SIMILAR PATTERNS OF AMINO ACIDS FOR 5NNA_B_BZMB301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1at3 | HERPES SIMPLEX VIRUSTYPE II PROTEASE (Humanalphaherpesvirus2) |
PF00716(Peptidase_S21) | 5 | ILE A 57LEU A 151VAL A 70GLY A 84TYR A 164 | None | 0.95A | 5nnaB-1at3A:undetectable | 5nnaB-1at3A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3c | PROTEIN(ADENYLOSUCCINATELYASE) (Thermotogamaritima) |
PF00206(Lyase_1)PF10397(ADSL_C) | 5 | ILE A 180LEU A 92SER A 210GLY A 178ASP A 99 | None | 1.19A | 5nnaB-1c3cA:undetectable | 5nnaB-1c3cA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eg7 | FORMYLTETRAHYDROFOLATE SYNTHETASE (Moorellathermoacetica) |
PF01268(FTHFS) | 5 | ILE A1028LEU A1294PRO A1257VAL A1033ASP A1046 | NoneNoneNoneNoneSO4 A 4 (-3.9A) | 1.21A | 5nnaB-1eg7A:0.0 | 5nnaB-1eg7A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f7u | ARGINYL-TRNASYNTHETASE (Saccharomycescerevisiae) |
PF00750(tRNA-synt_1d)PF03485(Arg_tRNA_synt_N)PF05746(DALR_1) | 5 | ILE A 127PRO A 535VAL A 591ASP A 133GLY A 135 | None | 1.12A | 5nnaB-1f7uA:undetectable | 5nnaB-1f7uA:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g82 | FIBROBLAST GROWTHFACTOR 9 (Homo sapiens) |
PF00167(FGF) | 5 | ILE A 82LEU A 74SER A 112GLY A 126GLY A 109 | None | 0.95A | 5nnaB-1g82A:undetectable | 5nnaB-1g82A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpe | PROTEIN (GLUCOSEOXIDASE) (Penicilliumamagasakiense) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ILE A 54LEU A 52VAL A 254ASP A 282GLY A 270 | NoneNoneFAD A 600 (-4.0A)NoneNone | 1.03A | 5nnaB-1gpeA:0.7 | 5nnaB-1gpeA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jzt | HYPOTHETICAL 27.5KDA PROTEIN INSPX19-GCR2INTERGENIC REGION (Saccharomycescerevisiae) |
PF03853(YjeF_N) | 5 | ILE A 190LEU A 160PRO A 188SER A 186GLY A 177 | None | 1.17A | 5nnaB-1jztA:0.3 | 5nnaB-1jztA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kv9 | TYPE IIQUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Pseudomonasputida) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 5 | ILE A 518LEU A 546TRP A 493GLY A 475GLY A 479 | None | 1.17A | 5nnaB-1kv9A:undetectable | 5nnaB-1kv9A:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1llu | ALCOHOLDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 263LEU A 285VAL A 240GLY A 239GLY A 236 | None | 1.24A | 5nnaB-1lluA:undetectable | 5nnaB-1lluA:24.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m66 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Leishmaniamexicana) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 5 | ILE A 241LEU A 238VAL A 205GLY A 202GLY A 252 | None | 1.12A | 5nnaB-1m66A:undetectable | 5nnaB-1m66A:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nmo | HYPOTHETICAL PROTEINYBGI (Escherichiacoli) |
PF01784(NIF3) | 5 | LEU A 98HIS A 64TRP A 68SER A 177GLY A 174 | None FE A 301 (-3.3A)NoneNoneNone | 1.17A | 5nnaB-1nmoA:undetectable | 5nnaB-1nmoA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1obb | ALPHA-GLUCOSIDASE (Thermotogamaritima) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 5 | HIS A 90SER A 334VAL A 303GLY A 301ASP A 298 | NAD A 500 (-4.2A)NoneNoneNoneNone | 1.15A | 5nnaB-1obbA:undetectable | 5nnaB-1obbA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oy1 | PUTATIVE SIGMACROSS-REACTINGPROTEIN 27A (Escherichiacoli) |
