SIMILAR PATTERNS OF AMINO ACIDS FOR 5NFP_A_8W5A804

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ARG A 752
MET A 780
GLN A 783
CYH A 784
MET A 787
 BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
None
None
BHM  A   1 (-3.6A)
 1.14A 5nfpA-2ax9A:
32.4		 5nfpA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 705
GLY A 708
GLN A 711
CYH A 784
PHE A 891
 BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
None
None
 0.92A 5nfpA-2ax9A:
32.4		 5nfpA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
CYH A 784
 BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
 0.77A 5nfpA-2ax9A:
32.4		 5nfpA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 708
GLN A 711
ARG A 752
GLN A 783
CYH A 784
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.8A)
None
None
BHM  A   1 (-3.6A)
 1.23A 5nfpA-2ax9A:
32.4		 5nfpA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 708
GLN A 711
MET A 742
ARG A 752
CYH A 784
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.6A)
 0.83A 5nfpA-2ax9A:
32.4		 5nfpA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 ASN A  33
GLN A  39
MET A  70
ARG A  80
CYH A 112
MET A 115
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
None
1CA  A 247 ( 3.7A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.67A 5nfpA-2q3yA:
36.6		 5nfpA-2q3yA:
58.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
MET A  70
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 1.09A 5nfpA-2q3yA:
36.6		 5nfpA-2q3yA:
58.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 719
GLY A 722
MET A 756
ARG A 766
CYH A 798
MET A 801
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.72A 5nfpA-3kbaA:
35.4		 5nfpA-3kbaA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 722
GLN A 725
MET A 756
ARG A 766
CYH A 798
MET A 801
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
 0.87A 5nfpA-3kbaA:
35.4		 5nfpA-3kbaA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
CYH A 112
MET A 115
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.61A 5nfpA-3ry9A:
36.6		 5nfpA-3ry9A:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
MET A  70
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.00A 5nfpA-3ry9A:
36.6		 5nfpA-3ry9A:
66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghn UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF03572
(Peptidase_S41) 		5 MET A 282
ASN A 280
GLY A 279
MET A 306
CYH A 288
 None
 1.31A 5nfpA-4ghnA:
undetectable		 5nfpA-4ghnA:
24.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 564
GLY A 568
GLN A 570
MET A 601
THR A 739
PHE A 749
 MOF  A 801 (-3.0A)
None
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 1.20A 5nfpA-4p6wA:
39.5		 5nfpA-4p6wA:
96.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 GLN A 570
MET A 601
ARG A 611
GLN A 642
CYH A 643
MET A 646
THR A 739
 MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
None
MOF  A 801 ( 3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
 1.11A 5nfpA-4p6wA:
39.5		 5nfpA-4p6wA:
96.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 MET A 560
ASN A 564
GLY A 567
GLN A 570
MET A 601
ARG A 611
MET A 639
CYH A 643
MET A 646
THR A 739
PHE A 749
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 0.61A 5nfpA-4p6wA:
39.5		 5nfpA-4p6wA:
96.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 770
GLN A 776
MET A 807
ARG A 817
CYH A 849
MET A 852
THR A 945
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.2A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-3.1A)
 0.55A 5nfpA-4udbA:
35.3		 5nfpA-4udbA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 770
GLN A 776
MET A 807
ARG A 817
MET A 852
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.57A 5nfpA-4udbA:
35.3		 5nfpA-4udbA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 770
GLY A 774
GLN A 776
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
None
CV7  A1987 (-3.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 1.32A 5nfpA-4udbA:
35.3		 5nfpA-4udbA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLN A 776
ARG A 817
MET A 840
CYH A 849
MET A 852
 CV7  A1987 (-3.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 4.2A)
CV7  A1987 ( 3.7A)
 0.91A 5nfpA-4udbA:
35.3		 5nfpA-4udbA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 ASN A 770
GLN A 776
MET A 807
ARG A 817
CYH A 849
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.59A 5nfpA-5mwpA:
35.2		 5nfpA-5mwpA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 ASN A 770
GLY A 774
GLN A 776
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 1.26A 5nfpA-5mwpA:
35.2		 5nfpA-5mwpA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 GLN A 776
MET A 807
ARG A 817
CYH A 849
MET A 852
 ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.7A)
 1.22A 5nfpA-5mwpA:
35.2		 5nfpA-5mwpA:
42.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 10 MET A 556
ASN A 560
GLY A 563
GLN A 566
MET A 597
ARG A 607
MET A 635
GLN A 638
CYH A 639
MET A 642
 None
486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
486  A 801 (-4.6A)
486  A 801 ( 3.9A)
486  A 801 ( 3.8A)
 0.83A 5nfpA-5uc1A:
26.7		 5nfpA-5uc1A:
81.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
GLN A  39
MET A  70
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
None
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 1.12A 5nfpA-5ufsA:
38.9		 5nfpA-5ufsA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 GLY A  36
GLN A  39
ARG A  80
GLN A 111
CYH A 112
MET A 115
 1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
None
1TA  A 301 ( 3.6A)
1TA  A 301 ( 2.8A)
 1.35A 5nfpA-5ufsA:
38.9		 5nfpA-5ufsA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 GLY A  36
GLN A  39
MET A  70
ARG A  80
MET A 108
CYH A 112
MET A 115
 1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 2.8A)
 0.83A 5nfpA-5ufsA:
38.9		 5nfpA-5ufsA:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		10 MET A  29
ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
CYH A 112
MET A 115
THR A 208
PHE A 218
 1TA  A 301 ( 2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.6A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.45A 5nfpA-5ufsA:
38.9		 5nfpA-5ufsA:
71.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewi REPLICATION PROTEIN
A

