SIMILAR PATTERNS OF AMINO ACIDS FOR 5NKN_A_LOCA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens) 		PF00191
(Annexin) 		5 GLY A 235
LEU A 118
ASP A 239
PHE A 153
THR A 149
 None
 1.37A 5nknA-1axnA:
undetectable		 5nknA-1axnA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		5 GLY A 373
ARG A 322
PHE A 354
THR A 347
TYR A 121
 None
CIT  A 526 (-3.3A)
None
None
None
 1.46A 5nknA-1f8rA:
0.7		 5nknA-1f8rA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 GLY A 630
PHE A 629
MET A 483
LEU A 536
THR A 619
 None
 1.36A 5nknA-1h17A:
0.0		 5nknA-1h17A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6v EMP46P

(Saccharomyces
cerevisiae) 		PF03388
(Lectin_leg-like) 		5 GLY A 106
PHE A 192
MET A 193
LEU A 132
PHE A 111
 None
 1.18A 5nknA-2a6vA:
0.0		 5nknA-2a6vA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME

(Agrobacterium
tumefaciens) 		PF00206
(Lyase_1) 		5 GLY A 349
PHE A 251
LEU A 138
ARG A 144
ASP A 145
 None
 1.00A 5nknA-2felA:
undetectable		 5nknA-2felA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Streptococcus
mutans) 		PF00694
(Aconitase_C) 		5 GLY A 105
PHE A 104
LEU A  42
PHE A  78
THR A  74
 None
 1.26A 5nknA-2hcuA:
0.0		 5nknA-2hcuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		5 GLY A 302
PHE A 275
LEU A 352
PHE A 303
THR A 277
 None
 1.29A 5nknA-2hxgA:
0.0		 5nknA-2hxgA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 GLY A  50
PHE A 256
LEU A 248
PHE A  54
TYR A  62
 DTP  A 301 ( 4.5A)
None
None
None
None
 1.42A 5nknA-2ocpA:
undetectable		 5nknA-2ocpA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		5 GLY A 324
LEU A 147
TRP A 246
THR A 138
TYR A 141
 243  A 601 (-3.8A)
None
None
None
None
 1.29A 5nknA-2rchA:
0.0		 5nknA-2rchA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		5 GLY A 384
PHE A 386
LEU A 304
PHE A 388
THR A 322
 None
 1.32A 5nknA-2wk8A:
0.0		 5nknA-2wk8A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		5 GLY A 384
PHE A 386
LEU A 359
PHE A 388
THR A 322
 None
 1.47A 5nknA-2wk8A:
0.0		 5nknA-2wk8A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cos ALCOHOL
DEHYDROGENASE 4

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 380
LEU A  22
ASP A 359
PHE A 358
THR A  44
 None
 1.15A 5nknA-3cosA:
undetectable		 5nknA-3cosA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		5 GLY A 279
LEU A 102
TRP A 201
THR A  93
TYR A  96
 None
 1.21A 5nknA-3danA:
undetectable		 5nknA-3danA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 GLY A 369
PHE A 375
LEU A 412
ASP A 365
TYR A 385
 None
 1.50A 5nknA-3dduA:
undetectable		 5nknA-3dduA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1n PROBABLE GLUTATHIONE
S-TRANSFERASE

(Bordetella
bronchiseptica) 		PF14497
(GST_C_3) 		5 GLY A 222
PHE A 133
LEU A 102
ARG A  14
PHE A 224
 CL  A 234 ( 3.9A)
None
None
None
None
 1.29A 5nknA-3h1nA:
undetectable		 5nknA-3h1nA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR

