SIMILAR PATTERNS OF AMINO ACIDS FOR 5NFJ_A_SAMA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aux SYNAPSIN IA

(Bos taurus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 ILE A 319
GLY A 320
LEU A 184
LEU A 116
LEU A 405
 None
 0.94A 5nfjA-1auxA:
undetectable		 5nfjA-1auxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP2)

(Cricket
paralysis virus) 		no annotation 5 LEU B 126
THR B 125
ALA B 124
LEU B 122
LEU B  76
 None
 0.96A 5nfjA-1b35B:
undetectable		 5nfjA-1b35B:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bru ELASTASE

(Sus scrofa) 		PF00089
(Trypsin) 		5 LEU P  68
GLY P  79
LEU P  46
LEU P 120
LEU P 114
 None
 1.01A 5nfjA-1bruP:
undetectable		 5nfjA-1bruP:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 LEU B2309
THR B2308
ALA B2311
LEU B2313
LEU B2248
 None
 0.97A 5nfjA-1e6yB:
undetectable		 5nfjA-1e6yB:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 LEU A1399
ALA A1394
ILE A1402
GLY A1401
THR A1360
 None
 0.85A 5nfjA-1e6yA:
undetectable		 5nfjA-1e6yA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		5 ILE A 319
GLY A 143
LEU A 109
LEU A  89
MET A  91
 None
 1.01A 5nfjA-1eg1A:
undetectable		 5nfjA-1eg1A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		5 LEU A 309
GLY A 125
LEU A 147
LEU A 315
LEU A 128
 None
 0.93A 5nfjA-1eg1A:
undetectable		 5nfjA-1eg1A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehi D-ALANINE:D-LACTATE
LIGASE

(Leuconostoc
mesenteroides) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ILE A  44
GLY A  48
LEU A  88
LEU A 114
LEU A 105
 None
 0.99A 5nfjA-1ehiA:
3.2		 5nfjA-1ehiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2i PROTEASE I

(Pyrococcus
horikoshii) 		PF01965
(DJ-1_PfpI) 		5 LEU A   6
THR A   7
ALA A   8
ILE A 105
GLY A 102
 None
 0.93A 5nfjA-1g2iA:
2.3		 5nfjA-1g2iA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		5 ILE A 467
GLY A 415
THR A 132
LEU A 410
MET A 426
 None
None
GNP  A 701 (-4.7A)
None
None
 0.91A 5nfjA-1gl6A:
undetectable		 5nfjA-1gl6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htw HI0065

(Haemophilus
influenzae) 		PF02367
(TsaE) 		5 LEU A  54
ILE A  57
GLY A  56
LEU A 111
LEU A  38
 None
 1.01A 5nfjA-1htwA:
undetectable		 5nfjA-1htwA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		5 LEU A 323
ILE A 397
LEU A 285
LEU A 385
MET A 388
 None
 0.69A 5nfjA-1hxjA:
undetectable		 5nfjA-1hxjA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j32 ASPARTATE
AMINOTRANSFERASE

(Phormidium
lapideum) 		PF00155
(Aminotran_1_2) 		5 ILE A 387
GLY A 386
LEU A 313
LEU A 307
LEU A 380
 None
 1.00A 5nfjA-1j32A:
undetectable		 5nfjA-1j32A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsw L-ASPARTATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		6 THR A 271
ALA A 270
ILE A 235
THR A 144
ASN A 229
LEU A 267
 None
 1.49A 5nfjA-1jswA:
undetectable		 5nfjA-1jswA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 LEU A 109
ILE A 394
GLY A 395
LEU A 247
LEU A  34
 None
None
TRP  A 601 ( 4.1A)
None
TRP  A 601 (-3.6A)
 0.92A 5nfjA-1k0gA:
undetectable		 5nfjA-1k0gA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		6 LEU A  81
THR A  80
ILE A 446
LEU A  73
ASN A  76
LEU A 321
 None
None
None
None
NAD  A 900 (-3.3A)
NAD  A 900 (-4.3A)
 1.45A 5nfjA-1la2A:
2.8		 5nfjA-1la2A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns5 HYPOTHETICAL PROTEIN
YBEA

