SIMILAR PATTERNS OF AMINO ACIDS FOR 5NFP_A_8W5A804_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ARG A 752
MET A 780
GLN A 783
CYH A 784
MET A 787
 BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
None
None
BHM  A   1 (-3.6A)
 1.14A 5nfpA-2ax9A:
32.4		 5nfpA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 705
GLY A 708
GLN A 711
CYH A 784
PHE A 891
 BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
None
None
 0.92A 5nfpA-2ax9A:
32.4		 5nfpA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
CYH A 784
 BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
 0.77A 5nfpA-2ax9A:
32.4		 5nfpA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 708
GLN A 711
ARG A 752
GLN A 783
CYH A 784
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
None
None
BHM  A   1 (-3.6A)
 1.23A 5nfpA-2ax9A:
32.4		 5nfpA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 708
GLN A 711
MET A 742
ARG A 752
CYH A 784
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.6A)
 0.83A 5nfpA-2ax9A:
32.4		 5nfpA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 ASN A  33
GLN A  39
MET A  70
ARG A  80
CYH A 112
MET A 115
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
None
1CA  A 247 ( 3.7A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.67A 5nfpA-2q3yA:
36.6		 5nfpA-2q3yA:
58.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
MET A  70
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 1.09A 5nfpA-2q3yA:
36.6		 5nfpA-2q3yA:
58.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 719
GLY A 722
MET A 756
ARG A 766
CYH A 798
MET A 801
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.72A 5nfpA-3kbaA:
35.4		 5nfpA-3kbaA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 722
GLN A 725
MET A 756
ARG A 766
CYH A 798
MET A 801
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
 0.87A 5nfpA-3kbaA:
35.4		 5nfpA-3kbaA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
CYH A 112
MET A 115
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.61A 5nfpA-3ry9A:
36.6		 5nfpA-3ry9A:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
MET A  70
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.00A 5nfpA-3ry9A:
36.6		 5nfpA-3ry9A:
66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghn UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF03572
(Peptidase_S41) 		5 MET A 282
ASN A 280
GLY A 279
MET A 306
CYH A 288
 None
 1.31A 5nfpA-4ghnA:
undetectable		 5nfpA-4ghnA:
24.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 564
GLY A 568
GLN A 570
MET A 601
THR A 739
PHE A 749
 MOF  A 801 (-3.0A)
None
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 1.20A 5nfpA-4p6wA:
39.5		 5nfpA-4p6wA:
96.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 GLN A 570
MET A 601
ARG A 611
GLN A 642
CYH A 643
MET A 646
THR A 739
 MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
None
MOF  A 801 ( 3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
 1.11A 5nfpA-4p6wA:
39.5		 5nfpA-4p6wA:
96.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 MET A 560
ASN A 564
GLY A 567
GLN A 570
MET A 601
ARG A 611
MET A 639
CYH A 643
MET A 646
THR A 739
PHE A 749
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 0.61A 5nfpA-4p6wA:
39.5		 5nfpA-4p6wA:
96.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 770
GLN A 776
MET A 807
ARG A 817
CYH A 849
MET A 852
THR A 945
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.2A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-3.1A)
 0.55A 5nfpA-4udbA:
35.3		 5nfpA-4udbA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 770
GLN A 776
MET A 807
ARG A 817
MET A 852
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.57A 5nfpA-4udbA:
35.3		 5nfpA-4udbA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 770
GLY A 774
GLN A 776
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
None
CV7  A1987 (-3.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 1.32A 5nfpA-4udbA:
35.3		 5nfpA-4udbA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLN A 776
ARG A 817
MET A 840
CYH A 849
MET A 852
 CV7  A1987 (-3.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 4.2A)
CV7  A1987 ( 3.7A)
 0.91A 5nfpA-4udbA:
35.3		 5nfpA-4udbA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 ASN A 770
GLN A 776
MET A 807
ARG A 817
CYH A 849
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.59A 5nfpA-5mwpA:
35.2		 5nfpA-5mwpA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 ASN A 770
GLY A 774
GLN A 776
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 1.26A 5nfpA-5mwpA:
35.2		 5nfpA-5mwpA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 GLN A 776
MET A 807
ARG A 817
CYH A 849
MET A 852
 ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.7A)
 1.22A 5nfpA-5mwpA:
35.2		 5nfpA-5mwpA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 10 MET A 556
ASN A 560
GLY A 563
GLN A 566
MET A 597
ARG A 607
MET A 635
GLN A 638
CYH A 639
MET A 642
 None
486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
486  A 801 (-4.6A)
486  A 801 ( 3.9A)
486  A 801 ( 3.8A)
 0.83A 5nfpA-5uc1A:
26.7		 5nfpA-5uc1A:
81.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
GLN A  39
MET A  70
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
None
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 1.12A 5nfpA-5ufsA:
38.9		 5nfpA-5ufsA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 GLY A  36
GLN A  39
ARG A  80
GLN A 111
CYH A 112
MET A 115
 1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
None
1TA  A 301 ( 3.6A)
1TA  A 301 ( 2.8A)
 1.35A 5nfpA-5ufsA:
38.9		 5nfpA-5ufsA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 GLY A  36
GLN A  39
MET A  70
ARG A  80
MET A 108
CYH A 112
MET A 115
 1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 2.8A)
 0.83A 5nfpA-5ufsA:
38.9		 5nfpA-5ufsA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		10 MET A  29
ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
CYH A 112
MET A 115
THR A 208
PHE A 218
 1TA  A 301 ( 2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.45A 5nfpA-5ufsA:
38.9		 5nfpA-5ufsA:
71.17