SIMILAR PATTERNS OF AMINO ACIDS FOR 5NOO_B_D16B402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana)
PF01261
(AP_endonuc_2)
4 TYR A 370
ILE A 325
GLY A 365
PHE A 366
None
0.88A 5nooB-1a0eA:
0.0
5nooB-1a0eA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua)
PF00026
(Asp)
4 ASP A 303
GLY A 302
PHE A 301
TYR A  14
None
0.80A 5nooB-1am5A:
undetectable
5nooB-1am5A:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bsf THYMIDYLATE SYNTHASE
A


(Bacillus
subtilis)
PF00303
(Thymidylat_synt)
5 ILE A  93
ASP A 184
GLY A 188
PHE A 191
TYR A 224
None
0.56A 5nooB-1bsfA:
30.7
5nooB-1bsfA:
34.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)


(Pneumocystis
carinii)
PF00303
(Thymidylat_synt)
5 ASP A 202
LEU A 205
GLY A 206
PHE A 209
TYR A 242
CB3  A 768 ( 3.6A)
CB3  A 768 ( 4.4A)
UMP  A 767 (-3.7A)
CB3  A 768 (-3.6A)
CB3  A 768 ( 4.7A)
0.73A 5nooB-1ci7A:
41.0
5nooB-1ci7A:
53.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)


(Pneumocystis
carinii)
PF00303
(Thymidylat_synt)
5 ILE A  86
ASP A 202
GLY A 206
PHE A 209
TYR A 242
CB3  A 768 (-3.6A)
CB3  A 768 ( 3.6A)
UMP  A 767 (-3.7A)
CB3  A 768 (-3.6A)
CB3  A 768 ( 4.7A)
0.62A 5nooB-1ci7A:
41.0
5nooB-1ci7A:
53.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cov COXSACKIEVIRUS COAT
PROTEIN


(Enterovirus B)
PF00073
(Rhv)
4 ILE 3 114
LEU 3 104
GLY 3 101
PHE 3  95
None
0.69A 5nooB-1cov3:
0.0
5nooB-1cov3:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv5 STROMELYSIN 3

(Mus musculus)
PF00413
(Peptidase_M10)
4 ILE A 159
LEU A 225
GLY A 222
PHE A 221
None
0.84A 5nooB-1hv5A:
0.0
5nooB-1hv5A:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens)
PF00303
(Thymidylat_synt)
6 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
0.68A 5nooB-1hvyA:
41.7
5nooB-1hvyA:
62.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae)
PF00026
(Asp)
5 ASP A 300
LEU A 303
GLY A 299
PHE A 298
TYR A  17
None
1.17A 5nooB-1izeA:
undetectable
5nooB-1izeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF03971
(IDH)
4 ASP A 655
GLY A 658
PHE A 661
TYR A 598
None
0.88A 5nooB-1j1wA:
0.0
5nooB-1j1wA:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
falciparum)
PF00303
(Thymidylat_synt)
4 ASP C 513
LEU C 516
GLY C 517
TYR C 553
UMP  C 611 (-4.9A)
None
UMP  C 611 (-3.5A)
UMP  C 611 (-4.9A)
0.70A 5nooB-1j3jC:
39.6
5nooB-1j3jC:
49.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
falciparum)
PF00303
(Thymidylat_synt)
4 ILE C 403
ASP C 513
GLY C 517
TYR C 553
None
UMP  C 611 (-4.9A)
UMP  C 611 (-3.5A)
UMP  C 611 (-4.9A)
0.48A 5nooB-1j3jC:
39.6
5nooB-1j3jC:
49.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n71 AAC(6')-II

(Enterococcus
faecium)
PF00583
(Acetyltransf_1)
4 TYR A 144
ILE A 154
LEU A 109
GLY A 110
None
0.62A 5nooB-1n71A:
undetectable
5nooB-1n71A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6y HYPOTHETICAL PROTEIN
YFDW