(Escherichia
coli) 		PF02590
(SPOUT_MTase) 		5 LEU A  72
ILE A 102
GLY A 103
LEU A 122
LEU A 127
 None
 0.80A 5nfjA-1ns5A:
5.9		 5nfjA-1ns5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poq YPM

(Yersinia
pseudotuberculosis) 		PF09144
(YpM) 		5 LEU A 112
THR A  20
ALA A  19
GLY A  23
LEU A 126
 None
 1.00A 5nfjA-1poqA:
undetectable		 5nfjA-1poqA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		5 LEU B2015
GLY B1939
THR B1985
LEU B1872
ASN B1899
 None
 0.99A 5nfjA-1sddB:
undetectable		 5nfjA-1sddB:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG

(Thermotoga
maritima) 		PF01628
(HrcA) 		5 LEU A 284
ILE A 279
GLY A 276
LEU A 253
LEU A 239
 None
 1.01A 5nfjA-1stzA:
undetectable		 5nfjA-1stzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su3 INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 ALA A 249
ILE A 256
GLY A 255
LEU A 235
LEU A 226
 None
 1.01A 5nfjA-1su3A:
2.0		 5nfjA-1su3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		5 ALA A  71
ILE A  45
GLY A  46
THR A  31
LEU A  66
 None
 1.00A 5nfjA-1tf1A:
undetectable		 5nfjA-1tf1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni) 		PF13580
(SIS_2) 		5 LEU A 180
ILE A 177
LEU A  35
LEU A  39
LEU A  64
 None
 0.99A 5nfjA-1tk9A:
undetectable		 5nfjA-1tk9A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  69
GLY A  76
LEU A 128
LEU A 125
ASN A  73
LEU A 153
 None
 1.28A 5nfjA-1ua2A:
undetectable		 5nfjA-1ua2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		5 THR A  48
ALA A  49
ILE A 228
GLY A  21
LEU A 108
 None
None
NAP  A3001 (-4.4A)
NAP  A3001 (-3.1A)
None
 0.83A 5nfjA-1vbjA:
undetectable		 5nfjA-1vbjA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Thermotoga
maritima) 		PF00248
(Aldo_ket_red) 		5 THR A  46
ALA A  47
ILE A 231
GLY A  20
LEU A 110
 None
None
NAP  A 300 (-4.7A)
NAP  A 300 (-3.4A)
None
 0.82A 5nfjA-1vp5A:
2.3		 5nfjA-1vp5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		6 LEU 1 363
THR 1 362
ILE 1 366
LEU 1 420
LEU 1 415
LEU 1 384
 None
 1.25A 5nfjA-1wao1:
undetectable		 5nfjA-1wao1:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		5 THR A 151
ILE A 129
GLY A 148
LEU A 153
ASN A 126
 None
 0.95A 5nfjA-1wczA:
undetectable		 5nfjA-1wczA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		6 LEU A 299
THR A 297
ALA A 294
ILE A 302
LEU A 315
MET A 316
 None
 1.28A 5nfjA-1wlsA:
undetectable		 5nfjA-1wlsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ALA A 159
GLY A 117
THR A 278
LEU A 161
LEU A  63
 None
 1.01A 5nfjA-1x9eA:
undetectable		 5nfjA-1x9eA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 THR A 133
ALA A 130
ILE A 138
LEU A 170
MET A 169
 None
SO4  A 329 ( 4.2A)
None
None
None
 0.96A 5nfjA-1xa0A:
undetectable		 5nfjA-1xa0A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhe AEROBIC RESPIRATION
CONTROL PROTEIN ARCA

(Escherichia
coli) 		PF00072
(Response_reg) 		5 ILE A 101
LEU A 117
LEU A 118
LEU A  80
MET A  78
 None
 1.02A 5nfjA-1xheA:
undetectable		 5nfjA-1xheA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjl ANNEXIN A2

(Homo sapiens) 		PF00191
(Annexin) 		5 LEU A 252
LEU A 170
LEU A 174
ASN A 258
LEU A 259
 None
 0.96A 5nfjA-1xjlA:
undetectable		 5nfjA-1xjlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN

(Homo sapiens) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU A 149
GLY A  11
LEU A 153
LEU A 157
LEU A   8
 None
GSP  A2466 (-3.1A)
None
None
None
 0.98A 5nfjA-1z5vA:
2.6		 5nfjA-1z5vA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a39 ENDOGLUCANASE I

(Humicola
insolens) 		PF00840
(Glyco_hydro_7) 		5 LEU A  13
ILE A  31
THR A 115
LEU A 389
LEU A 342
 None
 0.74A 5nfjA-2a39A:
undetectable		 5nfjA-2a39A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		5 ILE A 259
LEU A 217
LEU A 220
ASN A 277
LEU A 278
 None
 0.94A 5nfjA-2bbvA:
undetectable		 5nfjA-2bbvA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
DELTA CHAIN

(Torpedo
marmorata;
Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		6 LEU B 230
ILE B 233
GLY C 307
LEU B 263
LEU B 259
LEU B 237
 None
 1.47A 5nfjA-2bg9B:
undetectable		 5nfjA-2bg9B:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cnm MODIFICATION OF 30S
RIBOSOMAL SUBUNIT
PROTEIN S18

(Salmonella
enterica) 		PF00583
(Acetyltransf_1) 		5 LEU A  66
THR A  65
ALA A  64
ILE A  56
LEU A  41
 None
 0.88A 5nfjA-2cnmA:
undetectable		 5nfjA-2cnmA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		6 ILE A  11
GLY A  10
LEU A  27
LEU A  29
ASN A   5
LEU A   4
 None
 1.31A 5nfjA-2drwA:
undetectable		 5nfjA-2drwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		5 LEU A1059
ILE A1022
GLY A1020
THR A 872
LEU A1046
 None
 0.94A 5nfjA-2ec5A:
undetectable		 5nfjA-2ec5A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B

(Homo sapiens) 		PF14580
(LRR_9) 		5 LEU A  44
THR A  45
ALA A  46
ILE A  41
LEU A  70
 None
 0.99A 5nfjA-2ellA:
undetectable		 5nfjA-2ellA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		5 ILE A 775
THR A 947
LEU A 958
LEU A 959
LEU A 763
 None
 0.91A 5nfjA-2eyqA:
undetectable		 5nfjA-2eyqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f22 BH3987

(Bacillus
halodurans) 		PF05163
(DinB) 		5 LEU A  33
THR A  35
ILE A  30
LEU A  16
LEU A 126
 None
 0.93A 5nfjA-2f22A:
undetectable		 5nfjA-2f22A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		6 LEU A 123
ILE A 126
GLY A 125
LEU A  88
ASN A 116
LEU A 112
 None
 1.12A 5nfjA-2fgyA:
undetectable		 5nfjA-2fgyA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft0 TDP-FUCOSAMINE
ACETYLTRANSFERASE

(Escherichia
coli) 		no annotation 5 THR A 191
LEU A 193
LEU A  75
ASN A  78
LEU A 182
 None
 0.98A 5nfjA-2ft0A:
undetectable		 5nfjA-2ft0A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		5 GLY A  39
LEU A   4
LEU A   2
LEU A  57
LEU A  62
 None
 0.91A 5nfjA-2gmlA:
undetectable		 5nfjA-2gmlA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE

(Leishmania
major) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A 179
THR A 157
LEU A 185
LEU A 187
LEU A  21
 None
 0.87A 5nfjA-2hfsA:
undetectable		 5nfjA-2hfsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hy5 DSRH

(Allochromatium
vinosum) 		PF04077
(DsrH) 		5 THR C 451
ILE C 480
GLY C 479
LEU C 421
LEU C 457
 None
 0.92A 5nfjA-2hy5C:
undetectable		 5nfjA-2hy5C:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		6 LEU A 338
ILE A 335
LEU A 275
LEU A 283
LEU A 288
MET A 287
 None
 1.32A 5nfjA-2i0zA:
2.2		 5nfjA-2i0zA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		5 THR A 114
ALA A 111
ILE A 119
LEU A 148
MET A 147
 None
 0.85A 5nfjA-2i9uA:
undetectable		 5nfjA-2i9uA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j63 AP-ENDONUCLEASE

