SIMILAR PATTERNS OF AMINO ACIDS FOR 5NJV_D_SAMD301_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bbp | BILIN BINDINGPROTEIN (Pierisbrassicae) |
PF00061(Lipocalin) | 5 | GLY A 25TRP A 27LYS A 84ASP A 16VAL A 15 | None | 0.95A | 5njvD-1bbpA:undetectable | 5njvD-1bbpA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffv | CUTS, IRON-SULFURPROTEIN OF CARBONMONOXIDEDEHYDROGENASECUTL, MOLYBDOPROTEINOF CARBON MONOXIDEDEHYDROGENASE (Hydrogenophagapseudoflava;Hydrogenophagapseudoflava) |
PF00111(Fer2)PF01799(Fer2_2)PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | GLY A 98GLY B 695GLY A 140THR B 698ILE B 693 | NoneARO B 384 ( 3.9A)NoneNoneNone | 0.91A | 5njvD-1ffvA:undetectable | 5njvD-1ffvA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfw | CHITINASE B (Arthrobactersp. TAD20) |
PF00704(Glyco_hydro_18) | 5 | GLY A 199GLY A 252GLY A 195TRP A 193ASP A 248 | NoneNoneNoneGOL A 530 (-4.2A)None | 1.02A | 5njvD-1kfwA:0.0 | 5njvD-1kfwA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l2q | MONOMETHYLAMINEMETHYLTRANSFERASE (Methanosarcinabarkeri) |
PF05369(MtmB) | 5 | GLY A 387GLY A 129GLY A 366THR A 131ILE A 156 | NoneNoneNoneXPL A 202 ( 4.5A)None | 0.74A | 5njvD-1l2qA:0.0 | 5njvD-1l2qA:20.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r6a | GENOME POLYPROTEIN (Dengue virus) |
PF01728(FtsJ) | 12 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104LYS A 105HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A 887 (-3.0A)SAH A 887 (-3.6A)SAH A 887 (-3.6A)SAH A 887 (-3.5A)SAH A 887 (-4.5A)SO4 A 902 (-2.7A)SO4 A 901 ( 3.9A)NoneSAH A 887 ( 3.3A)SAH A 887 (-3.5A)SAH A 887 (-3.9A)SAH A 887 ( 4.2A) | 0.64A | 5njvD-1r6aA:39.1 | 5njvD-1r6aA:59.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v71 | HYPOTHETICAL PROTEINC320.14 INCHROMOSOME III (Schizosaccharomycespombe) |
PF00291(PALP) | 5 | GLY A 206GLY A 190GLY A 186ASP A 12VAL A 13 | NoneNonePLP A 350 (-3.1A)NoneNone | 1.04A | 5njvD-1v71A:0.3 | 5njvD-1v71A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcw | PROTEASE DEGS (Escherichiacoli) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | GLY A 214GLY A 82GLY A 202VAL A 106ILE A 91 | None | 0.93A | 5njvD-1vcwA:undetectable | 5njvD-1vcwA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wii | HYPOTHETICAL UPF0222PROTEIN MGC4549 (Mus musculus) |
PF05129(Elf1) | 5 | GLY A 46ASP A 73VAL A 70ASP A 40ILE A 61 | None | 1.05A | 5njvD-1wiiA:undetectable | 5njvD-1wiiA:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ywp | 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATEPHOSPHODIESTERASEGAMMA 1 (Rattusnorvegicus) |
PF00018(SH3_1) | 5 | GLY A 38GLY A 42TRP A 40GLU A 20ILE A 29 | None | 1.03A | 5njvD-1ywpA:undetectable | 5njvD-1ywpA:13.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2drm | ACANTHAMOEBA MYOSINIB (Acanthamoeba) |
PF00018(SH3_1) | 5 | GLY A 38GLY A 42TRP A 40GLU A 20ILE A 29 | None | 0.93A | 5njvD-2drmA:undetectable | 5njvD-2drmA:12.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2esw | RHO GUANINENUCLEOTIDE EXCHANGEFACTOR 7 (Mus musculus) |
PF07653(SH3_2) | 5 | GLY A 40GLY A 44TRP A 42GLU A 22ILE A 31 | None | 0.90A | 5njvD-2eswA:undetectable | 5njvD-2eswA:14.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hle | EPHRIN-B2 (Homo sapiens) |
PF00812(Ephrin) | 5 | GLY B 147GLY B 153GLU B 152ASP B 90ILE B 138 | None | 1.02A | 5njvD-2hleB:undetectable | 5njvD-2hleB:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nyu | PUTATIVE RIBOSOMALRNAMETHYLTRANSFERASE 2 (Homo sapiens) |
PF01728(FtsJ) | 5 | GLY A 30TRP A 36ASP A 79VAL A 80ASP A 104 | SAM A 201 (-3.5A)SAM A 201 (-3.9A)SAM A 201 (-3.3A)SAM A 201 (-3.9A)SAM A 201 (-3.7A) | 0.52A | 5njvD-2nyuA:14.1 | 5njvD-2nyuA:25.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nzo | PROTEIN CSAA (Bacillussubtilis) |
PF01588(tRNA_bind) | 5 | GLY A 15GLY A 106THR A 14ASP A 36ILE A 35 | None | 0.98A | 5njvD-2nzoA:undetectable | 5njvD-2nzoA:20.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oxt | NUCLEOSIDE-2'-O-METHYLTRANSFERASE (Meaban virus) |