(Chromobacterium
violaceum) 		PF13377
(Peripla_BP_3) 		5 GLY A 174
PHE A 252
PHE A 282
LEU A 196
PHE A 191
 None
 1.41A 5nknA-3h5oA:
undetectable		 5nknA-3h5oA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqm SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00917
(MATH) 		5 GLY A 132
PHE A 104
PHE A  32
PHE A 102
ASP A 130
 None
 1.33A 5nknA-3hqmA:
undetectable		 5nknA-3hqmA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 172
PHE A 173
MET A 156
ASP A 179
PHE A 178
 None
 1.05A 5nknA-3i6eA:
undetectable		 5nknA-3i6eA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 172
PHE A 173
MET A 156
LEU A 185
ASP A 179
 None
 1.15A 5nknA-3i6eA:
undetectable		 5nknA-3i6eA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 170
PHE A 171
MET A 154
ASP A 177
PHE A 176
 None
 1.15A 5nknA-3i6tA:
undetectable		 5nknA-3i6tA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 160
PHE A 161
PHE A 335
PHE A 345
THR A 139
 None
 1.35A 5nknA-3sjnA:
undetectable		 5nknA-3sjnA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLY A 418
PHE A 148
LEU A 350
ASP A  77
PHE A 417
 None
None
None
None
EDO  A 499 ( 3.7A)
 1.44A 5nknA-3snxA:
undetectable		 5nknA-3snxA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syx SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00568
(WH1) 		5 PHE A 103
LEU A  76
ARG A 117
ASP A 113
PHE A 112
 None
 1.34A 5nknA-3syxA:
undetectable		 5nknA-3syxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 GLY A 151
PHE A 152
PHE A 218
ASP A 117
PHE A 147
 None
 1.38A 5nknA-3wzfA:
undetectable		 5nknA-3wzfA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 GLY B 260
LEU B 292
ASP B 288
PHE B 223
THR B 254
 None
 1.32A 5nknA-4cakB:
undetectable		 5nknA-4cakB:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dw1 P2X PURINOCEPTOR

(Danio rerio) 		PF00864
(P2X_receptor) 		5 GLY A 317
PHE A 299
TRP A  87
THR A 313
TYR A 303
 None
 1.43A 5nknA-4dw1A:
undetectable		 5nknA-4dw1A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		5 GLY A  42
PHE A 319
LEU A 265
ARG A 199
ASP A 225
 None
 1.48A 5nknA-4joqA:
undetectable		 5nknA-4joqA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		5 GLY A  71
PHE A  73
MET A   8
LEU A 120
ASP A 214
 None
 1.50A 5nknA-4mnpA:
undetectable		 5nknA-4mnpA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE

(Geobacillus
kaustophilus) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		5 GLY A 303
PHE A 276
LEU A 351
PHE A 304
THR A 278
 None
 1.30A 5nknA-4r1pA:
undetectable		 5nknA-4r1pA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhc ALPHA-L-RHAMNOSIDASE

(Klebsiella
oxytoca) 		PF17389
(Bac_rhamnosid6H) 		5 GLY A 109
PHE A 153
PHE A  89
LEU A 136
PHE A 108
 None
 1.37A 5nknA-4xhcA:
undetectable		 5nknA-4xhcA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8z NEUTROPHIL ELASTASE

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 207
LEU A 155
TRP A  27
PHE A  29
THR A  45
 FUC  A 402 (-3.7A)
None
None
None
None
 1.44A 5nknA-5a8zA:
undetectable		 5nknA-5a8zA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE

(Pseudomonas
veronii) 		PF00561
(Abhydrolase_1) 		5 GLY A 230
PHE A 231
LEU A 323
ARG A 225
PHE A 237
 None
 1.26A 5nknA-5e4yA:
undetectable		 5nknA-5e4yA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		5 GLY A 341
LEU A 287
PHE A 247
THR A 251
TYR A 255
 7BV  A 500 (-3.9A)
None
7BV  A 500 (-4.0A)
7BV  A 500 (-4.4A)
None
 1.12A 5nknA-5gyzA:
undetectable		 5nknA-5gyzA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7s SECRETED RXLR
EFFECTOR PEPTIDE
PROTEIN