no annotation | 5 | ILE A 22SER A 12ASP A 18GLY A 13HIS A 54 | None | 1.04A | 5nnaB-1oy1A:undetectable | 5nnaB-1oy1A:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qot | CHITIN BINDINGLECTIN, UEA-II (Ulex europaeus) |
PF00139(Lectin_legB) | 5 | ILE A 152HIS A 144SER A 103GLY A 106GLY A 109 | None MN A 301 (-3.3A)NoneFUC A 501 (-3.7A)None | 1.15A | 5nnaB-1qotA:undetectable | 5nnaB-1qotA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tuu | ACETATE KINASE (Methanosarcinathermophila) |
PF00871(Acetate_kinase) | 5 | LEU A 236HIS A 184GLY A 210GLY A 239HIS A 180 | NoneNoneADP A 401 (-3.3A)NoneSO4 A 400 (-3.9A) | 1.19A | 5nnaB-1tuuA:undetectable | 5nnaB-1tuuA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vzv | VARICELLA-ZOSTERVIRUS PROTEASE (Humanalphaherpesvirus3) |
PF00716(Peptidase_S21) | 5 | ILE A 48LEU A 142VAL A 61GLY A 75TYR A 155 | None | 0.96A | 5nnaB-1vzvA:undetectable | 5nnaB-1vzvA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w6j | LANOSTEROL SYNTHASE (Homo sapiens) |
PF13243(SQHop_cyclase_C)PF13249(SQHop_cyclase_N) | 5 | ILE A 338TRP A 230GLY A 336GLY A 380HIS A 232 | R71 A1733 (-4.8A)NoneNoneR71 A1733 (-4.3A)R71 A1733 (-3.5A) | 1.14A | 5nnaB-1w6jA:undetectable | 5nnaB-1w6jA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w85 | PYRUVATEDEHYDROGENASE E1COMPONENT, BETASUBUNIT (Geobacillusstearothermophilus) |
PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ILE B 25LEU B 13VAL B 52GLY B 31GLY B 42 | None | 1.23A | 5nnaB-1w85B:undetectable | 5nnaB-1w85B:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1woy | METHIONYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1)PF09334(tRNA-synt_1g) | 5 | ILE A 450LEU A 451PRO A 454VAL A 473ASP A 39 | None | 1.09A | 5nnaB-1woyA:undetectable | 5nnaB-1woyA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wsv | AMINOMETHYLTRANSFERASE (Homo sapiens) |
PF01571(GCV_T)PF08669(GCV_T_C) | 5 | ILE A 308LEU A 348VAL A 319GLY A 335GLY A 294 | ILE A 308 ( 0.7A)LEU A 348 ( 0.6A)VAL A 319 ( 0.6A)GLY A 335 ( 0.0A)GLY A 294 ( 0.0A) | 1.01A | 5nnaB-1wsvA:undetectable | 5nnaB-1wsvA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zwx | SPHINGOMYELINASE-C (Listeriaivanovii) |
PF03372(Exo_endo_phos) | 5 | ILE A 226LEU A 246SER A 49GLY A 183GLY A 228 | None | 1.15A | 5nnaB-1zwxA:undetectable | 5nnaB-1zwxA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a3s | MYOCYTE NUCLEARFACTOR (Mus musculus) |
PF00250(Forkhead) | 5 | ILE A 51LEU A 11ASP A 44GLY A 46TYR A 40 | None | 1.23A | 5nnaB-2a3sA:undetectable | 5nnaB-2a3sA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b24 | NAPHTHALENEDIOXYGENASE LARGESUBUNIT (Rhodococcus sp.NCIMB 12038) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 5 | ILE A 243LEU A 251GLY A 412ASP A 172GLY A 246 | None | 1.06A | 5nnaB-2b24A:undetectable | 5nnaB-2b24A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvg | 6-HYDROXY-D-NICOTINEOXIDASE (Paenarthrobacternicotinovorans) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | ILE A 351LEU A 231PRO A 243GLY A 371GLY A 353 | None | 1.07A | 5nnaB-2bvgA:undetectable | 5nnaB-2bvgA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2chr | CHLOROMUCONATECYCLOISOMERASE (Cupriavidusnecator) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 334VAL A 44GLY A 45GLY A 304TYR A 31 | None | 1.23A | 5nnaB-2chrA:1.3 | 5nnaB-2chrA:24.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e1b | 216AA LONGHYPOTHETICALALANYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF01411(tRNA-synt_2c)PF07973(tRNA_SAD) | 5 | ILE A 98LEU A 95SER A 123GLY A 130GLY A 124 | NoneNone ZN A 300 ( 4.9A)NoneNone | 1.08A | 5nnaB-2e1bA:undetectable | 5nnaB-2e1bA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2epk | N-ACETYL-BETA-D-GLUCOSAMINIDASE (Streptococcusgordonii) |