(Leishmania
major) 		PF03372
(Exo_endo_phos) 		5 GLY A 186
LEU A 163
LEU A 165
LEU A 151
MET A 155
 None
 0.99A 5nfjA-2j63A:
undetectable		 5nfjA-2j63A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd0 LRR REPEATS AND
UBIQUITIN-LIKE
DOMAIN-CONTAINING
PROTEIN AT2G30105

(Arabidopsis
thaliana) 		PF00240
(ubiquitin) 		6 LEU A  67
ILE A  13
GLY A  73
LEU A  37
LEU A  41
LEU A  26
 None
 1.26A 5nfjA-2kd0A:
undetectable		 5nfjA-2kd0A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ILE A 181
GLY A 182
LEU A  22
LEU A 357
LEU A 187
 None
 0.98A 5nfjA-2p8uA:
undetectable		 5nfjA-2p8uA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjp SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Escherichia
coli) 		PF09107
(SelB-wing_3) 		5 THR A 537
ALA A 538
ILE A 535
GLY A 534
LEU A 527
 None
 0.87A 5nfjA-2pjpA:
undetectable		 5nfjA-2pjpA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb6 EXOPOLYPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 LEU A 322
ILE A 287
THR A 380
LEU A 320
LEU A 317
 None
None
SO4  A 501 ( 4.6A)
None
None
 0.96A 5nfjA-2qb6A:
undetectable		 5nfjA-2qb6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq5 PROTEIN JUMONJI

(Mus musculus) 		PF01388
(ARID) 		5 LEU A 695
ILE A 646
GLY A 647
THR A 687
LEU A 678
 None
 0.88A 5nfjA-2rq5A:
undetectable		 5nfjA-2rq5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rt6 PRIMOSOMAL
REPLICATION PROTEIN
N''

(Escherichia
coli) 		PF07445
(PriC) 		5 LEU A  50
ALA A  48
GLY A  54
LEU A  30
LEU A  79
 None
 0.87A 5nfjA-2rt6A:
undetectable		 5nfjA-2rt6A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyd HEMOPHORE HASA

(Serratia
marcescens) 		PF06438
(HasA) 		6 LEU X 151
THR X 149
ALA X 146
ILE X 154
GLY X 153
LEU X 139
 None
None
None
None
ZN  X 208 (-4.3A)
None
 1.46A 5nfjA-2uydX:
undetectable		 5nfjA-2uydX:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyd HEMOPHORE HASA

(Serratia
marcescens) 		PF06438
(HasA) 		6 LEU X 151
THR X 149
ALA X 146
ILE X 154
LEU X 147
LEU X 139
 None
 1.35A 5nfjA-2uydX:
undetectable		 5nfjA-2uydX:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vge RELA-ASSOCIATED
INHIBITOR