(Phytophthora
infestans) 		no annotation 5 GLY A 253
PHE A 252
PHE A 233
LEU A 274
ASP A 254
 None
 1.13A 5nknA-5l7sA:
undetectable		 5nknA-5l7sA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncr TYROSINE PHOSPHATASE

(Orf virus) 		PF00782
(DSPc) 		5 PHE A 161
PHE A 175
MET A 174
THR A 150
TYR A 146
 None
 1.38A 5nknA-5ncrA:
undetectable		 5nknA-5ncrA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		5 GLY A 373
ARG A 322
PHE A 354
THR A 347
TYR A 121
 None
 1.46A 5nknA-5ts5A:
undetectable		 5nknA-5ts5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vzt F-BOX ONLY PROTEIN
31

(Homo sapiens) 		no annotation 5 PHE B 192
LEU B 160
TRP B 149
ARG B 288
ASP B 224
 None
 1.38A 5nknA-5vztB:
3.8		 5nknA-5vztB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byr PROTEIN
(ENDONUCLEASE)

(Salmonella
enterica) 		PF13091
(PLDc_2) 		3 VAL A 125
LYS A  96
MET A  33
 None
 0.90A 5nknA-1byrA:
0.0		 5nknA-1byrA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A  58
LYS A 299
MET A 300
 None
 0.97A 5nknA-1d1tA:
0.0		 5nknA-1d1tA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlj UDP-GLUCOSE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 VAL A  28
LYS A   2
MET A   1
 None
 1.07A 5nknA-1dljA:
0.0		 5nknA-1dljA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4e CASPASE-8

(Homo sapiens) 		PF00656
(Peptidase_C14) 		3 VAL B2406
LYS B2461
MET B2459
 None
 1.08A 5nknA-1i4eB:
0.0		 5nknA-1i4eB:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 VAL A 434
LYS A 304
MET A 306
 None
 1.00A 5nknA-1kclA:
0.0		 5nknA-1kclA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38)
PF09261
(Alpha-mann_mid) 		3 VAL A 293
LYS B 347
MET A  62
 None
 0.58A 5nknA-1o7dA:
undetectable		 5nknA-1o7dA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		3 VAL A 284
LYS A 498
MET A 500
 None
 0.94A 5nknA-1qafA:
0.2		 5nknA-1qafA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhd ASPARTATE
1-DECARBOXYLASE
ALPHA CHAIN

(Helicobacter
pylori) 		PF02261
(Asp_decarbox) 		3 VAL A  47
LYS A  43
MET A  42
 None
 0.96A 5nknA-1uhdA:
0.0		 5nknA-1uhdA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uty NON-STRUCTURAL
PROTEIN 2

(Bluetongue
virus) 		PF04514
(BTV_NS2) 		3 VAL A  99
LYS A 120
MET A 104
 None
 0.93A 5nknA-1utyA:
0.0		 5nknA-1utyA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		3 VAL A 741
LYS A 591
MET A 592
 None
 1.06A 5nknA-1ygpA:
undetectable		 5nknA-1ygpA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhn RAB INTERACTING
LYSOSOMAL PROTEIN

(Homo sapiens) 		PF11461
(RILP) 		3 VAL B 294
LYS B 302
MET B 305
 None
 0.90A 5nknA-1yhnB:
undetectable		 5nknA-1yhnB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj7 ESCJ

(Escherichia
coli) 		PF01514
(YscJ_FliF) 		3 VAL A  45
LYS A  21
MET A  20
 None
 1.10A 5nknA-1yj7A:
undetectable		 5nknA-1yj7A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 VAL A 398
LYS A 404
MET A 407
 None
 1.05A 5nknA-1z1wA:
undetectable		 5nknA-1z1wA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 VAL A 675
LYS A 681
MET A 685
 None
 1.08A 5nknA-1z1wA:
undetectable		 5nknA-1z1wA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z77 TRANSCRIPTIONAL
REGULATOR (TETR
FAMILY)

