SIMILAR PATTERNS OF AMINO ACIDS FOR 5NR3_A_95EA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2z DEATH DOMAIN OF TUBE

(Drosophila
melanogaster) 		PF14786
(Death_2) 		4 ILE B 114
TRP B  54
ASP B  49
LYS B  46
 None
 1.26A 5nr3A-1d2zB:
0.0		 5nr3A-1d2zB:
25.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus musculus) 		PF00855
(PWWP) 		4 TRP A 270
ASP A 273
LYS A 275
SER A 304
 None
 0.29A 5nr3A-1khcA:
24.9		 5nr3A-1khcA:
93.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		4 ILE A  67
PHE A  80
TRP A  61
ASP A  59
 None
 1.40A 5nr3A-1kugA:
0.0		 5nr3A-1kugA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2

(Salmonella
virus PRD1) 		PF09214
(Prd1-P2) 		4 ILE A  20
TRP A  34
ASP A  26
SER A  28
 None
 0.94A 5nr3A-1n7uA:
undetectable		 5nr3A-1n7uA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqb TRANSCARBOXYLASE 5S
SUBUNIT

(Propionibacterium
freudenreichii) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 ILE A 302
PHE A 303
ASP A 185
SER A 226
 None
 1.30A 5nr3A-1rqbA:
undetectable		 5nr3A-1rqbA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 124
TRP A 109
ASP A 105
SER A  50
 None
 1.44A 5nr3A-1rvkA:
0.0		 5nr3A-1rvkA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yud HYPOTHETICAL PROTEIN
SO0799

(Shewanella
oneidensis) 		PF06172
(Cupin_5) 		4 ILE A  42
PHE A  44
TRP A  63
SER A 109
 None
 1.32A 5nr3A-1yudA:
0.0		 5nr3A-1yudA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 ILE A 633
PHE A 698
LYS A 544
SER A 538
 None
 1.44A 5nr3A-1z45A:
0.0		 5nr3A-1z45A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE

(Aquifex
aeolicus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		4 ILE A 191
TRP A  77
TRP A 195
ASP A 199
 None
 1.09A 5nr3A-1zjrA:
0.0		 5nr3A-1zjrA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 ILE A  74
PHE A  75
TRP A  40
ASP A  41
 None
None
6UL  A 312 (-4.7A)
None
 1.35A 5nr3A-2h26A:
undetectable		 5nr3A-2h26A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE

(Helicobacter
pylori) 		PF00852
(Glyco_transf_10) 		4 ILE A 262
PHE A 198
LYS A 295
SER A 204
 None
 1.27A 5nr3A-2nzxA:
undetectable		 5nr3A-2nzxA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p57 GTPASE-ACTIVATING
PROTEIN ZNF289

(Homo sapiens) 		PF01412
(ArfGap) 		4 ILE A  39
PHE A  62
TRP A  72
ASP A  69
 None
 1.45A 5nr3A-2p57A:
undetectable		 5nr3A-2p57A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Methanosarcina
mazei) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		4 ILE B 117
PHE B  94
ASP B  80
SER B 136
 None
 1.34A 5nr3A-2q2eB:
undetectable		 5nr3A-2q2eB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7n LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Mus musculus) 		PF00041
(fn3) 		4 ILE A 126
TRP A 157
TRP A 155
SER A 159
 None
 1.40A 5nr3A-2q7nA:
undetectable		 5nr3A-2q7nA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1

(Homo sapiens) 		PF13238
(AAA_18) 		4 ILE A 161
PHE A 103
TRP A 112
TRP A 163
 None
 1.28A 5nr3A-2ql6A:
undetectable		 5nr3A-2ql6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyo POLYSACCHARIDE
DEACETYLASE
DOMAIN-CONTAINING
PROTEIN ECU11_0510

(Encephalitozoon
cuniculi) 		PF01522
(Polysacc_deac_1) 		4 ILE A  28
PHE A 180
LYS A 205
SER A 168
 None
 1.36A 5nr3A-2vyoA:
undetectable		 5nr3A-2vyoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee1 EFFECTOR PROTEIN
VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		4 ILE A 323
PHE A 202
ASP A 267
SER A 263
 None
 1.00A 5nr3A-3ee1A:
undetectable		 5nr3A-3ee1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP1

