SIMILAR PATTERNS OF AMINO ACIDS FOR 5NO9_D_95ZD302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqc EXO-(B)-(1,3)-GLUCAN
ASE

(Candida
albicans) 		PF00150
(Cellulase) 		4 GLY A 359
ASP A 251
HIS A 254
ASN A 288
 None
 1.08A 5no9D-1eqcA:
0.0		 5no9D-1eqcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		4 GLY A 381
ASP A 406
HIS A 192
ASP A 380
 None
 0.99A 5no9D-1gjuA:
undetectable		 5no9D-1gjuA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htq GLUTAMINE SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 GLY A 300
HIS A 303
ASP A 424
ASP A 380
 None
 1.05A 5no9D-1htqA:
0.0		 5no9D-1htqA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq0 METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 GLY A 330
HIS A 331
ASP A 262
HIS A 231
 None
ZN  A 480 ( 3.4A)
ZN  A 479 (-2.2A)
MED  A 601 (-4.2A)
 0.82A 5no9D-1kq0A:
0.0		 5no9D-1kq0A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0x METHIONINE
AMINOPEPTIDASE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24) 		4 GLY A 173
HIS A 174
ASP A 111
HIS A  82
 None
 0.81A 5no9D-1o0xA:
0.5		 5no9D-1o0xA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 GLY A 283
HIS A 284
ASP A 220
HIS A 192
 None
ZN  A 401 (-3.3A)
ZN  A 402 ( 2.4A)
None
 0.74A 5no9D-1pv9A:
0.0		 5no9D-1pv9A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxy METHIONYL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00557
(Peptidase_M24) 		4 GLY A 167
HIS A 168
ASP A 104
HIS A  76
 None
CO  A1001 (-3.3A)
CO  A1002 (-2.4A)
M2C  A3001 ( 4.5A)
 0.86A 5no9D-1qxyA:
0.0		 5no9D-1qxyA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6m RIBONUCLEASE PH

(Pseudomonas
aeruginosa) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 ASP A 123
GLY A 124
ASP A  35
ASP A 177
 None
PO4  A 242 ( 4.1A)
None
None
 1.07A 5no9D-1r6mA:
0.0		 5no9D-1r6mA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		4 GLY A 237
ASP A 232
HIS A 202
ASN A 411
 None
 1.01A 5no9D-1sqgA:
0.0		 5no9D-1sqgA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 195
ASP A 249
HIS A  89
ASP A 194
 None
 1.09A 5no9D-1uokA:
undetectable		 5no9D-1uokA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 ASP A 250
GLY A 247
ASP A 184
ASN A 252
 None
 0.91A 5no9D-1uwyA:
undetectable		 5no9D-1uwyA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 229
GLY A 230
HIS A 399
ASN A 404
 None
None
CU  A1502 (-2.9A)
None
 1.02A 5no9D-1v10A:
undetectable		 5no9D-1v10A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 246
HIS A 453
ASP A 455
HIS A  64
 None
CU  A1500 (-3.4A)
None
CU  A1502 (-3.2A)
 1.09A 5no9D-1v10A:
undetectable		 5no9D-1v10A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 GLY A 286
HIS A 287
ASP A 223
HIS A 195
 None
ZN  A 406 (-3.3A)
ZN  A 405 (-2.3A)
CAC  A 403 ( 4.4A)
 0.73A 5no9D-1wy2A:
undetectable		 5no9D-1wy2A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adu METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 GLY A 330
HIS A 331
ASP A 262
HIS A 231
 None
CO  A 502 ( 3.2A)
CO  A 501 (-2.2A)
R20  A 906 (-4.4A)
 0.79A 5no9D-2aduA:
undetectable		 5no9D-2aduA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ASP A  16
GLY A  13
ASP A  20
ASN A  18
 None
 1.03A 5no9D-2b24A:
undetectable		 5no9D-2b24A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 4 ASP A 243
GLY A 114
ASP A 106
ASN A 112
 None
 1.00A 5no9D-2cl2A:
undetectable		 5no9D-2cl2A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f96 RIBONUCLEASE T

