetectable		 5nu7A-5v4fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00514
(Arm)
no annotation 		4 LEU A 213
ALA B 314
VAL A 212
HIS A 196
 None
 0.99A 5nu7A-5xjgA:
undetectable		 5nu7A-5xjgA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 4 LEU A 523
ALA A 471
VAL A 519
TYR A 568
 None
 0.97A 5nu7A-5xpgA:
undetectable		 5nu7A-5xpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 ALA 2 699
TYR 2 554
GLN 2 441
HIS 2 558
 None
 0.83A 5nu7A-5zvs2:
undetectable		 5nu7A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 4 LEU A 186
ALA A  73
VAL A 182
HIS A 222
 None
 0.92A 5nu7A-6c66A:
undetectable		 5nu7A-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 4 LEU K 632
ALA K 751
MET K 748
TYR K 765
 A  O  58 ( 4.4A)
A  O  59 ( 3.1A)
None
None
 0.97A 5nu7A-6d6qK:
undetectable		 5nu7A-6d6qK:
undetectable