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 1 110
PHE 1 237
LYS 1 113
SER 1 128
 SPH  1   0 (-4.5A)
SPH  1   0 ( 3.1A)
None
None
 1.37A 5nr3A-3epc1:
undetectable		 5nr3A-3epc1:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		4 ILE A 197
PHE A 313
ASP A 305
SER A 260
 None
 1.42A 5nr3A-3f0nA:
undetectable		 5nr3A-3f0nA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3llr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00855
(PWWP) 		5 PHE A  29
TRP A  32
TRP A  56
ASP A  59
LYS A  61
 BTB  A 154 (-3.2A)
BTB  A 154 (-3.6A)
BTB  A 154 (-3.4A)
BTB  A 154 (-2.7A)
BTB  A 154 (-3.6A)
 1.00A 5nr3A-3llrA:
25.1		 5nr3A-3llrA:
51.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		4 ILE A 416
PHE A 431
TRP A 439
SER A 448
 None
 1.26A 5nr3A-3m99A:
undetectable		 5nr3A-3m99A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		4 ILE A 436
PHE A 433
ASP A 408
SER A 411
 None
 1.33A 5nr3A-3nawA:
undetectable		 5nr3A-3nawA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 266
ASP A 250
LYS A 252
SER A  99
 None
GOL  A 383 ( 3.8A)
GOL  A 383 (-3.0A)
None
 1.10A 5nr3A-3r11A:
undetectable		 5nr3A-3r11A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4d LACTOSE
PHOSPHORYLASE

(Cellulomonas
uda) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 PHE A 597
TRP A 488
ASP A 422
SER A 518
 None
CBI  A 824 (-2.7A)
None
None
 1.37A 5nr3A-3s4dA:
undetectable		 5nr3A-3s4dA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 ILE A 414
PHE A 418
ASP A 385
SER A 387
 None
 1.40A 5nr3A-3sfzA:
undetectable		 5nr3A-3sfzA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 ILE A 414
TRP A 404
ASP A 385
SER A 387
 None
 1.40A 5nr3A-3sfzA:
undetectable		 5nr3A-3sfzA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to9 HISTONE
ACETYLTRANSFERASE
ESA1

(Saccharomyces
cerevisiae) 		PF01853
(MOZ_SAS) 		4 ILE A 239
PHE A 273
TRP A 247
SER A 255
 None
None
None
ALY  A 262 ( 3.7A)
 1.14A 5nr3A-3to9A:
undetectable		 5nr3A-3to9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		4 ILE A 222
PHE A 194
LYS A 201
SER A 251
 None
 1.23A 5nr3A-3vocA:
undetectable		 5nr3A-3vocA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus laevis) 		no annotation 4 ILE B 331
ASP B 486
LYS B 482
SER B 490
 None
 1.48A 5nr3A-3w0lB:
undetectable		 5nr3A-3w0lB:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		4 ILE A 285
PHE A 283
TRP A 276
SER A 228
 None
 1.19A 5nr3A-3wj9A:
undetectable		 5nr3A-3wj9A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl0 CELL CYCLE ARREST
PROTEIN BUB3
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF08171
(Mad3_BUB1_II) 		4 ILE B 343
PHE A 316
ASP A  12
SER A 312
 None
 1.37A 5nr3A-4bl0B:
undetectable		 5nr3A-4bl0B:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl0 CELL CYCLE ARREST
PROTEIN BUB3
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF08171
(Mad3_BUB1_II) 		4 ILE B 343
PHE A 316
ASP A  12
SER A 331
 None
 1.22A 5nr3A-4bl0B:
undetectable		 5nr3A-4bl0B:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 4 ILE A 378
PHE A 375
LYS A 393
SER A 122
 None
 1.47A 5nr3A-4cmrA:
undetectable		 5nr3A-4cmrA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 ILE W 367
TRP W 524
ASP W 525
SER W 527
 None
 1.40A 5nr3A-4f5xW:
undetectable		 5nr3A-4f5xW:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE B  52
PHE B  39
TRP B  96
LYS B  94
 None
 1.38A 5nr3A-4fzdB:
undetectable		 5nr3A-4fzdB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gsl AUTOPHAGY-RELATED
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF03986
(Autophagy_N)
PF03987
(Autophagy_act_C)
PF10381
(Autophagy_C) 		4 ILE C  70
PHE C  68
ASP C  55
SER C  57
 None
 1.47A 5nr3A-4gslC:
undetectable		 5nr3A-4gslC:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hde SCO1/SENC FAMILY
LIPOPROTEIN