(Pseudomonas
aeruginosa) 		PF00929
(RNase_T) 		4 ASP A 137
GLY A 131
ASP A  35
ASN A 133
 MG  A2001 ( 4.1A)
None
MG  A2001 (-2.5A)
None
 0.81A 5no9D-2f96A:
undetectable		 5no9D-2f96A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		4 GLY A 170
HIS A 171
ASP A 108
HIS A  79
 None
MN  A   1 ( 3.8A)
MN  A   1 ( 2.8A)
NLP  A3808 (-3.8A)
 0.64A 5no9D-2gtxA:
undetectable		 5no9D-2gtxA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyp HYPOTHETICAL PROTEIN
RV0805

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		4 ASP A  63
HIS A  23
ASP A  21
HIS A 140
 MN  A 555 (-2.6A)
FE  A 444 ( 3.4A)
FE  A 444 (-3.1A)
None
 1.02A 5no9D-2hypA:
undetectable		 5no9D-2hypA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 GLY A 480
ASP A 491
HIS A 160
ASP A 482
 None
 0.88A 5no9D-2inpA:
undetectable		 5no9D-2inpA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n51 ELONGATION FACTOR
1-DELTA

(Homo sapiens) 		PF00736
(EF1_GNE)
PF10587
(EF-1_beta_acid) 		4 ASP A 155
GLY A 149
ASP A 154
ASP A 156
 None
 1.09A 5no9D-2n51A:
undetectable		 5no9D-2n51A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 ASP A 274
GLY A 271
ASP A 207
ASN A 276
 None
 0.97A 5no9D-2nsmA:
undetectable		 5no9D-2nsmA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		4 GLY A 297
HIS A 273
ASP A 340
ASN A 333
 None
 0.78A 5no9D-2vqaA:
undetectable		 5no9D-2vqaA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		5 ASP A  56
GLY A 301
ASP A 346
HIS A 308
ASP A 304
 ZN  A1476 (-2.2A)
MG  A1477 ( 4.5A)
ZN  A1476 (-2.3A)
ZN  A1475 ( 3.2A)
ZN  A1475 ( 2.0A)
 1.49A 5no9D-2x98A:
undetectable		 5no9D-2x98A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ASP A 662
GLY A  69
ASP A 355
ASP A 660
 CA  A1772 (-3.0A)
None
B3P  A1773 (-2.8A)
None
 0.86A 5no9D-2xsgA:
undetectable		 5no9D-2xsgA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrt CHORD CONTAINING
PROTEIN-1

(Homo sapiens) 		PF04968
(CHORD) 		4 ASP A  28
GLY A  69
ASP A  29
ASN A  26
 None
 0.93A 5no9D-2yrtA:
undetectable		 5no9D-2yrtA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 195
ASP A 250
HIS A  89
ASP A 194
 None
 1.07A 5no9D-2ze0A:
undetectable		 5no9D-2ze0A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		4 GLY B 398
ASP B 115
HIS B 269
ASN B 108
 None
 0.91A 5no9D-3adaB:
undetectable		 5no9D-3adaB:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8y ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		4 ASP A 173
GLY A 174
HIS A 176
ASP A 195
 None
None
None
ADA  A 903 (-3.0A)
 1.07A 5no9D-3b8yA:
undetectable		 5no9D-3b8yA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c60 TCR YAE62 BETA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP B  93
GLY B  92
HIS B  27
ASN B  25
 None
 1.01A 5no9D-3c60B:
undetectable		 5no9D-3c60B:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0f PUTATIVE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bifidobacterium
adolescentis) 		PF02811
(PHP) 		4 GLY A 144
ASP A 150
HIS A 262
ASP A  24
 PO4  A 305 ( 3.9A)
None
ZN  A 301 ( 3.5A)
ZN  A 301 ( 2.2A)
 0.89A 5no9D-3e0fA:
undetectable		 5no9D-3e0fA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		5 ASP A  12
GLY A 270
ASP A 315
HIS A 277
ASP A 273
 ZN  A 602 (-2.2A)
MG  A 603 ( 4.5A)
ZN  A 602 (-2.4A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.1A)
 1.47A 5no9D-3e2dA:
undetectable		 5no9D-3e2dA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A 644
ASP A 970
HIS A 892
ASP A 608
 None
 0.97A 5no9D-3ecqA:
undetectable		 5no9D-3ecqA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 GLY A 209
HIS A 210
ASP A 141
HIS A 109
 None
FE  A 451 (-3.4A)
FE  A 452 ( 2.2A)
FUG  A 481 (-2.7A)
 0.76A 5no9D-3fmqA:
undetectable		 5no9D-3fmqA:
13.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gnu 25 KDA PROTEIN
ELICITOR

