SIMILAR PATTERNS OF AMINO ACIDS FOR 5NM5_B_LOCB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eav MOLYBDOPTERIN
BIOSYNTHESIS CNX1
PROTEIN

(Arabidopsis
thaliana) 		PF00994
(MoCF_biosynth) 		4 ASN A 140
SER A 112
ALA A 143
VAL A 144
 None
 1.08A 5nm5A-1eavA:
undetectable		 5nm5A-1eavA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		4 ASN A 123
SER A  29
ALA A  93
VAL A  92
 None
 1.20A 5nm5A-1fbnA:
4.3		 5nm5A-1fbnA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ASN B 202
SER B  58
ALA B  56
VAL B  54
 None
 1.33A 5nm5A-1hr7B:
undetectable		 5nm5A-1hr7B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 ASN A 434
SER A 348
ALA A 414
VAL A 413
 None
 1.20A 5nm5A-1la2A:
1.3		 5nm5A-1la2A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia) 		PF01425
(Amidase) 		4 ASN A 234
SER A 203
ALA A 207
VAL A 210
 None
 1.39A 5nm5A-1m22A:
undetectable		 5nm5A-1m22A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ASN A 323
SER A 330
ALA A 354
VAL A 355
 None
 1.39A 5nm5A-1ot5A:
2.9		 5nm5A-1ot5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ASN A  69
SER A   9
ALA A   7
VAL A  21
 None
 1.39A 5nm5A-1p43A:
undetectable		 5nm5A-1p43A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p99 HYPOTHETICAL PROTEIN
PG110

(Staphylococcus
aureus) 		PF03180
(Lipoprotein_9) 		4 ASN A  90
SER A 111
ALA A 241
VAL A 240
 None
 1.24A 5nm5A-1p99A:
undetectable		 5nm5A-1p99A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		4 ASN A 301
SER A 224
ALA A 226
VAL A 227
 None
 0.79A 5nm5A-1qoxA:
2.9		 5nm5A-1qoxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0d HUNTINGTIN
INTERACTING PROTEIN
12

(Homo sapiens) 		PF01608
(I_LWEQ) 		4 ASN A 948
SER A 955
ALA A 951
VAL A 950
 None
 1.31A 5nm5A-1r0dA:
undetectable		 5nm5A-1r0dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 ASN A  82
SER A 144
ALA A  85
VAL A  86
 None
 0.94A 5nm5A-1uqwA:
undetectable		 5nm5A-1uqwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASN A 191
SER A 196
ALA A 146
VAL A 147
 None
 1.29A 5nm5A-1zxoA:
0.7		 5nm5A-1zxoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE

(Streptococcus
pyogenes) 		PF09028
(Mac-1) 		4 ASN A 301
SER A 309
ALA A 307
VAL A 306
 None
 1.35A 5nm5A-2au1A:
undetectable		 5nm5A-2au1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ASN A 215
SER A 235
ALA A 232
VAL A 231
 None
 1.06A 5nm5A-2cgjA:
undetectable		 5nm5A-2cgjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 ASN A 179
SER A 148
ALA A 152
VAL A 155
 None
 1.37A 5nm5A-2dc0A:
undetectable		 5nm5A-2dc0A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASN A 352
SER A  47
ALA A  45
VAL A  44
 None
 0.70A 5nm5A-2e5vA:
2.7		 5nm5A-2e5vA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		4 ASN A 575
SER A 503
ALA A 562
VAL A 561
 None
 0.98A 5nm5A-2eaeA:
1.5		 5nm5A-2eaeA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 4 ASN I 196
SER I 486
ALA I 481
VAL I 480
 None
 1.37A 5nm5A-2gk1I:
2.2		 5nm5A-2gk1I:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu2 ASPA PROTEIN

(Rattus
norvegicus) 		PF04952
(AstE_AspA) 		4 ASN A 233
SER A 263
ALA A 239
VAL A 238
 None
 1.22A 5nm5A-2gu2A:
undetectable		 5nm5A-2gu2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipa PROTEIN ARSC

(Bacillus
subtilis) 		PF01451
(LMWPc) 		4 ASN B  47
SER B  17
ALA B  48
VAL B  49
 None
 1.04A 5nm5A-2ipaB:
3.8		 5nm5A-2ipaB:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 ASN A 156
SER A 314
ALA A 300
VAL A 299
 PLP  A1494 ( 4.7A)
PLP  A1494 ( 4.9A)
None
None
 1.03A 5nm5A-2jisA:
3.0		 5nm5A-2jisA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knj MICROPLUSIN
PREPROTEIN

(Rhipicephalus
microplus) 		no annotation 4 ASN A  34
SER A  62
ALA A  35
VAL A  36
 None
 1.37A 5nm5A-2knjA:
undetectable		 5nm5A-2knjA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kv8 REGULATOR OF
G-PROTEIN SIGNALING
12

(Homo sapiens) 		PF00595
(PDZ) 		4 ASN A  54
SER A   5
ALA A  49
VAL A  50
 None
 1.27A 5nm5A-2kv8A:
undetectable		 5nm5A-2kv8A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l80 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 13

(Homo sapiens) 		PF02148
(zf-UBP) 		4 ASN A  36
SER A  85
ALA A  70
VAL A  71
 None
 1.06A 5nm5A-2l80A:
undetectable		 5nm5A-2l80A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 ASN A 225
SER A 235
ALA A 224
VAL A 223
 None
 1.27A 5nm5A-2m56A:
undetectable		 5nm5A-2m56A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		4 ASN A  65
SER A 126
ALA A  89
VAL A  90
 None
 0.77A 5nm5A-2ntbA:
undetectable		 5nm5A-2ntbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 ASN A 706
SER A 678
ALA A 709
VAL A 699
 GOL  A   1 (-3.3A)
None
None
None
 1.30A 5nm5A-2o2qA:
0.8		 5nm5A-2o2qA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy3 MACROPHAGE RECEPTOR
MARCO