(Thermotoga
maritima) 		PF00440
(TetR_N) 		3 VAL A 187
LYS A 195
MET A 198
 None
 0.99A 5nknA-1z77A:
undetectable		 5nknA-1z77A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		3 VAL A 180
LYS A 172
MET A 170
 None
 1.00A 5nknA-1z7cA:
undetectable		 5nknA-1z7cA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjj HYPOTHETICAL PROTEIN
PH1952

(Pyrococcus
horikoshii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 VAL A 229
LYS A 225
MET A 224
 None
 1.05A 5nknA-1zjjA:
undetectable		 5nknA-1zjjA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2f EXOCYST COMPLEX
COMPONENT SEC15

(Drosophila
melanogaster) 		PF04091
(Sec15) 		3 VAL X  77
LYS X  85
MET X  88
 None
 1.02A 5nknA-2a2fX:
undetectable		 5nknA-2a2fX:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a39 ENDOGLUCANASE I

(Humicola
insolens) 		PF00840
(Glyco_hydro_7) 		3 VAL A  66
LYS A   2
MET A  75
 None
None
PCA  A   1 ( 4.0A)
 0.84A 5nknA-2a39A:
undetectable		 5nknA-2a39A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE

(Streptococcus
pyogenes) 		PF09028
(Mac-1) 		3 VAL A 298
LYS A 294
MET A 293
 None
 1.06A 5nknA-2au1A:
undetectable		 5nknA-2au1A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4g HYPOTHETICAL PROTEIN
BSU11850

(Bacillus
subtilis) 		PF13563
(2_5_RNA_ligase2) 		3 VAL A  81
LYS A  85
MET A  69
 None
 0.81A 5nknA-2d4gA:
undetectable		 5nknA-2d4gA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9z PUTATIVE SEPTATION
PROTEIN SPOVG

(Staphylococcus
epidermidis) 		PF04026
(SpoVG) 		3 VAL A  76
LYS A   2
MET A   1
 None
 0.86A 5nknA-2i9zA:
undetectable		 5nknA-2i9zA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		3 VAL A 117
LYS A 153
MET A  87
 None
 0.84A 5nknA-2ibpA:
undetectable		 5nknA-2ibpA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		3 VAL A 237
LYS A 153
MET A  87
 None
 0.91A 5nknA-2ibpA:
undetectable		 5nknA-2ibpA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig6 NIMC/NIMA FAMILY
PROTEIN

(Clostridium
acetobutylicum) 		PF01243
(Putative_PNPOx) 		3 VAL A 109
LYS A  38
MET A   1
 None
 0.93A 5nknA-2ig6A:
undetectable		 5nknA-2ig6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jz4 JASMONATE INDUCIBLE
PROTEIN ISOLOG

(Arabidopsis
thaliana) 		PF01419
(Jacalin) 		3 VAL A 229
LYS A 275
MET A 295
 None
 1.08A 5nknA-2jz4A:
undetectable		 5nknA-2jz4A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kym BUD EMERGENCE
PROTEIN 1

(Lodderomyces
elongisporus) 		PF00018
(SH3_1) 		3 VAL A  77
LYS A  85
MET A  -2
 None
 1.00A 5nknA-2kymA:
undetectable		 5nknA-2kymA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2luv INTEGRIN ALPHA-X

(Homo sapiens) 		PF00357
(Integrin_alpha) 		3 VAL A   2
LYS A  10
MET A  13
 None
 0.86A 5nknA-2luvA:
undetectable		 5nknA-2luvA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 VAL A 491
LYS A 401
MET A 397
 VAL  A 491 ( 0.6A)
LYS  A 401 ( 0.0A)
ILE  A 402 ( 3.8A)
 1.10A 5nknA-2nvvA:
undetectable		 5nknA-2nvvA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opc AVRL567-A