(Homo sapiens) 		PF04057
(Rep-A_N) 		4 LEU A  50
MET A  14
ILE A  28
LEU A  53
 None
 1.31A 5nfpA-1ewiA:
undetectable		 5nfpA-1ewiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 119
MET A 406
ILE A  85
LEU A 116
 None
 1.12A 5nfpA-1hrdA:
0.0		 5nfpA-1hrdA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m41 FMNH2-DEPENDENT
ALKANESULFONATE
MONOOXYGENASE

(Escherichia
coli) 		PF00296
(Bac_luciferase) 		4 LEU A 227
MET A   4
ILE A 230
LEU A 344
 None
 1.06A 5nfpA-1m41A:
undetectable		 5nfpA-1m41A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny1 PROBABLE
POLYSACCHARIDE
DEACETYLASE PDAA

(Bacillus
subtilis) 		PF01522
(Polysacc_deac_1) 		4 LEU A 220
MET A 209
ILE A 249
LEU A  70
 None
 1.33A 5nfpA-1ny1A:
0.0		 5nfpA-1ny1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovw ENDOGLUCANASE I

(Fusarium
oxysporum) 		PF00840
(Glyco_hydro_7) 		4 LEU A 122
MET A 332
ILE A 394
LEU A 283
 None
 1.15A 5nfpA-1ovwA:
0.0		 5nfpA-1ovwA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7r PREDICTED
AMIDOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF01174
(SNO) 		4 LEU A  43
MET A  99
ILE A   3
LEU A 164
 None
 1.35A 5nfpA-1q7rA:
0.0		 5nfpA-1q7rA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr4 PROTEIN (TENASCIN)

(Gallus gallus) 		PF00041
(fn3) 		4 LEU A  68
MET A  44
ILE A  82
LEU A  55
 None
 1.41A 5nfpA-1qr4A:
undetectable		 5nfpA-1qr4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0u TRANSLATION
INITIATION FACTOR 2
GAMMA SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 LEU A 128
MET A 134
ILE A  73
LEU A 123
 None
 1.31A 5nfpA-1s0uA:
0.0		 5nfpA-1s0uA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)