PF00728(Glyco_hydro_20) | 5 | ILE X 509LEU X 577ASP X 517GLY X 516HIS X 520 | None | 1.18A | 5nnaB-2epkX:1.8 | 5nnaB-2epkX:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fy1 | RNA-BINDING MOTIFPROTEIN, YCHROMOSOME, FAMILY 1MEMBER A1 (Homo sapiens) |
PF00076(RRM_1) | 5 | ILE A 12LEU A 24GLY A 14GLY A 49HIS A 74 | NoneNone C B 119 ( 2.7A) C B 119 ( 4.8A)None | 1.13A | 5nnaB-2fy1A:undetectable | 5nnaB-2fy1A:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g29 | NITRATE TRANSPORTPROTEIN NRTA (Synechocystissp.) |
PF13379(NMT1_2) | 5 | LEU A 257PRO A 244GLY A 154GLY A 240HIS A 266 | NoneNoneNoneNO3 A 700 (-3.2A)None | 1.21A | 5nnaB-2g29A:undetectable | 5nnaB-2g29A:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gv9 | DNA POLYMERASE (Humanalphaherpesvirus1) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 5 | ILE A 529LEU A 588PRO A 594GLY A 527ASP A 524 | None | 1.15A | 5nnaB-2gv9A:undetectable | 5nnaB-2gv9A:11.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwi | SERINE/THREONINE-PROTEIN KINASE PIM-2 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 164LEU A 180SER A 185GLY A 186HIS A 155 | None | 1.23A | 5nnaB-2iwiA:undetectable | 5nnaB-2iwiA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pbk | KSHV PROTEASE (Humangammaherpesvirus8) |
PF00716(Peptidase_S21) | 5 | ILE A 42LEU A 137GLY A 69GLY A 8TYR A 150 | None | 1.06A | 5nnaB-2pbkA:undetectable | 5nnaB-2pbkA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po2 | PROBABLE EXOSOMECOMPLEX EXONUCLEASE2 (Pyrococcusabyssi) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 5 | LEU B 161PRO B 193SER B 232ASP B 111GLY B 113 | None | 1.19A | 5nnaB-2po2B:undetectable | 5nnaB-2po2B:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pz0 | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Caldanaerobactersubterraneus) |
PF03009(GDPD) | 5 | ILE A 15LEU A 115HIS A 193GLY A 235ASP A 234 | None | 0.97A | 5nnaB-2pz0A:undetectable | 5nnaB-2pz0A:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] LARGE CHAIN (Azospirillumbrasilense) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | ILE A1149LEU A 831SER A 814GLY A1076ASP A1078 | None | 1.12A | 5nnaB-2vdcA:undetectable | 5nnaB-2vdcA:10.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5f | ENDO-1,4-BETA-XYLANASE Y (Ruminiclostridiumthermocellum) |
PF00331(Glyco_hydro_10)PF02018(CBM_4_9) | 5 | LEU A 446VAL A 423GLY A 422ASP A 455GLY A 453 | None | 1.23A | 5nnaB-2w5fA:undetectable | 5nnaB-2w5fA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wfc | PEROXIREDOXIN 5 (Arenicolamarina) |
PF08534(Redoxin) | 5 | ILE A 97VAL A 62GLY A 61ASP A 95GLY A 93 | None | 1.21A | 5nnaB-2wfcA:undetectable | 5nnaB-2wfcA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wkn | FORMAMIDASE (Delftiaacidovorans) |