(Mus musculus) 		PF00530
(SRCR) 		4 ASN A 452
SER A 471
ALA A 469
VAL A 515
 None
 1.40A 5nm5A-2oy3A:
undetectable		 5nm5A-2oy3A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4v TRANSCRIPTION
ELONGATION FACTOR
GREB

(Escherichia
coli) 		PF01272
(GreA_GreB)
PF03449
(GreA_GreB_N) 		4 ASN A  45
SER A  38
ALA A  36
VAL A  33
 None
 1.36A 5nm5A-2p4vA:
undetectable		 5nm5A-2p4vA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6h HYPOTHETICAL PROTEIN

(Aeropyrum
pernix) 		PF01894
(UPF0047) 		4 ASN A  90
SER A  96
ALA A  47
VAL A 117
 None
 0.99A 5nm5A-2p6hA:
undetectable		 5nm5A-2p6hA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 ASN A 579
SER A 628
ALA A 575
VAL A 574
 None
 1.08A 5nm5A-2pi5A:
undetectable		 5nm5A-2pi5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus) 		PF12796
(Ank_2) 		4 ASN A 125
SER A 116
ALA A 120
VAL A 121
 ASN  A 125 ( 0.6A)
SER  A 116 ( 0.0A)
ALA  A 120 ( 0.0A)
VAL  A 121 ( 0.6A)
 1.39A 5nm5A-2pnnA:
undetectable		 5nm5A-2pnnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psm INTERLEUKIN-15
RECEPTOR ALPHA CHAIN

(Mus musculus) 		no annotation 4 ASN F  31
SER F   9
ALA F  13
VAL F  29
 None
 1.29A 5nm5A-2psmF:
undetectable		 5nm5A-2psmF:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ASN G 612
SER G 639
ALA G 608
VAL G 607
 None
 1.27A 5nm5A-2uv8G:
undetectable		 5nm5A-2uv8G:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		PF00073
(Rhv) 		4 ASN 3 107
SER 3  52
ALA 3 207
VAL 3 206
 None
 1.22A 5nm5A-2ws93:
undetectable		 5nm5A-2ws93:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0h PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 ASN A 385
SER A 349
ALA A 361
VAL A 360
 None
 1.16A 5nm5A-2y0hA:
undetectable		 5nm5A-2y0hA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhl GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ASN A  63
SER A 139
ALA A  46
VAL A  47
 GAL  A1493 (-3.6A)
None
NAG  A1491 ( 3.9A)
None
 0.93A 5nm5A-2zhlA:
undetectable		 5nm5A-2zhlA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ASN A 495
SER A 518
ALA A 516
VAL A 515
 None
 1.04A 5nm5A-3actA:
undetectable		 5nm5A-3actA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al9 PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 ASN A  51
SER A  43
ALA A  66
VAL A  70
 None
 1.32A 5nm5A-3al9A:
undetectable		 5nm5A-3al9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		4 ASN A   8
SER A 400
ALA A 407
VAL A 408
 None
 1.26A 5nm5A-3ayxA:
undetectable		 5nm5A-3ayxA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b43 TITIN

(Oryctolagus
cuniculus) 		PF07679
(I-set) 		4 ASN A 541
SER A 535
ALA A 537
VAL A 487
 None
 1.22A 5nm5A-3b43A:
undetectable		 5nm5A-3b43A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		4 ASN A 331
SER A  24
ALA A 327
VAL A 326
 None
 1.34A 5nm5A-3e1tA:
undetectable		 5nm5A-3e1tA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewo NON-STRUCTURAL
PROTEIN 3

(Avian
coronavirus) 		PF01661
(Macro) 		4 ASN A  39
SER A  46
ALA A  41
VAL A  96
 None
 1.36A 5nm5A-3ewoA:
undetectable		 5nm5A-3ewoA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		4 ASN A 211
SER A 260
ALA A 245
VAL A 246
 None
 0.84A 5nm5A-3ihpA:
undetectable		 5nm5A-3ihpA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llb UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03471
(CorC_HlyC) 		4 ASN A  67
SER A  70
ALA A  68
VAL A  73
 None
 1.37A 5nm5A-3llbA:
undetectable		 5nm5A-3llbA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Arachis
duranensis;
Escherichia
coli) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		4 ASN A 367
SER A 337
ALA A 342
VAL A 343
 None
 1.33A 5nm5A-3ob4A:
undetectable		 5nm5A-3ob4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASN A  47
SER A 117
ALA A  72
VAL A  69
 None
 1.06A 5nm5A-3pblA:
undetectable		 5nm5A-3pblA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASN A  24
SER A  91
ALA A  49
VAL A  46
 None
 1.21A 5nm5A-3qakA:
undetectable		 5nm5A-3qakA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ASN A 488
SER A 511
ALA A 509
VAL A 508
 None
 1.22A 5nm5A-3qdeA:
undetectable		 5nm5A-3qdeA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4d LACTOSE
PHOSPHORYLASE