(Escherichia
coli)
PF02515
(CoA_transf_3)
4 TYR A 225
ASP A 239
GLY A 238
PHE A 237
None
0.84A 5nooB-1q6yA:
undetectable
5nooB-1q6yA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus)
PF00626
(Gelsolin)
4 TYR G 133
ILE G  70
LEU G 138
GLY G  60
None
0.84A 5nooB-1rgiG:
undetectable
5nooB-1rgiG:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE


(Cryptococcus
neoformans)
PF00475
(IGPD)
4 ILE A 181
LEU A  81
GLY A  82
PHE A  85
None
0.81A 5nooB-1rhyA:
undetectable
5nooB-1rhyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
4 ILE A  45
LEU A 210
GLY A 211
PHE A 214
None
0.57A 5nooB-1rtrA:
undetectable
5nooB-1rtrA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4)
PF00303
(Thymidylat_synt)
4 ASP A 179
GLY A 183
PHE A 186
TYR A 219
None
0.57A 5nooB-1tisA:
30.2
5nooB-1tisA:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4)
PF00303
(Thymidylat_synt)
4 ASP A 179
LEU A 182
GLY A 183
TYR A 219
None
0.57A 5nooB-1tisA:
30.2
5nooB-1tisA:
39.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3


(Homo sapiens)
PF01088
(Peptidase_C12)
4 ILE A 225
LEU A 100
GLY A  99
PHE A 170
None
0.85A 5nooB-1uchA:
undetectable
5nooB-1uchA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upn ECHOVIRUS 11 COAT
PROTEIN VP3


(Enterovirus B)
PF00073
(Rhv)
4 ILE C 114
LEU C 104
GLY C 101
PHE C  95
None
0.77A 5nooB-1upnC:
undetectable
5nooB-1upnC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE


(Sulfurisphaera
tokodaii)
PF00285
(Citrate_synt)
4 TYR A 310
ASP A 314
GLY A 256
PHE A 257
None
GOL  A 401 ( 4.5A)
None
None
0.79A 5nooB-1vgmA:
undetectable
5nooB-1vgmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
4 ILE A 831
LEU A 856
GLY A 855
PHE A 854
None
0.88A 5nooB-1zy4A:
undetectable
5nooB-1zy4A:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans)
PF00303
(Thymidylat_synt)
4 ASP A 219
LEU A 222
GLY A 223
TYR A 259
CB3  A2351 ( 3.6A)
CB3  A2351 (-4.1A)
CB3  A2351 ( 3.2A)
CB3  A2351 ( 4.3A)
0.76A 5nooB-2aazA:
undetectable
5nooB-2aazA:
49.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE


(Thermus
thermophilus)
PF01053
(Cys_Met_Meta_PP)
4 LEU A 185
GLY A 180
PHE A 179
TYR A   3
None
0.88A 5nooB-2cb1A:
undetectable
5nooB-2cb1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7


(Arabidopsis
thaliana)
PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind)
4 ILE A 339
ASP A 272
LEU A 320
GLY A 319
None
0.89A 5nooB-2exrA:
undetectable
5nooB-2exrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti)
PF00285
(Citrate_synt)
4 TYR A 367
ASP A 371
GLY A 310
PHE A 311
None
CMX  A5001 (-2.8A)
CMX  A5001 (-3.4A)
None
0.81A 5nooB-2h12A:
undetectable
5nooB-2h12A:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Trypanosoma
cruzi)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 ASP A 426
LEU A 429
GLY A 430
PHE A 433
TYR A 466
None
None
DU  A 611 (-3.5A)
None
DU  A 611 (-4.6A)
0.79A 5nooB-2h2qA:
40.8
5nooB-2h2qA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Trypanosoma
cruzi)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 ILE A 316
ASP A 426
GLY A 430
PHE A 433
TYR A 466
None
None
DU  A 611 (-3.5A)
None
DU  A 611 (-4.6A)
0.59A 5nooB-2h2qA:
40.8
5nooB-2h2qA:
36.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i53 CYCLIN K