PF01728(FtsJ) | 9 | GLY A 59GLY A 82GLY A 84TRP A 88THR A 105HIS A 111GLU A 112ASP A 132ASP A 147 | SAM A 300 (-3.1A)SAM A 300 (-3.3A)SAM A 300 (-3.5A)SAM A 300 (-3.8A)SAM A 300 (-4.6A)SAM A 300 (-3.6A)NoneSAM A 300 (-3.9A)SAM A 300 (-3.9A) | 0.53A | 5njvD-2oxtA:38.7 | 5njvD-2oxtA:51.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oy0 | METHYLTRANSFERASE (West Nile virus) |
PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A 301 (-3.4A)SAH A 301 (-3.0A)SAH A 301 (-3.2A)SAH A 301 (-3.7A)SAH A 301 (-4.4A)SAH A 301 (-4.4A)SAH A 301 (-3.2A)SAH A 301 (-3.8A)SAH A 301 (-4.2A)SAH A 301 ( 4.3A) | 0.55A | 5njvD-2oy0A:39.2 | 5njvD-2oy0A:69.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oy0 | METHYLTRANSFERASE (West Nile virus) |
PF01728(FtsJ) | 8 | GLY A 58GLY A 83TRP A 87THR A 104HIS A 110GLU A 111VAL A 132ASP A 146 | SAH A 301 (-3.4A)SAH A 301 (-3.2A)SAH A 301 (-3.7A)SAH A 301 (-4.4A)SAH A 301 (-4.4A)SAH A 301 (-3.5A)SAH A 301 (-3.8A)SAH A 301 (-4.2A) | 0.84A | 5njvD-2oy0A:39.2 | 5njvD-2oy0A:69.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oy0 | METHYLTRANSFERASE (West Nile virus) |
PF01728(FtsJ) | 8 | GLY A 81GLY A 83TRP A 87THR A 104LYS A 105VAL A 132ASP A 146ILE A 147 | SAH A 301 (-3.0A)SAH A 301 (-3.2A)SAH A 301 (-3.7A)SAH A 301 (-4.4A)NoneSAH A 301 (-3.8A)SAH A 301 (-4.2A)SAH A 301 ( 4.3A) | 0.90A | 5njvD-2oy0A:39.2 | 5njvD-2oy0A:69.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oy0 | METHYLTRANSFERASE (West Nile virus) |
PF01728(FtsJ) | 7 | GLY A 83TRP A 87THR A 104LYS A 105GLU A 111VAL A 132ASP A 146 | SAH A 301 (-3.2A)SAH A 301 (-3.7A)SAH A 301 (-4.4A)NoneSAH A 301 (-3.5A)SAH A 301 (-3.8A)SAH A 301 (-4.2A) | 1.14A | 5njvD-2oy0A:39.2 | 5njvD-2oy0A:69.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oy0 | METHYLTRANSFERASE (West Nile virus) |
PF01728(FtsJ) | 6 | GLY A 86TRP A 87HIS A 110VAL A 132ASP A 146ILE A 147 | SAH A 301 (-3.0A)SAH A 301 (-3.7A)SAH A 301 (-4.4A)SAH A 301 (-3.8A)SAH A 301 (-4.2A)SAH A 301 ( 4.3A) | 1.44A | 5njvD-2oy0A:39.2 | 5njvD-2oy0A:69.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2px5 | GENOME POLYPROTEIN[CONTAINS: CAPSIDPROTEIN C (COREPROTEIN) ENVELOPE PROTEIN M(MATRIX PROTEIN) MAJOR ENVELOPEPROTEIN E NON-STRUCTURALPROTEIN 1 (NS1) NON-STRUCTURALPROTEIN 2A (NS2A) FLAVIVIRIN PROTEASENS2B REGULATORYSUBUNIT FLAVIVIRIN PROTEASENS3 CATALYTICSUBUNIT NON-STRUCTURALPROTEIN 4A (NS4A) NON-STRUCTURALPROTEIN 4B (NS4B) RNA-DIRECTED RNAPOLYMERASE (EC2.7.7.48) (NS5)] (Murray Valleyencephalitisvirus) |
PF01728(FtsJ) | 11 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104LYS A 105HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A 500 (-3.3A)SAH A 500 (-3.4A)SAH A 500 ( 3.7A)SAH A 500 (-3.4A)SAH A 500 ( 4.6A)NoneSAH A 500 (-3.9A)SAH A 500 (-3.5A)SAH A 500 (-3.6A)SAH A 500 (-3.6A)SAH A 500 ( 4.3A) | 0.51A | 5njvD-2px5A:41.2 | 5njvD-2px5A:67.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2px5 | GENOME POLYPROTEIN[CONTAINS: CAPSIDPROTEIN C (COREPROTEIN) ENVELOPE PROTEIN M(MATRIX PROTEIN) MAJOR ENVELOPEPROTEIN E NON-STRUCTURALPROTEIN 1 (NS1) NON-STRUCTURALPROTEIN 2A (NS2A) FLAVIVIRIN PROTEASENS2B REGULATORYSUBUNIT FLAVIVIRIN PROTEASENS3 CATALYTICSUBUNIT NON-STRUCTURALPROTEIN 4A (NS4A) NON-STRUCTURALPROTEIN 4B (NS4B) RNA-DIRECTED RNAPOLYMERASE (EC2.7.7.48) (NS5)] (Murray Valleyencephalitisvirus) |
PF01728(FtsJ) | 7 | GLY A 58GLY A 83TRP A 87THR A 104LYS A 105GLU A 111ASP A 146 | SAH A 500 (-3.3A)SAH A 500 ( 3.7A)SAH A 500 (-3.4A)SAH A 500 ( 4.6A)NoneSAH A 500 ( 3.2A)SAH A 500 (-3.6A) | 0.78A | 5njvD-2px5A:41.2 | 5njvD-2px5A:67.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2px5 | GENOME POLYPROTEIN[CONTAINS: CAPSIDPROTEIN C (COREPROTEIN) ENVELOPE PROTEIN M(MATRIX PROTEIN) MAJOR ENVELOPEPROTEIN E NON-STRUCTURALPROTEIN 1 (NS1) NON-STRUCTURALPROTEIN 2A (NS2A) FLAVIVIRIN PROTEASENS2B REGULATORYSUBUNIT FLAVIVIRIN PROTEASENS3 CATALYTICSUBUNIT NON-STRUCTURALPROTEIN 4A (NS4A) NON-STRUCTURALPROTEIN 4B (NS4B) RNA-DIRECTED RNAPOLYMERASE (EC2.7.7.48) (NS5)] (Murray Valleyencephalitisvirus) |