(Melampsora lini) 		PF11529
(AvrL567-A) 		3 VAL A  49
LYS A  70
MET A 107
 None
 0.75A 5nknA-2opcA:
undetectable		 5nknA-2opcA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		3 VAL B 463
LYS B 485
MET B 508
 CFA  B 602 (-4.6A)
IHP  B 601 (-2.5A)
None
 0.98A 5nknA-2p1nB:
undetectable		 5nknA-2p1nB:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvt AVRL567-D

(Melampsora lini) 		PF11529
(AvrL567-A) 		3 VAL A  49
LYS A  70
MET A 107
 None
 0.67A 5nknA-2qvtA:
undetectable		 5nknA-2qvtA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 VAL A 101
LYS A 130
MET A   7
 None
 0.89A 5nknA-2rgwA:
undetectable		 5nknA-2rgwA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE

(Dictyostelium
discoideum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 VAL A 200
LYS A 313
MET A 266
 None
 1.10A 5nknA-2uuuA:
undetectable		 5nknA-2uuuA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Geobacillus
stearothermophilus) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 VAL A 419
LYS A 204
MET A 209
 None
 1.09A 5nknA-2w8zA:
undetectable		 5nknA-2w8zA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		3 VAL A 411
LYS A 359
MET A 669
 None
 1.02A 5nknA-2xsgA:
1.5		 5nknA-2xsgA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf4 ETHYL TERT-BUTYL
ETHER DEGRADATION
ETHD PROTEIN

(Cupriavidus
pinatubonensis) 		PF07110
(EthD) 		3 VAL A   4
LYS A  30
MET A  28
 None
 0.83A 5nknA-3bf4A:
undetectable		 5nknA-3bf4A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cng NUDIX HYDROLASE

(Nitrosomonas
europaea) 		PF00293
(NUDIX)
PF14803
(Nudix_N_2) 		3 VAL A 150
LYS A 156
MET A 159
 CL  A 519 ( 3.9A)
None
None
 1.02A 5nknA-3cngA:
undetectable		 5nknA-3cngA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed8 YELLOW FLUORESCENCE
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		3 VAL A  16
LYS A 113
MET A  88
 None
 1.08A 5nknA-3ed8A:
undetectable		 5nknA-3ed8A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP1

(Enterovirus C) 		PF00073
(Rhv) 		3 VAL 1  77
LYS 1 262
MET 1 261
 None
None
SC4  1 999 ( 4.6A)
 0.88A 5nknA-3epf1:
undetectable		 5nknA-3epf1:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evp GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		3 VAL A 174
LYS A 271
MET A 246
 None
 1.08A 5nknA-3evpA:
undetectable		 5nknA-3evpA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		3 VAL A  93
LYS A 168
MET A 169
 None
 1.02A 5nknA-3fahA:
undetectable		 5nknA-3fahA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fb2 SPECTRIN ALPHA
CHAIN, BRAIN
SPECTRIN

(Homo sapiens) 		PF00435
(Spectrin) 		3 VAL A1529
LYS A1537
MET A1540
 None
 0.98A 5nknA-3fb2A:
undetectable		 5nknA-3fb2A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 324
LYS A 194
MET A 195
 None
 1.08A 5nknA-3fmeA:
undetectable		 5nknA-3fmeA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwr YQZB PROTEIN

(Bacillus
subtilis) 		PF00571
(CBS) 		3 VAL A 108
LYS A 196
MET A 199
 None
 1.09A 5nknA-3fwrA:
undetectable		 5nknA-3fwrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga2 ENDONUCLEASE V

(Bacillus
subtilis) 		PF04493
(Endonuclease_5) 		3 VAL A   6
LYS A   2
MET A   1
 None
 0.89A 5nknA-3ga2A:
undetectable		 5nknA-3ga2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h05 UNCHARACTERIZED
PROTEIN VPA0413