(Homo sapiens)
PF00134
(Cyclin_N)
PF02984
(Cyclin_C)
4 ILE A 117
ASP A 134
GLY A 133
PHE A 132
None
0.86A 5nooB-2i53A:
undetectable
5nooB-2i53A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idv EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-1


(Triticum
aestivum)
PF01652
(IF4E)
4 ILE A 166
ASP A 148
GLY A 147
PHE A 144
None
0.72A 5nooB-2idvA:
undetectable
5nooB-2idvA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE


(Cryptosporidium
parvum)
PF00348
(polyprenyl_synt)
4 ILE A 355
GLY A 247
PHE A 249
TYR A 214
None
0.88A 5nooB-2o1oA:
undetectable
5nooB-2o1oA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR


(Cryptosporidium
hominis)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
4 ASP A 426
LEU A 429
GLY A 430
TYR A 466
CB3  A 604 ( 3.9A)
CB3  A 604 ( 4.4A)
CB3  A 604 ( 3.4A)
UMP  A 603 ( 4.3A)
0.77A 5nooB-2oipA:
40.1
5nooB-2oipA:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfc PLCR PROTEIN

(Bacillus
thuringiensis)
PF01381
(HTH_3)
4 ILE A 135
ASP A 176
LEU A 177
GLY A 174
None
0.88A 5nooB-2qfcA:
undetectable
5nooB-2qfcA:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei)
PF00303
(Thymidylat_synt)
4 ILE A  81
ASP A 221
GLY A 225
TYR A 261
THF  A 568 ( 4.8A)
UFP  A 529 (-4.7A)
UFP  A 529 ( 4.0A)
UFP  A 529 (-4.7A)
0.64A 5nooB-2tddA:
32.7
5nooB-2tddA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei)
PF00303
(Thymidylat_synt)
4 LEU A 224
GLY A 225
PHE A 228
TYR A 261
THF  A 568 (-3.6A)
UFP  A 529 ( 4.0A)
THF  A 568 (-4.8A)
UFP  A 529 (-4.7A)
0.89A 5nooB-2tddA:
32.7
5nooB-2tddA:
41.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum)
PF00026
(Asp)
4 ASP A 300
GLY A 299
PHE A 298
TYR A  17
None
0.73A 5nooB-2wedA:
undetectable
5nooB-2wedA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E


(Pisum sativum)
PF01652
(IF4E)
4 ILE A 179
ASP A 161
GLY A 160
PHE A 157
None
0.64A 5nooB-2wmcA:
undetectable
5nooB-2wmcA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN-TYPE


(Toxoplasma
gondii)
PF00160
(Pro_isomerase)
4 ILE A 121
ASP A 144
LEU A 143
GLY A 142
None
0.75A 5nooB-3bo7A:
undetectable
5nooB-3bo7A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE


(Trichoderma
reesei)
PF00026
(Asp)
5 ASP A 304
LEU A 307
GLY A 303
PHE A 302
TYR A  14
None
1.16A 5nooB-3emyA:
undetectable
5nooB-3emyA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale)
PF00266
(Aminotran_5)
4 TYR A 121
LEU A 129
GLY A 128
PHE A 126
GOL  A 361 (-4.1A)
None
None
None
0.83A 5nooB-3f0hA:
undetectable
5nooB-3f0hA:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ix6 THYMIDYLATE SYNTHASE

(Brucella
melitensis)
PF00303
(Thymidylat_synt)
4 ASP A 169
LEU A 172
GLY A 173
TYR A 209
None
0.86A 5nooB-3ix6A:
32.8
5nooB-3ix6A:
38.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ix6 THYMIDYLATE SYNTHASE

(Brucella
melitensis)
PF00303
(Thymidylat_synt)
4 ILE A  79
ASP A 169
GLY A 173
TYR A 209
None
0.49A 5nooB-3ix6A:
32.8
5nooB-3ix6A:
38.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyj MAJOR CAPSID PROTEIN
L1