(Homo sapiens) 		PF00023
(Ank)
PF14604
(SH3_9) 		5 ILE A 661
GLY A 660
LEU A 712
ASN A 685
LEU A 664
 None
 0.79A 5nfjA-2vgeA:
undetectable		 5nfjA-2vgeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		5 GLY A 322
LEU A 422
LEU A 409
LEU A 361
LEU A 359
 None
 0.84A 5nfjA-2vsaA:
undetectable		 5nfjA-2vsaA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 648
ILE A 676
GLY A 677
LEU A 627
MET A 632
 None
 0.85A 5nfjA-2wanA:
undetectable		 5nfjA-2wanA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsi FAD SYNTHETASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		5 LEU A  77
LEU A 102
LEU A 129
LEU A  70
LEU A  72
 None
 0.95A 5nfjA-2wsiA:
undetectable		 5nfjA-2wsiA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ILE A 218
GLY A 219
LEU A  59
LEU A 394
LEU A 224
 None
 0.96A 5nfjA-2wyaA:
undetectable		 5nfjA-2wyaA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		5 THR A 297
ILE A 302
LEU A 243
LEU A 258
LEU A 263
 None
 1.02A 5nfjA-2z6gA:
undetectable		 5nfjA-2z6gA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		6 LEU A 580
ILE A 579
GLY A 575
LEU A 527
LEU A 491
LEU A 517
 None
 1.49A 5nfjA-2z6hA:
undetectable		 5nfjA-2z6hA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococcus
jannaschii) 		PF04013
(Methyltrn_RNA_2) 		5 LEU X 136
ILE X 155
GLY X 156
LEU X 179
LEU X 184
 SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 (-4.4A)
SAM  X 501 (-4.3A)
 0.72A 5nfjA-3ai9X:
7.4		 5nfjA-3ai9X:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 THR A 571
ILE A 546
GLY A 545
LEU A 574
LEU A 566
 None
 1.02A 5nfjA-3b2dA:
undetectable		 5nfjA-3b2dA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 LEU A 573
ILE A 576
LEU A 569
LEU A 600
LEU A 595
 None
 0.99A 5nfjA-3b2rA:
undetectable		 5nfjA-3b2rA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 THR A  50
ALA A  51
ILE A 234
GLY A  23
LEU A 114
 None
 0.80A 5nfjA-3b3dA:
2.3		 5nfjA-3b3dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		5 LEU A 415
THR A 414
ILE A 412
LEU A 420
LEU A 427
 None
 0.95A 5nfjA-3bh1A:
undetectable		 5nfjA-3bh1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans) 		PF12697
(Abhydrolase_6) 		5 LEU A  90
ALA A  88
ILE A  95
GLY A  94
LEU A  86
 EDO  A 296 ( 3.9A)
None
None
None
None
 1.01A 5nfjA-3bwxA:
undetectable		 5nfjA-3bwxA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3f YVGN PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 THR A  50
ALA A  51
ILE A 230
GLY A  23
LEU A 110
 None
None
NDP  A   1 (-4.6A)
NDP  A   1 (-2.9A)
None
 0.84A 5nfjA-3d3fA:
undetectable		 5nfjA-3d3fA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ILE A 253
GLY A 252
LEU A 213
LEU A 215
LEU A 225
 None
 1.00A 5nfjA-3d3uA:
undetectable		 5nfjA-3d3uA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		5 LEU A 124
ALA A 360
GLY A 126
THR A 129
LEU A 371
 None
None
None
FMT  A  11 (-3.6A)
None
 1.00A 5nfjA-3d5eA:
undetectable		 5nfjA-3d5eA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbi SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		6 LEU A 308
ILE A 304
LEU A  64
LEU A  96
LEU A 149
MET A 124
 None
 1.22A 5nfjA-3dbiA:
undetectable		 5nfjA-3dbiA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgz THIOREDOXIN
REDUCTASE 2

(Mus musculus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 280
ILE A 173
GLY A 172
LEU A 204
LEU A 209
 None
 0.99A 5nfjA-3dgzA:
2.6		 5nfjA-3dgzA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 5 LEU A 718
ILE A 793
LEU A 716
LEU A 798
LEU A 637
 None
 0.91A 5nfjA-3f95A:
undetectable		 5nfjA-3f95A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		6 ALA P 304
ILE P   6
GLY P  13
THR P 297
LEU P 307
LEU P  31
 None
 1.39A 5nfjA-3fg2P:
4.0		 5nfjA-3fg2P:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE

([Candida]
glabrata) 		PF01507
(PAPS_reduct) 		5 LEU A  78
LEU A 103
LEU A 130
LEU A  71
LEU A  73
 None
 0.89A 5nfjA-3g5aA:
undetectable		 5nfjA-3g5aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 LEU A  11
ALA A   9
GLY A 335
THR A 137
LEU A 108
 FAD  A 444 (-4.2A)
None
FAD  A 444 (-3.3A)
FAD  A 444 ( 4.8A)
None
 0.99A 5nfjA-3g5sA:
2.3		 5nfjA-3g5sA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		5 THR A 345
ILE A 374
GLY A 373
LEU A 314
LEU A 312
 None
 1.00A 5nfjA-3geiA:
undetectable		 5nfjA-3geiA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 LEU A 335
GLY A 337
LEU B1191
ASN A 345
LEU A 346
 None
 0.92A 5nfjA-3h0gA:
undetectable		 5nfjA-3h0gA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		5 LEU A 262
THR A 263
ALA A 264
GLY A 187
LEU A  90
 None
 0.96A 5nfjA-3h9pA:
undetectable		 5nfjA-3h9pA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		5 ILE A  87
GLY A  86
THR A 142
LEU A  26
LEU A  35
 None
 0.90A 5nfjA-3hzuA:
undetectable		 5nfjA-3hzuA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		6 LEU A  72
ALA A  70
ILE A  77
GLY A  76
LEU A  68
LEU A 412
 None
 1.17A 5nfjA-3k7tA:
2.6		 5nfjA-3k7tA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0d GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bartonella
henselae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A  96
ILE A  17
GLY A  14
LEU A 120
MET A 324
 None
 0.87A 5nfjA-3l0dA:
3.2		 5nfjA-3l0dA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		5 LEU A 209
THR A 208
ILE A 212
LEU A 274
LEU A 269
 None
 1.01A 5nfjA-3ll8A:
undetectable		 5nfjA-3ll8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		6 LEU A  71
THR A  69
ILE A  67
LEU A 237
LEU A 234
LEU A 446
 None
None
None
None
None
FAD  A 500 (-3.7A)
 1.39A 5nfjA-3lovA:
2.9		 5nfjA-3lovA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1g PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Corynebacterium
glutamicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		6 LEU A 341
THR A 340
ALA A 170
GLY A 343
LEU A 173
LEU A  79
 None
 1.40A 5nfjA-3m1gA:
undetectable		 5nfjA-3m1gA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 LEU A 167
THR A 168
ALA A 169
LEU A 177
LEU A 108
 None
GOL  A 265 (-2.9A)
None
None
EDO  A 263 ( 4.9A)
 0.87A 5nfjA-3moyA:
undetectable		 5nfjA-3moyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		5 THR A 345
ILE A 343
GLY A 342
LEU A 353
LEU A 334
 None
 0.98A 5nfjA-3mpgA:
undetectable		 5nfjA-3mpgA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msx RHO
GTPASE-ACTIVATING
PROTEIN 20

(Homo sapiens) 		PF00620
(RhoGAP) 		5 ILE B 430
LEU B 414
LEU B 362
LEU B 387
MET B 383
 None
 0.92A 5nfjA-3msxB:
undetectable		 5nfjA-3msxB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3w RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		5 LEU A 115
ILE A 119
GLY A  43
LEU A  89
ASN A  36
 None
 0.98A 5nfjA-3n3wA:
undetectable		 5nfjA-3n3wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A   8
GLY A  14
LEU A 291
LEU A 306
LEU A 446
 None
 0.91A 5nfjA-3nksA:
3.5		 5nfjA-3nksA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0k ALDO/KETO REDUCTASE

(Brucella
abortus) 		PF00248
(Aldo_ket_red) 		5 THR A  65
ALA A  66
ILE A 247
GLY A  39
LEU A 125
 None
 0.87A 5nfjA-3o0kA:
undetectable		 5nfjA-3o0kA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE

(Caulobacter
vibrioides) 		PF00348
(polyprenyl_synt) 		5 LEU A 293
ALA A 295
ILE A 288
GLY A 289
LEU A 297
 None
 0.97A 5nfjA-3oyrA:
undetectable		 5nfjA-3oyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2

(Helicobacter
mustelae) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		6 LEU C 194
ALA C 212
ILE C 215
GLY C 216
LEU C 182
LEU C 506
 None
 1.40A 5nfjA-3qgkC:
undetectable		 5nfjA-3qgkC:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT

(Mycobacterium
marinum) 		PF00202
(Aminotran_3) 		5 LEU A 421
ILE A 378
THR A  69
LEU A 436
LEU A 353
 None
 0.99A 5nfjA-3r4tA:
undetectable		 5nfjA-3r4tA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		5 LEU A 125
ALA A  98
ILE A 128
GLY A 127
LEU A  94
 None
 0.99A 5nfjA-3r5bA:
undetectable		 5nfjA-3r5bA:
21.99