(Pythium
aphanidermatum) 		PF05630
(NPP1) 		5 ASP P  93
GLY P 100
ASP P 104
HIS P 128
ASP P 158
 None
None
None
GAI  P 214 (-4.1A)
GAI  P 214 (-2.7A)
 1.38A 5no9D-3gnuP:
39.0		 5no9D-3gnuP:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ASP A 317
GLY A 319
HIS A 342
ASP A 313
 None
 1.08A 5no9D-3hskA:
undetectable		 5no9D-3hskA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0c E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN

(Venezuelan
equine
encephalitis
virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		4 GLY B  40
HIS B  41
HIS A  50
ASP B  39
 None
 1.02A 5no9D-3j0cB:
undetectable		 5no9D-3j0cB:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv1 TRANSCRIPTIONAL
REPRESSOR

(Aliivibrio
fischeri) 		PF04198
(Sugar-bind) 		4 ASP A 155
GLY A 154
ASP A 157
ASN A 159
 None
GOL  A 271 ( 3.8A)
None
GOL  A 271 (-3.6A)
 1.09A 5no9D-3kv1A:
undetectable		 5no9D-3kv1A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr1 METHIONINE
AMINOPEPTIDASE

(Rickettsia
prowazekii) 		PF00557
(Peptidase_M24) 		4 GLY A 167
HIS A 168
ASP A 105
HIS A  77
 None
MN  A 249 ( 3.4A)
MN  A 250 (-2.5A)
PO4  A 252 (-4.2A)
 0.71A 5no9D-3mr1A:
undetectable		 5no9D-3mr1A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtq PUTATIVE
PHOSPHOENOLPYRUVATE-
DEPENDENT SUGAR
PHOSPHOTRANSFERASE
SYSTEM (PTS)
PERMEASE

(Klebsiella
pneumoniae) 		PF03610
(EIIA-man) 		4 GLY A  90
HIS A  10
ASP A  66
ASN A  73
 None
 1.05A 5no9D-3mtqA:
undetectable		 5no9D-3mtqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae) 		PF02126
(PTE) 		4 ASP A 272
GLY A 274
ASP A 238
HIS A 186
 ZN  A 362 (-2.7A)
None
None
ZN  A 363 (-3.5A)
 1.06A 5no9D-3ovgA:
undetectable		 5no9D-3ovgA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2s PUTATIVE
PYRAZINAMIDASE/NICOT
INAMIDASE

(Streptococcus
mutans) 		PF00857
(Isochorismatase) 		4 ASP A  53
GLY A  54
HIS A  55
HIS A 105
 ZN  A 184 (-2.6A)
None
ZN  A 184 (-3.3A)
None
 1.06A 5no9D-3s2sA:
undetectable		 5no9D-3s2sA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6b METHIONINE
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24) 		4 GLY A 269
HIS A 270
ASP A 204
HIS A 176
 None
FE  A 370 (-3.7A)
FE  A 370 (-3.0A)
None
 0.71A 5no9D-3s6bA:
undetectable		 5no9D-3s6bA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sng NUCLEASE