PF03069(FmdA_AmdA) | 5 | TRP A 167PRO A 75GLY A 156GLY A 245HIS A 220 | None | 1.06A | 5nnaB-2wknA:undetectable | 5nnaB-2wknA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xgt | ASPARAGINYL-TRNASYNTHETASE,CYTOPLASMIC (Brugia malayi) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | ILE A 180LEU A 199VAL A 178GLY A 131ASP A 150 | None | 1.12A | 5nnaB-2xgtA:undetectable | 5nnaB-2xgtA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xr1 | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTOR100 KD SUBUNIT (Methanosarcinamazei) |
PF07521(RMMBL)PF07650(KH_2)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | HIS A 580VAL A 214GLY A 193GLY A 211HIS A 604 | NoneNoneNoneNone ZN A1639 (-3.3A) | 1.22A | 5nnaB-2xr1A:undetectable | 5nnaB-2xr1A:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z1a | 5'-NUCLEOTIDASE (Thermusthermophilus) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 5 | ILE A 234LEU A 224SER A 239GLY A 236GLY A 217 | None | 1.23A | 5nnaB-2z1aA:undetectable | 5nnaB-2z1aA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6v | PUTATIVEUNCHARACTERIZEDPROTEIN (Mycobacteriumavium) |
PF13469(Sulfotransfer_3) | 5 | LEU A 300HIS A 252ASP A 308GLY A 307HIS A 313 | None | 1.18A | 5nnaB-2z6vA:undetectable | 5nnaB-2z6vA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zvb | PRECORRIN-3C17-METHYLTRANSFERASE (Thermusthermophilus) |
PF00590(TP_methylase) | 5 | ILE A 243LEU A 227VAL A 178ASP A 175GLY A 172 | None | 1.16A | 5nnaB-2zvbA:undetectable | 5nnaB-2zvbA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aiv | BETA-GLUCOSIDASE (Secale cereale) |
PF00232(Glyco_hydro_1) | 5 | HIS A 193TRP A 289SER A 211GLY A 201TYR A 228 | None | 1.03A | 5nnaB-3aivA:undetectable | 5nnaB-3aivA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ck2 | CONSERVEDUNCHARACTERIZEDPROTEIN (PREDICTEDPHOSPHOESTERASECOG0622) (Streptococcuspneumoniae) |
PF12850(Metallophos_2) | 5 | LEU A 84VAL A 54GLY A 37ASP A 38GLY A 109 | NoneNoneNone MN A 202 ( 2.9A)None | 1.20A | 5nnaB-3ck2A:undetectable | 5nnaB-3ck2A:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmg | PUTATIVEBETA-GALACTOSIDASE (Bacteroidesfragilis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | VAL A 164GLY A 165ASP A 166GLY A 387HIS A 571 | None | 1.15A | 5nnaB-3cmgA:1.6 | 5nnaB-3cmgA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3b | 30S RIBOSOMALPROTEIN S10 (Escherichiacoli) |
PF00338(Ribosomal_S10) | 5 | ILE J 25LEU J 10VAL J 26ASP J 54GLY J 38 | None | 1.24A | 5nnaB-3d3bJ:undetectable | 5nnaB-3d3bJ:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gay | FRUCTOSE-BISPHOSPHATE ALDOLASE (Giardiaintestinalis) |
PF01116(F_bP_aldolase) | 5 | ILE A 46LEU A 6SER A 303GLY A 21GLY A 19 | None | 1.15A | 5nnaB-3gayA:undetectable | 5nnaB-3gayA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gt0 | PYRROLINE-5-CARBOXYLATE REDUCTASE (Bacillus cereus) |
PF03807(F420_oxidored)PF14748(P5CR_dimer) | 5 | ILE A 18LEU A 51SER A 70GLY A 14GLY A 9 | None | 1.05A | 5nnaB-3gt0A:undetectable | 5nnaB-3gt0A:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hcy | PUTATIVETWO-COMPONENT SENSORHISTIDINE KINASEPROTEIN (Sinorhizobiummeliloti) |
PF13185(GAF_2) | 5 | ILE A 82LEU A 90VAL A 83GLY A 86ASP A 110 | None | 1.21A | 5nnaB-3hcyA:undetectable | 5nnaB-3hcyA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrd | NICOTINATEDEHYDROGENASE MEDIUMMOLYBDOPTERINSUBUNIT (Eubacteriumbarkeri) |