(Cellulomonas
uda) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ASN A 495
SER A 518
ALA A 516
VAL A 515
 None
 1.10A 5nm5A-3s4dA:
undetectable		 5nm5A-3s4dA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv6 GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ASN A  63
SER A 139
ALA A  46
VAL A  47
 GAL  A 402 (-3.9A)
None
None
None
 0.86A 5nm5A-3wv6A:
undetectable		 5nm5A-3wv6A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		4 ASN A 197
SER A 166
ALA A 170
VAL A 173
 None
 1.36A 5nm5A-4cp8A:
undetectable		 5nm5A-4cp8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp8 ANTIBODY C05, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASN H  52
SER H  97
ALA H  33
VAL H  34
 None
 0.84A 5nm5A-4fp8H:
undetectable		 5nm5A-4fp8H:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN A 329
SER A 378
ALA A 357
VAL A 358
 None
 0.76A 5nm5A-4ggaA:
undetectable		 5nm5A-4ggaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnj TRIOSEPHOSPHATE
ISOMERASE

(Leishmania sp.
'siamensis') 		PF00121
(TIM) 		4 ASN A  12
SER A  45
ALA A  43
VAL A  42
 None
 1.39A 5nm5A-4gnjA:
undetectable		 5nm5A-4gnjA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxr MALONYL COA
SYNTHETASE,
BENZOATE-COA LIGASE
CHIMERIC PROTEIN

(Paraburkholderia
xenovorans;
Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASN A 484
SER A 277
ALA A 488
VAL A 489
 None
CO3  A 608 ( 2.3A)
None
MLY  A 491 ( 4.9A)
 1.17A 5nm5A-4gxrA:
undetectable		 5nm5A-4gxrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gys ALLOPHANATE
HYDROLASE

(Granulibacter
bethesdensis) 		PF01425
(Amidase) 		4 ASN A 180
SER A 149
ALA A 153
VAL A 156
 None
 1.39A 5nm5A-4gysA:
undetectable		 5nm5A-4gysA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASN A 283
SER A 380
ALA A 378
VAL A 377
 None
 1.26A 5nm5A-4hjhA:
undetectable		 5nm5A-4hjhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 ASN A 368
SER A 338
ALA A 343
VAL A 344
 None
 1.38A 5nm5A-4irlA:
undetectable		 5nm5A-4irlA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		4 ASN A 185
SER A 154
ALA A 158
VAL A 161
 None
 1.40A 5nm5A-4issA:
undetectable		 5nm5A-4issA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jy4 PGT121 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASN A  50
SER A  30
ALA A  32
VAL A  33
 None
 1.15A 5nm5A-4jy4A:
undetectable		 5nm5A-4jy4A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jy6 PGT123 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASN A  50
SER A  30
ALA A  32
VAL A  33
 ZN  A 307 ( 4.0A)
None
None
None
 1.13A 5nm5A-4jy6A:
undetectable		 5nm5A-4jy6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX

(Pseudomonas
aeruginosa) 		no annotation 4 ASN B 291
SER B 269
ALA B 293
VAL B 266
 None
 1.37A 5nm5A-4kncB:
undetectable		 5nm5A-4kncB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lps HYDROGENASE/UREASE
NICKEL INCORPORATION
PROTEIN HYPB

(Helicobacter
pylori) 		PF02492
(cobW) 		4 ASN A  50
SER A 238
ALA A 150
VAL A  48
 None
MLI  A 309 ( 4.2A)
None
None
 1.20A 5nm5A-4lpsA:
undetectable		 5nm5A-4lpsA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE

(Planctopirus
limnophila) 		PF01048
(PNP_UDP_1) 		4 ASN A 135
SER A 189
ALA A 187
VAL A 186
 None
 1.29A 5nm5A-4m1eA:
3.0		 5nm5A-4m1eA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ

(Pseudomonas
putida) 		PF16822
(ALGX) 		4 ASN A 311
SER A 288
ALA A 313
VAL A 285
 None
 1.37A 5nm5A-4o8vA:
undetectable		 5nm5A-4o8vA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 ASN B 414
SER B 467
ALA B 471
VAL B 472
 None
 1.34A 5nm5A-4oavB:
undetectable		 5nm5A-4oavB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oca UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF01041
(DegT_DnrJ_EryC1) 		4 ASN A  41
SER A  61
ALA A  59
VAL A  58
 None
 1.22A 5nm5A-4ocaA:
undetectable		 5nm5A-4ocaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 ASN A 247
SER A 181
ALA A 389
VAL A 282
 None
None
2UO  A 502 ( 4.1A)
2UO  A 502 ( 4.4A)
 0.96A 5nm5A-4oqrA:
undetectable		 5nm5A-4oqrA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ASN A 278
SER A 134
ALA A 132
VAL A 131
 ARG  A 805 ( 4.6A)
None
None
None
 1.24A 5nm5A-4rf7A:
undetectable		 5nm5A-4rf7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE

(Macrobdella
decora) 		PF02973
(Sialidase)
PF13088
(BNR_2) 		4 ASN A 675
SER A 701
ALA A 703
VAL A 704
 None
 1.23A 5nm5A-4sliA:
undetectable		 5nm5A-4sliA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tm3 KTZI

(Kutzneria sp.
744) 		PF13434
(K_oxygenase) 		4 ASN A 240
SER A 277
ALA A 238
VAL A 237
 None
 1.39A 5nm5A-4tm3A:
2.3		 5nm5A-4tm3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wec SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 ASN A  87
SER A 136
ALA A  85
VAL A  13
 None
 1.22A 5nm5A-4wecA:
5.6		 5nm5A-4wecA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		4 ASN A 175
SER A 200
ALA A 238
VAL A 237
 None
 0.96A 5nm5A-4zu9A:
5.4		 5nm5A-4zu9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmn LATROPHILIN-3

(Homo sapiens) 		PF02191
(OLF) 		4 ASN E 312
SER E 155
ALA E 366
VAL E 378
 CA  E 401 (-3.3A)
None
None
None
 1.40A 5nm5A-5cmnE:
undetectable		 5nm5A-5cmnE:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6s EPOXYQUEUOSINE
REDUCTASE