(Bacillus
anthracis) 		PF02630
(SCO1-SenC) 		4 ILE A 115
PHE A 114
TRP A 125
ASP A  63
 None
 1.42A 5nr3A-4hdeA:
undetectable		 5nr3A-4hdeA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN

(Chaetomium
thermophilum) 		PF00557
(Peptidase_M24) 		4 ILE A 138
PHE A 146
TRP A 357
ASP A 125
 None
 1.44A 5nr3A-4ipaA:
undetectable		 5nr3A-4ipaA:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ld6 PWWP
DOMAIN-CONTAINING
PROTEIN 2B

(Homo sapiens) 		PF00855
(PWWP) 		4 ILE A 498
PHE A 501
TRP A 504
TRP A 530
 GOL  A3001 (-4.7A)
GOL  A3001 (-3.2A)
GOL  A3001 (-3.6A)
GOL  A3001 (-3.4A)
 0.27A 5nr3A-4ld6A:
10.3		 5nr3A-4ld6A:
32.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE B  52
PHE B  39
TRP B  96
LYS B  94
 None
 1.46A 5nr3A-4o27B:
undetectable		 5nr3A-4o27B:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puc SUSD HOMOLOG

(Bacteroides
uniformis) 		PF12741
(SusD-like) 		4 ILE A 140
TRP A 261
TRP A 350
SER A  60
 None
 1.43A 5nr3A-4pucA:
undetectable		 5nr3A-4pucA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q69 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 ILE A 457
ASP A 487
LYS A 483
SER A 435
 None
NA  A 501 (-3.1A)
None
None
 1.18A 5nr3A-4q69A:
undetectable		 5nr3A-4q69A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis) 		PF00557
(Peptidase_M24) 		4 ILE A 247
PHE A 232
ASP A 239
LYS A 241
 None
 1.32A 5nr3A-4rzzA:
undetectable		 5nr3A-4rzzA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqk LECTIN 2

(Agrocybe
aegerita) 		PF13517
(VCBS) 		4 TRP A 279
ASP A 272
LYS A 277
SER A 320
 NAG  A 505 (-3.5A)
NAG  A 505 (-2.8A)
NAG  A 505 (-4.4A)
None
 1.48A 5nr3A-4tqkA:
undetectable		 5nr3A-4tqkA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 ILE A 540
PHE A 449
ASP A 445
SER A 381
 None
None
ZN  A 802 (-2.0A)
None
 1.44A 5nr3A-4tweA:
undetectable		 5nr3A-4tweA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 ILE L 125
PHE L 268
ASP L 276
SER L 158
 None
 1.39A 5nr3A-4u9iL:
undetectable		 5nr3A-4u9iL:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtl SODIUM PUMPING
RHODOPSIN

(Dokdonia
eikasta) 		PF01036
(Bac_rhodopsin) 		4 ILE A 150
TRP A 113
ASP A 251
SER A 214
 None
LYR  A 255 ( 4.1A)
LYR  A 255 ( 3.8A)
None
 1.30A 5nr3A-4xtlA:
undetectable		 5nr3A-4xtlA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yam BETA-ETHERASE

(Sphingobium sp.
SYK-6) 		PF13417
(GST_N_3) 		4 ILE A 172
PHE A 169
ASP A 188
SER A 190
 None
 1.40A 5nr3A-4yamA:
undetectable		 5nr3A-4yamA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7

