SIMILAR PATTERNS OF AMINO ACIDS FOR 5NOO_D_D16D402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 ASP A 303
LEU A 306
GLY A 302
PHE A 301
TYR A  14
 None
 1.25A 5nooD-1am5A:
undetectable		 5nooD-1am5A:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bsf THYMIDYLATE SYNTHASE
A

(Bacillus
subtilis) 		PF00303
(Thymidylat_synt) 		5 ILE A  93
ASP A 184
GLY A 188
PHE A 191
TYR A 224
 None
 0.58A 5nooD-1bsfA:
30.8		 5nooD-1bsfA:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 ASP A 536
LEU A 535
GLY A 534
PHE A 533
 None
None
AMO  A 831 (-3.4A)
None
 0.85A 5nooD-1c0aA:
0.0		 5nooD-1c0aA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		7 ARG A  56
ILE A  86
ASP A 202
LEU A 205
GLY A 206
PHE A 209
TYR A 242
 None
CB3  A 768 (-3.6A)
CB3  A 768 ( 3.6A)
CB3  A 768 ( 4.4A)
UMP  A 767 (-3.7A)
CB3  A 768 (-3.6A)
CB3  A 768 ( 4.7A)
 0.84A 5nooD-1ci7A:
12.5		 5nooD-1ci7A:
53.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cov COXSACKIEVIRUS COAT
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		4 ILE 3 114
LEU 3 104
GLY 3 101
PHE 3  95
 None
 0.66A 5nooD-1cov3:
undetectable		 5nooD-1cov3:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 114
LEU A 150
GLY A 149
TYR A 153
 None
 0.90A 5nooD-1d6hA:
0.0		 5nooD-1d6hA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)

(Homo sapiens) 		PF00156
(Pribosyltran) 		4 TYR A 194
ILE A 207
GLY A 189
PHE A 198
 None
 0.86A 5nooD-1d6nA:
0.0		 5nooD-1d6nA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		4 ILE A1060
ASP A1056
LEU A1292
GLY A1057
 None
 0.89A 5nooD-1eg7A:
undetectable		 5nooD-1eg7A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		4 TYR A 102
ILE A 140
ASP A 130
GLY A 129
 None
 0.91A 5nooD-1fbnA:
0.0		 5nooD-1fbnA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		5 TYR A 162
ILE A 177
ASP A 169
GLY A 170
PHE A 164
 None
 1.46A 5nooD-1fbwA:
undetectable		 5nooD-1fbwA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6q HNRNP ARGININE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF06325
(PrmA) 		4 TYR 1 178
ILE 1 206
LEU 1 173
GLY 1 253
 None
 0.74A 5nooD-1g6q1:
undetectable		 5nooD-1g6q1:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		4 ILE A 524
LEU A 609
GLY A 610
PHE A 614
 None
 0.89A 5nooD-1gxlA:
undetectable		 5nooD-1gxlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htw HI0065

(Haemophilus
influenzae) 		PF02367
(TsaE) 		4 ILE A  24
ASP A 126
LEU A 148
GLY A 149
 None
 0.85A 5nooD-1htwA:
undetectable		 5nooD-1htwA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv5 STROMELYSIN 3

(Mus musculus) 		PF00413
(Peptidase_M10) 		4 ILE A 159
LEU A 225
GLY A 222
PHE A 221
 None
 0.83A 5nooD-1hv5A:
undetectable		 5nooD-1hv5A:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		6 ARG A  78
ILE A 108
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 None
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.85A 5nooD-1hvyA:
20.8		 5nooD-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		6 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.64A 5nooD-1hvyA:
20.8		 5nooD-1hvyA:
62.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		5 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.19A 5nooD-1izeA:
undetectable		 5nooD-1izeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		4 ASP A 655
GLY A 658
PHE A 661
TYR A 598
 None
 0.86A 5nooD-1j1wA:
undetectable		 5nooD-1j1wA:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		4 ASP C 513
LEU C 516
GLY C 517
TYR C 553
 UMP  C 611 (-4.9A)
None
UMP  C 611 (-3.5A)
UMP  C 611 (-4.9A)
 0.69A 5nooD-1j3jC:
12.4		 5nooD-1j3jC:
49.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		4 ILE C 403
ASP C 513
GLY C 517
TYR C 553
 None
UMP  C 611 (-4.9A)
UMP  C 611 (-3.5A)
UMP  C 611 (-4.9A)
 0.50A 5nooD-1j3jC:
12.4		 5nooD-1j3jC:
49.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		4 TYR A  64
ASP A  68
GLY A  67
PHE A  65
 None
 0.91A 5nooD-1j5tA:
undetectable		 5nooD-1j5tA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION

(Escherichia
coli) 		PF08943
(CsiD) 		5 ARG A 242
TYR A 243
ILE A 266
ASP A 194
LEU A 193
 None
 1.18A 5nooD-1jr7A:
undetectable		 5nooD-1jr7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 ARG A 754
LEU A 744
GLY A 743
PHE A 742
 None
 0.90A 5nooD-1kspA:
undetectable		 5nooD-1kspA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ARG A 275
ILE A 367
LEU A 304
GLY A 305
 None
 0.91A 5nooD-1llaA:
undetectable		 5nooD-1llaA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt3 HEAT-LABILE
ENTEROTOXIN

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		4 ARG A 146
TYR A 121
ILE A  16
GLY A 118
 None
 0.89A 5nooD-1lt3A:
undetectable		 5nooD-1lt3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltt HEAT-LABILE
ENTEROTOXIN, SUBUNIT
A

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		4 ARG A 146
TYR A 121
ILE A  16
GLY A 118
 None
 0.91A 5nooD-1lttA:
undetectable		 5nooD-1lttA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdu GELSOLIN PRECURSOR

(Homo sapiens) 		PF00626
(Gelsolin) 		4 TYR A 109
ILE A  46
LEU A 114
GLY A  36
 None
None
None
TRS  A 472 ( 4.7A)
 0.91A 5nooD-1mduA:
undetectable		 5nooD-1mduA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi5 TCR ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 ARG D  36
TYR D  35
GLY D 107
PHE D 106
 None
 0.90A 5nooD-1mi5D:
undetectable		 5nooD-1mi5D:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxs KDPG ALDOLASE

(Pseudomonas
putida) 		PF01081
(Aldolase) 		4 ARG A 143
ILE A 108
LEU A 123
GLY A 116
 None
 0.86A 5nooD-1mxsA:
undetectable		 5nooD-1mxsA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n71 AAC(6')-II

(Enterococcus
faecium) 		PF00583
(Acetyltransf_1) 		4 TYR A 144
ILE A 154
LEU A 109
GLY A 110
 None
 0.59A 5nooD-1n71A:
undetectable		 5nooD-1n71A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ARG A 284
ILE A 107
LEU A 219
GLY A 216
 None
 0.86A 5nooD-1nugA:
undetectable		 5nooD-1nugA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmj BETA-1,4-MANNANASE

(Caldicellulosiruptor
saccharolyticus) 		PF09212
(CBM27) 		4 ILE X 173
ASP X  61
GLY X 164
PHE X 103
 None
 0.90A 5nooD-1pmjX:
undetectable		 5nooD-1pmjX:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6y HYPOTHETICAL PROTEIN
YFDW

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		4 TYR A 225
ASP A 239
GLY A 238
PHE A 237
 None
 0.85A 5nooD-1q6yA:
undetectable		 5nooD-1q6yA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		5 TYR A 146
ILE A  80
ASP A  99
LEU A  98
GLY A  97
 None
 1.26A 5nooD-1qoxA:
undetectable		 5nooD-1qoxA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 ARG A  83
ILE A 281
ASP A  57
LEU A  56
GLY A  55
 None
 1.06A 5nooD-1qpoA:
undetectable		 5nooD-1qpoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 TYR G 133
ILE G  70
LEU G 138
GLY G  60
 None
 0.85A 5nooD-1rgiG:
undetectable		 5nooD-1rgiG:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE

(Cryptococcus
neoformans) 		PF00475
(IGPD) 		4 ILE A 181
LEU A  81
GLY A  82
PHE A  85
 None
 0.87A 5nooD-1rhyA:
undetectable		 5nooD-1rhyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 ILE A  45
LEU A 210
GLY A 211
PHE A 214
 None
 0.50A 5nooD-1rtrA:
undetectable		 5nooD-1rtrA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ILE A 534
ASP A 714
GLY A 720
PHE A 719
 None
 0.87A 5nooD-1sb3A:
0.0		 5nooD-1sb3A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 ILE A 220
ASP A 251
GLY A 295
PHE A 296
 None
 0.90A 5nooD-1t1eA:
undetectable		 5nooD-1t1eA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		5 ARG A 144
ASP A  83
LEU A  82
PHE A  92
TYR A  81
 None
 1.47A 5nooD-1t8qA:
undetectable		 5nooD-1t8qA:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		5 ASP A 179
LEU A 182
GLY A 183
PHE A 186
TYR A 219
 None
 0.92A 5nooD-1tisA:
30.2		 5nooD-1tisA:
39.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 ILE A 225
LEU A 100
GLY A  99
PHE A 170
 None
 0.89A 5nooD-1uchA:
undetectable		 5nooD-1uchA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upn ECHOVIRUS 11 COAT
PROTEIN VP3