PF02738(Ald_Xan_dh_C2) | 5 | ILE B 30LEU B 108GLY B 34ASP B 127GLY B 143 | None | 1.24A | 5nnaB-3hrdB:undetectable | 5nnaB-3hrdB:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jrk | TAGATOSE1,6-DIPHOSPHATEALDOLASE 2 (Streptococcuspyogenes) |
PF01791(DeoC) | 5 | ILE A 304LEU A 56TRP A 295SER A 245GLY A 273 | None | 1.20A | 5nnaB-3jrkA:undetectable | 5nnaB-3jrkA:25.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lov | PROTOPORPHYRINOGENOXIDASE (Exiguobacteriumsibiricum) |
PF01593(Amino_oxidase) | 5 | LEU A 304VAL A 444GLY A 443ASP A 442GLY A 438 | NoneFAD A 500 (-4.9A)NoneNoneFAD A 500 (-3.6A) | 0.94A | 5nnaB-3lovA:undetectable | 5nnaB-3lovA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myo | TAGATOSE1,6-DIPHOSPHATEALDOLASE 1 (Streptococcuspyogenes) |
PF01791(DeoC) | 5 | ILE A 307LEU A 59TRP A 298SER A 248GLY A 276 | None | 1.20A | 5nnaB-3myoA:undetectable | 5nnaB-3myoA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nm1 | THIAMINEBIOSYNTHETICBIFUNCTIONAL ENZYME ([Candida]glabrata) |
PF02110(HK)PF02581(TMP-TENI) | 5 | ILE A 73LEU A 41SER A 114GLY A 112GLY A 136 | NoneNonePOP A 543 ( 3.0A)NoneIFP A 542 (-3.1A) | 1.05A | 5nnaB-3nm1A:undetectable | 5nnaB-3nm1A:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3now | UNC-45 PROTEIN,SD10334P (Drosophilamelanogaster) |
PF11701(UNC45-central) | 5 | ILE A 385LEU A 336VAL A 418GLY A 419GLY A 414 | None | 0.89A | 5nnaB-3nowA:undetectable | 5nnaB-3nowA:15.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pv4 | DEGQ (Legionellafallonii) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | ILE A 86LEU A 118SER A 193VAL A 85GLY A 194 | None | 1.21A | 5nnaB-3pv4A:undetectable | 5nnaB-3pv4A:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qve | HMG BOX-CONTAININGPROTEIN 1 (Homo sapiens) |
PF08517(AXH) | 6 | TRP A 212VAL A 333GLY A 261GLY A 285TYR A 257HIS A 213 | NoneEDO A 13 ( 4.6A)EDO A 13 (-4.4A)EDO A 13 (-3.6A)NoneNone | 1.24A | 5nnaB-3qveA:undetectable | 5nnaB-3qveA:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r9p | ACKA (Mycobacteriumavium) |
PF00871(Acetate_kinase) | 5 | LEU A 225HIS A 173GLY A 199GLY A 228HIS A 169 | NoneNonePGE A 390 ( 4.4A)NonePGE A 390 (-3.9A) | 1.24A | 5nnaB-3r9pA:undetectable | 5nnaB-3r9pA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4o | PROTEIN TYROSINEPHOSPHATASE-LIKEPROTEIN (Leishmaniamajor) |
PF00782(DSPc) | 5 | ILE A 108LEU A 90HIS A 68TRP A 70GLY A 109 | None | 1.21A | 5nnaB-3s4oA:undetectable | 5nnaB-3s4oA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tad | LIPRIN-BETA-1 (Mus musculus) |
PF00536(SAM_1)PF07647(SAM_2) | 5 | ILE C 651LEU C 660SER C 626GLY C 650GLY C 627 | None | 1.24A | 5nnaB-3tadC:undetectable | 5nnaB-3tadC:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v5q | NT-3 GROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE A 600LEU A 595VAL A 601GLY A 696ASP A 697HIS A 677 | 0F4 A 902 (-4.1A)0F4 A 902 ( 4.8A)None0F4 A 902 (-3.3A)None0F4 A 902 (-4.1A) | 1.24A | 5nnaB-3v5qA:undetectable | 5nnaB-3v5qA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) |
