SIMILAR PATTERNS OF AMINO ACIDS FOR 5NKN_A_LOCA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens) 		PF00191
(Annexin) 		5 GLY A 235
LEU A 118
ASP A 239
PHE A 153
THR A 149
 None
 1.37A 5nknA-1axnA:
undetectable		 5nknA-1axnA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		5 GLY A 373
ARG A 322
PHE A 354
THR A 347
TYR A 121
 None
CIT  A 526 (-3.3A)
None
None
None
 1.46A 5nknA-1f8rA:
0.7		 5nknA-1f8rA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 GLY A 630
PHE A 629
MET A 483
LEU A 536
THR A 619
 None
 1.36A 5nknA-1h17A:
0.0		 5nknA-1h17A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6v EMP46P

(Saccharomyces
cerevisiae) 		PF03388
(Lectin_leg-like) 		5 GLY A 106
PHE A 192
MET A 193
LEU A 132
PHE A 111
 None
 1.18A 5nknA-2a6vA:
0.0		 5nknA-2a6vA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME

(Agrobacterium
tumefaciens) 		PF00206
(Lyase_1) 		5 GLY A 349
PHE A 251
LEU A 138
ARG A 144
ASP A 145
 None
 1.00A 5nknA-2felA:
undetectable		 5nknA-2felA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Streptococcus
mutans) 		PF00694
(Aconitase_C) 		5 GLY A 105
PHE A 104
LEU A  42
PHE A  78
THR A  74
 None
 1.26A 5nknA-2hcuA:
0.0		 5nknA-2hcuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		5 GLY A 302
PHE A 275
LEU A 352
PHE A 303
THR A 277
 None
 1.29A 5nknA-2hxgA:
0.0		 5nknA-2hxgA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 GLY A  50
PHE A 256
LEU A 248
PHE A  54
TYR A  62
 DTP  A 301 ( 4.5A)
None
None
None
None
 1.42A 5nknA-2ocpA:
undetectable		 5nknA-2ocpA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		5 GLY A 324
LEU A 147
TRP A 246
THR A 138
TYR A 141
 243  A 601 (-3.8A)
None
None
None
None
 1.29A 5nknA-2rchA:
0.0		 5nknA-2rchA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		5 GLY A 384
PHE A 386
LEU A 304
PHE A 388
THR A 322
 None
 1.32A 5nknA-2wk8A:
0.0		 5nknA-2wk8A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		5 GLY A 384
PHE A 386
LEU A 359
PHE A 388
THR A 322
 None
 1.47A 5nknA-2wk8A:
0.0		 5nknA-2wk8A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cos ALCOHOL
DEHYDROGENASE 4

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 380
LEU A  22
ASP A 359
PHE A 358
THR A  44
 None
 1.15A 5nknA-3cosA:
undetectable		 5nknA-3cosA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		5 GLY A 279
LEU A 102
TRP A 201
THR A  93
TYR A  96
 None
 1.21A 5nknA-3danA:
undetectable		 5nknA-3danA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 GLY A 369
PHE A 375
LEU A 412
ASP A 365
TYR A 385
 None
 1.50A 5nknA-3dduA:
undetectable		 5nknA-3dduA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1n PROBABLE GLUTATHIONE
S-TRANSFERASE

(Bordetella
bronchiseptica) 		PF14497
(GST_C_3) 		5 GLY A 222
PHE A 133
LEU A 102
ARG A  14
PHE A 224
 CL  A 234 ( 3.9A)
None
None
None
None
 1.29A 5nknA-3h1nA:
undetectable		 5nknA-3h1nA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR

(Chromobacterium
violaceum) 		PF13377
(Peripla_BP_3) 		5 GLY A 174
PHE A 252
PHE A 282
LEU A 196
PHE A 191
 None
 1.41A 5nknA-3h5oA:
undetectable		 5nknA-3h5oA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqm SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00917
(MATH) 		5 GLY A 132
PHE A 104
PHE A  32
PHE A 102
ASP A 130
 None
 1.33A 5nknA-3hqmA:
undetectable		 5nknA-3hqmA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 172
PHE A 173
MET A 156
ASP A 179
PHE A 178
 None
 1.05A 5nknA-3i6eA:
undetectable		 5nknA-3i6eA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 172
PHE A 173
MET A 156
LEU A 185
ASP A 179
 None
 1.15A 5nknA-3i6eA:
undetectable		 5nknA-3i6eA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 170
PHE A 171
MET A 154
ASP A 177
PHE A 176
 None
 1.15A 5nknA-3i6tA:
undetectable		 5nknA-3i6tA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 160
PHE A 161
PHE A 335
PHE A 345
THR A 139
 None
 1.35A 5nknA-3sjnA:
undetectable		 5nknA-3sjnA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLY A 418
PHE A 148
LEU A 350
ASP A  77
PHE A 417
 None
None
None
None
EDO  A 499 ( 3.7A)
 1.44A 5nknA-3snxA:
undetectable		 5nknA-3snxA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syx SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00568
(WH1) 		5 PHE A 103
LEU A  76
ARG A 117
ASP A 113
PHE A 112
 None
 1.34A 5nknA-3syxA:
undetectable		 5nknA-3syxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 GLY A 151
PHE A 152
PHE A 218
ASP A 117
PHE A 147
 None
 1.38A 5nknA-3wzfA:
undetectable		 5nknA-3wzfA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 GLY B 260
LEU B 292
ASP B 288
PHE B 223
THR B 254
 None
 1.32A 5nknA-4cakB:
undetectable		 5nknA-4cakB:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dw1 P2X PURINOCEPTOR

(Danio rerio) 		PF00864
(P2X_receptor) 		5 GLY A 317
PHE A 299
TRP A  87
THR A 313
TYR A 303
 None
 1.43A 5nknA-4dw1A:
undetectable		 5nknA-4dw1A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		5 GLY A  42
PHE A 319
LEU A 265
ARG A 199
ASP A 225
 None
 1.48A 5nknA-4joqA:
undetectable		 5nknA-4joqA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		5 GLY A  71
PHE A  73
MET A   8
LEU A 120
ASP A 214
 None
 1.50A 5nknA-4mnpA:
undetectable		 5nknA-4mnpA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE

(Geobacillus
kaustophilus) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		5 GLY A 303
PHE A 276
LEU A 351
PHE A 304
THR A 278
 None
 1.30A 5nknA-4r1pA:
undetectable		 5nknA-4r1pA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhc ALPHA-L-RHAMNOSIDASE

(Klebsiella
oxytoca) 		PF17389
(Bac_rhamnosid6H) 		5 GLY A 109
PHE A 153
PHE A  89
LEU A 136
PHE A 108
 None
 1.37A 5nknA-4xhcA:
undetectable		 5nknA-4xhcA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8z NEUTROPHIL ELASTASE

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 207
LEU A 155
TRP A  27
PHE A  29
THR A  45
 FUC  A 402 (-3.7A)
None
None
None
None
 1.44A 5nknA-5a8zA:
undetectable		 5nknA-5a8zA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE

(Pseudomonas
veronii) 		PF00561
(Abhydrolase_1) 		5 GLY A 230
PHE A 231
LEU A 323
ARG A 225
PHE A 237
 None
 1.26A 5nknA-5e4yA:
undetectable		 5nknA-5e4yA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		5 GLY A 341
LEU A 287
PHE A 247
THR A 251
TYR A 255
 7BV  A 500 (-3.9A)
None
7BV  A 500 (-4.0A)
7BV  A 500 (-4.4A)
None
 1.12A 5nknA-5gyzA:
undetectable		 5nknA-5gyzA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7s SECRETED RXLR
EFFECTOR PEPTIDE
PROTEIN

(Phytophthora
infestans) 		no annotation 5 GLY A 253
PHE A 252
PHE A 233
LEU A 274
ASP A 254
 None
 1.13A 5nknA-5l7sA:
undetectable		 5nknA-5l7sA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncr TYROSINE PHOSPHATASE

(Orf virus) 		PF00782
(DSPc) 		5 PHE A 161
PHE A 175
MET A 174
THR A 150
TYR A 146
 None
 1.38A 5nknA-5ncrA:
undetectable		 5nknA-5ncrA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		5 GLY A 373
ARG A 322
PHE A 354
THR A 347
TYR A 121
 None
 1.46A 5nknA-5ts5A:
undetectable		 5nknA-5ts5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vzt F-BOX ONLY PROTEIN
31

(Homo sapiens) 		no annotation 5 PHE B 192
LEU B 160
TRP B 149
ARG B 288
ASP B 224
 None
 1.38A 5nknA-5vztB:
3.8		 5nknA-5vztB:
20.00