(Solanum
lycopersicum) 		PF02265
(S1-P1_nuclease) 		4 GLY A  30
HIS A  31
ASP A  70
ASP A 185
 None
ZN  A 401 (-3.2A)
ZN  A 402 (-2.9A)
ZN  A 403 (-2.1A)
 1.04A 5no9D-3sngA:
undetectable		 5no9D-3sngA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE

(Pyrobaculum
neutrophilum) 		PF01950
(FBPase_3) 		4 ASP A  96
GLY A  94
HIS A  18
ASP A  11
 MG  A 408 ( 4.1A)
None
MG  A 410 (-3.3A)
MG  A 410 ( 2.6A)
 1.09A 5no9D-3t2cA:
undetectable		 5no9D-3t2cA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tav METHIONINE
AMINOPEPTIDASE

(Mycobacteroides
abscessus) 		PF00557
(Peptidase_M24) 		4 GLY A 183
HIS A 184
ASP A 115
HIS A  86
 None
MG  A 266 (-3.4A)
MG  A 269 ( 2.1A)
LMR  A 271 (-3.9A)
 0.77A 5no9D-3tavA:
undetectable		 5no9D-3tavA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb5 METHIONINE
AMINOPEPTIDASE

(Enterococcus
faecalis) 		PF00557
(Peptidase_M24) 		4 GLY A 167
HIS A 168
ASP A 105
HIS A  77
 None
CIT  A 265 (-3.8A)
CIT  A 265 (-4.2A)
CIT  A 265 (-3.4A)
 1.03A 5no9D-3tb5A:
undetectable		 5no9D-3tb5A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		4 ASP A 233
GLY A 232
HIS A 196
ASP A  20
 None
None
PO4  A 442 ( 4.9A)
None
 1.07A 5no9D-3tr1A:
undetectable		 5no9D-3tr1A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u07 UNCHARACTERIZED
PROTEIN VPA0106

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 GLY A 226
ASP A 232
ASP A 158
ASN A 230
 None
 1.00A 5no9D-3u07A:
undetectable		 5no9D-3u07A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ved DYPB

(Rhodococcus
jostii) 		PF04261
(Dyp_perox) 		4 GLY A 154
ASP A 147
HIS A 226
ASN A 246
 HEM  A 401 (-3.1A)
HEM  A 401 (-4.3A)
HEM  A 401 (-3.2A)
CL  A 404 (-3.2A)
 0.93A 5no9D-3vedA:
undetectable		 5no9D-3vedA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		4 GLY A 105
HIS A 178
ASP A 180
HIS A   7
 None
None
MN  A1001 (-3.1A)
None
 0.89A 5no9D-3vylA:
undetectable		 5no9D-3vylA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		5 ASP A  12
GLY A 266
ASP A 311
HIS A 273
ASP A 269
 ZN  A 505 ( 2.1A)
MG  A 501 ( 4.4A)
ZN  A 505 (-2.5A)
ZN  A 504 (-3.4A)
ZN  A 504 ( 2.1A)
 1.50A 5no9D-3wbhA:
undetectable		 5no9D-3wbhA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 GLY A 249
ASP A 183
HIS A 127
ASP A  94
 None
None
PO4  A1597 ( 4.0A)
ZN  A1595 (-2.4A)
 0.83A 5no9D-3zu0A:
undetectable		 5no9D-3zu0A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 ASP A 500
GLY A 563
ASP A 501
ASN A 561
 PGE  A1684 ( 3.8A)
None
None
None
 0.97A 5no9D-3zukA:
undetectable		 5no9D-3zukA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		4 ASP A 217
GLY A 172
HIS A 173
ASP A 214
 None
 0.84A 5no9D-4avcA:
undetectable		 5no9D-4avcA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 ASP A 129
GLY A 128
ASP A 131
ASP A 179
 CA  A 402 (-2.0A)
None
CA  A 402 (-2.9A)
CA  A 402 (-3.7A)
 1.09A 5no9D-4b52A:
undetectable		 5no9D-4b52A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		4 ASP A 581
GLY A 579
HIS A 540
ASN A 575
 None
 0.92A 5no9D-4b8bA:
undetectable		 5no9D-4b8bA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo7 METHIONINE
AMINOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF00557
(Peptidase_M24) 		4 GLY A 169
HIS A 170
ASP A 107
HIS A  79
 None
MN  A 301 (-3.5A)
MN  A 302 ( 2.7A)
None
 0.70A 5no9D-4fo7A:
undetectable		 5no9D-4fo7A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuk METHIONINE
AMINOPEPTIDASE