(Vibrio
parahaemolyticus) 		PF01467
(CTP_transf_like) 		3 VAL A 104
LYS A   3
MET A   1
 None
 0.91A 5nknA-3h05A:
undetectable		 5nknA-3h05A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw 50S RIBOSOMAL
PROTEIN L7AE

(Pyrococcus
furiosus) 		PF01248
(Ribosomal_L7Ae) 		3 VAL C 112
LYS C 120
MET C 123
 None
 1.07A 5nknA-3hjwC:
undetectable		 5nknA-3hjwC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		3 VAL 1  57
LYS 1 247
MET 1 268
 None
 0.62A 5nknA-3i9v1:
undetectable		 5nknA-3i9v1:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II

(Escherichia
coli) 		PF00294
(PfkB) 		3 VAL A  83
LYS A 115
MET A 144
 None
 1.10A 5nknA-3iq0A:
undetectable		 5nknA-3iq0A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus) 		PF00901
(Orbi_VP5) 		3 VAL D 345
LYS D 349
MET D 352
 None
 0.82A 5nknA-3j9eD:
undetectable		 5nknA-3j9eD:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		3 VAL A  75
LYS A  63
MET A  80
 None
 0.97A 5nknA-3muuA:
undetectable		 5nknA-3muuA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 VAL A 241
LYS A   2
MET A   1
 None
 1.08A 5nknA-3oytA:
undetectable		 5nknA-3oytA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3piw TYPE I INTERFERON 2

(Danio rerio) 		PF00143
(Interferon) 		3 VAL A  92
LYS A 100
MET A 103
 None
 0.88A 5nknA-3piwA:
undetectable		 5nknA-3piwA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qit POLYKETIDE SYNTHASE

(Moorea
producens) 		PF00561
(Abhydrolase_1) 		3 VAL A 112
LYS A 225
MET A 254
 None
 1.06A 5nknA-3qitA:
undetectable		 5nknA-3qitA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvq PHOSPHODIESTERASE
OLEI02445

(Oleispira
antarctica) 		PF03009
(GDPD) 		3 VAL A 234
LYS A  38
MET A 111
 None
CL  A 259 ( 4.8A)
None
 0.99A 5nknA-3qvqA:
undetectable		 5nknA-3qvqA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		3 VAL A 280
LYS A 323
MET A 374
 None
 1.03A 5nknA-3t33A:
undetectable		 5nknA-3t33A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u78 LYSINE-SPECIFIC
DEMETHYLASE 7

(Homo sapiens) 		PF02373
(JmjC) 		3 VAL A 432
LYS A 440
MET A 443
 None
 0.82A 5nknA-3u78A:
undetectable		 5nknA-3u78A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF07361
(Cytochrom_B562) 		3 VAL A  16
LYS A 221
MET A 196
 None
 1.04A 5nknA-3u8pA:
undetectable		 5nknA-3u8pA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		3 VAL A 245
LYS A 178
MET A 175
 None
 0.94A 5nknA-3wrtA:
undetectable		 5nknA-3wrtA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz2 UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09754
(PAC2) 		3 VAL A 205
LYS A  39
MET A  43
 None
 0.92A 5nknA-3wz2A:
undetectable		 5nknA-3wz2A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1

(Toxoplasma
gondii) 		PF01150
(GDA1_CD39) 		3 VAL A 142
LYS A 150
MET A 153
 None
 0.81A 5nknA-4a5aA:
undetectable		 5nknA-4a5aA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 VAL A 574
LYS A 540
MET A 541
 None
0T8  A 901 (-3.5A)
None
 0.85A 5nknA-4feqA:
undetectable		 5nknA-4feqA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI

(Staphylococcus
aureus) 		PF13561
(adh_short_C2) 		3 VAL A  73
LYS A 133
MET A 136
 None
 1.05A 5nknA-4fs3A:
undetectable		 5nknA-4fs3A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkv ALCOHOL
DEHYDROGENASE,
PROPANOL-PREFERRING