(Enterovirus B) 		PF00073
(Rhv) 		4 ILE C 114
LEU C 104
GLY C 101
PHE C  95
 None
 0.74A 5nooD-1upnC:
undetectable		 5nooD-1upnC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		4 TYR A 310
ASP A 314
GLY A 256
PHE A 257
 None
GOL  A 401 ( 4.5A)
None
None
 0.81A 5nooD-1vgmA:
undetectable		 5nooD-1vgmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		4 TYR A 306
ASP A 310
GLY A 251
PHE A 252
 None
 0.91A 5nooD-1vgpA:
undetectable		 5nooD-1vgpA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9j SEC1 FAMILY DOMAIN
CONTAINING PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		4 ARG A  20
ILE A  51
PHE A  86
TYR A 106
 None
 0.89A 5nooD-1y9jA:
undetectable		 5nooD-1y9jA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		4 ILE A 129
GLY A 288
PHE A 307
TYR A 268
 None
 0.84A 5nooD-1z7mA:
undetectable		 5nooD-1z7mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ILE A 831
LEU A 856
GLY A 855
PHE A 854
 None
 0.90A 5nooD-1zy4A:
undetectable		 5nooD-1zy4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a81 CARB

(Pectobacterium
carotovorum) 		PF00378
(ECH_1) 		5 ARG A 173
TYR A 172
ILE A 157
LEU A 114
TYR A  87
 None
 1.41A 5nooD-2a81A:
undetectable		 5nooD-2a81A:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		6 ARG A  70
ILE A 100
ASP A 219
LEU A 222
GLY A 223
TYR A 259
 None
CB3  A2351 (-3.6A)
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
 1.38A 5nooD-2aazA:
undetectable		 5nooD-2aazA:
49.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		5 ILE A 100
LEU A 222
GLY A 223
PHE A 226
TYR A 259
 CB3  A2351 (-3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 (-3.8A)
CB3  A2351 ( 4.3A)
 1.14A 5nooD-2aazA:
undetectable		 5nooD-2aazA:
49.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amy PHOSPHOMANNOMUTASE 2

(Homo sapiens) 		PF03332
(PMM) 		4 ILE A 240
ASP A 209
GLY A 208
PHE A 207
 None
 0.83A 5nooD-2amyA:
undetectable		 5nooD-2amyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 ARG A 270
TYR A 271
ASP A 275
GLY A 274
 None
 0.71A 5nooD-2b5mA:
undetectable		 5nooD-2b5mA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ARG A 287
ILE A 320
LEU A 386
GLY A 385
 None
 0.92A 5nooD-2bwsA:
undetectable		 5nooD-2bwsA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 185
GLY A 180
PHE A 179
TYR A   3
 None
 0.84A 5nooD-2cb1A:
undetectable		 5nooD-2cb1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjk NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
4

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		5 ARG A 198
LEU A 166
GLY A 164
PHE A 202
TYR A 178
 None
None
U  B   5 ( 2.4A)
U  B   5 ( 3.0A)
None
 1.47A 5nooD-2cjkA:
undetectable		 5nooD-2cjkA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2col BIFUNCTIONAL
HEMOLYSIN-ADENYLATE
CYCLASE

(Bordetella
pertussis) 		PF03497
(Anthrax_toxA) 		4 ARG A  41
ILE A  27
PHE A 314
TYR A 342
 None
 0.91A 5nooD-2colA:
undetectable		 5nooD-2colA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 ARG A 472
ILE A 414
GLY A 560
PHE A 562
 None
 0.88A 5nooD-2d0vA:
undetectable		 5nooD-2d0vA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 ARG A 343
ILE A  37
LEU A 372
GLY A 373
 None
 0.90A 5nooD-2dkhA:
undetectable		 5nooD-2dkhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 ILE A 339
ASP A 272
LEU A 320
GLY A 319
 None
 0.89A 5nooD-2exrA:
undetectable		 5nooD-2exrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 447
LEU A 512
GLY A 513
PHE A 514
 None
 0.89A 5nooD-2fqdA:
undetectable		 5nooD-2fqdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		5 ARG A 190
ILE A 151
ASP A  45
GLY A  49
PHE A  51
 None
 1.30A 5nooD-2gk9A:
undetectable		 5nooD-2gk9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gxf HYPOTHETICAL PROTEIN
YYBH

