SIMILAR PATTERNS OF AMINO ACIDS FOR 5NFJ_C_SAMC501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0n PROTEIN (CSDB
PROTEIN)

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 LEU A 287
ALA A 289
ILE A 284
GLY A 282
LEU A 291
 None
 1.17A 5nfjC-1c0nA:
undetectable		 5nfjC-1c0nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 LEU A1399
ALA A1394
ILE A1402
GLY A1401
THR A1360
 None
 0.90A 5nfjC-1e6yA:
undetectable		 5nfjC-1e6yA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fb5 ORNITHINE
TRANSCARBAMOYLASE

(Ovis aries) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 209
ILE A 172
THR A  49
LEU A 215
LEU A 244
 None
 1.13A 5nfjC-1fb5A:
undetectable		 5nfjC-1fb5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3r CELL DIVISION
INHIBITOR

(Pyrococcus
furiosus) 		PF13614
(AAA_31) 		5 ILE A 165
GLY A 155
LEU A 194
LEU A 229
LEU A 138
 None
 1.05A 5nfjC-1g3rA:
2.4		 5nfjC-1g3rA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		5 LEU A  94
ALA A 120
ILE A  29
GLY A 100
LEU A 277
 None
 1.03A 5nfjC-1hkhA:
undetectable		 5nfjC-1hkhA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htw HI0065

(Haemophilus
influenzae) 		PF02367
(TsaE) 		5 LEU A  54
ILE A  57
GLY A  56
LEU A 111
LEU A  38
 None
 1.05A 5nfjC-1htwA:
undetectable		 5nfjC-1htwA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A 160
GLY A 157
THR A 126
SER A 125
LEU A 108
 None
None
NDP  A1501 (-4.0A)
None
None
 1.11A 5nfjC-1rpnA:
2.2		 5nfjC-1rpnA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		5 LEU B2015
GLY B1939
THR B1985
LEU B1872
ASN B1899
 None
 0.99A 5nfjC-1sddB:
undetectable		 5nfjC-1sddB:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  69
GLY A  76
LEU A 128
ASN A  73
LEU A 153
 None
 1.02A 5nfjC-1ua2A:
undetectable		 5nfjC-1ua2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjl ANNEXIN A2

(Homo sapiens) 		PF00191
(Annexin) 		5 LEU A 252
LEU A 170
LEU A 174
ASN A 258
LEU A 259
 None
 0.97A 5nfjC-1xjlA:
undetectable		 5nfjC-1xjlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a39 ENDOGLUCANASE I

(Humicola
insolens) 		PF00840
(Glyco_hydro_7) 		5 LEU A  13
ILE A  31
THR A 115
LEU A 389
LEU A 342
 None
 0.76A 5nfjC-2a39A:
undetectable		 5nfjC-2a39A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		5 ILE A 259
LEU A 217
LEU A 220
ASN A 277
LEU A 278
 None
 0.93A 5nfjC-2bbvA:
undetectable		 5nfjC-2bbvA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		5 ILE A 113
GLY A 114
ASP A 160
LEU A 176
LEU A 177
 None
None
MG  A 300 ( 3.6A)
None
None
 1.24A 5nfjC-2br4A:
undetectable		 5nfjC-2br4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ce9 TRANSDUCIN-LIKE
ENHANCER PROTEIN 1

(Homo sapiens) 		PF00400
(WD40) 		5 ILE A 533
GLY A 503
LEU A 545
LEU A 559
LEU A 524
 None
 1.03A 5nfjC-2ce9A:
undetectable		 5nfjC-2ce9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		5 ILE A  11
GLY A  10
LEU A  27
LEU A  29
ASN A   5
 None
 1.16A 5nfjC-2drwA:
undetectable		 5nfjC-2drwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		5 ILE A  11
GLY A  10
LEU A  29
ASN A   5
LEU A   4
 None
 1.07A 5nfjC-2drwA:
undetectable		 5nfjC-2drwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej9 PUTATIVE BIOTIN
LIGASE

(Methanocaldococcus
jannaschii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 LEU A 107
ILE A  96
GLY A 109
LEU A 142
LEU A 150
 None
None
BTN  A1301 (-3.4A)
None
None
 1.12A 5nfjC-2ej9A:
undetectable		 5nfjC-2ej9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcc ENDONUCLEASE V