(Deltapapillomavirus
4)
no annotation 4 ILE F  99
LEU F 461
GLY F 462
PHE F 465
None
0.84A 5nooB-3iyjF:
undetectable
5nooB-3iyjF:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kgb THYMIDYLATE SYNTHASE
1/2


(Encephalitozoon
cuniculi)
PF00303
(Thymidylat_synt)
4 LEU A 200
GLY A 201
PHE A 204
TYR A 237
None
0.76A 5nooB-3kgbA:
36.6
5nooB-3kgbA:
50.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE


(Babesia bovis)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
4 ASP A 416
LEU A 419
GLY A 420
TYR A 456
None
0.71A 5nooB-3kjrA:
39.4
5nooB-3kjrA:
35.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 GASTRIC INTRINSIC
FACTOR


(Homo sapiens)
PF01122
(Cobalamin_bind)
PF14478
(DUF4430)
4 TYR A 195
ILE A 187
GLY A 200
PHE A 199
None
0.87A 5nooB-3kq4A:
undetectable
5nooB-3kq4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE


(Pseudomonas
aeruginosa)
PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N)
4 ILE A 128
LEU A 113
GLY A 193
PHE A 210
None
0.84A 5nooB-3r5bA:
undetectable
5nooB-3r5bA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suj CERATO-PLATANIN 1

(Moniliophthora
perniciosa)
PF07249
(Cerato-platanin)
4 TYR A  29
ILE A 101
GLY A  56
PHE A  55
None
0.76A 5nooB-3sujA:
undetectable
5nooB-3sujA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uca GERANYLTRANSTRANSFER
ASE


(Clostridium
perfringens)
PF00348
(polyprenyl_synt)
4 ILE A  54
LEU A 220
GLY A 221
PHE A 224
None
0.75A 5nooB-3ucaA:
undetectable
5nooB-3ucaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
falciparum)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
4 ASP A 513
LEU A 516
GLY A 517
TYR A 553
UMP  A 611 (-4.9A)
None
UMP  A 611 (-3.3A)
UMP  A 611 (-4.5A)
0.72A 5nooB-3um6A:
39.3
5nooB-3um6A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
falciparum)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
4 ILE A 403
ASP A 513
GLY A 517
TYR A 553
None
UMP  A 611 (-4.9A)
UMP  A 611 (-3.3A)
UMP  A 611 (-4.5A)
0.46A 5nooB-3um6A:
39.3
5nooB-3um6A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE


(Pseudoalteromonas
sp. BB1)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
4 ILE A 210
ASP A 287
GLY A 288
PHE A 289
None
0.64A 5nooB-3uszA:
undetectable
5nooB-3uszA:
17.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis)
PF00303
(Thymidylat_synt)
5 ASP A 217
LEU A 220
GLY A 221
PHE A 224
TYR A 257
None
None
None
None
CIT  A 400 (-4.5A)
0.85A 5nooB-3v8hA:
33.4
5nooB-3v8hA:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg8 PENICILLIN-BINDING
PROTEIN 4


(Listeria
monocytogenes)
PF00905
(Transpeptidase)
PF00912
(Transgly)
4 TYR B 213
ILE B 229
ASP B 220
PHE B 214
None
0.81A 5nooB-3zg8B:
undetectable
5nooB-3zg8B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION


(Staphylothermus
marinus)
PF00128
(Alpha-amylase)
4 ILE A 447
LEU A 472
GLY A 470
TYR A 489
None
0.85A 5nooB-4aeeA:
undetectable
5nooB-4aeeA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli)
PF00350
(Dynamin_N)
4 ILE A 158
ASP A  90
GLY A 111
PHE A 113
None
0.89A 5nooB-4aurA:
undetectable
5nooB-4aurA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus)
PF00303
(Thymidylat_synt)
4 ASP A 224
LEU A 227
GLY A 228
TYR A 264
None
None
UMP  A 501 ( 4.0A)
UMP  A 501 (-4.2A)
0.81A 5nooB-4dq1A:
33.4
5nooB-4dq1A:
44.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus)
PF00303
(Thymidylat_synt)
5 ILE A  84
ASP A 224
GLY A 228
PHE A 231
TYR A 264
None
None
UMP  A 501 ( 4.0A)
None
UMP  A 501 (-4.2A)
0.44A 5nooB-4dq1A:
33.4
5nooB-4dq1A:
44.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fog THYMIDYLATE SYNTHASE

(Mycobacterium
tuberculosis)
PF00303
(Thymidylat_synt)
4 ILE A  79
ASP A 169
GLY A 173
TYR A 209
C2F  A 302 (-3.3A)
C2F  A 302 ( 3.9A)
C2F  A 302 (-3.2A)
C2F  A 302 ( 4.6A)
0.65A 5nooB-4fogA:
35.6
5nooB-4fogA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h0u THYMIDYLATE SYNTHASE

(Corynebacterium
glutamicum)
PF00303
(Thymidylat_synt)
4 ASP A 172
LEU A 175
GLY A 176
TYR A 212
None
None
UMP  A 301 (-3.6A)
UMP  A 301 (-4.5A)
0.80A 5nooB-4h0uA:
35.2
5nooB-4h0uA:
42.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h0u THYMIDYLATE SYNTHASE

(Corynebacterium
glutamicum)
PF00303
(Thymidylat_synt)
4 ILE A  82
ASP A 172
GLY A 176
TYR A 212
None
None
UMP  A 301 (-3.6A)
UMP  A 301 (-4.5A)
0.40A 5nooB-4h0uA:
35.2
5nooB-4h0uA:
42.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2


(Streptococcus
pneumoniae)
PF12849
(PBP_like_2)
4 ILE A 212
LEU A 143
GLY A 144
PHE A 147
None
0.59A 5nooB-4h1xA:
undetectable
5nooB-4h1xA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN


(Saccharomyces
cerevisiae)
PF00248
(Aldo_ket_red)
4 ILE A 292
LEU A  36
GLY A  37
TYR A  24
None
0.77A 5nooB-4ijrA:
undetectable
5nooB-4ijrA:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqq THYMIDYLATE SYNTHASE

(Caenorhabditis
elegans)
PF00303
(Thymidylat_synt)
7 TYR A  82
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
D16  A 402 (-3.6A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
0.28A 5nooB-4iqqA:
46.2
5nooB-4iqqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmq BACTERIOPHAGE T5
DISTAL TAIL PROTEIN


(Escherichia
virus T5)
no annotation 4 TYR A  62
ILE A 196
LEU A  15
GLY A  14
None
0.83A 5nooB-4jmqA:
undetectable
5nooB-4jmqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG


(Salmonella
enterica)
PF03372
(Exo_endo_phos)
4 ILE F 124
ASP F 131
LEU F 151
GLY F 150
None
0.77A 5nooB-4k6lF:
undetectable
5nooB-4k6lF:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzs LPP20 LIPOFAMILY
PROTEIN


(Helicobacter
pylori)
PF02169
(LPP20)
4 ILE A 171
ASP A 130
GLY A 127
PHE A 124
None
0.88A 5nooB-4kzsA:
undetectable
5nooB-4kzsA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohq TRIOSEPHOSPHATE
ISOMERASE,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00121
(TIM)
5 ILE A  60
ASP A  28
LEU A  25
GLY A 239
PHE A 242
None
1.32A 5nooB-4ohqA:
undetectable
5nooB-4ohqA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY


(Shewanella
oneidensis)
PF07804
(HipA_C)
PF13657
(Couple_hipA)
4 ILE A  95
ASP A  75
LEU A  74
GLY A  73
None
0.88A 5nooB-4pu5A:
undetectable
5nooB-4pu5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhh ESTERASE