(Bacillus
subtilis) 		PF13474
(SnoaL_3) 		4 TYR A 104
ILE A   9
LEU A  72
PHE A 106
 MES  A 201 (-3.3A)
MES  A 201 (-4.2A)
None
MES  A 201 (-4.7A)
 0.81A 5nooD-2gxfA:
undetectable		 5nooD-2gxfA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti) 		PF00285
(Citrate_synt) 		4 TYR A 367
ASP A 371
GLY A 310
PHE A 311
 None
CMX  A5001 (-2.8A)
CMX  A5001 (-3.4A)
None
 0.82A 5nooD-2h12A:
undetectable		 5nooD-2h12A:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		7 ARG A 286
ILE A 316
ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 None
None
None
None
DU  A 611 (-3.5A)
None
DU  A 611 (-4.6A)
 0.78A 5nooD-2h2qA:
26.1		 5nooD-2h2qA:
36.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		5 ILE A 272
ASP A 308
LEU A 311
GLY A 307
TYR A  14
 None
 1.37A 5nooD-2h6tA:
undetectable		 5nooD-2h6tA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hh6 BH3980 PROTEIN

(Bacillus
halodurans) 		PF06304
(DUF1048) 		5 ILE A  38
ASP A  63
LEU A  62
GLY A  59
PHE A  58
 None
 1.28A 5nooD-2hh6A:
undetectable		 5nooD-2hh6A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i53 CYCLIN K

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 ILE A 117
ASP A 134
GLY A 133
PHE A 132
 None
 0.86A 5nooD-2i53A:
undetectable		 5nooD-2i53A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idv EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-1

(Triticum
aestivum) 		PF01652
(IF4E) 		4 ILE A 166
ASP A 148
GLY A 147
PHE A 144
 None
 0.73A 5nooD-2idvA:
undetectable		 5nooD-2idvA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivg CYANATE LYASE

(Escherichia
coli) 		PF02560
(Cyanate_lyase) 		4 ILE A 121
ASP A 118
GLY A 117
PHE A 116
 None
 0.89A 5nooD-2ivgA:
undetectable		 5nooD-2ivgA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 5 ARG B 615
TYR B 607
LEU B 665
GLY B 664
TYR B 286
 None
 1.44A 5nooD-2j04B:
undetectable		 5nooD-2j04B:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00156
(Pribosyltran) 		4 TYR A 202
ILE A 215
GLY A 197
PHE A 206
 None
 0.74A 5nooD-2jbhA:
undetectable		 5nooD-2jbhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4j PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Helicobacter
pylori) 		PF00486
(Trans_reg_C) 		4 ILE A  23
LEU A 113
GLY A  58
TYR A 111
 None
 0.86A 5nooD-2k4jA:
undetectable		 5nooD-2k4jA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5i IRON TRANSPORT
PROTEIN

(Ruminiclostridium
thermocellum) 		PF04023
(FeoA) 		5 ARG A 120
TYR A 121
ILE A 138
LEU A 106
GLY A 107
 None
 1.21A 5nooD-2k5iA:
undetectable		 5nooD-2k5iA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2

(Gallus gallus) 		PF01115
(F_actin_cap_B)
PF01267
(F-actin_cap_A) 		4 TYR A 198
ILE B 531
LEU B 489
GLY B 490
 None
 0.85A 5nooD-2kxpA:
undetectable		 5nooD-2kxpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzr UBIQUITIN
THIOESTERASE OTU1