(Trypanosoma
brucei) 		PF00557
(Peptidase_M24) 		4 GLY A 284
HIS A 285
ASP A 222
HIS A 194
 None
ZN  A 401 (-3.2A)
ZN  A 402 ( 2.3A)
None
 0.69A 5no9D-4fukA:
undetectable		 5no9D-4fukA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghn UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF03572
(Peptidase_S41) 		4 GLY A 350
HIS A 182
HIS A 115
ASP A 352
 None
 1.06A 5no9D-4ghnA:
undetectable		 5no9D-4ghnA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 GLY A 228
HIS A 177
HIS A  57
ASP A 113
 None
 0.81A 5no9D-4gpgA:
undetectable		 5no9D-4gpgA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Salipiger
bermudensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 270
HIS A 274
HIS A 108
ASP A 104
 None
 0.91A 5no9D-4h2hA:
undetectable		 5no9D-4h2hA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 GLY A 302
HIS A 303
ASP A 240
HIS A 212
 None
CO  A 401 (-3.3A)
CO  A 402 ( 2.3A)
CO  A 403 ( 3.3A)
 0.70A 5no9D-4hxxA:
undetectable		 5no9D-4hxxA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD

(Legionella
pneumophila) 		no annotation 4 ASP A  92
GLY A  47
ASP A 110
ASP A 327
 None
None
MG  A 401 ( 2.8A)
None
 0.99A 5no9D-4iikA:
undetectable		 5no9D-4iikA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD

(Legionella
pneumophila) 		no annotation 4 GLY A 114
ASP A 327
HIS A  50
ASP A  89
 CL  A 412 (-4.1A)
None
None
None
 1.04A 5no9D-4iikA:
undetectable		 5no9D-4iikA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 GLY A 302
HIS A 303
ASP A 240
HIS A 212
 None
CO  A 401 (-3.1A)
CO  A 402 ( 2.2A)
CO  A 403 ( 3.1A)
 0.79A 5no9D-4iu6A:
undetectable		 5no9D-4iu6A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 374
HIS A 373
HIS A  31
ASP A 376
 None
 1.04A 5no9D-4kwsA:
undetectable		 5no9D-4kwsA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLY A 195
ASP A 249
HIS A  88
ASP A 194
 None
 1.09A 5no9D-4m8uA:
undetectable		 5no9D-4m8uA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsy LYSYL ENDOPEPTIDASE