(Streptococcus
thermophilus) 		PF08331
(DUF1730)
PF13484
(Fer4_16) 		4 ASN A 251
SER A 161
ALA A  73
VAL A  72
 None
 1.26A 5nm5A-5d6sA:
undetectable		 5nm5A-5d6sA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ASN A 213
SER A 200
ALA A 209
VAL A 208
 None
 1.10A 5nm5A-5f06A:
undetectable		 5nm5A-5f06A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASN A 189
SER A 227
ALA A 211
VAL A 210
 None
None
None
C8E  A1722 ( 4.7A)
 0.94A 5nm5A-5fokA:
undetectable		 5nm5A-5fokA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g53 ADENOSINE RECEPTOR
A2A

(Homo sapiens) 		PF00001
(7tm_1) 		4 ASN A  24
SER A  91
ALA A  49
VAL A  46
 None
 1.19A 5nm5A-5g53A:
undetectable		 5nm5A-5g53A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA

(Lactobacillus
plantarum) 		PF09861
(DUF2088) 		4 ASN A 307
SER A 282
ALA A 280
VAL A 412
 None
 1.27A 5nm5A-5huqA:
undetectable		 5nm5A-5huqA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASN A 185
SER A 154
ALA A 158
VAL A 161
 None
 1.36A 5nm5A-5i8iA:
undetectable		 5nm5A-5i8iA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 ASN A4034
SER A4004
ALA A4009
VAL A4010
 None
 1.39A 5nm5A-5ii5A:
undetectable		 5nm5A-5ii5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l51 (-)-MENTHONE:(+)-NEO
MENTHOL REDUCTASE

(Mentha x
piperita) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		4 ASN A 185
SER A 307
ALA A 269
VAL A 270
 None
 1.20A 5nm5A-5l51A:
6.6		 5nm5A-5l51A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 ASN A  51
SER A  43
ALA A  66
VAL A  70
 None
 1.30A 5nm5A-5l5gA:
undetectable		 5nm5A-5l5gA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN Q 329
SER Q 378
ALA Q 357
VAL Q 358
 None
 0.68A 5nm5A-5lcwQ:
undetectable		 5nm5A-5lcwQ:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN R 329
SER R 378
ALA R 357
VAL R 358
 None
 0.69A 5nm5A-5lcwR:
undetectable		 5nm5A-5lcwR:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpq TRANSGLYCOSYLASE

(Neisseria
meningitidis) 		PF01464
(SLT)
PF14718
(SLT_L) 		4 ASN A  51
SER A  42
ALA A  46
VAL A  47
 None
 1.34A 5nm5A-5mpqA:
undetectable		 5nm5A-5mpqA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 ASN A 190
SER A 228
ALA A 212
VAL A 211
 None
 0.93A 5nm5A-5necA:
undetectable		 5nm5A-5necA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szx ZTA TRANSCRIPTION
FACTOR

(Human
gammaherpesvirus
4) 		no annotation 4 ASN A 182
SER A 189
ALA A 185
VAL A 184
 None
 1.17A 5nm5A-5szxA:
undetectable		 5nm5A-5szxA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bacillus
anthracis) 		PF00496
(SBP_bac_5) 		4 ASN A 121
SER A 183
ALA A 124
VAL A 125
 None
 0.91A 5nm5A-5u4oA:
undetectable		 5nm5A-5u4oA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 ASN A  27
SER A  94
ALA A  52
VAL A  49
 None
None
None
OLA  A1203 (-4.0A)
 1.07A 5nm5A-5uenA:
undetectable		 5nm5A-5uenA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ASN A 154
SER A 120
ALA A 148
VAL A 130
 None
NAD  A 401 (-3.2A)
None
None
 1.35A 5nm5A-5vmtA:
undetectable		 5nm5A-5vmtA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ASN B 778
SER B 706
ALA B 686
VAL B 685
 None
 1.28A 5nm5A-5vniB:
5.3		 5nm5A-5vniB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 4 ASN A 162
SER A  29
ALA A 131
VAL A 132
 None
 1.23A 5nm5A-6a8mA:
undetectable		 5nm5A-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ASN A  24
SER A  91
ALA A  49
VAL A  46
 None
 1.14A 5nm5A-6aqfA:
undetectable		 5nm5A-6aqfA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 4 ASN A  52
SER A 121
ALA A  77
VAL A  74
 None
 1.08A 5nm5A-6cm4A:
undetectable		 5nm5A-6cm4A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 4 ASN R  27
SER R  94
ALA R  52
VAL R  49
 None
 1.23A 5nm5A-6d9hR:
undetectable		 5nm5A-6d9hR:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxt -

(-) 		no annotation 4 ASN A 211
SER A 260
ALA A 245
VAL A 246
 UNX  A 702 ( 4.2A)
None
None
None
 0.81A 5nm5A-6dxtA:
undetectable		 5nm5A-6dxtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 4 ASN A 165
SER A 323
ALA A 309
VAL A 308
 PLP  A 601 ( 4.5A)
PLP  A 601 ( 4.8A)
None
None
 1.09A 5nm5A-6enzA:
3.2		 5nm5A-6enzA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 ASN A1246
SER A1173
ALA A1186
VAL A1196
 None
 1.39A 5nm5A-6eojA:
undetectable		 5nm5A-6eojA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 LEU A 259
ASN A 209
ALA A 207
ILE A 203
ILE A 167
 None
 1.29A 5nm5B-1dysA:
2.2		 5nm5B-1dysA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g61 TRANSLATION
INITIATION FACTOR 6