PF01728(FtsJ) | 6 | GLY A 86TRP A 87LYS A 105HIS A 110ASP A 146ILE A 147 | SAH A 500 (-3.2A)SAH A 500 (-3.4A)NoneSAH A 500 (-3.9A)SAH A 500 (-3.6A)SAH A 500 ( 4.3A) | 1.40A | 5njvD-2px5A:41.2 | 5njvD-2px5A:67.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3u | PROTEASE DEGS (Escherichiacoli) |
PF13365(Trypsin_2) | 5 | GLY A 214GLY A 82GLY A 202VAL A 106ILE A 91 | None | 0.91A | 5njvD-2r3uA:undetectable | 5njvD-2r3uA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vz9 | FATTY ACID SYNTHASE (Sus scrofa) |
PF00107(ADH_zinc_N)PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08242(Methyltransf_12)PF08659(KR)PF14765(PS-DH)PF16197(KAsynt_C_assoc) | 5 | GLY A1897GLY A2064GLY A2067GLU A2071ASP A2077 | NoneNoneNAP A3002 (-3.3A)NoneNone | 0.94A | 5njvD-2vz9A:undetectable | 5njvD-2vz9A:7.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wa2 | NON-STRUCTURALPROTEIN 5 (Modoc virus) |
PF01728(FtsJ) | 11 | GLY A 59GLY A 82GLY A 84TRP A 88THR A 105HIS A 111GLU A 112ASP A 132VAL A 133ASP A 147ILE A 148 | SAM A1248 ( 3.7A)SAM A1248 (-3.3A)SAM A1248 (-3.4A)SAM A1248 (-3.7A)SAM A1248 (-4.5A)SAM A1248 (-3.8A)NoneSAM A1248 (-3.6A)SAM A1248 (-3.4A)SAM A1248 (-3.7A)SAM A1248 ( 4.0A) | 0.36A | 5njvD-2wa2A:33.1 | 5njvD-2wa2A:50.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yoy | RBAM17540 (Bacillusamyloliquefaciens) |
PF03067(LPMO_10) | 5 | GLY A 89GLY A 58GLY A 96LYS A 56ILE A 61 | None | 0.98A | 5njvD-2yoyA:undetectable | 5njvD-2yoyA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a5r | BENZALACETONESYNTHASE (Rheum palmatum) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | GLY A 156GLY A 365GLU A 373VAL A 306ILE A 268 | HC4 A 400 (-3.6A)NoneNoneNoneNone | 1.02A | 5njvD-3a5rA:undetectable | 5njvD-3a5rA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cpq | 50S RIBOSOMALPROTEIN L30E (Methanocaldococcusjannaschii) |
PF01248(Ribosomal_L7Ae) | 5 | GLY A 77GLY A 25ASP A 54VAL A 55ILE A 47 | None | 0.91A | 5njvD-3cpqA:undetectable | 5njvD-3cpqA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eei | 5-METHYLTHIOADENOSINENUCLEOSIDASE/S-ADENOSYLHOMOCYSTEINENUCLEOSIDASE (Neisseriameningitidis) |
PF01048(PNP_UDP_1) | 5 | GLY A 84GLY A 95GLY A 147THR A 96VAL A 194 | None | 1.02A | 5njvD-3eeiA:undetectable | 5njvD-3eeiA:22.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3elu | METHYLTRANSFERASE (Wesselsbronvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104HIS A 110GLU A 111VAL A 132ASP A 146ILE A 147 | SAM A4633 ( 3.7A)SAM A4633 (-3.2A)SAM A4633 (-3.4A)SAM A4633 (-3.5A)SAM A4633 (-4.5A)SAM A4633 (-3.6A)NoneSAM A4633 (-3.4A)SAM A4633 (-3.7A)SAM A4633 ( 4.2A) | 0.49A | 5njvD-3eluA:38.5 | 5njvD-3eluA:54.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3evc | RNA-DIRECTED RNAPOLYMERASE NS5 (Yellow fevervirus) |
PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104HIS A 110ASP A 131ASP A 146ILE A 147 | SAH A 901 (-3.2A)SAH A 901 (-3.4A)SAH A 901 (-3.3A)SAH A 901 (-3.6A)SAH A 901 (-4.5A)SAH A 901 (-3.8A)SAH A 901 (-3.7A)SAH A 901 (-3.8A)SAH A 901 ( 4.2A) | 0.28A | 5njvD-3evcA:40.5 | 5njvD-3evcA:53.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fxg | RHAMNONATEDEHYDRATASE (Fusariumgraminearum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 82GLY A 24THR A 81VAL A 134ASP A 26 | None | 1.03A | 5njvD-3fxgA:undetectable | 5njvD-3fxgA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g48 | CHAPERONE CSAA (Bacillusanthracis) |
PF01588(tRNA_bind) | 5 | GLY A 15GLY A 105GLU A 39ASP A 36ILE A 35 | None | 0.94A | 5njvD-3g48A:undetectable | 5njvD-3g48A:16.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gcz | POLYPROTEIN (Yokose virus) |