(Salmonella
enterica) 		PF00440
(TetR_N)
PF09209
(DUF1956) 		4 LEU A 100
MET A 106
ILE A  95
LEU A 148
 None
 1.31A 5nfpA-1t33A:
0.0		 5nfpA-1t33A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		4 LEU A  25
MET A 141
ILE A 131
LEU A  39
 None
 1.37A 5nfpA-1umfA:
0.0		 5nfpA-1umfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		4 LEU A 292
MET A 268
ILE A 313
LEU A 278
 None
 1.36A 5nfpA-1v4vA:
undetectable		 5nfpA-1v4vA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		4 LEU A 307
MET A 230
ILE A 302
LEU A 320
 None
 1.33A 5nfpA-1xr5A:
undetectable		 5nfpA-1xr5A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 LEU A 307
MET A 231
ILE A 302
LEU A 320
 None
 1.21A 5nfpA-1xr6A:
undetectable		 5nfpA-1xr6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		4 LEU A 149
MET A 270
ILE A  49
LEU A  27
 None
 1.34A 5nfpA-1ywfA:
undetectable		 5nfpA-1ywfA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		4 LEU A  56
MET A 147
ILE A  40
LEU A   7
 None
 1.14A 5nfpA-2abqA:
undetectable		 5nfpA-2abqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		PF13091
(PLDc_2) 		4 LEU A  71
MET A 170
ILE A 103
LEU A 182
 None
 1.37A 5nfpA-2c1lA:
undetectable		 5nfpA-2c1lA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB

(Thermococcus
kodakarensis) 		PF08423
(Rad51) 		4 LEU A 182
MET A 206
ILE A 211
LEU A 185
 None
 1.22A 5nfpA-2cvhA:
undetectable		 5nfpA-2cvhA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it2 UPF0130 PROTEIN
PH1069

(Pyrococcus
horikoshii) 		PF02676
(TYW3) 		4 LEU A 156
MET A  63
ILE A 173
LEU A 102
 None
 0.96A 5nfpA-2it2A:
undetectable		 5nfpA-2it2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A 209
MET A 136
ILE A 103
LEU A 181
 None
 1.41A 5nfpA-2oq5A:
undetectable		 5nfpA-2oq5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyb MEMBRANE PROTEIN,
PUTATIVE

(Geobacter
sulfurreducens) 		PF13185
(GAF_2) 		4 LEU A 124
MET A  20
ILE A  73
LEU A  40
 None
 1.17A 5nfpA-2qybA:
undetectable		 5nfpA-2qybA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfk AKAP18 DELTA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		4 LEU A 248
MET A 125
ILE A 253
LEU A 110
 None
 1.40A 5nfpA-2vfkA:
undetectable		 5nfpA-2vfkA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		4 LEU B 130
MET B 135
ILE B 109
LEU B 173
 None
 1.12A 5nfpA-2xwuB:
undetectable		 5nfpA-2xwuB:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		4 LEU A 345
MET A 340
ILE A 347
LEU A 205
 None
 1.42A 5nfpA-2yiaA:
undetectable		 5nfpA-2yiaA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu0 INTERFERON-ACTIVABLE
PROTEIN 205

(Mus musculus) 		PF02758
(PYRIN) 		4 LEU A  62
MET A  52
ILE A   8
LEU A  14
 None
 1.34A 5nfpA-2yu0A:
undetectable		 5nfpA-2yu0A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 646
MET A 578
ILE A 716
LEU A 651
 None
 1.30A 5nfpA-3b2rA:
3.7		 5nfpA-3b2rA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 646
MET A 578
ILE A 716
LEU A 651
 None
 1.35A 5nfpA-3bjcA:
3.8		 5nfpA-3bjcA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3m RESPONSE REGULATOR
RECEIVER PROTEIN

(Methanoculleus
marisnigri) 		PF00072
(Response_reg) 		4 LEU A  65
MET A  59
ILE A  77
LEU A  39
 None
 1.27A 5nfpA-3c3mA:
undetectable		 5nfpA-3c3mA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A A SUBUNIT

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		4 LEU A 411
MET A 427
ILE A  17
LEU A 405
 None
 1.28A 5nfpA-3c5wA:
undetectable		 5nfpA-3c5wA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua) 		PF06028
(DUF915) 		4 LEU A   8
MET A  96
ILE A 130
LEU A 108
 None
 0.87A 5nfpA-3ds8A:
undetectable		 5nfpA-3ds8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dz1 DIHYDRODIPICOLINATE
SYNTHASE