(Escherichia
virus T4) 		PF03013
(Pyr_excise) 		5 ALA A  19
ILE A  85
LEU A  17
LEU A  12
LEU A  74
 None
 1.21A 5nfjC-2fccA:
undetectable		 5nfjC-2fccA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fez PROBABLE REGULATORY
PROTEIN EMBR

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C)
PF00498
(FHA)
PF03704
(BTAD) 		5 LEU A  15
ILE A  44
THR A 164
LEU A  19
LEU A 153
 None
 1.26A 5nfjC-2fezA:
undetectable		 5nfjC-2fezA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 ILE A 436
GLY A 437
ASP A 442
LEU A 386
LEU A 409
 None
 1.21A 5nfjC-2fknA:
undetectable		 5nfjC-2fknA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		5 LEU A 531
ILE A 564
GLY A 536
LEU A 502
LEU A 515
 None
 1.02A 5nfjC-2g28A:
undetectable		 5nfjC-2g28A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iee PROBABLE ABC
TRANSPORTER
EXTRACELLULAR-BINDIN
G PROTEIN YCKB

(Bacillus
subtilis) 		PF00497
(SBP_bac_3) 		5 LEU A 178
ILE A 177
GLY A 137
THR A 140
LEU A 130
 None
 1.24A 5nfjC-2ieeA:
undetectable		 5nfjC-2ieeA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		5 LEU A 186
ILE A 198
GLY A 195
LEU A  97
LEU A 145
 None
 1.24A 5nfjC-2pfvA:
undetectable		 5nfjC-2pfvA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb6 EXOPOLYPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 LEU A 322
ILE A 287
THR A 380
LEU A 320
LEU A 317
 None
None
SO4  A 501 ( 4.6A)
None
None
 0.88A 5nfjC-2qb6A:
undetectable		 5nfjC-2qb6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzq AXIN INTERACTOR,
DORSALIZATION
ASSOCIATED PROTEIN

(Danio rerio) 		PF14186
(Aida_C2) 		5 LEU A  66
ALA A 103
ILE A  64
ASP A 146
LEU A  61
 None
 1.22A 5nfjC-2qzqA:
undetectable		 5nfjC-2qzqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjn TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Vibrio cholerae) 		PF01614
(IclR) 		5 ALA A 106
ILE A 199
GLY A 198
SER A 144
LEU A  97
 None
 1.26A 5nfjC-3bjnA:
undetectable		 5nfjC-3bjnA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 LEU A 347
ILE A 348
ASP A 316
LEU A 394
LEU A 397
 None
None
PRO  A5119 (-3.7A)
None
None
 1.02A 5nfjC-3cmmA:
2.9		 5nfjC-3cmmA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq0 PUTATIVE
TRANSALDOLASE
YGR043C

(Saccharomyces
cerevisiae) 		PF00923
(TAL_FSA) 		5 ILE A 251
ASP A 212
LEU A  19
LEU A 264
MET A 254
 None
 1.17A 5nfjC-3cq0A:
undetectable		 5nfjC-3cq0A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		5 LEU A 124
ALA A 360
GLY A 126
THR A 129
LEU A 371
 None
None
None
FMT  A  11 (-3.6A)
None
 1.06A 5nfjC-3d5eA:
undetectable		 5nfjC-3d5eA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhw PRIMOSOMAL
REPLICATION PROTEIN
N

(Bordetella
parapertussis) 		no annotation 5 LEU A  26
GLY A  55
LEU A  28
LEU A  30
LEU A  90
 None
 1.16A 5nfjC-3fhwA:
undetectable		 5nfjC-3fhwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fok UNCHARACTERIZED
PROTEIN CGL0159

(Corynebacterium
glutamicum) 		no annotation 5 GLY A 273
LEU A  98
LEU A 104
LEU A  80
MET A  76
 None
 1.15A 5nfjC-3fokA:
3.7		 5nfjC-3fokA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL

(Gallus gallus;
Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF09165
(Ubiq-Cytc-red_N) 		5 ALA B  66
ILE I  68
GLY I  67
THR B 101
SER B 100
 None
 1.13A 5nfjC-3h1lB:
undetectable		 5nfjC-3h1lB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL

(Gallus gallus;
Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF09165
(Ubiq-Cytc-red_N) 		5 ILE I  68
GLY I  67
THR B 101
SER B 100
LEU B 144
 None
 1.22A 5nfjC-3h1lI:
undetectable		 5nfjC-3h1lI:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLY A 334
LEU A 321
LEU A 392
ASN A 258
LEU A 257
 None
 1.13A 5nfjC-3hdiA:
undetectable		 5nfjC-3hdiA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 SER A 264
LEU A 321
LEU A 392
ASN A 258
LEU A 257
 None
 1.10A 5nfjC-3hdiA:
undetectable		 5nfjC-3hdiA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		5 ILE A  87
GLY A  86
THR A 142
LEU A  26
LEU A  35
 None
 0.91A 5nfjC-3hzuA:
undetectable		 5nfjC-3hzuA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01423
(LSM)
PF01423
(LSM) 		5 ILE F  69
THR F  23
LEU G  53
LEU G 101
MET G  99
 None
 1.25A 5nfjC-3jb9F:
undetectable		 5nfjC-3jb9F:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Brucella
abortus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 325
ILE A 100
GLY A  99
ASP A 375
LEU A  92
 None
 1.20A 5nfjC-3k5pA:
undetectable		 5nfjC-3k5pA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A   8
GLY A  14
LEU A 291
LEU A 306
LEU A 446
 None
 0.89A 5nfjC-3nksA:
3.1		 5nfjC-3nksA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		5 LEU B 257
ILE B 238
LEU B 231
ASN B 210
LEU B 209
 None
 1.02A 5nfjC-3ojaB:
undetectable		 5nfjC-3ojaB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE

(Caulobacter
vibrioides) 		PF00348
(polyprenyl_synt) 		5 LEU A 293
ALA A 295
ILE A 288
GLY A 289
LEU A 297
 None
 0.97A 5nfjC-3oyrA:
undetectable		 5nfjC-3oyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phu RNA-DIRECTED RNA
POLYMERASE L

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02338
(OTU) 		5 ALA A 141
ILE A 131
GLY A 130
ASN A 143
LEU A 144
 None
 1.00A 5nfjC-3phuA:
undetectable		 5nfjC-3phuA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		5 LEU A 373
ILE A 414
GLY A 413
ASN A 377
LEU A 378
 None
 1.20A 5nfjC-3pt1A:
1.9		 5nfjC-3pt1A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzd MYOSIN-X

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4)
PF00788
(RA) 		5 LEU A1649
ILE A1645
GLY A1644
LEU A1676
LEU A1640
 None
 1.26A 5nfjC-3pzdA:
undetectable		 5nfjC-3pzdA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 233
GLY A 251
LEU A 212
LEU A 214
LEU A 224
 None
 1.15A 5nfjC-3qdqA:
undetectable		 5nfjC-3qdqA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmc UNCHARACTERIZED
PROTEIN

(Bdellovibrio
bacteriovorus) 		PF13487
(HD_5) 		5 LEU A 270
ALA A 282
ILE A 271
ASN A 302
LEU A 301
 None
 1.15A 5nfjC-3tmcA:
undetectable		 5nfjC-3tmcA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE

(Bacillus
subtilis) 		PF01884
(PcrB) 		5 LEU A  13
ILE A  37
GLY A  38
ASN A  16
MET A  51
 None
None
None
None
CL  A 710 ( 4.0A)
 1.00A 5nfjC-3vzxA:
undetectable		 5nfjC-3vzxA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		5 ALA A 153
GLY A 401
THR A 257
LEU A 142
LEU A 266
 None
None
HEM  A 501 (-3.5A)
None
None
 1.17A 5nfjC-3wecA:
undetectable		 5nfjC-3wecA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 413
ILE A 231
GLY A 406
THR A 102
LEU A 112
 None
 1.15A 5nfjC-3wmeA:
undetectable		 5nfjC-3wmeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		5 ILE A  67
GLY A 404
LEU A 317
LEU A 321
MET A  58
 None
 1.25A 5nfjC-4au2A:
undetectable		 5nfjC-4au2A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayi LIPOPROTEIN GNA1870
CCOMPND 7