PF01728(FtsJ) | 11 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A4633 (-3.5A)SAM A4633 (-3.4A)SAM A4633 (-3.4A)SAM A4633 (-3.6A)SAM A4633 (-4.5A)SAM A4633 (-3.5A)NoneSAM A4633 (-3.7A)SAM A4633 (-3.6A)SAM A4633 (-3.7A)SAM A4633 ( 4.2A) | 0.44A | 5njvD-3gczA:40.9 | 5njvD-3gczA:56.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iic | CHEC DOMAIN PROTEIN (Shewanellaloihica) |
PF13690(CheX) | 5 | GLY A 40GLY A 44THR A 93VAL A 96ILE A 148 | None | 0.99A | 5njvD-3iicA:undetectable | 5njvD-3iicA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kg9 | CURK (Lyngbyamajuscula) |
PF14765(PS-DH) | 5 | GLY A1193GLY A1084GLU A1083VAL A1016ILE A1012 | None | 1.05A | 5njvD-3kg9A:undetectable | 5njvD-3kg9A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lgi | PROTEASE DEGS (Escherichiacoli) |
PF13365(Trypsin_2) | 5 | GLY A 214GLY A 82GLY A 202VAL A 106ILE A 91 | None | 0.87A | 5njvD-3lgiA:undetectable | 5njvD-3lgiA:23.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lkz | NON-STRUCTURALPROTEIN 5 (West Nile virus) |
PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SFG A 301 (-2.9A)SFG A 301 (-3.5A)SFG A 301 (-3.3A)SFG A 301 (-3.7A)SFG A 301 ( 4.7A)SFG A 301 (-3.9A)SFG A 301 (-3.1A)SFG A 301 (-4.1A)SFG A 301 (-3.8A)SFG A 301 (-4.1A) | 0.51A | 5njvD-3lkzA:40.8 | 5njvD-3lkzA:63.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lkz | NON-STRUCTURALPROTEIN 5 (West Nile virus) |
PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104LYS A 105GLU A 111VAL A 132ASP A 146 | SFG A 301 (-2.9A)SFG A 301 (-3.5A)SFG A 301 (-3.3A)SFG A 301 (-3.7A)SFG A 301 ( 4.7A)NoneSFG A 301 (-3.7A)SFG A 301 (-4.1A)SFG A 301 (-3.8A) | 0.96A | 5njvD-3lkzA:40.8 | 5njvD-3lkzA:63.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lkz | NON-STRUCTURALPROTEIN 5 (West Nile virus) |
PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104LYS A 105VAL A 132ASP A 146ILE A 147 | SFG A 301 (-2.9A)SFG A 301 (-3.5A)SFG A 301 (-3.3A)SFG A 301 (-3.7A)SFG A 301 ( 4.7A)NoneSFG A 301 (-4.1A)SFG A 301 (-3.8A)SFG A 301 (-4.1A) | 0.79A | 5njvD-3lkzA:40.8 | 5njvD-3lkzA:63.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lop | SUBSTRATE BINDINGPERIPLASMIC PROTEIN (Ralstoniasolanacearum) |
PF13458(Peripla_BP_6) | 5 | GLY A 58GLY A 319GLU A 318ASP A 311VAL A 310 | None | 0.92A | 5njvD-3lopA:3.4 | 5njvD-3lopA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nlc | UNCHARACTERIZEDPROTEIN VP0956 (Vibrioparahaemolyticus) |
no annotation | 6 | GLY A 104GLY A 162GLY A 159THR A 163GLU A 158ILE A 514 | FAD A 601 (-3.1A)FAD A 601 (-3.1A)NoneNoneNoneFAD A 601 (-3.9A) | 1.18A | 5njvD-3nlcA:undetectable | 5njvD-3nlcA:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nlc | UNCHARACTERIZEDPROTEIN VP0956 (Vibrioparahaemolyticus) |
no annotation | 5 | GLY A 264GLY A 162GLY A 160THR A 163ILE A 514 | FAD A 601 (-3.2A)FAD A 601 (-3.1A)FAD A 601 (-3.4A)NoneFAD A 601 (-3.9A) | 0.78A | 5njvD-3nlcA:undetectable | 5njvD-3nlcA:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pv2 | DEGQ (Legionellafallonii) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | GLY A 206GLY A 69GLY A 194VAL A 94ILE A 79 | None | 0.97A | 5njvD-3pv2A:undetectable | 5njvD-3pv2A:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pv4 | DEGQ (Legionellafallonii) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | GLY A 206GLY A 69GLY A 194VAL A 94ILE A 79 | None | 0.97A | 5njvD-3pv4A:undetectable | 5njvD-3pv4A:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ufk | UNDA (Shewanella sp.HRCR_06) |
PF13435(Cytochrome_C554) | 5 | GLY A 520GLY A 588GLY A 590ASP A 484VAL A 485 | None | 0.97A | 5njvD-3ufkA:undetectable | 5njvD-3ufkA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ulr | SRC SUBSTRATECORTACTIN (Mus musculus) |