(Rhodopseudomonas
palustris) 		PF00701
(DHDPS) 		4 LEU A 224
MET A 207
ILE A  13
LEU A 195
 None
 1.38A 5nfpA-3dz1A:
undetectable		 5nfpA-3dz1A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		4 LEU A 265
MET A 147
ILE A 497
LEU A  96
 None
 1.40A 5nfpA-3e2dA:
undetectable		 5nfpA-3e2dA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 LEU A 245
MET A 191
ILE A 289
LEU A 252
 None
 1.34A 5nfpA-3ed4A:
undetectable		 5nfpA-3ed4A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN

(Rhodobacter
sphaeroides) 		PF00142
(Fer4_NifH) 		4 LEU A  51
MET A 234
ILE A  57
LEU A 250
 None
 1.42A 5nfpA-3fwyA:
undetectable		 5nfpA-3fwyA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvc PROBABLE SHORT-CHAIN
TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 LEU A 253
MET A 246
ILE A 157
LEU A 160
 None
 1.36A 5nfpA-3gvcA:
undetectable		 5nfpA-3gvcA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hin PUTATIVE
3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Rhodopseudomonas
palustris) 		PF00378
(ECH_1) 		4 LEU A  75
MET A  45
ILE A 118
LEU A 124
 None
 1.31A 5nfpA-3hinA:
undetectable		 5nfpA-3hinA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 417
MET A 482
ILE A 453
LEU A 385
 None
 1.36A 5nfpA-3hn7A:
undetectable		 5nfpA-3hn7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9u HEME OXYGENASE 1

(Rattus
norvegicus) 		PF01126
(Heme_oxygenase) 		4 LEU A 181
MET A 186
ILE A 172
LEU A 138
 None
None
None
HEM  A 300 ( 4.5A)
 1.28A 5nfpA-3i9uA:
undetectable		 5nfpA-3i9uA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 304
MET A 298
ILE A 359
LEU A 337
 None
 1.35A 5nfpA-3kdnA:
undetectable		 5nfpA-3kdnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1c KINESIN-14 NCD

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 LEU A 611
MET A 643
ILE A 620
LEU A 606
 None
 1.33A 5nfpA-3l1cA:
undetectable		 5nfpA-3l1cA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE

(Exiguobacterium
sibiricum) 		PF01212
(Beta_elim_lyase) 		4 LEU A 178
MET A 257
ILE A 214
LEU A 207
 None
 1.37A 5nfpA-3lwsA:
undetectable		 5nfpA-3lwsA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 LEU A1030
MET A 851
ILE A1048
LEU A 942
 None
 1.33A 5nfpA-3nzuA:
undetectable		 5nfpA-3nzuA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A  70
MET A 337
ILE A  97
LEU A 105
 None
 1.08A 5nfpA-3ov3A:
undetectable		 5nfpA-3ov3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhy BETA-LACTAMASE

(Bacillus
anthracis) 		PF13354
(Beta-lactamase2) 		4 LEU A  81
MET A 211
ILE A 142
LEU A  75
 None
 1.29A 5nfpA-3qhyA:
undetectable		 5nfpA-3qhyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 LEU A 158
MET A 161
ILE A 136
LEU A 168
 None
 1.22A 5nfpA-3qk8A:
undetectable		 5nfpA-3qk8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Alicyclobacillus
acidocaldarius) 		PF13472
(Lipase_GDSL_2) 		4 LEU A 133
MET A 130
ILE A 154
LEU A 116
 None
 1.15A 5nfpA-3rjtA:
undetectable		 5nfpA-3rjtA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 544
MET A 579
ILE A 551
LEU A 512
 LEU  A 544 ( 0.6A)
MET  A 579 ( 0.0A)
ILE  A 551 ( 0.7A)
LEU  A 512 ( 0.6A)
 1.40A 5nfpA-3sagA:
undetectable		 5nfpA-3sagA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		4 LEU A 196
MET A 203
ILE A 231
LEU A  42
 None
 1.36A 5nfpA-3sg1A:
undetectable		 5nfpA-3sg1A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Brucella
abortus) 		PF00218
(IGPS) 		4 LEU A 209
MET A 146
ILE A 239
LEU A 189
 None
 1.34A 5nfpA-3tsmA:
undetectable		 5nfpA-3tsmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzt GLYCOSYL TRANSFERASE
FAMILY 8