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A  12
LYS A   2
MET A   1
 None
 0.98A 5nknA-4gkvA:
undetectable		 5nknA-4gkvA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		3 VAL B 203
LYS B 223
MET B 140
 None
 0.78A 5nknA-4hdsB:
undetectable		 5nknA-4hdsB:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8i HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16227
(DUF4886) 		3 VAL A 153
LYS A  33
MET A  61
 None
 0.92A 5nknA-4i8iA:
undetectable		 5nknA-4i8iA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqy O-ACETYL-ADP-RIBOSE
DEACETYLASE MACROD2

(Homo sapiens) 		PF01661
(Macro) 		3 VAL A 227
LYS A 233
MET A 236
 None
 1.07A 5nknA-4iqyA:
undetectable		 5nknA-4iqyA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		3 VAL A 111
LYS A  74
MET A  76
 None
 1.09A 5nknA-4kfvA:
undetectable		 5nknA-4kfvA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lms CRYPTOPHYTE
PHYCOCYANIN (ALPHA-1
CHAIN)
CRYPTOPHYTE
PHYCOCYANIN (BETA
CHAIN)

(Chroomonas sp.) 		PF00502
(Phycobilisome)
PF02972
(Phycoerythr_ab) 		3 VAL B  19
LYS B  15
MET A  43
 None
None
P6G  B 204 (-3.6A)
 0.72A 5nknA-4lmsB:
undetectable		 5nknA-4lmsB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		3 VAL A 587
LYS A 728
MET A 726
 None
 1.03A 5nknA-4n3nA:
undetectable		 5nknA-4n3nA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		3 VAL A 563
LYS A 555
MET A 552
 None
 1.06A 5nknA-4ni2A:
undetectable		 5nknA-4ni2A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ole NEXT TO BRCA1 GENE 1
PROTEIN

(Homo sapiens) 		PF16158
(N_BRCA1_IG) 		3 VAL A 404
LYS A 399
MET A 398
 EDO  A1005 (-3.9A)
SO4  A1002 (-2.6A)
None
 1.06A 5nknA-4oleA:
undetectable		 5nknA-4oleA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		3 VAL A 803
LYS A 900
MET A 875
 None
 0.86A 5nknA-4p7hA:
undetectable		 5nknA-4p7hA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		3 VAL A 476
LYS A 472
MET A 350
 None
 0.91A 5nknA-4q2cA:
undetectable		 5nknA-4q2cA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmi CYTOSKELETON-ASSOCIA
TED PROTEIN 5

(Homo sapiens) 		PF12348
(CLASP_N) 		3 VAL A1069
LYS A1077
MET A1080
 None
 1.03A 5nknA-4qmiA:
undetectable		 5nknA-4qmiA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF00551
(Formyl_trans_N) 		3 VAL A   6
LYS A   2
MET A   1
 None
 1.05A 5nknA-4s1nA:
undetectable		 5nknA-4s1nA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE

(Macrobdella
decora) 		PF02973
(Sialidase)
PF13088
(BNR_2) 		3 VAL A 193
LYS A 256
MET A  87
 None
 0.95A 5nknA-4sliA:
undetectable		 5nknA-4sliA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		3 VAL A2551
LYS A2559
MET A2562
 None
 1.03A 5nknA-4x0qA:
undetectable		 5nknA-4x0qA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 VAL A 238
LYS A   2
MET A   1
 None
 1.06A 5nknA-4xoxA:
undetectable		 5nknA-4xoxA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6i BROMODOMAIN-CONTAINI
NG PROTEIN 9

(Homo sapiens) 		PF00439
(Bromodomain) 		3 VAL A  82
LYS A  90
MET A  92
 None
 1.04A 5nknA-4z6iA:
undetectable		 5nknA-4z6iA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP1