(Methanocaldococcus
jannaschii) 		PF01912
(eIF-6) 		5 LEU A2020
LEU A2107
LEU A2070
ILE A2053
ILE A2084
 None
 0.98A 5nm5B-1g61A:
undetectable		 5nm5B-1g61A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU E 205
LEU E 187
ALA E 207
ILE E 198
ALA E 190
 None
 1.29A 5nm5B-1nfiE:
undetectable		 5nm5B-1nfiE:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu9 YJGF PROTEIN

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		5 LEU A  66
ALA A 125
ASN A  25
ILE A   5
ALA A  64
 None
 1.07A 5nm5B-1qu9A:
undetectable		 5nm5B-1qu9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 CYH A 929
LEU A 926
ALA A 889
LEU A 885
ILE A 806
 None
 1.07A 5nm5B-1sojA:
undetectable		 5nm5B-1sojA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 386
ASN A 420
THR A 489
ALA A 506
ALA A 279
 None
 1.09A 5nm5B-1t6pA:
undetectable		 5nm5B-1t6pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 LEU A  80
LEU A 200
MET A 159
THR A 183
ALA A 199
 None
 1.31A 5nm5B-1v9cA:
4.1		 5nm5B-1v9cA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N) 		5 LEU A1075
THR A1135
ILE A1145
ALA A1144
ILE A 157
 None
 1.21A 5nm5B-1w1wA:
undetectable		 5nm5B-1w1wA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012

(Homo sapiens) 		PF08925
(DUF1907) 		5 CYH A 140
LEU A 142
THR A 267
ILE A 218
ALA A 131
 None
 0.94A 5nm5B-1xcrA:
undetectable		 5nm5B-1xcrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		5 LEU A  51
MET A  89
ILE A 225
ALA A 162
ILE A  39
 None
 1.27A 5nm5B-1z9dA:
undetectable		 5nm5B-1z9dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		5 LEU A  13
MET A  38
ILE A  30
ALA A  27
ILE A  34
 LEU  A  13 ( 0.6A)
MET  A  38 ( 0.0A)
ILE  A  30 ( 0.6A)
ALA  A  27 ( 0.0A)
ILE  A  34 ( 0.6A)
 1.33A 5nm5B-2b92A:
undetectable		 5nm5B-2b92A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.22A 5nm5B-2ffhA:
3.9		 5nm5B-2ffhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 LEU A 185
LEU A 292
MET A 295
ALA A 282
ILE A 278
 None
 0.96A 5nm5B-2fj0A:
3.0		 5nm5B-2fj0A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		5 LEU A  49
LEU A 135
ILE A   7
ALA A  50
ILE A   9
 None
 0.89A 5nm5B-2jk0A:
2.2		 5nm5B-2jk0A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kan UNCHARACTERIZED
PROTEIN AR3433A

(Arabidopsis
thaliana) 		PF00240
(ubiquitin) 		5 LEU A  71
LEU A  57
MET A  55
THR A  50
ILE A  44
 None
 1.29A 5nm5B-2kanA:
undetectable		 5nm5B-2kanA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A   5
LEU A 292
ILE A  34
ALA A  37
ILE A  13
 None
 1.28A 5nm5B-2ng1A:
3.8		 5nm5B-2ng1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 LEU A 288
ALA A 189
LEU A 191
THR A 196
ILE A 232
 None
None
None
NAP  A 402 (-3.3A)
NAP  A 402 ( 4.8A)
 1.21A 5nm5B-2o7pA:
undetectable		 5nm5B-2o7pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.85A 5nm5B-2oi6A:
undetectable		 5nm5B-2oi6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3v INOSITOL-1-MONOPHOSP
HATASE

(Thermotoga
maritima) 		PF00459
(Inositol_P) 		5 LEU A1179
ALA A1113
ALA A1186
ILE A1208
ILE A1135
 None
 0.91A 5nm5B-2p3vA:
undetectable		 5nm5B-2p3vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		5 LEU A 222
THR A 263
ALA A   3
ALA A  88
ILE A 265
 None
 1.25A 5nm5B-2qc3A:
undetectable		 5nm5B-2qc3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 208
LEU A 151
THR A 127
ALA A 224
ILE A 185
 None
 0.82A 5nm5B-2qo3A:
undetectable		 5nm5B-2qo3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE

(Bacillus
anthracis) 		PF01467
(CTP_transf_like) 		5 LEU A  19
ALA A  63
LEU A  60
ILE A   7
ALA A  22
 None
 1.31A 5nm5B-2qtnA:
undetectable		 5nm5B-2qtnA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9v SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09105
(SelB-wing_1)
PF09106
(SelB-wing_2) 		5 LEU A 405
LEU A 414
MET A 417
ALA A 403
ILE A 387
 None
 0.99A 5nm5B-2v9vA:
undetectable		 5nm5B-2v9vA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmd DISCOIDIN-2

(Dictyostelium
discoideum) 		PF00754
(F5_F8_type_C)
PF09458
(H_lectin) 		5 CYH A  10
LEU A  11
THR A  96
ALA A 153
ILE A 134
 None
 1.21A 5nm5B-2vmdA:
undetectable		 5nm5B-2vmdA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2g NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		5 LEU A 504
LEU A 412
THR A 450
ILE A 459
ALA A 474
 None
 1.31A 5nm5B-2w2gA:
undetectable		 5nm5B-2w2gA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wiz ARCHAEAL HJC