(Anaerococcus
prevotii) 		PF01501
(Glyco_transf_8) 		4 LEU A   5
MET A  17
ILE A  32
LEU A  54
 None
 1.35A 5nfpA-3tztA:
undetectable		 5nfpA-3tztA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxm PROTEIN PELOTA
HOMOLOG

(Aeropyrum
pernix) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		4 LEU B 248
MET B 149
ILE B 244
LEU B 236
 None
 1.37A 5nfpA-3wxmB:
undetectable		 5nfpA-3wxmB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akx EXOU

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		4 LEU B 372
MET B 123
ILE B 357
LEU B 109
 None
 1.39A 5nfpA-4akxB:
undetectable		 5nfpA-4akxB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 LEU A 997
MET A 817
ILE A1015
LEU A 909
 None
 1.29A 5nfpA-4bfrA:
undetectable		 5nfpA-4bfrA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx HISTONE DEACETYLASE
1

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 LEU B 293
MET B 245
ILE B 131
LEU B 259
 None
 1.31A 5nfpA-4bkxB:
undetectable		 5nfpA-4bkxB:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 376
MET A 358
ILE A 430
LEU A 420
 None
 1.38A 5nfpA-4c13A:
undetectable		 5nfpA-4c13A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c75 BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 LEU A  81
MET A 211
ILE A 142
LEU A  75
 None
 1.23A 5nfpA-4c75A:
undetectable		 5nfpA-4c75A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A  13
MET A  38
ILE A  18
LEU A  31
 None
 1.20A 5nfpA-4c7vA:
undetectable		 5nfpA-4c7vA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases) 		4 LEU A  96
MET A 159
ILE A 215
LEU A  72
 None
 1.29A 5nfpA-4ci0A:
undetectable		 5nfpA-4ci0A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyu DNA PROTECTION
DURING STARVATION
PROTEIN

(Yersinia pestis) 		PF00210
(Ferritin) 		4 LEU A  77
MET A 147
ILE A  38
LEU A  33
 None
 1.42A 5nfpA-4dyuA:
undetectable		 5nfpA-4dyuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elz DNA GYRASE SUBUNIT A

(Aliivibrio
fischeri) 		PF00521
(DNA_topoisoIV) 		4 LEU A 385
MET A 423
ILE A 390
LEU A 475
 None
 1.25A 5nfpA-4elzA:
undetectable		 5nfpA-4elzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		4 LEU A 356
MET A 374
ILE A 280
LEU A 313
 None
 1.38A 5nfpA-4fj6A:
undetectable		 5nfpA-4fj6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)

(Schistosoma
japonicum) 		PF00248
(Aldo_ket_red) 		4 LEU A 180
MET A   6
ILE A 109
LEU A 106
 None
 1.34A 5nfpA-4hbkA:
undetectable		 5nfpA-4hbkA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8i HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16227
(DUF4886) 		4 LEU A  35
MET A 155
ILE A  62
LEU A 244
 None
 1.35A 5nfpA-4i8iA:
undetectable		 5nfpA-4i8iA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k4k PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
uniformis) 		PF13149
(Mfa_like_1) 		4 LEU A 229
MET A 237
ILE A 136
LEU A 165
 None
 1.32A 5nfpA-4k4kA:
undetectable		 5nfpA-4k4kA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf8 NUP188