PF14604(SH3_9) | 5 | GLY B 524GLY B 528TRP B 526GLU B 506ILE B 515 | None | 1.03A | 5njvD-3ulrB:undetectable | 5njvD-3ulrB:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wsv | L-LACTATEDEHYDROGENASE (Enterococcusmundtii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLY A 82GLY A 17GLY A 14THR A 18ILE A 10 | None | 0.95A | 5njvD-3wsvA:undetectable | 5njvD-3wsvA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zlb | PHOSPHOGLYCERATEKINASE (Streptococcuspneumoniae) |
PF00162(PGK) | 6 | GLY A 296GLY A 334GLY A 324THR A 335ASP A 340ILE A 304 | ANP A1401 (-4.2A)NoneANP A1401 (-3.3A)NoneNoneNone | 1.48A | 5njvD-3zlbA:2.1 | 5njvD-3zlbA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ecg | PUTATIVEIRON-REGULATEDPROTEIN A (Parabacteroidesdistasonis) |
PF09375(Peptidase_M75) | 5 | GLY A 395GLY A 260GLY A 257ASP A 127ILE A 264 | NoneNoneNone CA A 503 ( 4.1A)None | 1.02A | 5njvD-4ecgA:undetectable | 5njvD-4ecgA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fe4 | XYLOSE OPERONREGULATORY PROTEIN (Escherichiacoli) |
PF12833(HTH_18)PF13377(Peripla_BP_3) | 5 | GLY A 243GLY A 25GLU A 24ASP A 63VAL A 83 | None | 1.03A | 5njvD-4fe4A:undetectable | 5njvD-4fe4A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4grs | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE,2-DEHYDRO-3-DEOXYPHOSPHOHEPTONATEALDOLASE (Pyrococcusfuriosus;Thermotogamaritima) |
PF00793(DAHP_synth_1) | 5 | GLY A 93GLY A 291ASP A 251ASP A 293ILE A 266 | None | 0.97A | 5njvD-4grsA:undetectable | 5njvD-4grsA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcn | GLUTAMYLENDOPEPTIDASE (Staphylococcusepidermidis) |
PF13365(Trypsin_2) | 5 | GLY A 248GLY A 104GLY A 236VAL A 131ILE A 112 | None | 1.02A | 5njvD-4jcnA:undetectable | 5njvD-4jcnA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0e | HEAVY METAL CATIONTRICOMPONENT EFFLUXPUMP ZNEA(CZCA-LIKE) (Cupriavidusmetallidurans) |
PF00873(ACR_tran) | 5 | GLY A 177GLY A 600THR A 601VAL A 50ASP A 598 | None | 1.05A | 5njvD-4k0eA:undetectable | 5njvD-4k0eA:13.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k6m | POLYPROTEIN (Japaneseencephalitisvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 83THR A 104HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A1001 (-3.1A)SAH A1001 (-3.3A)SAH A1001 ( 3.7A)SAH A1001 (-4.7A)SAH A1001 ( 3.6A)SO4 A1011 (-4.9A)SAH A1001 (-3.7A)SAH A1001 (-3.7A)SAH A1001 (-3.6A)SAH A1001 ( 4.3A) | 0.47A | 5njvD-4k6mA:40.6 | 5njvD-4k6mA:68.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k6m | POLYPROTEIN (Japaneseencephalitisvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146 | SAH A1001 (-3.1A)SAH A1001 (-3.3A)SAH A1001 ( 3.7A)SAH A1001 (-3.9A)SAH A1001 (-4.7A)SAH A1001 ( 3.6A)SO4 A1011 (-4.9A)SAH A1001 (-3.7A)SAH A1001 (-3.7A)SAH A1001 (-3.6A) | 0.57A | 5njvD-4k6mA:40.6 | 5njvD-4k6mA:68.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k6m | POLYPROTEIN (Japaneseencephalitisvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 6 | GLY A 81GLY A 83THR A 104LYS A 105VAL A 132ILE A 147 | SAH A1001 (-3.3A)SAH A1001 ( 3.7A)SAH A1001 (-4.7A)NoneSAH A1001 (-3.7A)SAH A1001 ( 4.3A) | 1.08A | 5njvD-4k6mA:40.6 | 5njvD-4k6mA:68.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pel | PENICILLIN G ACYLASESUBUNIT BETA (Kluyveracryocrescens) |
PF01804(Penicil_amidase) | 5 | GLY B 41GLY B 61THR B 62VAL B 497ASP B 43 | None | 1.02A | 5njvD-4pelB:undetectable | 5njvD-4pelB:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4phb | UNCHARACTERIZEDPROTEIN (Ruminiclostridiumthermocellum) |
PF14262(Cthe_2159) | 5 | GLY A 124GLY A 184GLY A 159GLU A 120ILE A 186 | None | 0.97A | 5njvD-4phbA:undetectable | 5njvD-4phbA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pu5 | TOXIN-ANTITOXINSYSTEM TOXIN HIPAFAMILY (Shewanellaoneidensis) |
PF07804(HipA_C)PF13657(Couple_hipA) | 5 | GLY A 19HIS A 33GLU A 20ASP A 52ILE A 49 | None | 1.04A | 5njvD-4pu5A:undetectable | 5njvD-4pu5A:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qi4 | CELLOBIOSEDEHYDROGENASE (Crassicarponhotsonii) |