(Lysobacter
enzymogenes) 		PF13365
(Trypsin_2) 		4 GLY A 228
HIS A 177
HIS A  57
ASP A 113
 None
None
2OY  A 301 (-2.7A)
None
 0.85A 5no9D-4nsyA:
undetectable		 5no9D-4nsyA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		4 GLY A 204
HIS A 205
ASP A 142
HIS A 114
 None
CO  A 302 (-3.2A)
CO  A 301 ( 2.5A)
CO  A 303 (-3.4A)
 0.70A 5no9D-4ookA:
undetectable		 5no9D-4ookA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 ASP A 310
GLY A 334
HIS A 264
ASP A 311
 MN  A 702 (-4.2A)
MN  A 702 ( 4.3A)
MN  A 701 (-3.4A)
MN  A 701 (-2.5A)
 0.96A 5no9D-4ox2A:
undetectable		 5no9D-4ox2A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 ASP A 350
GLY A 209
HIS A 352
HIS A 242
 LLP  A 353 ( 3.8A)
LLP  A 353 ( 4.2A)
LLP  A 353 ( 4.0A)
LLP  A 353 (-3.6A)
 1.00A 5no9D-4q6rA:
undetectable		 5no9D-4q6rA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg8 EXONUCLEASE I

(Methylocaldum
szegediense) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		4 ASP A 104
GLY A  97
ASP A  11
ASN A  99
 MG  A 501 ( 4.1A)
None
MG  A 501 (-2.4A)
None
 1.08A 5no9D-4rg8A:
undetectable		 5no9D-4rg8A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhm ARGINASE

(Trypanosoma
brucei) 		PF00491
(Arginase) 		4 ASP A 149
HIS A 147
ASP A 224
ASP A 153
 MN  A 402 (-2.5A)
None
MN  A 402 (-3.0A)
None
 0.99A 5no9D-4rhmA:
undetectable		 5no9D-4rhmA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rx4 HIV-1 CLADE A
Q842.D12 GP120

(Human
immunodeficiency
virus 1) 		no annotation 5 ASP G 477
GLY G 472
HIS G 105
ASP G 474
ASN G 478
 EDO  G 509 (-2.1A)
None
None
EDO  G 509 (-3.4A)
None
 1.32A 5no9D-4rx4G:
undetectable		 5no9D-4rx4G:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 GLY P 486
HIS P 487
ASP P 424
HIS P 392
 None
ZN  P 702 ( 3.7A)
ZN  P 701 (-2.4A)
None
 0.78A 5no9D-4s2tP:
undetectable		 5no9D-4s2tP:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		4 ASP A 416
HIS A 400
ASP A 419
ASN A 440
 None
 0.99A 5no9D-4txgA:
undetectable		 5no9D-4txgA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		4 GLY A 437
ASP A 416
HIS A 400
ASP A 419
 None
 0.91A 5no9D-4txgA:
undetectable		 5no9D-4txgA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unw H3 HAEMAGGLUTININ
HA1 CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ASP A  73
HIS A  75
ASP A  68
ASN A  63
 None
None
None
NAG  A 421 (-1.9A)
 1.08A 5no9D-4unwA:
undetectable		 5no9D-4unwA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		4 ASP A  47
HIS A 299
HIS A 174
ASP A 143
 MN  A 580 (-3.2A)
MN  A 580 (-3.6A)
MN  A 581 (-3.3A)
MN  A 581 ( 2.9A)
 1.08A 5no9D-4uwqA:
undetectable		 5no9D-4uwqA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Nakamurella
multipartita) 		PF00561
(Abhydrolase_1) 		4 GLY A  46
HIS A  37
ASP A  64
ASP A  44
 None
 1.08A 5no9D-4y7dA:
undetectable		 5no9D-4y7dA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh8 SPLICING FACTOR U2AF
23 KDA SUBUNIT

(Schizosaccharomyces
pombe) 		PF00076
(RRM_1)
PF00642
(zf-CCCH) 		4 GLY A 161
ASP A 101
HIS A  57
ASN A  98
 None
 0.97A 5no9D-4yh8A:
undetectable		 5no9D-4yh8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		4 GLY A 209
ASP A 236
HIS A 126
ASP A 208
 None
 1.02A 5no9D-5a2aA:
undetectable		 5no9D-5a2aA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 GLY A 644
ASP A 970
HIS A 892
ASP A 608
 None
 0.99A 5no9D-5a55A:
undetectable		 5no9D-5a55A:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cde PROLINE DIPEPTIDASE