(Thermothelomyces
thermophila) 		no annotation 4 LEU A1607
MET A1572
ILE A1670
LEU A1613
 None
 1.07A 5nfpA-4kf8A:
undetectable		 5nfpA-4kf8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lma CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		4 LEU A  16
MET A  39
ILE A  32
LEU A 264
 None
 1.23A 5nfpA-4lmaA:
undetectable		 5nfpA-4lmaA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		4 LEU A  16
MET A  39
ILE A  32
LEU A 264
 None
 1.19A 5nfpA-4lmbA:
undetectable		 5nfpA-4lmbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mec HEME OXYGENASE 1

(Rattus
norvegicus) 		PF01126
(Heme_oxygenase) 		4 LEU A 181
MET A 186
ILE A 172
LEU A 138
 None
None
None
ZNH  A 300 ( 4.4A)
 1.23A 5nfpA-4mecA:
undetectable		 5nfpA-4mecA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi7 BACTERIOPHAGE
ENCODED VIRULENCE
FACTOR

(Salmonella
enterica) 		no annotation 4 LEU A 150
MET A 139
ILE A  84
LEU A  89
 None
 1.37A 5nfpA-4mi7A:
undetectable		 5nfpA-4mi7A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		4 LEU A 431
MET A 438
ILE A 356
LEU A 347
 None
 1.42A 5nfpA-4mz1A:
undetectable		 5nfpA-4mz1A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oiv BILE ACID RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 388
MET A 381
ILE A 394
LEU A 334
 None
 1.41A 5nfpA-4oivA:
16.4		 5nfpA-4oivA:
24.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 563
MET A 604
ILE A 747
LEU A 753
 MOF  A 801 (-3.9A)
None
MOF  A 801 ( 4.4A)
None
 0.38A 5nfpA-4p6wA:
39.5		 5nfpA-4p6wA:
96.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 397
MET A 282
ILE A 443
LEU A 406
 None
 1.16A 5nfpA-4pdsA:
undetectable		 5nfpA-4pdsA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 LEU A1227
MET A1294
ILE A1237
LEU A1275
 None
 1.33A 5nfpA-4pj3A:
undetectable		 5nfpA-4pj3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qre METHIONYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 LEU A 470
MET A 412
ILE A 428
LEU A 421
 None
 1.38A 5nfpA-4qreA:
undetectable		 5nfpA-4qreA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 4 LEU C 236
MET C 179
ILE C 242
LEU C 197
 None
 1.37A 5nfpA-4wzsC:
undetectable		 5nfpA-4wzsC:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 LEU A2001
MET A1820
ILE A2019
LEU A1911
 None
 1.14A 5nfpA-4yknA:
undetectable		 5nfpA-4yknA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 LEU A1273
MET A1257
ILE A1278
LEU A1110
 None
 1.36A 5nfpA-5a22A:
undetectable		 5nfpA-5a22A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwf DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 LEU A  57
MET A   5
ILE A  76
LEU A  12
 None
 1.27A 5nfpA-5cwfA:
undetectable		 5nfpA-5cwfA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joq LMO2184 PROTEIN

(Listeria
monocytogenes) 		PF01497
(Peripla_BP_2) 		4 LEU A 133
MET A 126
ILE A 140
LEU A 146
 None
 1.30A 5nfpA-5joqA:
undetectable		 5nfpA-5joqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Legionella
pneumophila) 		PF00290
(Trp_syntA) 		4 LEU A 153
MET A 163
ILE A 231
LEU A 208
 None
 1.30A 5nfpA-5k9xA:
undetectable		 5nfpA-5k9xA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 LEU A 144
MET A 369
ILE A 119
LEU A 334
 None
 1.37A 5nfpA-5kc8A:
undetectable		 5nfpA-5kc8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 LEU A 630
MET A 855
ILE A 605
LEU A 820
 None
 1.41A 5nfpA-5kcaA:
undetectable		 5nfpA-5kcaA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdm MAJOR TEGUMENT
PROTEIN

(Human
gammaherpesvirus
4) 		PF12818
(Tegument_dsDNA) 		4 LEU D 394
MET D 566
ILE D 439
LEU D 525
 None
 1.20A 5nfpA-5kdmD:
undetectable		 5nfpA-5kdmD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkp PSEUDOURIDYLATE
SYNTHASE 7