PF00732(GMC_oxred_N)PF00734(CBM_1)PF05199(GMC_oxred_C) | 5 | GLY A 484GLY A 241GLY A 236ASP A 737ILE A 736 | FAD A 901 ( 4.3A)NoneFAD A 901 (-3.3A)FAD A 901 (-4.3A)None | 0.89A | 5njvD-4qi4A:undetectable | 5njvD-4qi4A:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qi6 | CELLOBIOSEDEHYDROGENASE (Crassicarponhotsonii) |
PF00732(GMC_oxred_N)PF00734(CBM_1)PF05199(GMC_oxred_C)PF16010(CDH-cyt) | 5 | GLY A 484GLY A 241GLY A 236ASP A 737ILE A 736 | FAD A 902 ( 4.2A)NoneFAD A 902 (-3.5A)FAD A 902 (-4.8A)None | 0.89A | 5njvD-4qi6A:undetectable | 5njvD-4qi6A:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqk | LECTIN 2 (Agrocybeaegerita) |
PF13517(VCBS) | 5 | GLY A 53GLY A 29TRP A 55VAL A 23ILE A 75 | NAG A 502 (-4.2A)NoneNAG A 502 (-3.6A)NoneNone | 1.00A | 5njvD-4tqkA:undetectable | 5njvD-4tqkA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u36 | SEED LECTIN (Vataireamacrocarpa) |
PF00139(Lectin_legB) | 5 | GLY A 105GLY A 139GLU A 146VAL A 189ASP A 125 | TNR A 303 (-3.2A)NoneNoneNone CA A 302 ( 2.1A) | 0.84A | 5njvD-4u36A:undetectable | 5njvD-4u36A:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xr9 | CALS8 (Micromonosporaechinospora) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | GLY A 96GLY A 24GLY A 21THR A 25ILE A 17 | NAD A 501 ( 4.1A)NoneNAD A 501 (-3.4A)NoneNone | 0.96A | 5njvD-4xr9A:undetectable | 5njvD-4xr9A:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynn | PROTEASE DO (Legionellapneumophila) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | GLY A 203GLY A 66GLY A 191VAL A 91ILE A 76 | None | 0.84A | 5njvD-4ynnA:undetectable | 5njvD-4ynnA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zqg | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE (Moraxellacatarrhalis) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 5 | GLY A 87GLY A 12GLY A 39THR A 14ILE A 10 | NoneNAD A 501 (-3.3A)NAD A 501 (-3.6A)NAD A 501 (-3.6A)None | 0.98A | 5njvD-4zqgA:undetectable | 5njvD-4zqgA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5brr | TISSUE-TYPEPLASMINOGENACTIVATOR (Homo sapiens) |
PF00089(Trypsin) | 5 | GLY E 211GLY E 44GLY E 196VAL E 66ILE E 52 | None | 1.00A | 5njvD-5brrE:undetectable | 5njvD-5brrE:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ccx | TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASECATALYTIC SUBUNITTRMT61A (Homo sapiens) |
PF08704(GCD14) | 6 | GLY A 111GLY A 113ASP A 163VAL A 164ASP A 181ILE A 182 | SAH A 301 (-3.2A)SAH A 301 (-2.9A)SAH A 301 (-2.7A)SAH A 301 (-4.0A)SAH A 301 (-2.4A)SAH A 301 ( 3.8A) | 0.92A | 5njvD-5ccxA:8.8 | 5njvD-5ccxA:25.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d04 | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE (Neisseriameningitidis) |
PF00793(DAHP_synth_1) | 5 | GLY C 203GLY C 226THR C 225HIS C 210GLU C 176 | None | 0.99A | 5njvD-5d04C:undetectable | 5njvD-5d04C:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d86 | PROBABLE SIDEROPHOREBIOSYNTHESIS PROTEINSBNA (Staphylococcusaureus) |
PF00291(PALP) | 5 | GLY A 43GLY A 76GLY A 79THR A 74ASP A 98 | None | 1.00A | 5njvD-5d86A:undetectable | 5njvD-5d86A:24.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e9q | GENOME POLYPROTEIN (Dengue virus) |
PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104HIS A 110ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A 301 (-3.2A)SAM A 301 (-3.3A)SAM A 301 (-3.1A)SAM A 301 (-3.6A)SAM A 301 (-4.6A)SAM A 301 ( 3.7A)SAM A 301 (-3.4A)SAM A 301 (-3.6A)SAM A 301 (-3.8A)SAM A 301 ( 4.2A) | 0.41A | 5njvD-5e9qA:40.5 | 5njvD-5e9qA:64.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e9q | GENOME POLYPROTEIN (Dengue virus) |
PF01728(FtsJ) | 8 | GLY A 81GLY A 83TRP A 87THR A 104LYS A 105ASP A 131VAL A 132ILE A 147 | SAM A 301 (-3.3A)SAM A 301 (-3.1A)SAM A 301 (-3.6A)SAM A 301 (-4.6A)NoneSAM A 301 (-3.4A)SAM A 301 (-3.6A)SAM A 301 ( 4.2A) | 0.83A | 5njvD-5e9qA:40.5 | 5njvD-5e9qA:64.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7o | METHYLTHIOADENOSINEPHOSPHORYLASE (Schistosomamansoni) |