(Thermogutta
terrifontis)
PF00561
(Abhydrolase_1)
4 ILE A 154
ASP A  38
LEU A  37
PHE A  35
None
0.87A 5nooB-4uhhA:
undetectable
5nooB-4uhhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x04 SOLUTE BINDING
PROTEIN


(Citrobacter
koseri)
PF03480
(DctP)
4 TYR A 244
ILE A 260
LEU A 242
GLY A 146
None
0.83A 5nooB-4x04A:
undetectable
5nooB-4x04A:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3)
PF00303
(Thymidylat_synt)
4 ASP A 206
LEU A 209
GLY A 210
TYR A 246
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
0.74A 5nooB-4xscA:
39.2
5nooB-4xscA:
56.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3)
PF00303
(Thymidylat_synt)
5 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
0.37A 5nooB-4xscA:
39.2
5nooB-4xscA:
56.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis)
PF00303
(Thymidylat_synt)
4 ASP A 212
LEU A 215
GLY A 216
TYR A 252
None
None
UMP  A 401 (-3.5A)
UMP  A 401 (-4.6A)
0.78A 5nooB-5by6A:
42.8
5nooB-5by6A:
58.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis)
PF00303
(Thymidylat_synt)
5 ILE A 102
ASP A 212
GLY A 216
PHE A 219
TYR A 252
DTT  A 402 ( 4.3A)
None
UMP  A 401 (-3.5A)
DTT  A 402 ( 4.1A)
UMP  A 401 (-4.6A)
0.39A 5nooB-5by6A:
42.8
5nooB-5by6A:
58.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi)
PF01400
(Astacin)
4 ILE A  94
LEU A 148
GLY A 145
PHE A 144
None
0.88A 5nooB-5czwA:
undetectable
5nooB-5czwA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E


(Corynebacterium
glutamicum)
PF14602
(Hexapep_2)
PF14789
(THDPS_M)
4 ILE A  89
LEU A  74
GLY A 153
PHE A 170
None
0.70A 5nooB-5e3qA:
undetectable
5nooB-5e3qA:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h3a ORF70

(Human
gammaherpesvirus
8)
PF00303
(Thymidylat_synt)
5 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
0.28A 5nooB-5h3aA:
42.2
5nooB-5h3aA:
58.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
5 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
None
1.14A 5nooB-5hctA:
undetectable
5nooB-5hctA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j7w THYMIDYLATE SYNTHASE

(Enterococcus
faecalis)
PF00303
(Thymidylat_synt)
4 ASP A 220
LEU A 223
GLY A 224
TYR A 260
None
0.80A 5nooB-5j7wA:
33.1
5nooB-5j7wA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j7w THYMIDYLATE SYNTHASE

(Enterococcus
faecalis)
PF00303
(Thymidylat_synt)
4 ILE A  80
ASP A 220
GLY A 224
TYR A 260
None
0.64A 5nooB-5j7wA:
33.1
5nooB-5j7wA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j7w THYMIDYLATE SYNTHASE

(Enterococcus
faecalis)
PF00303
(Thymidylat_synt)
4 ILE A  80
GLY A 224
PHE A 227
TYR A 260
None
0.65A 5nooB-5j7wA:
33.1
5nooB-5j7wA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j7w THYMIDYLATE SYNTHASE

(Enterococcus
faecalis)
PF00303
(Thymidylat_synt)
4 LEU A 223
GLY A 224
PHE A 227
TYR A 260
None
0.83A 5nooB-5j7wA:
33.1
5nooB-5j7wA:
43.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP3

(Rhinovirus C)
PF00073
(Rhv)
4 ILE B 112
LEU B 102
GLY B  99
PHE B  93
None
0.88A 5nooB-5k0uB:
undetectable
5nooB-5k0uB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me6 EUKARYOTIC
TRANSCRIPTION
INITIATION FACTOR 4E