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		5 LEU D 111
ILE D 105
GLY D 109
THR D 153
LEU D 113
 None
 1.24A 5nfjC-4ayiD:
undetectable		 5nfjC-4ayiD:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 ILE A 214
THR A  33
SER A  36
LEU A 285
LEU A 289
 None
 1.25A 5nfjC-4bejA:
undetectable		 5nfjC-4bejA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 ALA A 525
ILE A 532
GLY A 531
LEU A 523
LEU A 518
 None
 0.76A 5nfjC-4cgyA:
undetectable		 5nfjC-4cgyA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB

(Caulobacter
vibrioides) 		PF06723
(MreB_Mbl) 		5 LEU A 292
ALA A 317
ILE A 163
GLY A 295
LEU A 150
 None
 1.02A 5nfjC-4czeA:
undetectable		 5nfjC-4czeA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU A 329
ILE A 359
GLY A 337
LEU A 305
ASN A 356
 None
 0.97A 5nfjC-4ddwA:
2.5		 5nfjC-4ddwA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF01746
(tRNA_m1G_MT) 		6 LEU A 186
ILE A 205
GLY A 206
LEU A 232
LEU A 234
LEU A 246
 SAH  A 301 (-4.1A)
SAH  A 301 (-4.5A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.8A)
SAH  A 301 (-4.1A)
 0.39A 5nfjC-4fmwA:
26.2		 5nfjC-4fmwA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE

(Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		5 LEU A 310
ILE A 100
LEU A 122
LEU A 147
MET A 324
 None
 0.95A 5nfjC-4hw8A:
undetectable		 5nfjC-4hw8A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE

(Scaptomyza
nigrita) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A  83
ILE A  23
GLY A  78
LEU A  98
LEU A  70
 None
 1.26A 5nfjC-4i97A:
undetectable		 5nfjC-4i97A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Kitasatospora
aureofaciens;
Influenza A
virus) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		5 LEU A  94
ALA A 120
ILE A  29
GLY A 100
LEU A 275
 None
 1.02A 5nfjC-4iq4A:
undetectable		 5nfjC-4iq4A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Schizosaccharomyces
pombe) 		PF01746
(tRNA_m1G_MT) 		6 LEU A 183
ALA A 185
ILE A 202
GLY A 203
LEU A 229
LEU A 243
 None
None
ACY  A 302 ( 4.8A)
ACY  A 302 (-3.9A)
None
None
 0.61A 5nfjC-4jwgA:
24.7		 5nfjC-4jwgA:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Schizosaccharomyces
pombe) 		PF01746
(tRNA_m1G_MT) 		7 LEU A 183
ALA A 185
ILE A 202
GLY A 203
ASP A 207
LEU A 229
LEU A 243
 SAH  A 401 (-4.2A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.0A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
 0.54A 5nfjC-4jwhA:
25.9		 5nfjC-4jwhA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01746
(tRNA_m1G_MT) 		6 LEU A 186
ALA A 188
GLY A 206
ASP A 210
LEU A 232
LEU A 246
 SAH  A 302 (-4.2A)
SAH  A 302 (-3.5A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.0A)
SAH  A 302 (-3.8A)
SAH  A 302 (-4.2A)
 0.72A 5nfjC-4jwjA:
23.2		 5nfjC-4jwjA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01520
(Amidase_3) 		5 LEU A 140
ILE A 145
GLY A 144
LEU A 202
LEU A  57
 None
 1.17A 5nfjC-4lq6A:
undetectable		 5nfjC-4lq6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 THR A 621
LEU A 569
LEU A 605
LEU A 658
MET A 659
 None
 1.14A 5nfjC-4nurA:
undetectable		 5nfjC-4nurA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		5 ILE A 207
GLY A 208
THR A  43
LEU A 180
LEU A 215
 None
 1.08A 5nfjC-4ookA:
undetectable		 5nfjC-4ookA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou4 ALPHA/BETA HYDROLASE
FOLD-3 DOMAIN
PROTEIN

(Pseudomonas sp.
ECU1011) 		PF07859
(Abhydrolase_3) 		5 LEU A 208
GLY A 205
LEU A  91
LEU A  24
MET A 212
 None
 1.03A 5nfjC-4ou4A:
undetectable		 5nfjC-4ou4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)