(Archaeoglobus
fulgidus) 		PF01870
(Hjc) 		5 ALA A  23
LEU A  48
ALA A 124
ILE A 120
ALA A  19
 None
 1.05A 5nm5B-2wizA:
undetectable		 5nm5B-2wizA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A 439
ALA A 373
THR A  40
ALA A 317
ILE A 437
 None
None
NAG  A 802 ( 4.0A)
None
None
 1.07A 5nm5B-2yp2A:
undetectable		 5nm5B-2yp2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		5 LEU A 186
LEU A 107
ALA A 192
ALA A 125
ILE A 127
 None
TRP  A1464 ( 4.4A)
TRP  A1464 (-4.6A)
None
None
 1.30A 5nm5B-2ypqA:
undetectable		 5nm5B-2ypqA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a64 CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		5 LEU A  22
LEU A  93
THR A  67
ILE A  75
ILE A  71
 None
 1.27A 5nm5B-3a64A:
2.8		 5nm5B-3a64A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydia
trachomatis) 		PF00155
(Aminotran_1_2) 		5 CYH A 227
LEU A 254
THR A 120
ILE A 199
ALA A 192
 None
 1.33A 5nm5B-3asaA:
undetectable		 5nm5B-3asaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		5 LEU A 374
ASN A 378
ALA A 358
ALA A 333
ILE A 360
 None
 0.95A 5nm5B-3bz5A:
undetectable		 5nm5B-3bz5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR-SORTING
PROTEIN SNF8

(Homo sapiens) 		PF04157
(EAP30) 		5 LEU A 236
ALA A 222
LEU A 213
ALA A 187
ILE A 198
 None
 1.07A 5nm5B-3cuqA:
undetectable		 5nm5B-3cuqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.84A 5nm5B-3k1jA:
undetectable		 5nm5B-3k1jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		5 LEU A  63
ASN A  81
THR A   5
ALA A   7
ILE A  85
 None
 1.30A 5nm5B-3k53A:
2.8		 5nm5B-3k53A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klb PUTATIVE
FLAVOPROTEIN

(Bacteroides
fragilis) 		PF12682
(Flavodoxin_4) 		5 LEU A 128
ASN A 127
ALA A  92
ALA A 114
ILE A  96
 None
 1.15A 5nm5B-3klbA:
4.7		 5nm5B-3klbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		5 ALA A  68
THR A 184
ALA A 133
ILE A 131
ILE A 182
 None
NAD  A 300 ( 4.4A)
None
None
None
 1.07A 5nm5B-3r3sA:
7.1		 5nm5B-3r3sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 525
LEU A 498
LEU A 503
THR A 459
ILE A 486
 None
 1.05A 5nm5B-3rg1A:
undetectable		 5nm5B-3rg1A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
 None
 0.78A 5nm5B-3twdA:
undetectable		 5nm5B-3twdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		6 LEU A  75
LEU A 437
ALA A  77
ILE A 427
ALA A 433
ILE A 424
 None
 1.48A 5nm5B-3ubrA:
undetectable		 5nm5B-3ubrA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans) 		PF00221
(Lyase_aromatic) 		5 CYH A 486
LEU A 412
ALA A 490
LEU A 254
ILE A 396
 None
 1.06A 5nm5B-3unvA:
undetectable		 5nm5B-3unvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtc PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00106
(adh_short) 		5 LEU A  73
THR A  11
ALA A   9
ILE A   7
ILE A  33
 None
 0.99A 5nm5B-3wtcA:
7.1		 5nm5B-3wtcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 LEU A 361
ALA A 380
LEU A 377
ILE A 346
ALA A 344
 None
 1.29A 5nm5B-3zh4A:
undetectable		 5nm5B-3zh4A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 284
LEU A 236
LEU A 262
ASN A 241
ILE A 246
 None
 1.18A 5nm5B-3zyoA:
undetectable		 5nm5B-3zyoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4an7 TRYPSIN INHIBITOR

(Tamarindus
indica) 		PF00197
(Kunitz_legume) 		5 LEU B  76
ASN B  77
ILE B  67
ALA B  65
ILE B  70
 None
 1.32A 5nm5B-4an7B:
undetectable		 5nm5B-4an7B:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 LEU A  94
ALA A 277
LEU A 274
ILE A 174
ILE A 176
 None
 1.32A 5nm5B-4bb9A:
4.7		 5nm5B-4bb9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 LEU A  17
MET A  37
ILE A 411
ALA A  60
ILE A 447
 None
 1.32A 5nm5B-4cnsA:
2.4		 5nm5B-4cnsA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		5 CYH A  34
ASN A 100
ILE A  51
ALA A  97
ILE A  71
 None
 1.10A 5nm5B-4d7pA:
undetectable		 5nm5B-4d7pA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A 140
ALA A 308
LEU A 297
ILE A 100
ALA A  99
 None
 0.88A 5nm5B-4e51A:
undetectable		 5nm5B-4e51A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA) 		5 LEU A  65
ALA A  75
MET A  53
ALA A   7
ILE A  60
 None
 1.13A 5nm5B-4ew6A:
4.5		 5nm5B-4ew6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fq0 FLAGELLAR MOTOR
SWITCH PROTEIN

(Helicobacter
pylori) 		PF14841
(FliG_M) 		5 LEU C 195
LEU C 122
ASN C 153
ILE C 134
ALA C 131
 None
 1.34A 5nm5B-4fq0C:
undetectable		 5nm5B-4fq0C:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1) 		PF00661
(Matrix) 		5 LEU A 206
LEU A 204
MET A 242
ALA A 282
ILE A 261
 None
 1.19A 5nm5B-4g1gA:
undetectable		 5nm5B-4g1gA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6q PROLINE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF01619
(Pro_dh) 		5 LEU A  82
LEU A 279
ASN A  58
ILE A  44
ALA A  86
 None
 1.15A 5nm5B-4h6qA:
2.9		 5nm5B-4h6qA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE

(Photorhabdus
laumondii) 		PF01494
(FAD_binding_3) 		5 LEU A 334
LEU A 315
ALA A 337
THR A 124
ALA A 160
 None
 1.08A 5nm5B-4hb9A:
undetectable		 5nm5B-4hb9A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhu OR280

(synthetic
construct) 		no annotation 5 LEU A  20
LEU A  65
ILE A   6
ALA A  62
ILE A  47
 AE4  A 201 (-4.8A)
None
None
None
None
 1.06A 5nm5B-4hhuA:
undetectable		 5nm5B-4hhuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhu OR280

(synthetic
construct) 		no annotation 5 LEU A 101
LEU A 146
ILE A  87
ALA A 143
ILE A 128
 None
 1.19A 5nm5B-4hhuA:
undetectable		 5nm5B-4hhuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A  83
ALA A 103
ASN A 134
ILE A  94
ALA A  86
 None
 1.24A 5nm5B-4hrlA:
undetectable		 5nm5B-4hrlA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		5 LEU A 753
LEU A 799
THR A 812
ILE A 770
ILE A 776
 None
 1.17A 5nm5B-4i2wA:
undetectable		 5nm5B-4i2wA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iau BETA-GAMMA-CRYSTALLI
N

(Geodia cydonium) 		PF00030
(Crystall) 		5 LEU A 101
LEU A 156
ALA A 116
ILE A 118
ALA A  86
 None
 0.97A 5nm5B-4iauA:
undetectable		 5nm5B-4iauA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Escherichia
coli) 		no annotation 5 LEU A 198
LEU A 190
ALA A 211
ALA A 166
ILE A 169
 None
 1.09A 5nm5B-4iqzA:
undetectable		 5nm5B-4iqzA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 LEU A 184
LEU A 153
ALA A 192
ILE A 199
ALA A  89
 None
 1.27A 5nm5B-4kpgA:
2.6		 5nm5B-4kpgA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 LEU A 184
LEU A 153
ALA A 192
ILE A 199
ALA A  89
 None
 1.30A 5nm5B-4m1zA:
2.6		 5nm5B-4m1zA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0g PROTEIN PHOSPHATASE
2C 37

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 CYH A 321
LEU A 389
LEU A 346
ASN A 360
ALA A 342
 None
 1.29A 5nm5B-4n0gA:
undetectable		 5nm5B-4n0gA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nez ENGINEERED PROTEIN
OR276

(synthetic
construct) 		no annotation 5 LEU A 103
LEU A 148
ILE A  89
ALA A 145
ILE A 130
 None
 1.14A 5nm5B-4nezA:
undetectable		 5nm5B-4nezA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR

(Gallus gallus) 		PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2) 		5 LEU A 146
LEU A  94
ASN A 117
ILE A 132
ILE A 110
 None
 1.04A 5nm5B-4pbvA:
undetectable		 5nm5B-4pbvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 5 LEU H  88
LEU H   8
ALA H  10
ILE H  70
ALA H  73
 None
 1.17A 5nm5B-4qslH:
undetectable		 5nm5B-4qslH:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 LEU A 325
LEU A 338
LEU A 761
MET A 764
ILE A 772
 None
 1.14A 5nm5B-4r7zA:
undetectable		 5nm5B-4r7zA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpg PROTON:OLIGOPEPTIDE
SYMPORTER POT FAMILY

(Shewanella
oneidensis) 		PF00854
(PTR2) 		5 LEU A 160
LEU A  34
ALA A 181
ASN A 169
ALA A 323
 None
 0.92A 5nm5B-4tpgA:
undetectable		 5nm5B-4tpgA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti) 		PF00884
(Sulfatase)
PF12411
(Choline_sulf_C) 		5 ALA A  36
LEU A  34
ILE A 291
ALA A 324
ILE A  11
 None
 1.22A 5nm5B-4ug4A:
undetectable		 5nm5B-4ug4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		5 LEU A 493
MET A 421
ALA A 439
ALA A 500
ILE A 427
 None
 1.19A 5nm5B-4wyiA:
5.1		 5nm5B-4wyiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF13855
(LRR_8) 		5 LEU B 180
LEU B 133
LEU B 161
ASN B 138
ILE B 145
 None
 1.23A 5nm5B-4yebB:
undetectable		 5nm5B-4yebB:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhg GH5

(Bacteroidetes
bacterium AC2a) 		PF00150
(Cellulase) 		5 ALA A  99
LEU A  58
ASN A  56
ALA A  50
ILE A 354
 None
 1.13A 5nm5B-4yhgA:
2.8		 5nm5B-4yhgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		5 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.87A 5nm5B-4zpxA:
undetectable		 5nm5B-4zpxA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		5 LEU A 360
LEU A 431
ASN A 434
MET A 435
ALA A 366
 None
EDO  A1579 ( 4.3A)
None
None
None
 1.16A 5nm5B-5a29A:
undetectable		 5nm5B-5a29A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw9 DE NOVO DESIGNED
FERREDOXIN-FERREDOXI
N DOMAIN INSERTION
PROTEIN

(synthetic
construct) 		no annotation 5 LEU A  53
LEU A  98
ILE A  39
ALA A  95
ILE A  80
 None
 1.11A 5nm5B-5cw9A:
undetectable		 5nm5B-5cw9A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwi DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 5 CYH A 127
LEU A 114
ASN A 180
ALA A 184
ILE A 188
 None
 1.16A 5nm5B-5cwiA:
undetectable		 5nm5B-5cwiA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyq YD REPEAT-CONTAINING
PROTEIN