(Cucumis melo)
PF01652
(IF4E)
4 ILE A 186
ASP A 168
GLY A 167
PHE A 164
ILE  A 186 ( 0.7A)
ASP  A 168 ( 0.6A)
GLY  A 167 ( 0.0A)
PHE  A 164 ( 1.3A)
0.88A 5nooB-5me6A:
undetectable
5nooB-5me6A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5min QUINOPROTEIN GLUCOSE
DEHYDROGENASE B


(Acinetobacter
calcoaceticus)
no annotation 4 ILE A  94
LEU A 149
GLY A  81
PHE A  82
None
0.74A 5nooB-5minA:
undetectable
5nooB-5minA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
5 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
None
1.13A 5nooB-5p60A:
undetectable
5nooB-5p60A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1


(Mus musculus)
PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3)
4 ILE B 271
ASP B 147
GLY B 148
PHE B 149
None
0.85A 5nooB-5sy5B:
undetectable
5nooB-5sy5B:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Toxoplasma
gondii)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 ASP A 513
LEU A 516
GLY A 517
PHE A 520
TYR A 553
CB3  A 703 ( 3.8A)
CB3  A 703 (-3.7A)
CB3  A 703 ( 3.0A)
CB3  A 703 (-3.8A)
UMP  A 701 (-4.4A)
0.48A 5nooB-5t0lA:
40.6
5nooB-5t0lA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Toxoplasma
gondii)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
4 ILE A 402
LEU A 516
GLY A 517
PHE A 520
CB3  A 703 (-3.4A)
CB3  A 703 (-3.7A)
CB3  A 703 ( 3.0A)
CB3  A 703 (-3.8A)
0.54A 5nooB-5t0lA:
40.6
5nooB-5t0lA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgr ATLASTIN-3

(Homo sapiens)
PF02263
(GBP)
PF02841
(GBP_C)
4 ILE A 178
GLY A 228
PHE A 231
TYR A 299
None
0.82A 5nooB-5vgrA:
undetectable
5nooB-5vgrA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica)
no annotation 4 TYR M 278
ILE M 253
LEU M 312
GLY M 311
None
0.87A 5nooB-5wc8M:
undetectable
5nooB-5wc8M:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23


(Caenorhabditis
elegans)
no annotation 4 ILE A 949
LEU A1031
GLY A1030
PHE A1029
None
0.74A 5nooB-5wnoA:
undetectable
5nooB-5wnoA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xz3 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN


(Apis mellifera)
no annotation 4 TYR A  72
ILE A  70
GLY A  87
TYR A  26
None
0.87A 5nooB-5xz3A:
undetectable
5nooB-5xz3A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6auj THYMIDYLATE SYNTHASE

(Elizabethkingia
anophelis)
PF00303
(Thymidylat_synt)
5 ILE A  87
ASP A 177
GLY A 181
PHE A 184
TYR A 217
PGE  A 301 ( 4.2A)
None
PGE  A 301 ( 4.0A)
PGE  A 301 (-3.7A)
None
0.54A 5nooB-6aujA:
33.4
5nooB-6aujA:
43.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cdz THYMIDYLATE SYNTHASE

(Escherichia
coli)
no annotation 6 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
0.56A 5nooB-6cdzA:
35.6
5nooB-6cdzA:
39.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE


(Saccharomyces
cerevisiae)
no annotation 4 ILE U 200
LEU U 100
GLY U 101
PHE U 104
None
0.84A 5nooB-6ezmU:
undetectable
5nooB-6ezmU:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkx ACETYL XYLAN
ESTERASE


(metagenome)
no annotation 4 TYR C  93
LEU C 190
GLY C 189
PHE C 210
None
0.77A 5nooB-6fkxC:
undetectable
5nooB-6fkxC:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2


(Aspergillus
oryzae)
no annotation 4 TYR A 411
ILE A 363
GLY A 371
PHE A 410
None
0.77A 5nooB-6g21A:
undetectable
5nooB-6g21A:
15.20