(Agrobacterium
vitis) 		PF01547
(SBP_bac_1) 		5 ILE A  84
GLY A  85
SER A 301
LEU A 101
LEU A 104
 None
 1.18A 5nfjC-4ryaA:
undetectable		 5nfjC-4ryaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 309
GLY A 311
LEU A 284
ASN A 264
LEU A 263
 None
 1.09A 5nfjC-4u08A:
undetectable		 5nfjC-4u08A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wji PUTATIVE
CYCLOHEXADIENYL
DEHYDROGENASE AND
ADH PREPHENATE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02153
(PDH) 		5 ALA A   9
ILE A  20
GLY A  17
THR A  37
LEU A  68
 None
None
None
NAP  A 301 (-3.1A)
None
 1.22A 5nfjC-4wjiA:
undetectable		 5nfjC-4wjiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsr ALR3699 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 5 LEU B 273
ALA B 275
ILE B 232
GLY B 204
LEU B 191
 None
 1.08A 5nfjC-4xsrB:
3.5		 5nfjC-4xsrB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5f BACTERIOPHYTOCHROME

(Deinococcus
radiodurans) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 LEU A 103
THR A  60
LEU A  78
LEU A  74
LEU A 124
 None
 1.15A 5nfjC-4y5fA:
undetectable		 5nfjC-4y5fA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 SLIT AND NTRK-LIKE
PROTEIN 2

(Mus musculus) 		PF13855
(LRR_8) 		5 LEU B 165
ILE B 146
LEU B 139
ASN B 118
LEU B 117
 None
 1.09A 5nfjC-4y61B:
undetectable		 5nfjC-4y61B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 642
GLY A 614
LEU A 665
LEU A 633
MET A 638
 None
 1.10A 5nfjC-4yhcA:
undetectable		 5nfjC-4yhcA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		5 LEU A  97
ILE A 100
GLY A  99
THR A 142
SER A 133
 None
 1.25A 5nfjC-4yjiA:
undetectable		 5nfjC-4yjiA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 5 LEU A 710
ILE A 699
LEU A 660
LEU A 628
LEU A 692
 None
 1.13A 5nfjC-4zuzA:
undetectable		 5nfjC-4zuzA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aid MEP2

(Candida
albicans) 		PF00909
(Ammonium_transp) 		5 ALA A  86
THR A   8
LEU A  83
ASN A  98
LEU A  96
 None
 1.13A 5nfjC-5aidA:
undetectable		 5nfjC-5aidA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 LEU A 353
GLY A 348
LEU A 244
ASN A 441
LEU A 356
 None
 0.95A 5nfjC-5d6bA:
undetectable		 5nfjC-5d6bA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE

(Escherichia
coli) 		PF02574
(S-methyl_trans) 		5 LEU A  19
ILE A  67
LEU A  17
LEU A  10
LEU A 117
 None
 1.11A 5nfjC-5dmnA:
undetectable		 5nfjC-5dmnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		5 ILE A 317
GLY A 314
LEU A 256
LEU A 291
MET A 293
 None
 1.19A 5nfjC-5dneA:
undetectable		 5nfjC-5dneA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 LEU A  71
ILE A 103
LEU A 188
LEU A 172
LEU A  99
 None
 1.14A 5nfjC-5fi0A:
undetectable		 5nfjC-5fi0A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ALA C  47
ILE C 164
GLY C 165
SER C  32
LEU C  45
 None
 1.19A 5nfjC-5fmgC:
undetectable		 5nfjC-5fmgC:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq0 EPITHIOSPECIFIER
PROTEIN

(Arabidopsis
thaliana) 		no annotation 5 LEU B  42
ILE B  48
GLY B  40
SER B  25
ASN B  45
 None
 1.07A 5nfjC-5gq0B:
undetectable		 5nfjC-5gq0B:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7e RNA 2',3'-CYCLIC
PHOSPHODIESTERASE