PF00708(Acylphosphatase)PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 5 | SER A 596VAL A 517GLY A 510GLY A 508TYR A 409 | NoneNoneAP2 A 806 ( 4.8A)AP2 A 806 (-3.0A)AP2 A 806 (-4.2A) | 1.13A | 5nnaB-3vthA:undetectable | 5nnaB-3vthA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wig | DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 205LEU A 152TRP A 374GLY A 203GLY A 149 | NoneNoneNone CL A 407 ( 4.4A)None | 1.21A | 5nnaB-3wigA:undetectable | 5nnaB-3wigA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wv4 | NON-RIBOSOMALPEPTIDE SYNTHETASE (Streptomyceshalstedii) |
PF00501(AMP-binding) | 5 | SER A 68VAL A 104GLY A 103GLY A 98HIS A 199 | None | 1.19A | 5nnaB-3wv4A:undetectable | 5nnaB-3wv4A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwx | S12 FAMILY PEPTIDASE (Streptomycessp. 82F2) |
PF00144(Beta-lactamase) | 5 | ILE A 87LEU A 280SER A 367GLY A 336TYR A 82 | None | 1.15A | 5nnaB-3wwxA:undetectable | 5nnaB-3wwxA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci0 | F420-REDUCINGHYDROGENASE, SUBUNITBETA (Methanothermobactermarburgensis) |
PF04422(FrhB_FdhB_N)PF04432(FrhB_FdhB_C) | 5 | ILE C 220LEU C 3SER C 212GLY C 208GLY C 211 | NoneNoneNoneFAD C1283 (-3.6A)None | 1.13A | 5nnaB-4ci0C:undetectable | 5nnaB-4ci0C:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dmo | N-HYDROXYARYLAMINEO-ACETYLTRANSFERASE (Bacillus cereus) |
PF00797(Acetyltransf_2) | 5 | LEU A 121PRO A 131VAL A 124GLY A 125TYR A 184 | None | 1.22A | 5nnaB-4dmoA:undetectable | 5nnaB-4dmoA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gzi | GLUCANENDO-1,3-BETA-D-GLUCOSIDASE (Solanumtuberosum) |
PF00332(Glyco_hydro_17) | 5 | ILE A 139LEU A 87VAL A 154ASP A 78GLY A 116 | None | 1.22A | 5nnaB-4gziA:0.9 | 5nnaB-4gziA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3g | BETA-GLUCOSIDASE (Streptomycesvenezuelae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | ILE A 283PRO A 278GLY A 286ASP A 253GLY A 251 | None | 1.07A | 5nnaB-4i3gA:undetectable | 5nnaB-4i3gA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ifr | 2-AMINO-3-CARBOXYMUCONATE 6-SEMIALDEHYDEDECARBOXYLASE (Pseudomonasfluorescens) |
PF04909(Amidohydro_2) | 5 | HIS A 11VAL A 176ASP A 268GLY A 230HIS A 9 | ZN A 401 (-3.4A)NoneNoneNone ZN A 401 (-3.5A) | 1.10A | 5nnaB-4ifrA:1.7 | 5nnaB-4ifrA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igm | 2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDEDECARBOXYLASE (Homo sapiens) |
PF04909(Amidohydro_2) | 5 | HIS A 8VAL A 173ASP A 265GLY A 226HIS A 6 | ZN A 401 (-3.5A)NoneNoneNone ZN A 401 (-3.4A) | 1.21A | 5nnaB-4igmA:2.1 | 5nnaB-4igmA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ijn | ACETATE KINASE (Mycolicibacteriumsmegmatis) |
PF00871(Acetate_kinase) | 5 | LEU A 217HIS A 165GLY A 191GLY A 220HIS A 161 | NoneNoneAMP A 402 (-3.4A)NoneEDO A 404 ( 3.7A) | 1.20A | 5nnaB-4ijnA:undetectable | 5nnaB-4ijnA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iuw | NEUTRALENDOPEPTIDASE (Lactobacillusrhamnosus) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 5 | LEU A 400HIS A 309TRP A 306PRO A 84GLY A 81 | NoneCO3 A 713 (-4.1A)NoneNoneNone | 1.21A | 5nnaB-4iuwA:undetectable | 5nnaB-4iuwA:16.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m8d | PUTATIVEUNCHARACTERIZEDPROTEIN (Labrenziaaggregata) |
PF04199(Cyclase) | 5 | ILE A 195HIS A 77PRO A 169ASP A 198GLY A 200 | None MN A 301 ( 3.3A)NoneNoneNone | 1.18A | 5nnaB-4m8dA:39.4 | 5nnaB-4m8dA:49.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m8d | PUTATIVEUNCHARACTERIZEDPROTEIN (Labrenziaaggregata) |