(Homo sapiens) 		PF01142
(TruD) 		4 LEU A 531
MET A 487
ILE A 476
LEU A 551
 None
 1.28A 5nfpA-5kkpA:
undetectable		 5nfpA-5kkpA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l10 N-ACYLHOMOSERINE
LACTONE DEPENDENT
REGULATORY PROTEIN

(Burkholderia
cenocepacia) 		PF03472
(Autoind_bind) 		4 LEU A 129
MET A 162
ILE A  78
LEU A 126
 None
None
GOL  A 201 ( 4.1A)
None
 1.26A 5nfpA-5l10A:
undetectable		 5nfpA-5l10A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 LEU A 144
MET A 369
ILE A 119
LEU A 334
 None
 1.33A 5nfpA-5l2eA:
undetectable		 5nfpA-5l2eA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3

(Bos taurus) 		PF00146
(NADHdh)
PF00507
(Oxidored_q4) 		4 LEU H 294
MET H 184
ILE A  95
LEU H 300
 None
 1.39A 5nfpA-5lc5H:
undetectable		 5nfpA-5lc5H:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m04 GTPASE OBGE/CGTA

(Escherichia
coli) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 LEU A  53
MET A 108
ILE A  57
LEU A 154
 None
 1.37A 5nfpA-5m04A:
undetectable		 5nfpA-5m04A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN

(Lactobacillus
reuteri) 		no annotation 4 LEU A 373
MET A 449
ILE A 337
LEU A 387
 None
 1.28A 5nfpA-5nxkA:
undetectable		 5nfpA-5nxkA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5o RNASE ADAPTER
PROTEIN RAPZ

(Escherichia
coli) 		PF03668
(ATP_bind_2) 		4 LEU A 132
MET A 147
ILE A   5
LEU A  85
 None
 1.21A 5nfpA-5o5oA:
undetectable		 5nfpA-5o5oA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 4 LEU A 150
MET A 225
ILE A 157
LEU A 218
 None
 1.40A 5nfpA-5o7gA:
undetectable		 5nfpA-5o7gA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 LEU A  63
MET A  29
ILE A  97
LEU A  22
 None
 1.40A 5nfpA-5w4bA:
undetectable		 5nfpA-5w4bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8q BIS3 BIPHENYL
SYNTHASE

(Malus domestica) 		no annotation 4 LEU A  65
MET A 334
ILE A  92
LEU A 100
 BU4  A 400 ( 3.8A)
None
None
None
 1.17A 5nfpA-5w8qA:
undetectable		 5nfpA-5w8qA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 4 LEU A 106
MET A  41
ILE A 139
LEU A  49
 GOL  A 801 (-3.9A)
None
None
None
 1.18A 5nfpA-5wabA:
undetectable		 5nfpA-5wabA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 LEU A 247
MET A 221
ILE A 288
LEU A 255
 None
 1.41A 5nfpA-5wy4A:
undetectable		 5nfpA-5wy4A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 4 LEU A1001
MET A 820
ILE A1019
LEU A 911
 None
 1.28A 5nfpA-5xgjA:
undetectable		 5nfpA-5xgjA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 4 LEU A 739
MET A 744
ILE A 626
LEU A 613
 None
 1.37A 5nfpA-5yimA:
undetectable		 5nfpA-5yimA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zov -

(-) 		no annotation 4 LEU A 442
MET A 447
ILE A 425
LEU A 168
 None
 1.39A 5nfpA-5zovA:
undetectable		 5nfpA-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5c KATANIN P60
ATPASE-CONTAINING
SUBUNIT A-LIKE 1

(Homo sapiens) 		no annotation 4 LEU A 355
MET A 336
ILE A 376
LEU A 372
 None
 1.27A 5nfpA-6b5cA:
undetectable		 5nfpA-6b5cA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus) 		no annotation 4 LEU L 283
MET L 175
ILE L  98
LEU L 105
 None
 1.33A 5nfpA-6cfwL:
undetectable		 5nfpA-6cfwL:
14.83