(Mus musculus) 		no annotation 4 ARG A   4
ILE A  33
LEU A  17
GLY A  16
 None
 0.71A 5nooD-2kzrA:
undetectable		 5nooD-2kzrA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		4 ILE A 243
LEU A 221
GLY A  85
PHE A  87
 None
 0.89A 5nooD-2nq2A:
undetectable		 5nooD-2nq2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C) 		4 TYR A 137
ILE A  99
LEU A 180
GLY A 164
 None
None
None
EDO  A7009 (-4.7A)
 0.82A 5nooD-2nttA:
undetectable		 5nooD-2nttA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		4 TYR A 183
ILE A 211
ASP A 190
GLY A 191
 None
 0.88A 5nooD-2nuxA:
undetectable		 5nooD-2nuxA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		4 ILE A 355
GLY A 247
PHE A 249
TYR A 214
 None
 0.88A 5nooD-2o1oA:
undetectable		 5nooD-2o1oA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ILE A 315
ASP A 426
LEU A 429
GLY A 430
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
 0.78A 5nooD-2oipA:
20.3		 5nooD-2oipA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ILE A 315
LEU A 429
GLY A 430
PHE A 433
TYR A 466
 CB3  A 604 ( 3.7A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
CB3  A 604 ( 3.9A)
UMP  A 603 ( 4.3A)
 1.25A 5nooD-2oipA:
20.3		 5nooD-2oipA:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5z TYPE VI SECRETION
SYSTEM COMPONENT

(Escherichia
coli) 		PF05954
(Phage_GPD) 		4 ARG X  42
TYR X  43
ASP X  63
GLY X  64
 None
 0.85A 5nooD-2p5zX:
undetectable		 5nooD-2p5zX:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF03009
(GDPD) 		4 TYR A 166
ILE A 156
LEU A  90
TYR A 176
 None
 0.84A 5nooD-2p76A:
undetectable		 5nooD-2p76A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ARG A 289
ILE A 112
ASP A 191
LEU A 190
 None
 0.84A 5nooD-2q3zA:
undetectable		 5nooD-2q3zA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfc PLCR PROTEIN

(Bacillus
thuringiensis) 		PF01381
(HTH_3) 		4 ILE A 135
ASP A 176
LEU A 177
GLY A 174
 None
 0.91A 5nooD-2qfcA:
undetectable		 5nooD-2qfcA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis) 		PF03401
(TctC) 		4 ARG A  27
ILE A 250
GLY A 231
TYR A 101
 None
 0.74A 5nooD-2qpqA:
undetectable		 5nooD-2qpqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		4 ILE A 251
ASP A 301
GLY A 303
PHE A 307
 None
None
None
CMC  A 701 ( 4.3A)
 0.87A 5nooD-2r26A:
undetectable		 5nooD-2r26A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		4 TYR A 313
ASP A 317
GLY A 259
PHE A 260
 None
CMC  A 701 (-2.7A)
CMC  A 701 (-3.3A)
None
 0.85A 5nooD-2r26A:
undetectable		 5nooD-2r26A:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		4 ILE A  81
ASP A 221
GLY A 225
TYR A 261
 THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
 0.67A 5nooD-2tddA:
32.8		 5nooD-2tddA:
41.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ARG A 450
ILE A 675
ASP A 651
LEU A 650
 None
 0.88A 5nooD-2vdcA:
undetectable		 5nooD-2vdcA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vod LUPUS LA PROTEIN

(Homo sapiens) 		PF00076
(RRM_1)
PF05383
(La) 		4 ILE A  40
ASP A  27
GLY A  26
PHE A  25
 None
 0.90A 5nooD-2vodA:
undetectable		 5nooD-2vodA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		5 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
 None
 1.23A 5nooD-2wedA:
undetectable		 5nooD-2wedA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Pisum sativum) 		PF01652
(IF4E) 		4 ILE A 179
ASP A 161
GLY A 160
PHE A 157
 None
 0.63A 5nooD-2wmcA:
undetectable		 5nooD-2wmcA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 ILE A 240
GLY A 147
PHE A 140
TYR A 109
 DLL  A1441 (-4.7A)
DLL  A1441 (-3.6A)
DLL  A1441 (-3.6A)
None
 0.78A 5nooD-2y4oA:
undetectable		 5nooD-2y4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		4 ARG D 313
ILE D 326
ASP D 304
GLY D 305
 None
 0.75A 5nooD-2ynmD:
undetectable		 5nooD-2ynmD:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ARG A 132
ILE A 173
ASP A 162
LEU A 161
PHE A 164
 PLP  A 401 ( 4.0A)
None
None
None
None
 0.98A 5nooD-2yxxA:
undetectable		 5nooD-2yxxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		5 ARG B  40
ASP B  47
LEU B  48
GLY B  46
PHE B  45
 None
 1.48A 5nooD-3a0gB:
undetectable		 5nooD-3a0gB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ILE A  18
LEU A 154
GLY A 322
TYR A 152
 None
 0.84A 5nooD-3a31A:
undetectable		 5nooD-3a31A:
20.13