(Enterovirus D) 		PF00073
(Rhv) 		3 VAL A  59
LYS A 242
MET A 241
 None
 0.87A 5nknA-5bnnA:
undetectable		 5nknA-5bnnA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 VAL A 232
LYS A 214
MET A 215
 None
 1.09A 5nknA-5f7cA:
undetectable		 5nknA-5f7cA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		3 VAL A1437
LYS A1477
MET A1242
 None
 0.96A 5nknA-5fv0A:
undetectable		 5nknA-5fv0A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 VAL A 607
LYS A 623
MET A 622
 748  A1001 ( 4.7A)
CL  A1003 (-3.1A)
None
 0.99A 5nknA-5grnA:
undetectable		 5nknA-5grnA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7y BROMODOMAIN-CONTAINI
NG PROTEIN 9

(Homo sapiens) 		PF00439
(Bromodomain) 		3 VAL A  82
LYS A  90
MET A  92
 None
 1.06A 5nknA-5i7yA:
undetectable		 5nknA-5i7yA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kua PILIN

(Neisseria
meningitidis) 		PF00114
(Pilin)
PF07963
(N_methyl) 		3 VAL A 124
LYS A 103
MET A  91
 None
 1.03A 5nknA-5kuaA:
undetectable		 5nknA-5kuaA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lon KLLA0E01827P

(Kluyveromyces
lactis) 		PF06058
(DCP1) 		3 VAL B  37
LYS B 151
MET B 139
 None
 1.01A 5nknA-5lonB:
undetectable		 5nknA-5lonB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		3 VAL A 873
LYS A 721
MET A 723
 None
 0.86A 5nknA-5lrbA:
undetectable		 5nknA-5lrbA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 3 VAL A 741
LYS A 745
MET A 746
 None
 0.92A 5nknA-5nprA:
undetectable		 5nknA-5nprA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9

(Homo sapiens) 		PF00439
(Bromodomain) 		3 VAL A 198
LYS A 206
MET A 208
 None
 1.04A 5nknA-5twxA:
undetectable		 5nknA-5twxA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		3 VAL A 358
LYS A 291
MET A 270
 None
 0.99A 5nknA-5u4hA:
undetectable		 5nknA-5u4hA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj0 POLYNUCLEOTIDE
KINASE

(Escherichia
virus T4) 		no annotation 3 VAL A 232
LYS A 172
MET A 173
 None
 0.94A 5nknA-5uj0A:
undetectable		 5nknA-5uj0A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uro PREDICTED PROTEIN

(Trichoderma
reesei) 		PF00561
(Abhydrolase_1) 		3 VAL A  41
LYS A 134
MET A 276
 None
 0.88A 5nknA-5uroA:
undetectable		 5nknA-5uroA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3q ENVELOPE
GLYCOPROTEIN

(Talaromyces
marneffei) 		no annotation 3 VAL A  81
LYS A  89
MET A  92
 None
 0.56A 5nknA-5x3qA:
undetectable		 5nknA-5x3qA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoe ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E

(Staphylococcus
aureus) 		no annotation 3 VAL A  37
LYS A   3
MET A   1
 None
 1.05A 5nknA-5xoeA:
undetectable		 5nknA-5xoeA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvs GDP/UDP-N,N'-DIACETY
LBACILLOSAMINE
2-EPIMERASE
(HYDROLYZING)

(Acinetobacter
baumannii) 		no annotation 3 VAL A   6
LYS A   2
MET A   1
 None
 0.97A 5nknA-5xvsA:
undetectable		 5nknA-5xvsA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE

(Mus musculus) 		PF03281
(Mab-21) 		3 VAL A 220
LYS A 190
MET A 182
 None
 1.06A 5nknA-5xzbA:
undetectable		 5nknA-5xzbA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnn -

(-) 		no annotation 3 VAL C  32
LYS C   2
MET C   1
 None
 0.99A 5nknA-6fnnC:
undetectable		 5nknA-6fnnC:
undetectable