(Homo sapiens) 		PF03133
(TTL) 		4 ILE A  52
TRP A  76
ASP A  78
LYS A  49
 None
 1.20A 5nr3A-4ylrA:
undetectable		 5nr3A-4ylrA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans) 		PF08652
(RAI1) 		4 ILE A 120
PHE A 359
TRP A 327
SER A   9
 None
 1.34A 5nr3A-5bthA:
undetectable		 5nr3A-5bthA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvr ALPHA-ACTININ-LIKE
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 ILE A 110
PHE A  14
ASP A 214
SER A   8
 None
None
ZN  A 303 (-2.9A)
None
 1.33A 5nr3A-5bvrA:
undetectable		 5nr3A-5bvrA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium) 		PF00202
(Aminotran_3) 		4 ILE A 443
PHE A  55
LYS A 367
SER A 450
 None
 1.30A 5nr3A-5g0aA:
undetectable		 5nr3A-5g0aA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gle ISCHORISMATE LYASE

(Vibrio
anguillarum) 		no annotation 4 PHE A 169
ASP A  27
LYS A  30
SER A 206
 None
 1.41A 5nr3A-5gleA:
undetectable		 5nr3A-5gleA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdi CYTOCHROME P450 144

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 ILE A 377
TRP A  77
ASP A  78
SER A  62
 None
 1.41A 5nr3A-5hdiA:
undetectable		 5nr3A-5hdiA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 ILE A 319
PHE A 365
ASP A 445
SER A 212
 None
 1.40A 5nr3A-5ktkA:
undetectable		 5nr3A-5ktkA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN

(Homo sapiens) 		PF00023
(Ank)
PF00225
(Kinesin)
PF12796
(Ank_2) 		4 ILE C 449
PHE C 401
ASP C 492
SER C 470
 None
None
MG  C 801 (-2.8A)
None
 1.48A 5nr3A-5mioC:
undetectable		 5nr3A-5mioC:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2x GLYCOSIDE HYDROLASE
FAMILY 61

(Trichoderma
reesei) 		PF03443
(Glyco_hydro_61) 		4 ILE A 159
TRP A 140
ASP A  92
SER A 231
 None
None
None
MAN  A 311 (-1.4A)
 1.34A 5nr3A-5o2xA:
undetectable		 5nr3A-5o2xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t77 PUTATIVE LIPID II
FLIPPASE MURJ

(Thermosipho
africanus) 		PF03023
(MVIN) 		4 ILE A  45
PHE A  49
ASP A  25
SER A 254
 None
 1.40A 5nr3A-5t77A:
undetectable		 5nr3A-5t77A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ted LMO0488 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 ILE B 219
PHE B 195
ASP B 198
SER B 200
 None
None
None
SKM  B 401 (-2.8A)
 0.97A 5nr3A-5tedB:
undetectable		 5nr3A-5tedB:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00439
(Bromodomain) 		4 ILE A 392
PHE A 398
TRP A 308
SER A 440
 None
None
SO4  A 502 (-4.4A)
None
 1.49A 5nr3A-5u9nA:
undetectable		 5nr3A-5u9nA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v89 DCN1-LIKE PROTEIN 4

(Homo sapiens) 		PF03556
(Cullin_binding) 		4 ILE A 262
PHE A 258
TRP A 275
ASP A 280
 None
 1.40A 5nr3A-5v89A:
undetectable		 5nr3A-5v89A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 ILE B 565
PHE B 561
LYS B 473
SER B 578
 None
 1.43A 5nr3A-5wwpB:
undetectable		 5nr3A-5wwpB:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu5 ALGINATE LYASE

(Vibrio
splendidus) 		no annotation 4 ILE A 359
PHE A 461
ASP A 330
LYS A 425
 None
 1.29A 5nr3A-5zu5A:
undetectable		 5nr3A-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zwp GLUTATHIONE
S-TRANSFERASE 1

(Musca domestica) 		no annotation 4 PHE A 127
ASP A 172
LYS A 175
SER A 170
 None
 1.44A 5nr3A-5zwpA:
undetectable		 5nr3A-5zwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 4 ILE A 110
PHE A 117
LYS A  46
SER A 263
 None
 1.49A 5nr3A-6cc4A:
undetectable		 5nr3A-6cc4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 ILE A 711
PHE A 725
TRP A 744
TRP A 753
 None
 1.50A 5nr3A-6eksA:
undetectable		 5nr3A-6eksA:
11.50