PF04199(Cyclase) | 6 | ILE A 195LEU A 35PRO A 169ASP A 198GLY A 200HIS A 212 | None23J A 302 (-4.8A)NoneNoneNone23J A 302 (-4.0A) | 1.35A | 5nnaB-4m8dA:39.4 | 5nnaB-4m8dA:49.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m8d | PUTATIVEUNCHARACTERIZEDPROTEIN (Labrenziaaggregata) |
PF04199(Cyclase) | 6 | ILE A 195PRO A 169GLY A 196ASP A 198GLY A 200HIS A 212 | NoneNone23J A 302 (-3.5A)NoneNone23J A 302 (-4.0A) | 1.38A | 5nnaB-4m8dA:39.4 | 5nnaB-4m8dA:49.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m8d | PUTATIVEUNCHARACTERIZEDPROTEIN (Labrenziaaggregata) |
PF04199(Cyclase) | 7 | LEU A 35HIS A 83TRP A 84PRO A 169ASP A 198GLY A 200HIS A 212 | 23J A 302 (-4.8A)23J A 302 (-3.6A)NoneNoneNoneNone23J A 302 (-4.0A) | 1.46A | 5nnaB-4m8dA:39.4 | 5nnaB-4m8dA:49.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m8d | PUTATIVEUNCHARACTERIZEDPROTEIN (Labrenziaaggregata) |
PF04199(Cyclase) | 9 | LEU A 37HIS A 83TRP A 84PRO A 169SER A 171GLY A 196ASP A 198GLY A 200HIS A 212 | None23J A 302 (-3.6A)NoneNoneNone23J A 302 (-3.5A)NoneNone23J A 302 (-4.0A) | 0.38A | 5nnaB-4m8dA:39.4 | 5nnaB-4m8dA:49.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mlz | PERIPLASMIC BINDINGPROTEIN (Jonesiadenitrificans) |
PF01497(Peripla_BP_2) | 5 | LEU A 62PRO A 77VAL A 201GLY A 202HIS A 208 | None | 1.23A | 5nnaB-4mlzA:undetectable | 5nnaB-4mlzA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pw0 | ALPHA/BETA HYDROLASEFOLD PROTEIN (Chitinophagapinensis) |
PF00561(Abhydrolase_1) | 5 | LEU A 251SER A 261VAL A 130GLY A 131GLY A 228 | None | 1.14A | 5nnaB-4pw0A:1.1 | 5nnaB-4pw0A:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q51 | UNCHARACTERIZEDPROTEIN (Burkholderiacenocepacia) |
PF10703(MoaF)PF17409(MoaF_C) | 5 | ILE A 46LEU A 51TRP A 224GLY A 229TYR A 212 | NoneNone CA A 401 ( 4.9A)NoneNone | 1.22A | 5nnaB-4q51A:undetectable | 5nnaB-4q51A:26.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qhr | ALANINE RACEMASE (Acinetobacterbaumannii) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | LEU A 49PRO A 210SER A 194GLY A 211HIS A 40 | NoneNoneLLP A 34 ( 2.4A)LLP A 34 ( 3.4A)None | 1.15A | 5nnaB-4qhrA:undetectable | 5nnaB-4qhrA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u9p | UPF0264 PROTEINMJ1099 (Methanocaldococcusjannaschii) |
PF04476(4HFCP_synth) | 5 | ILE A 69LEU A 100VAL A 59GLY A 60ASP A 61 | None | 1.20A | 5nnaB-4u9pA:undetectable | 5nnaB-4u9pA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v08 | UL26 (Suidalphaherpesvirus1) |
PF00716(Peptidase_S21) | 5 | ILE A 39LEU A 131VAL A 52GLY A 66TYR A 144 | None | 1.01A | 5nnaB-4v08A:undetectable | 5nnaB-4v08A:25.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wa8 | FLAP ENDONUCLEASE 1 (Methanopyruskandleri) |
PF00752(XPG_N)PF00867(XPG_I) | 5 | ILE A 185LEU A 68VAL A 182GLY A 167TYR A 77 | None | 1.15A | 5nnaB-4wa8A:undetectable | 5nnaB-4wa8A:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yrd | CAPSULARPOLYSACCHARIDESYNTHESIS ENZYMECAP5F (Staphylococcusaureus) |