PF01048(PNP_UDP_1) | 5 | GLY A 42GLU A 41VAL A 265ASP A 15ILE A 8 | None | 0.98A | 5njvD-5f7oA:undetectable | 5njvD-5f7oA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fq6 | SUSC/RAGA FAMILYTONB-LINKED OUTERMEMBRANE PROTEIN (Bacteroidesthetaiotaomicron) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | GLY B 762GLY B 965GLY B 962THR B 954GLU B 961 | None | 1.04A | 5njvD-5fq6B:undetectable | 5njvD-5fq6B:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gnd | PUTATIVE SERINEPROTEASE HHOA (Synechocystissp. PCC 6803) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | GLY A 250GLY A 114GLY A 238VAL A 138ILE A 123 | None | 1.00A | 5njvD-5gndA:undetectable | 5njvD-5gndA:19.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikm | NS5 METHYLTRANSFERASE (Dengue virus) |
PF01728(FtsJ) | 11 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAM A 311 (-3.3A)SAM A 311 (-3.2A)SAM A 311 (-3.3A)SAM A 311 (-3.5A)SAM A 311 (-4.5A)SAM A 311 (-4.1A)NoneMLT A 313 ( 2.6A)SAM A 311 (-3.7A)SAM A 311 (-3.8A)SAM A 311 ( 4.3A) | 0.65A | 5njvD-5ikmA:39.8 | 5njvD-5ikmA:62.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikm | NS5 METHYLTRANSFERASE (Dengue virus) |
PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104LYS A 105HIS A 110VAL A 132ASP A 146ILE A 147 | SAM A 311 (-3.3A)SAM A 311 (-3.2A)SAM A 311 (-3.3A)SAM A 311 (-3.5A)SAM A 311 (-4.5A)MLT A 313 ( 3.0A)SAM A 311 (-4.1A)SAM A 311 (-3.7A)SAM A 311 (-3.8A)SAM A 311 ( 4.3A) | 0.65A | 5njvD-5ikmA:39.8 | 5njvD-5ikmA:62.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikm | NS5 METHYLTRANSFERASE (Dengue virus) |
PF01728(FtsJ) | 6 | GLY A 86TRP A 87LYS A 105HIS A 110ASP A 146ILE A 147 | SAM A 311 (-3.3A)SAM A 311 (-3.5A)MLT A 313 ( 3.0A)SAM A 311 (-4.1A)SAM A 311 (-3.8A)SAM A 311 ( 4.3A) | 1.48A | 5njvD-5ikmA:39.8 | 5njvD-5ikmA:62.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5im4 | PHOSPHOTRANSFERASESYSTEM,MANNOSE/FRUCTOSE-SPECIFIC COMPONENT IIA (Caldanaerobactersubterraneus) |
PF03610(EIIA-man) | 5 | GLY F 17GLY F 36GLY F 12VAL F 46ILE F 9 | None | 1.00A | 5njvD-5im4F:undetectable | 5njvD-5im4F:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jd8 | PERIPLASMIC SERINEPEPTIDASE DEGS (Yersinia pestis) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | GLY A 213GLY A 82GLY A 201VAL A 106ILE A 91 | None | 0.85A | 5njvD-5jd8A:undetectable | 5njvD-5jd8A:21.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jjr | GENOME POLYPROTEIN (Dengue virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 9 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A1003 (-3.2A)SAH A1003 (-3.4A)SAH A1003 (-3.5A)SAH A1003 (-3.4A)SAH A1003 (-4.6A)SAH A1003 (-3.0A)SAH A1003 (-3.7A)SAH A1003 (-3.8A)SAH A1003 ( 4.3A) | 0.38A | 5njvD-5jjrA:40.0 | 5njvD-5jjrA:31.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jjr | GENOME POLYPROTEIN (Dengue virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 10 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104LYS A 105HIS A 110VAL A 132ASP A 146ILE A 147 | SAH A1003 (-3.2A)SAH A1003 (-3.4A)SAH A1003 (-3.5A)SAH A1003 (-3.4A)SAH A1003 (-4.6A)SAH A1003 (-4.8A)SAH A1003 (-3.7A)SAH A1003 (-3.7A)SAH A1003 (-3.8A)SAH A1003 ( 4.3A) | 0.68A | 5njvD-5jjrA:40.0 | 5njvD-5jjrA:31.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jjr | GENOME POLYPROTEIN (Dengue virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 7 | GLY A 58GLY A 83TRP A 87THR A 104LYS A 105HIS A 110GLU A 111 | SAH A1003 (-3.2A)SAH A1003 (-3.5A)SAH A1003 (-3.4A)SAH A1003 (-4.6A)SAH A1003 (-4.8A)SAH A1003 (-3.7A)SAH A1003 (-3.3A) | 1.04A | 5njvD-5jjrA:40.0 | 5njvD-5jjrA:31.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jjr | GENOME POLYPROTEIN (Dengue virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 6 | GLY A 86TRP A 87LYS A 105HIS A 110ASP A 146ILE A 147 | SAH A1003 (-3.0A)SAH A1003 (-3.4A)SAH A1003 (-4.8A)SAH A1003 (-3.7A)SAH A1003 (-3.8A)SAH A1003 ( 4.3A) | 1.50A | 5njvD-5jjrA:40.0 | 5njvD-5jjrA:31.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kpg | PAVINEN-METHYLTRANSFERASE (Thalictrumflavum) |