(Verrucosispora
maris) 		no annotation 5 LEU A  45
ALA A 135
MET A 139
ALA A 108
ILE A  87
 None
 1.25A 5nm5B-5dyqA:
undetectable		 5nm5B-5dyqA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1v POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		no annotation 5 LEU B  62
ALA B  94
ILE B  92
ALA B 114
ILE B  80
 None
 0.94A 5nm5B-5e1vB:
undetectable		 5nm5B-5e1vB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA

(Moorella
thermoacetica) 		PF00037
(Fer4)
PF01558
(POR) 		5 LEU B 186
ALA B  38
ILE B  31
ALA B 171
ILE B  15
 None
 1.27A 5nm5B-5exeB:
undetectable		 5nm5B-5exeB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A 494
MET A 436
ILE A 215
ALA A 212
ILE A 219
 None
 0.88A 5nm5B-5fkuA:
undetectable		 5nm5B-5fkuA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4v GLUTAMATE--TRNA
LIGASE

(Xanthomonas
oryzae) 		no annotation 5 LEU A 395
ALA A 391
LEU A 388
ILE A 432
ALA A 453
 None
 1.28A 5nm5B-5h4vA:
undetectable		 5nm5B-5h4vA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 LEU A 373
LEU A 367
THR A 274
ILE A 376
ALA A 366
 None
 1.30A 5nm5B-5hqnA:
undetectable		 5nm5B-5hqnA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 463
ALA A 241
ILE A 268
ALA A 279
ILE A 476
 None
 0.98A 5nm5B-5i4eA:
undetectable		 5nm5B-5i4eA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ieb SENSORY TRANSDUCTION
REGULATORY PROTEIN

(Sphingomonas
melonis) 		PF00072
(Response_reg) 		5 ALA A 115
LEU A 113
ALA A  52
ILE A  54
ILE A   7
 None
 1.27A 5nm5B-5iebA:
3.2		 5nm5B-5iebA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le9 DD_OFF7_09_3G124

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A  51
ALA A  71
ASN A 102
ILE A  62
ALA A  54
 None
 1.23A 5nm5B-5le9A:
undetectable		 5nm5B-5le9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le9 DD_OFF7_09_3G124

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A 206
ALA A 226
ASN A 257
ILE A 217
ALA A 209
 None
 1.24A 5nm5B-5le9A:
undetectable		 5nm5B-5le9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leb DDD_D12_06_D12_06_D1
2

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A  84
ALA A 104
ASN A 135
ILE A  95
ALA A  87
 None
 1.25A 5nm5B-5lebA:
undetectable		 5nm5B-5lebA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Escherichia
coli) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		5 LEU A 266
ALA A 234
ILE A 236
ALA A 226
ILE A 271
 None
 1.05A 5nm5B-5lm7A:
undetectable		 5nm5B-5lm7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mad 3G61

(synthetic
construct) 		no annotation 5 LEU A  83
ALA A 103
ASN A 134
ILE A  94
ALA A  86
 None
 1.30A 5nm5B-5madA:
undetectable		 5nm5B-5madA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mak R7

(synthetic
construct) 		no annotation 5 LEU A  51
ALA A  71
ASN A 102
ILE A  62
ALA A  54
 None
 1.24A 5nm5B-5makA:
undetectable		 5nm5B-5makA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  64
LEU A  53
LEU A  20
ALA A  11
ALA A  69
 None
 1.26A 5nm5B-5mdhA:
undetectable		 5nm5B-5mdhA:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 MET A 257
THR A 311
ALA A 313
ALA A 351
ILE A 367
 None
 0.57A 5nm5B-5mjsA:
53.8		 5nm5B-5mjsA:
58.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 LEU B 165
LEU B 341
ALA B 244
ILE B 246
ILE B   6
 None
 1.15A 5nm5B-5my0B:
undetectable		 5nm5B-5my0B:
10.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LEU B 255
ASN B 258
MET B 259
THR B 314
ILE B 378
 None
 0.93A 5nm5B-5n5nB:
54.6		 5nm5B-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LEU B 255
MET B 259
THR B 314
ALA B 316
ILE B 378
 None
 1.05A 5nm5B-5n5nB:
54.6		 5nm5B-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 MET B 259
THR B 314
ALA B 316
ALA B 354
ILE B 378
 None
 0.76A 5nm5B-5n5nB:
54.6		 5nm5B-5n5nB:
97.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2s DARPIN K27

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU B  94
ALA B 114
ASN B 145
ILE B 105
ALA B  97
 None
 1.25A 5nm5B-5o2sB:
undetectable		 5nm5B-5o2sB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 LEU T2027
ALA T2032
ILE T2029
ALA T2028
ILE T2123
 None
 1.33A 5nm5B-5ojsT:
undetectable		 5nm5B-5ojsT:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		5 LEU A 442
LEU A 437
LEU A 368
ILE A 234
ALA A 375
 None
None
UDP  A 501 (-3.9A)
GOL  A 503 (-4.4A)
None
 1.15A 5nm5B-5tvgA:
undetectable		 5nm5B-5tvgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9j PRHC

(Penicillium
brasilianum) 		no annotation 5 LEU A 109
ASN A 108
ILE A  89
ALA A  14
ILE A 111
 None
 0.97A 5nm5B-5x9jA:
undetectable		 5nm5B-5x9jA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
aureus) 		no annotation 5 LEU A 202
LEU A 177
ALA A 204
ILE A 509
ALA A 191
 None
 1.34A 5nm5B-5xexA:
undetectable		 5nm5B-5xexA:
21.49