(Xanthomonas
campestris) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 GLY A 330
HIS A 331
ASP A 262
HIS A 234
 None
ZN  A 403 ( 3.2A)
ZN  A 402 ( 2.3A)
ZN  A 404 ( 3.1A)
 0.79A 5no9D-5cdeA:
undetectable		 5no9D-5cdeA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 GLY A 291
HIS A 292
ASP A 223
HIS A 195
 None
ZN  A 401 (-3.3A)
ZN  A 402 (-2.5A)
CAC  A 403 (-4.1A)
 0.90A 5no9D-5cnxA:
undetectable		 5no9D-5cnxA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 GLY B 193
ASP B 248
HIS B  90
ASP B 192
 None
 1.07A 5no9D-5do8B:
undetectable		 5no9D-5do8B:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 225
GLY A 226
HIS A 398
ASN A 403
 None
None
CU  A 509 ( 3.1A)
None
 1.08A 5no9D-5ehfA:
undetectable		 5no9D-5ehfA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbb NUCLEASE S1

(Aspergillus
oryzae) 		PF02265
(S1-P1_nuclease) 		4 GLY A  25
HIS A  26
ASP A  65
ASP A 172
 None
ZN  A 401 ( 3.2A)
PO4  A 601 ( 2.7A)
ZN  A 403 ( 2.1A)
 0.98A 5no9D-5fbbA:
undetectable		 5no9D-5fbbA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf DNA REPAIR HELICASE
RAD25, SSL2

(Saccharomyces
cerevisiae) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 GLY 1 299
HIS 1 347
HIS 1 314
ASP 1 307
 None
 1.04A 5no9D-5fmf1:
undetectable		 5no9D-5fmf1:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		4 GLY B 209
ASP B 247
HIS B 109
ASP B 208
 None
 1.07A 5no9D-5m99B:
undetectable		 5no9D-5m99B:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 4 GLY A 162
ASP A 274
ASP A 143
ASN A 146
 None
 0.95A 5no9D-5mg5A:
undetectable		 5no9D-5mg5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN12
26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF08375
(Rpn3_C)
PF10075
(CSN8_PSD8_EIF3K) 		4 GLY S 245
ASP S 375
HIS T 132
ASN S 243
 None
 1.09A 5no9D-5mpdS:
undetectable		 5no9D-5mpdS:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASP A 247
GLY A 248
ASP A 246
HIS A 220
ASP A 250
 CA  A 601 ( 3.3A)
None
CA  A 602 (-2.5A)
RAM  A 605 ( 3.6A)
AQA  A 606 ( 3.1A)
 1.45A 5no9D-5olsA:
undetectable		 5no9D-5olsA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqj RESPONSE REGULATOR
RECEIVER PROTEIN

(Paraburkholderia
phymatum) 		PF00072
(Response_reg) 		4 ASP A  12
GLY A  18
ASP A  59
ASP A  14
 None
EDO  A 204 ( 4.4A)
None
None
 0.92A 5no9D-5tqjA:
undetectable		 5no9D-5tqjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um0 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Neisseria
gonorrhoeae) 		PF00300
(His_Phos_1) 		4 GLY A 148
HIS A  88
HIS A 132
ASP A 147
 None
 1.05A 5no9D-5um0A:
undetectable		 5no9D-5um0A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 GLY A 369
ASP A 394
HIS A 293
ASP A 368
 None
 1.00A 5no9D-5ww1A:
undetectable		 5no9D-5ww1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 4 ASP A 340
GLY A 339
HIS A 338
ASP A 358
 None
None
None
DL1  A 601 (-3.1A)
 1.05A 5no9D-6bfnA:
undetectable		 5no9D-6bfnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 4 GLY A 706
HIS A 795
ASP A 792
ASN A 961
 None
 1.03A 5no9D-6cg0A:
undetectable		 5no9D-6cg0A:
21.11