PF02353(CMAS) | 5 | GLY A 135GLY A 137THR A 158ASP A 185VAL A 186 | SAH A 401 (-3.7A)SAH A 401 ( 3.8A)NoneSAH A 401 (-3.5A)SAH A 401 (-3.8A) | 0.61A | 5njvD-5kpgA:7.3 | 5njvD-5kpgA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4l | CERULOPLASMIN (Rattusnorvegicus) |
no annotation | 5 | GLY A 369GLY A 398ASP A 570ASP A 364ILE A 362 | None | 0.93A | 5njvD-5n4lA:undetectable | 5njvD-5n4lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6y | NITROGENASEVANADIUM-IRONPROTEIN BETA CHAIN (Azotobactervinelandii) |
no annotation | 5 | GLY E 259GLY E 35GLY E 161GLU E 164VAL E 60 | None | 0.98A | 5njvD-5n6yE:undetectable | 5njvD-5n6yE:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nil | MACROLIDE EXPORTATP-BINDING/PERMEASEPROTEIN MACB (Escherichiacoli) |
PF00005(ABC_tran)PF02687(FtsX)PF12704(MacB_PCD) | 5 | GLY J 374GLY J 435ASP J 418VAL J 419ILE J 434 | None | 1.01A | 5njvD-5nilJ:undetectable | 5njvD-5nilJ:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nju | GENOME POLYPROTEIN (Zika virus) |
no annotation | 11 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A1001 (-3.3A)SAH A1001 (-3.4A)SAH A1001 (-3.4A)SAH A1001 (-3.5A)SAH A1001 (-4.4A)SAH A1001 (-4.0A)NoneSAH A1001 (-3.9A)SAH A1001 (-3.6A)SAH A1001 (-3.7A)SAH A1001 (-4.2A) | 0.40A | 5njvD-5njuA:42.7 | 5njvD-5njuA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nju | GENOME POLYPROTEIN (Zika virus) |
no annotation | 7 | GLY A 81GLY A 83TRP A 87THR A 104LYS A 105VAL A 132ILE A 147 | SAH A1001 (-3.4A)SAH A1001 (-3.4A)SAH A1001 (-3.5A)SAH A1001 (-4.4A)NoneSAH A1001 (-3.6A)SAH A1001 (-4.2A) | 1.21A | 5njvD-5njuA:42.7 | 5njvD-5njuA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nvj | - (-) |
no annotation | 5 | GLY A 39GLY A 43TRP A 41GLU A 21ILE A 30 | NoneNoneNoneCIT A 103 (-4.0A)None | 1.02A | 5njvD-5nvjA:undetectable | 5njvD-5nvjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTEN-CONTAININGFORMYLMETHANOFURANDEHYDROGENASE 2SUBUNIT CTUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT FWDD (Methanothermobacterwolfeii;Methanothermobacterwolfeii) |
PF01493(GXGXG)PF01568(Molydop_binding) | 5 | GLY C 111GLY C 133GLY C 114ASP D 93ASP C 131 | None | 1.02A | 5njvD-5t5iC:undetectable | 5njvD-5t5iC:19.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tmh | POLYPROTEIN (Zika virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 11 | GLY A 58GLY A 81GLY A 83TRP A 87THR A 104HIS A 110GLU A 111ASP A 131VAL A 132ASP A 146ILE A 147 | SAH A1001 (-3.2A)SAH A1001 (-3.4A)SAH A1001 ( 3.8A)SAH A1001 (-3.5A)SAH A1001 ( 4.9A)SAH A1001 (-3.6A)NoneSAH A1001 (-4.0A)SAH A1001 (-4.0A)SAH A1001 (-3.8A)SAH A1001 ( 4.8A) | 0.55A | 5njvD-5tmhA:41.3 | 5njvD-5tmhA:96.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vwi | PROTEIN SCRIBBLEHOMOLOG (Homo sapiens) |
no annotation | 5 | GLY A 61GLU A 14ASP A 75VAL A 76ASP A 66 | None | 0.97A | 5njvD-5vwiA:undetectable | 5njvD-5vwiA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xg9 | UNCONVENTIONALMYOSIN IB (Entamoebahistolytica) |
no annotation | 5 | GLY B 35GLY B 39TRP B 37GLU B 18ILE B 27 | 1PE B 101 (-4.1A)NoneNonePEU B 102 (-4.4A)None | 0.86A | 5njvD-5xg9B:undetectable | 5njvD-5xg9B:14.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y2d | - (-) |
no annotation | 5 | GLY A 234GLY A 102GLY A 222VAL A 126ILE A 111 | None | 1.00A | 5njvD-5y2dA:undetectable | 5njvD-5y2dA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6alk | - (-) |
no annotation | 5 | GLY A 48GLY A 46GLU A 45VAL A 23ILE A 71 | None | 1.05A | 5njvD-6alkA:undetectable | 5njvD-6alkA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6day | DIHYDROPTEROATESYNTHASE (Xanthomonasalbilineans) |
no annotation | 5 | GLY A 24HIS A 249ASP A 264ASP A 61ILE A 25 | NoneNoneNoneNoneSO4 A 403 (-4.3A) | 0.94A | 5njvD-6dayA:undetectable | 5njvD-6dayA:undetectable |