PF01370(Epimerase) | 5 | ILE A 5LEU A 16TRP A 130GLY A 7GLY A 10 | None | 1.24A | 5nnaB-4yrdA:undetectable | 5nnaB-4yrdA:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjj | BETA-GLUCOSIDASE (Aspergillusoryzae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | ILE A 548LEU A 501PRO A 463SER A 579GLY A 580 | None | 1.09A | 5nnaB-5fjjA:undetectable | 5nnaB-5fjjA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ILE A 657LEU A 651VAL A 658ASP A 836HIS A 816 | 748 A1001 ( 4.4A)None748 A1001 ( 4.8A)748 A1001 (-4.8A)748 A1001 (-3.8A) | 1.24A | 5nnaB-5grnA:undetectable | 5nnaB-5grnA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h83 | HETEROYOHIMBINESYNTHASE HYS (Catharanthusroseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 310LEU A 161VAL A 147GLY A 96GLY A 98 | None | 1.09A | 5nnaB-5h83A:undetectable | 5nnaB-5h83A:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6b | ALDEHYDEDEHYDROGENASE (Burkholderiathailandensis) |
PF00171(Aldedh) | 5 | ILE A 291LEU A 305SER A 438GLY A 276TYR A 278 | None | 1.24A | 5nnaB-5j6bA:undetectable | 5nnaB-5j6bA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l46 | DIMETHYLGLYCINEDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF01266(DAO)PF01571(GCV_T)PF08669(GCV_T_C)PF16350(FAO_M) | 5 | ILE A 378HIS A 100GLY A 398GLY A 396HIS A 403 | NoneNoneFAD A 901 (-4.4A)NoneNone | 1.00A | 5nnaB-5l46A:undetectable | 5nnaB-5l46A:14.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nmp | ISATIN HYDROLASE (Ralstoniasolanacearum) |
no annotation | 7 | LEU A 39HIS A 84TRP A 85ASP A 200GLY A 202TYR A 211HIS A 214 | NoneSIN A 302 (-3.7A)NoneNoneNoneNoneSIN A 302 (-4.2A) | 0.86A | 5nnaB-5nmpA:38.4 | 5nnaB-5nmpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnb | ISATIN HYDROLASE A (Labrenziaaggregata) |
no annotation | 6 | ILE A 32LEU A 34HIS A 79ASP A 193GLY A 197HIS A 207 | 92K A 302 (-4.1A)92K A 302 (-4.4A)92K A 302 (-3.2A)NoneNone92K A 302 (-4.0A) | 1.32A | 5nnaB-5nnbA:43.8 | 5nnaB-5nnbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnb | ISATIN HYDROLASE A (Labrenziaaggregata) |
no annotation | 12 | ILE A 32LEU A 34HIS A 79TRP A 80PRO A 163SER A 165VAL A 190GLY A 191ASP A 193GLY A 195TYR A 204HIS A 207 | 92K A 302 (-4.1A)92K A 302 (-4.4A)92K A 302 (-3.2A)NoneNoneNoneNone92K A 302 ( 4.3A)NoneNone92K A 302 (-3.6A)92K A 302 (-4.0A) | 0.40A | 5nnaB-5nnbA:43.8 | 5nnaB-5nnbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o3w | PEPTIDE CYCLASE 1 (Gypsophilavaccaria) |
no annotation | 5 | PRO A 490SER A 408VAL A 445ASP A 386GLY A 388 | None | 1.01A | 5nnaB-5o3wA:undetectable | 5nnaB-5o3wA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o5l | ADENYLATE CYCLASE (Mycobacteriumintracellulare) |
no annotation | 5 | ILE A 243PRO A 228VAL A 356GLY A 355TYR A 247 | NoneSO4 A 504 (-4.4A)NoneNoneNone | 1.17A | 5nnaB-5o5lA:undetectable | 5nnaB-5o5lA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cz4 | PROTEIN-TYROSINEKINASE 6 (Homo sapiens) |
no annotation | 5 | ILE A 247LEU A 242GLY A 329ASP A 330HIS A 310 | FKY A9001 (-4.1A)FKY A9001 (-4.7A)FKY A9001 (-3.4A)NoneFKY A9001 (-3.9A) | 0.94A | 5nnaB-6cz4A:undetectable | 5nnaB-6cz4A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dgi | D-ALANINE--D-ALANINELIGASE (Vibrio cholerae) |
no annotation | 5 | LEU A 96TRP A 49PRO A 108SER A 111GLY A 90 | NoneNoneGOL A 401 (-4.6A)NoneGOL A 401 (-4.6A) | 1.19A | 5nnaB-6dgiA:undetectable | 5nnaB-6dgiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6e12 | - (-) |
no annotation | 5 | ILE A 31LEU A 156HIS A 120SER A 23GLY A 26 | OLA A 301 (-4.6A)NoneOLA A 301 (-3.8A)NoneOLA A 301 (-3.9A) | 1.19A | 5nnaB-6e12A:undetectable | 5nnaB-6e12A:undetectable |