(Deinococcus
radiodurans) 		PF02834
(LigT_PEase) 		5 ALA A 144
ILE A 151
GLY A 150
LEU A 142
LEU A 100
 None
 1.25A 5nfjC-5h7eA:
undetectable		 5nfjC-5h7eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2) 		PF13614
(AAA_31) 		5 LEU A 187
ILE A 186
LEU A 232
LEU A 227
LEU A 178
 None
 1.23A 5nfjC-5k5zA:
undetectable		 5nfjC-5k5zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE B 343
GLY B 344
THR B 179
SER B 180
LEU B 315
 None
GCP  B 401 (-3.5A)
GCP  B 401 (-3.6A)
GCP  B 401 ( 4.9A)
None
 1.21A 5nfjC-5l3rB:
undetectable		 5nfjC-5l3rB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		5 LEU A 190
ALA A 188
THR A 160
LEU A 186
LEU A 212
 None
 1.20A 5nfjC-5l9sA:
undetectable		 5nfjC-5l9sA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)

(Helicobacter
pylori) 		PF04085
(MreC) 		5 LEU C 120
GLY C 143
LEU C 243
LEU C 128
LEU C 114
 None
 1.13A 5nfjC-5lp5C:
undetectable		 5nfjC-5lp5C:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0j SWI5-DEPENDENT HO
EXPRESSION PROTEIN
2,SWI5-DEPENDENT HO
EXPRESSION PROTEIN 3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU D 121
ASP D 145
LEU D  55
LEU D  35
LEU D 113
 None
 1.26A 5nfjC-5m0jD:
undetectable		 5nfjC-5m0jD:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2

(Homo sapiens) 		no annotation 5 LEU A 791
LEU A 709
LEU A 713
ASN A 797
LEU A 798
 None
 1.05A 5nfjC-5n7fA:
undetectable		 5nfjC-5n7fA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo sapiens) 		no annotation 12 LEU A 290
ALA A 292
ILE A 309
GLY A 310
ASP A 314
THR A 321
SER A 322
LEU A 336
LEU A 338
ASN A 350
LEU A 351
MET A 356
 SAM  A 501 (-4.2A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.2A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.9A)
SAM  A 501 (-4.7A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.0A)
SAM  A 501 (-3.5A)
 0.19A 5nfjC-5nfjA:
33.2		 5nfjC-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1

(Homo sapiens) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF08412
(Ion_trans_N) 		5 LEU A 357
ALA A 383
ILE A 359
GLY A 360
THR A 375
 None
 1.03A 5nfjC-5u6oA:
undetectable		 5nfjC-5u6oA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		no annotation 5 ILE A  76
GLY A  78
LEU A  48
LEU A  19
LEU A  29
 None
 1.17A 5nfjC-5u8qA:
undetectable		 5nfjC-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		5 LEU A 986
THR A 912
SER A 911
LEU A1083
LEU A 979
 None
 1.07A 5nfjC-5ue8A:
undetectable		 5nfjC-5ue8A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE

(Sinorhizobium
meliloti) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 225
ILE A 248
GLY A 223
LEU A 253
LEU A 274
 None
 0.98A 5nfjC-5v72A:
2.1		 5nfjC-5v72A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		no annotation 5 GLY B 123
THR B  39
SER B  75
LEU B  64
LEU B 105
 MRD  B 301 (-3.4A)
None
None
None
None
 1.21A 5nfjC-5wybB:
undetectable		 5nfjC-5wybB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE

(Escherichia
coli) 		no annotation 5 ILE A 221
GLY A 220
LEU A 199
LEU A 230
LEU A 213
 None
 1.13A 5nfjC-5z03A:
2.4		 5nfjC-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anr COLIBACTIN
SELF-PROTECTION
PROTEIN CLBS

(Escherichia
coli) 		no annotation 5 LEU A 112
ILE A  57
THR A 103
LEU A 161
LEU A  52
 None
 1.22A 5nfjC-6anrA:
undetectable		 5nfjC-6anrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs9 STAGE III
SPORULATION PROTEIN
AB

(Bacillus
subtilis) 		no annotation 5 LEU A  64
ILE A  60
ASP A  77
LEU A 101
LEU A  71
 None
 1.12A 5nfjC-6bs9A:
undetectable		 5nfjC-6bs9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A  12
ILE A  11
GLY A   7
LEU A 156
LEU A 128
 None
 1.11A 5nfjC-6cc0A:
undetectable		 5nfjC-6cc0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 5 LEU B 194
ALA B 203
ILE B 206
ASP B 189
SER B 185
 None
 1.16A 5nfjC-6ckcB:
undetectable		 5nfjC-6ckcB:
undetectable